AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth CareGeographicals
Glomerular Filtration RateKidneyCreatinineKidney Function TestsKidney DiseasesCystatin CInulinRenal CirculationRenal Insufficiency, ChronicTechnetium Tc 99m PentetateIothalamic AcidAlbuminuriaKidney Failure, ChronicNatriuresisProteinuriaRenal InsufficiencyDiuresisKidney GlomerulusKidney TubulesBlood PressureRenal Plasma FlowDiabetic NephropathiesCystatinsNephronsFiltrationIohexolRadioisotope RenographySodiumBiological MarkersChromium RadioisotopesNephrectomyKidney TransplantationAcute Kidney InjuryGlomerular Filtration BarrierChronic DiseaseRisk FactorsHypertensionHemodynamicsFollow-Up StudiesMetabolic Clearance Ratep-Aminohippuric AcidRenal Artery ObstructionAminohippuric AcidsTime FactorsFurosemideReninProspective StudiesRenal Plasma Flow, EffectiveRetrospective StudiesKidney Tubules, ProximalHypertension, RenalDogsCohort StudiesCross-Sectional StudiesRenal ArteryUrineDisease ProgressionPuncturesPredictive Value of TestsAngiotensin-Converting Enzyme InhibitorsWater-Electrolyte BalanceAbsorptionNephrosclerosisUric AcidElectrolytesVascular ResistanceKidney CortexDiureticsKidney Concentrating AbilityPrognosisAntihypertensive AgentsPlasma VolumeHypertension, RenovascularAtrial Natriuretic FactorDiabetes Mellitus, Type 2Pentetic AcidBody Surface AreaTreatment OutcomeEdetic AcidCaptoprilReference ValuesLipocalinsBlood Urea NitrogenCardiovascular DiseasesEnalaprilRisk AssessmentUrodynamicsRenal DialysisPodocytesRenin-Angiotensin SystemSeverity of Illness IndexSodium ChlorideRegional Blood FlowAngiotensin IIOsmolar ConcentrationCardio-Renal SyndromeKidney Tubules, DistalPotassiumPrevalenceIodohippuric Acid
Estimate glomerular filtProgressionAlbuminLipoproteinProteinuria1.73AlbuminuriaChronic kidneyAcute kidneyCholesterolMortalityEquationReductionPrevalenceLowerUrinaryHepatorenalCardiovascularDeclineDosesParticipantsCystatinFractureRenal functionRiskDiabetesMiceSerum creatinineKidney FailureUltimatelyHypertensionSlowerCongestive heart fLevels of creatininePlasmaDiseaseStudiesCardiacExposureComplicationsKidneysHazardBlood pressureIncidenceEligibilityValues
Estimate glomerular filt1
Progression4
  • Clinically significant CKD is defined by an increased urinary albumin to creatinine ratio (UACR) and/or an estimated glomerular filtration rate (eGFR) lower than 60 mL/min/1.73 m 2 , as patients with these features are at much higher risk of disease progression [ 3 ]. (karger.com)
  • There are things we do to try to delay progression of kidney failure and people like this and there are certain things we need to start watching for like high potassium in patients so we now have low GFR. (aacc.org)
  • Individuals with CKD have disproportionately high rates of cardiovascular disease, progression to end-stage kidney disease requiring renal replacement therapy, and death [2-5] . (lww.com)
  • However, there are little data examining their long-term impact on ESRD progression rates. (nephcure.org)
Albumin5
  • Chronic kidney disease (CKD) is a chronic complication of diabetes, characterized by the presence of pathological quantities of urine albumin excretion and/or accompanied by a gradual deterioration in the glomerular filtration rate (GFR). (medsci.org)
  • After adjustment for risk factors and eGFR, an eightfold higher albumin- or protein-to-creatinine ratio was significantly associated with mortality (pooled HR 1.40) without evidence of significant heterogeneity and with ESRD (pooled HR 3.04), with significant heterogeneity between HR estimates. (ox.ac.uk)
  • We included all adult participants with available data on body mass index, estimated glomerular filtration rate (eGFR), urine albumin to creatinine ratio (UACR), and each of the MS components. (karger.com)
  • Aim: Rare genetic variants in the CUBN gene encoding the main albumin-transporter in the proximal tubule of the kidneys have previously been associated with microalbuminuria and higher urine albumin levels, also in diabetes. (lu.se)
  • An aggregated genetic risk score (GRS) was associated with higher urine albumin levels and eGFR creatinine . (lu.se)
Lipoprotein1
  • When each of the MS components was evaluated separately, elevated blood pressure and low high-density lipoprotein cholesterol were associated with both UACR and reduced eGFR, while elevated blood glucose and triglycerides were only associated with UACR. (karger.com)
Proteinuria3
1.734
