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Hidradenitis SuppurativaAcne VulgarisPurpura FulminansSweat Gland DiseasesHidradenitisPropionibacterium acnesDermatologic AgentsPurpura, Schoenlein-HenochApocrine GlandsTabooSebumSuppurationIsotretinoinPurpuraBenzoyl PeroxideAcquired Hyperostosis SyndromePyoderma GangrenosumSacroiliitisFolliculitisSebaceous GlandsProtein C DeficiencyProteus vulgarisIce CreamPerineumMite InfestationsAdministration, TopicalKeratolytic AgentsPropionibacteriumProtein CRosaceaDesulfovibrio vulgarisOintmentsAxillaMeningococcal InfectionsCopyrightCosmetic TechniquesLipDermatologyComputer SecurityCommunicationInjections
ConglobataSuppurativaKeloidalis nuchaePathophysiologySebumNeonatalScarringFollicularVariantsPyodermaComedonesBenzoyl peroxideLesionsCystsInfantileSeverityMedscapeRosaceaInflammationNodulesPustular acnePediatricSymptomsSyndromeForm of acnePatients with acnePomadePapules and pustulesSevere inflammatory acneSebocytesInterplayAcneiformNodularPustulesAdolescentsPyogenicTherapiesAlgorithmOccurMildCommonlyTreatmentSkinSkinned patientsSecondaryGeneticFace
Conglobata18
  • Acne conglobata is another form of severe, nodulocystic acne. (dermatologyadvisor.com)
  • Acne conglobata is included in the follicular occlusion tetrad along with hidradenitis suppurativa, dissecting cellulitis of the scalp and pilonidal cysts. (dermatologyadvisor.com)
  • Acne conglobata (AC) is an uncommon and unusually severe form of acne characterized by burrowing and interconnecting abscesses and irregular scars (both keloidal and atrophic), often producing pronounced disfigurement. (medscape.com)
  • [ 1 ] Acne conglobata may develop as a result of a sudden deterioration of existing active papular or pustular acne, or it may occur as the recrudescence of acne that has been quiescent for many years. (medscape.com)
  • Pyogenic arthritis, pyoderma gangrenosum , and acne conglobata are clinically distinct inflammatory disorders that may be seen rarely in the same patient in a syndrome known as PAPA Syndrome. (medscape.com)
  • It was originally reported in a 3-generation kindred with autosomal dominant transmission The PAPA syndrome is related to the triad of pyoderma gangrenosum, acne conglobata, and suppurative hidradenitis, known as the PASH syndrome. (medscape.com)
  • [ 2 ] The simultaneous presence of pyoderma gangrenosum, acne conglobata, suppurative hidradenitis, and seronegative spondyloarthritis has been suggested as a new linkage with the designation being PASS syndrome. (medscape.com)
  • [ 3 ] Micali and Lacarrubba adroitly observed that secondary comedones in acne conglobata may correlate with double-ended pseudocomedones in hidradenitis suppurativa. (medscape.com)
  • Acne conglobata can produce pronounced disfigurement. (medscape.com)
  • individuals with acne conglobata are often ostracized, or they may feel excluded. (medscape.com)
  • Acne conglobata has also been responsible for anxiety and depression in many patients. (medscape.com)
  • The therapy of choice for acne conglobata (AC) includes isotretinoin 0.5-1 mg/kg for 4-6 months. (medscape.com)
  • The primary causes of acne conglobata remain unknown. (medscape.com)
  • Chromosomal defects in the XYY karyotype may be responsible for severe forms of acne conglobata. (medscape.com)
  • however, 1 patient with the unusual combination of Klinefelter syndrome and acne conglobata has been reported. (medscape.com)
  • The HLA-A and HLA-B phenotypes were evaluated in 65 patients with acne conglobata, in whom antigen frequencies were found to be normal. (medscape.com)
  • Acne Conglobata -- 16. (nshealth.ca)
  • In severe cases (acne conglobata ), follicular ruptures due to comedone components lead to pronounced inflammatory processes deep into the dermis, with furunculoid, often confluent, painful abscesses (acne conglobata ). (altmeyers.org)
Suppurativa2
Keloidalis nuchae1
  • Other acne-related Medscape articles include Acne Fulminans , Acne Keloidalis Nuchae , Acne Vulgaris , and Acneiform Eruptions . (medscape.com)
