• subunit
  • Crystallographic insights into sodium-channel odulation by the ?4 subunit. (jhmi.edu)
  • Removal of the NH2-terminal domain, either by trypsin or molecular biology techniques, results in a b-subunit that does not inactivate the channel, so the currents are sustained and more suitable for kinetic and Ca2+ sensitivity comparisons. (epfl.ch)
  • Molecular
  • Our goal is to address fundamental questions on the identities of the Nav channel signaling complex components and to resolve their mechanisms of action at the molecular level. (jhmi.edu)
  • The evidence we have from molecular biology, together with the toxic nature of prolonged high Ca2+ levels inside cells, argues strongly that primeval cells must have had Ca2+ pumps to keep their free intracellular Ca2+ low, setting the scene for the ' calcium pressure' across then plasma membrane to be exploited to act as the source for cell activation. (heavenforum.org)
  • calcium
  • All biological cells have a low cytosolic (liquid found inside Cells ) calcium concentration, can and must keep this even when the free calcium outside is up to 20,000 times higher concentrated! (heavenforum.org)
  • BMS-204352 (BMS) was developed as a neuroprotective drug for disease conditions such as ischemic stroke and it has been shown to have a protective effect, due to activation of big-conductance calcium-activating potassium (BKCa) channels (Gribkoff et al. (epfl.ch)
  • Various pharmaceutical companies developed synthetic molecules activating these channels in order to prevent excessive neurotoxic calcium entry in neurons . (epfl.ch)