  • Cutoff values of 15 spot-forming cells (SFCs)/200,000 peripheral blood mononuclear cells (PBMCs) for anti-IE, 40 SFCs/200,000 PBMCs for anti-pp65, and 46.6 mL/min/1.73 m2 for eGFR, respectively, predicted the risk of CMV infection with high sensitivity and specificity (area under the receiver operating characteristic curve >0.75). (unical.it)
  • Using a classification tree model, we identified as high-risk patients those showing anti-pp65 <42 SFCs/200,000 PBMCs and eGFR <62 mL/min/1.73 m2, as well as anti-pp65 ≥42 and anti-IE-1 <6.5 SFCs/200,000 PBMCs. (unical.it)
  • The rs141640975 variant was also associated with higher levels of eGFR creatinine-cystatin C (ml/min/1.73 m 2 , CKD-EPI 2021 , natural log-transformed) and lower circulating cystatin C levels. (lu.se)
  • bedside Schwartz formula) 60 mL/min/1.73m2 or higher. (who.int)
Albuminuria4
  • A uACR level of 30 mg/g or higher can be a sign of albuminuria . (kidney.org)
  • Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. (ox.ac.uk)
  • We studied here the independent associations of estimated glomerular filtration rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in individuals with chronic kidney disease (CKD). (ox.ac.uk)
  • The odds ratios comparing participants in the highest with the lowest quartiles of both cadmium and lead were 2.34 (95% CI: 1.72, 3.18) for albuminuria, 1.98 (95% CI: 1.27, 3.10) for reduced eGFR, and 4.10 (95% CI: 1.58, 10.65) for both outcomes. (cdc.gov)
Chronic kidney7
  • If you have diabetes, you have a higher risk for chronic kidney disease. (cdc.gov)
  • High creatinine levels can be a sign of acute kidney injury and/or chronic kidney disease . (kidney.org)
  • Given that there are more than 20 million Americans living with [chronic kidney disease], among whom the hazard of fluoridation would be highest in those with severe disease, further research is needed to assure water safety for all. (drbicuspid.com)
  • 10 µg/dL, increase the risk of chronic kidney disease (CKD), with decreased estimated glomerular filtration rate (eGFR) and creatinine clearance. (medscape.com)
  • Additional associations with diverse renal function measures (lower cystatin C and higher eGFR creatinine-cystatin C levels) and a CUBN-focused GRS further suggests an important role of CUBN in the future personalization of chronic kidney disease management in people without diabetes. (lu.se)
  • NCDs among 402 private-sector workers in Dakar, Senegal: high blood pressure (HBP), diabetes, obesity, and chronic kidney disease (CKD). (cdc.gov)
  • A representative sample of workers was randomly selected and screened during routine occupational health visits for high blood pressure (HBP), diabetes, obesity, and chronic kidney disease (CKD). (cdc.gov)
Acute kidney1
Cholesterol1
  • Older adults (age>65ys) with high CVD risk defined by two or more CVD risk factors smoking (S), high blood pressure (HBP), high total cholesterol , low HDL cholesterol , diabetes (DM), metabolic syndrome or previous cardiovascular event, were prospectively included at our ambulatory Endocrine Clinic. (bvsalud.org)
Mortality6
  • Patients with CKD are at a high risk of cardiovascular disease and mortality and are associated with increased treatment costs [ 2 ]. (medsci.org)
  • Hypothyroidism is associated with impaired glomerular filtration rate (GFR), a recognized cardiovascular disease (CVD), and mortality risk factor . (bvsalud.org)
  • In clinically stable asymptomatic patients with left ventricular dysfunction (ejection fraction ≤ 35 percent), VASOTEC decreases the rate of development of overt heart failure and decreases the incidence of hospitalization for heart failure (see CLINICAL PHARMACOLOGY , Heart Failure , Mortality Trials for details and limitations of survival trials ). (rxlist.com)
  • Its presence does not necessitate additional investigations or interventions, nor does it significantly influence mortality or hospitalization rates. (medpagetoday.com)
  • Conclusion In a cohort of high-risk adult patients undergoing cardiac surgery, there was an increase in postoperative AKI and 1-year mortality from the first to the third tertile of preoperative serum NGAL. (bmj.com)
  • Peripheral arterial disease has become a global health problem [4] , with high mortality and cardiovascular morbidity [4] . (researchsquare.com)
Equation2
Reduction2
  • Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal. (globalrph.com)
  • Those provided with both doses of raloxifene seemingly demonstrated slower reduction in glomerular filtration rate (GFR). (healthjockey.com)
Prevalence6
  • A higher prevalence of Kidney failure was found in ScH (80 vs. 46%, p=0.003) vs. euthyroid individuals. (bvsalud.org)