Pathophysiology1
Sebum3
  • Papules and pustules occur when C. acnes colonizes the closed comedones, breaking down sebum into free fatty acids that irritate the follicular epithelium and eliciting an inflammatory response by neutrophils and then lymphocytes, which further disrupts the epithelium. (msdmanuals.com)
  • As a result of the plug-like closure of the follicular excretory duct and simultaneous seborrhea, the sebum is backed up into the follicular gland unit = comedo (acne comedonica ). (altmeyers.org)
  • 2017). Free oleic acid in acne sebum promotes hyperconolization of the site germ P. acnes. (altmeyers.org)
Neonatal2
  • Neonatal acne (acne occurring from birth to about 3 months) affects about 20% of healthy newborns and typically presents as small inflamed papules and pustules on the cheeks and nasal bridge. (dermatologyadvisor.com)
  • Neonatal and Infantile Acne -- 52. (nshealth.ca)
Scarring8
Follicular1
  • Follicular pustules (acne papulopustulosa ) develop due to purulent melting. (altmeyers.org)
Variants2
  • It is organized into sections by subtype of condition (e.g., infections, genetic syndromes, medication-caused) and includes a section of variants of acne that may be misdiagnosed. (nshealth.ca)
  • Variants of Acne Vulgaris -- 15. (nshealth.ca)
Pyoderma1
Comedones4
  • The presence of inflammatory papules and pustules along with comedones, involving the face, chest, shoulders and back, are hallmarks of acne vulgaris. (dermatologyadvisor.com)
  • Lesions of acne include open and closed comedones. (dermatologyadvisor.com)
  • Acne vulgaris is the formation of comedones, papules, pustules, nodules, and/or cysts as a result of obstruction and inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). (msdmanuals.com)
  • Closed comedones are the precursor lesions to inflammatory acne. (msdmanuals.com)
Benzoyl peroxide1
  • Benzoyl peroxide products are also effective against C acnes , and bacterial resistance to benzoyl peroxide has not been reported. (medscape.com)
Lesions11
  • The clinically inflammatory lesions seen in acne vary from papules and pustules to more severe nodules and nodulocystic lesions (Figure 3). (dermatologyadvisor.com)
  • Erosive crusting lesions on the back of a young male with acne fulminans. (rooksdermatology.com)
  • Moderate to severe inflammatory acne including a mixture of non‐inflammatory and inflammatory lesions with seborrhoea. (rooksdermatology.com)
  • elevated levels of IGF-1 (see insulin-like growth factor ) correlate with the total number of acne lesions. (altmeyers.org)
  • Acne lesions may occasionally need to be physically removed because they are at risk of causing anacne scar, or they are in a particularly unsightly location. (dermatologistsnyc.com)
  • Incision and drainage may be required for cases of severe acne in order to treat deep acne lesions that have developed into cysts. (dermatologistsnyc.com)
  • Acne surgery is the term which refers to several surgical approaches for removing acne lesions. (dermatologistsnyc.com)
  • R emoval of non-red or non-inflamed acne lesions differs from that of red or inflamed lesions. (dermatologistsnyc.com)
  • However, the rare, large, deep acne lesions may not respond to cortisones and may have to be incised. (dermatologistsnyc.com)
  • Cutting open or incising large acne lesions is always done by the dermatologist. (dermatologistsnyc.com)
  • Flat lesions are more readily camouflaged with makeup or a tinted acne lotion. (dermatologistsnyc.com)
Cysts2
  • Nodules and cysts are other manifestations of inflammatory acne. (msdmanuals.com)
  • Acne cysts usually shrink after 12 hours to 3 days after the injection. (dermatologistsnyc.com)
Infantile1
  • Infantile acne generally occurs between 3 and 6 months of age, lasting throughout the first and into the second year of life. (dermatologyadvisor.com)
Severity3
  • The presence of nodules often correlates with greater acne severity. (dermatologyadvisor.com)
  • The grade and severity of the acne help in determining which of the following treatments, alone or in combination, is most appropriate. (medscape.com)
  • In Germany, 70-80% of all adolescents show signs of acne vulgaris of varying severity. (altmeyers.org)
Medscape1
  • Fast Five Quiz: Acne Practice Essentials - Medscape - Jan 15, 2020. (medscape.com)
Rosacea1
Inflammation1
  • Treatment of acne fulminans is aimed at controlling the inflammation quickly while preventing an isotretinon-associated flare (see treatment).Typically oral corticosteroids are started with a gradual introduction of isotretinoin. (dermatologyadvisor.com)
Nodules1
  • The acne appears abruptly over the face and upper body with uniform papules and friable nodules that can coalesce, suppurate and bleed. (dermatologyadvisor.com)
Pustular acne1
Pediatric2
  • Pediatric Dermatoses Mimicking Acne -- 49. (nshealth.ca)
  • Contains new and updated tables on psoriasis co-morbidities, genetic syndrome classifications, acne therapies, pediatric histiocytoses, PHACE syndrome criteria, HSV therapies and juvenile dermatomyositis. (medicscenter.com)
Symptoms1
Syndrome1
Form of acne2
  • Acne fulminans is a severe, eruptive form of acne that primarily occurs in teenaged boys, ages 13-16. (dermatologyadvisor.com)
  • This inflammatory form of acne may be associated with necrotizing scleritis, a potentially sight‐threatening subtype of anterior scleritis sometimes seen with underlying inflammatory disorders. (medscape.com)
Patients with acne1
  • Because antibiotic resistance is a concern, topical or oral antibiotics should not be used as monotherapy in patients with acne . (medscape.com)
Pomade1
Papules and pustules1
Severe inflammatory acne1
Sebocytes1
Interplay1
  • Acne arises from a complex interplay of various pathogenetic factors. (altmeyers.org)
Acneiform2
Nodular2
Pustules1
  • Scattered pustules appear on the face of this person with acne. (msdmanuals.com)
Adolescents1
  • Acne is an exceptionally common disorder in adolescents, affecting up to 85% of 12-24-year olds. (dermatologyadvisor.com)
Pyogenic1
Therapies3
Algorithm1
Occur1
  • Acne is the term for pimples and complexion problems which commonly occur in teenagers and frequently continue into adulthood. (dermatologistsnyc.com)
Mild1
  • Current consensus recommends a combination of topical retinoid and antimicrobial therapy as first-line therapy for almost all patients with mild acne. (medscape.com)
Commonly2
  • Dermatologists commonly treat acne, which affects 40 to 50 million Americans each year and about 85 percent of all patients at some point in their lives. (nshealth.ca)
  • Women are more commonly affected by late acne or acne tarda than men. (altmeyers.org)
Treatment4
  • Treatment should be directed toward the known pathogenic factors involved in acne. (medscape.com)
  • Spironolactone may also be used in the treatment of acne. (medscape.com)
  • Cortisone injection therapy is useful as the sole method of treatment of intermittent acne (acne that only flares from time to time). (dermatologistsnyc.com)
  • It is helpful as an additional treatment when acne is not adequately suppressed with antibiotics. (dermatologistsnyc.com)
Skin2
  • Acne is the most common skin disease in the US and affects 80% of the population at some point in life. (msdmanuals.com)
  • Acne is only a skin problem, and does not affect your general health. (dermatologistsnyc.com)
Skinned patients1
  • In darker skinned patients, post-inflammatory hyperpigmentation is often present and can last for several months after resolution of inflammatory acne, and in rare instances may be permanent. (dermatologyadvisor.com)
Secondary1
Genetic1
Face3
  • Acne develops on the face and upper trunk. (msdmanuals.com)
  • Associations between acne exacerbations and inadequate face washing, masturbation, and sex are unfounded. (msdmanuals.com)
  • The Leeds photometric acne grading scale used to assess the face and trunk. (rooksdermatology.com)