  • 0.001), higher prevalence of myocardial infarction ( p = 0.047), STEMI ( p = 0.045), atrial fibrillation ( p = 0.047), and anemia: lower erythrocytes count ( p = 0.037), hemoglobin concentration ( p = 0.034), and hematocrit ( p = 0.046), compared to "non-remodeled phenotype. (karger.com)
  • The high prevalence of CVD in Iranian patients with type 2 diabetes underscores the importance of better detection and treatment of metabolic risk factors of CVD in these patients. (who.int)
  • Studies have suggested enhanced reabsorption and reduced secretion of uric acid, explaining the high prevalence of gout. (medscape.com)
  • According to an epidemiological study in China, the standardized prevalence rate of PAD was 6.6%, the awareness rate was 4.9%, the treatment rate was 1.9%, and the control rate was 0.2% [3] . (researchsquare.com)
  • Similarly, anaemia is a frequent comorbidity in HF, although prevalence rates vary, depending on the definition used and populations studied [ 4 ]. (springer.com)
Lower10
  • In older adults with high CVD risk , ScH is associated with lower renal function, and this relationship is present regardless of other cardiometabolic risk factors . (bvsalud.org)
  • The current transplant waitlist requirement for patients regardless of race is eGFR 20 ml/min, significantly lower than 90 ml/min or higher, which is considered normal. (scienceblog.com)
  • Fluoride levels were higher in the blood of U.S. adolescents with lower renal function, according to a study published June 7 in Environmental Research . (drbicuspid.com)
  • Exposure to levels of fluoride found commonly in drinking water in the United States result in significantly higher levels of fluoride in blood in those with lower kidney function," wrote the authors, led by Dr. John Danziger of Beth Israel Deaconess Medical Center at Harvard Medical School in Boston. (drbicuspid.com)
  • Our analysis suggests higher levels of plasma fluoride accumulation in those with lower renal function is of public health concern," they wrote. (drbicuspid.com)
  • With lead nephropathy, uric acid excretion is substantially lower than would be expected on the basis of the patient's glomerular filtration rate (GFR). (medscape.com)
  • 10% decline in eGFR on dapagliflozin were older age, lower eGFR, higher ejection fraction, and type 2 diabetes. (gla.ac.uk)
  • Here we show in two large, unrelated cohorts that decline in kidney function associated with APOL1 risk variants was dependent on plasma suPAR levels: APOL1-related risk was attenuated in patients with lower suPAR, and strengthened in those with higher suPAR levels. (nephcure.org)
  • Researchers found that lower estimated glomerular filtration rate levels were associated with higher plasma concentrations of phosphorylated and unphosphorylated tau peptides. (medscape.com)
  • The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associated with the presence of kidney dysfunction, and to examine whether higher fluid intake is associated with lower circulating copeptin and thereby preserves kidney health among sugarcane workers exposed to hot conditions. (cdc.gov)
Urinary1
  • Myeloperoxidase-anti-neutrophil cytoplasmic antibody associated vasculitis patients with predominant urinary isomorphic red blood cells at diagnosis had more severe clinical manifestations and a higher risk of poor renal outcomes. (springer.com)
Hepatorenal1
  • Hepatorenal syndrome is diagnosed when a creatinine clearance rate of less than 40 mL/min is present or when a serum creatinine level of greater than 1.5 mg/dL, a urine volume of less than 500 mL/day, and a urine sodium level of less than 10 mEq/L are present. (medscape.com)
Cardiovascular3
  • Low glomerular filtration rate values are associated with higher TSH in an elderly population at high cardiovascular disease risk. (bvsalud.org)
  • Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. (globalrph.com)
  • Current findings emphasize that higher AST / ALT level can be biomarkers for cardiovascular diseases. (researchsquare.com)
Decline1
  • Background: In a post hoc analysis, the frequency of occurrence of an early decline ("dip") in estimated glomerular filtration rate (eGFR) after initiation of dapagliflozin, and its association with outcomes, was evaluated in patients with heart failure and reduced ejection fraction (HFrEF) randomized in the Dapagliflozin and Prevention of Adverse outcomes in Heart Failure trial. (gla.ac.uk)
Doses1
  • In Starting dose is a risk factor for allopurinol hypersensitivity syndrome: a proposed safe starting dose of allopurinol , Stamp and colleagues compared allopurinol doses and estimated glomerular filtration rate (GFR). (goutpal.com)
Participants1
Cystatin3
  • Doctor, your study looked at both cystatin C and creatinine for estimating glomerular filtration rates. (aacc.org)
  • Well certainly creatinine and cystatin C, they both work to measure GFR because they are freely filtered and then they also have a relatively constant rate of production so that at a given steady state the blood level will reflect what your kidney function is. (aacc.org)
  • The researchers looked at two new eGFR formulas that do not include a race adjustment: one used creatinine alone - the standard test - and the second looked at both creatinine and cystatin, a newer blood test that is thought to improve accuracy when kidney function is at higher ranges. (scienceblog.com)
Fracture1
  • Although SGLT2i are associated with abnormalities of bone and mineral metabolism, they have not been linked to a higher risk of fracture among patients with CKD. (lww.com)
Renal function4
  • As a result, one should look at the calculated eGFR (estimated glomerular filtration rate), as reported from the measured serum creatinine, to assess renal function. (medscape.com)
  • In the study, higher plasma fluoride in children ages 12 to 19 was associated with an increase in water fluoride levels and a decrease in renal function. (drbicuspid.com)
  • In comparison, water fluoridation concentration was linked with a 0.20 umol/L plasma fluoride level in those with the highest renal function, they wrote. (drbicuspid.com)
  • Page 2 of 7 health care provider does routinely measure blood pressure and weight, other factors such as renal function and obesity are not assessed, even in high-risk people. (cdc.gov)
Risk15
  • We aimed to determine the relationship of elevated TSH with GFR in an elderly population at high CVD risk . (bvsalud.org)
  • people with renal artery stenosis may be at higher risk. (wikipedia.org)
  • people who are also taking spironolactone or eplerenone may be at higher risk. (wikipedia.org)
  • Conclusion: Monitoring CMV-specific T-cell responses and eGFR in the first month post transplant can identify patients at high risk of CMV infection, for whom preemptive antiviral therapy is recommended. (unical.it)
  • Given that the lifetime risk is so high, we first investigated whether a proportional hazards model in time-to-event analysis yields a better fit than logistic regression. (elifesciences.org)
  • However, previous studies on vascular interventions in patients with TA have shown inconsistent results, ranging from a high risk of restenosis to good longterm efficacy and patency, although open revascularization resulted in superior patency rates compared with endovascular intervention 4 , 6 , 9 , 10 , 11 . (jrheum.org)
  • They recommend a specific gene, HLA-B*5801 should be tested for in high-risk groups prior to starting allopurinol. (goutpal.com)
  • The panel recognized that white people did not fall into the high-risk category. (goutpal.com)
  • Thus, it is expected that by addressing modifiable risk factors clinical practitioners especially in surgical departments would be able to optimize the clinical management for those patients identified with high risk of developing postoperative delirium (POD). (biomedcentral.com)
  • 20%), or high (≥20%) 10-year risk. (acc.org)
  • A higher AST/ALT ratio (≥1.65) was associated with PAD risk in Chinese adults with hypertension. (researchsquare.com)
  • The presented results suggested that AST / ALT may help us highlight patients who are at high risk of vascular endpoints. (researchsquare.com)
  • All high-risk patients (FRS 10-year risk ≥20%), and patients with a statin-indicated condition (above) with the following caveat regarding CKD: treat those age ≥50 years and not on dialysis. (therapeuticresearch.com)
  • male ≥50 years of age or female ≥60 years of age with one additional risk factor (low HDL, impaired glucose tolerance, high waist circumference, smoker, hypertension), or presence of a risk modifier (e.g. (therapeuticresearch.com)
  • [ 6-9 ] For instance, low 25(OH)D was associated with a high risk of coronary heart disease or reduced bone mineral density in whites, but not in blacks. (medscape.com)
Diabetes3
  • The aim of this study was therefore to evaluate the plasma levels of FABP3 at different stages of estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM). (medsci.org)
  • To test this hypothesis, Olfr1393 wild-type (WT) and knockout (KO) mice were challenged with a high-fat diet to induce early-stage type 2 diabetes. (nih.gov)
  • Vasotec (enalapril maleate) is an ACE ( angiotensin converting enzyme ) inhibitor used to treat high blood pressure ( hypertension ), congestive heart failure , kidney problems caused by diabetes , and to improve survival after a heart attack . (rxlist.com)
Mice1
  • After 16 wk on the high-fat diet, fasting blood glucose values were increased and glucose tolerance was impaired in the male WT mice. (nih.gov)
Serum creatinine3
Kidney Failure1
  • The earlier a patient is waitlisted prior to kidney failure, the higher priority the patient has in getting a transplant and the more likely a patient could potentially avoid dialysis," said first author Elaine Ku , MD, of the UCSF Division of Nephrology and of the Department of Epidemiology and Biostatistics . (scienceblog.com)
Ultimately2
  • An earlier study , in which Ku was the first author, found that registering Black patients on the waitlist at a slightly higher level of kidney function than whites might ultimately improve racial equity in transplant access. (scienceblog.com)
  • Chronic lead poisoning may also result in lead nephropathy, which is characterized by tubulointerstitial fibrosis, tubular atrophy, glomerular sclerosis, and ultimately diminished glomerular filtration rate (GFR). (medscape.com)
Hypertension2
  • Hypertension, or abnormally high blood pressure, is common in the US, affecting approximately 45% of adults ( Centers for Disease Control and Prevention, National Center for Health Statistics, 2018 ). (elifesciences.org)
  • However, in all three groups, there was an inflection point in middle age after which the probability of having hypertension increased at a slower rate ( Figure 2 ). (elifesciences.org)
Slower1
  • Women on the 60 mg raloxifene dose reported a statistically slower yearly rate of elevation in blood creatinine level. (healthjockey.com)
Congestive heart f1
Levels of creatinine2
Plasma2
  • For those in the quartile with the lowest kidney function, a 1 mg/L higher drinking water fluoride concentration was associated with a 0.35 umol/L higher plasma fluoride level. (drbicuspid.com)
  • These findings suggest that plasma measures of the phosphorylated to unphosphorylated tau ratios are more accurate than p-tau forms alone, as they correlate less with individual difference in glomerular filtration rate or impaired kidney function. (medscape.com)
Disease2
Studies2
  • This phase I trial studies the side effects and the best dose of wild-type reovirus (viral therapy) when given with sargramostim in treating younger patients with high grade brain tumors that have come back or that have not responded to standard therapy. (mayo.edu)
  • Mechanistically, surface plasmon resonance studies identified high-affinity interactions between suPAR, APOL1 and αvβ3 integrin, whereby APOL1 protein variants G1 and G2 exhibited higher affinity for suPAR-activated avb3 integrin than APOL1 G0. (nephcure.org)
Cardiac1
  • Higher median FI were seen in orthopedic than cardiac surgery patients (0.28 versus 0.23), and in women (0.28 versus 0.25 in men). (biomedcentral.com)
Exposure1
  • Environmental cadmium and lead exposures are widespread, and both metals are nephrotoxic at high exposure levels. (cdc.gov)
Complications1
  • Hyperglycemic rats showed diabetic complications including polydipsia, polyuria, glycosuria, renal hypertrophy and increased glomerular filtration rate. (nih.gov)
Kidneys3
  • Glomerular filtration rate (GFR) is a test used to check how well the kidneys are working. (ucsfhealth.org)
  • The estimated glomerular filtration rate (eGFR) is an estimate of how well your kidneys are removing waste products from the blood. (kidney.org)
  • The kidneys are responsible for filtering waste products out of the blood and exporting them via the urine, and high levels of C3 can become lodged into the glomeruli of the kidney and prevent this filtering function. (rareshare.org)
Hazard1
  • In all groups, baseline hazard rates increased until nearly 60 years of age and then decreased but did not reach zero. (elifesciences.org)
Blood pressure1
  • For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). (globalrph.com)
Incidence1
  • In hospital delirium incidence rates range from 10-82%, with highest rates on ICU and postoperative wards [ 2 ]. (biomedcentral.com)
Eligibility1
Values2
  • Theoretically, low values may also reflect increased glomerular filtration rates (GFRs). (medscape.com)
  • Current equations have limited precision and systematically underestimate measured GFR at higher values. (globalrph.com)