Yet, in all groups, epibatidine-induced strip contractions were similarly inhibited by mecamylamine and hexamethonium (ganglionic nicotinic receptor antagonists), SR 16584 (α3β4 neuronal nicotinic receptor antagonist), atracurium and tubocurarine (neuromuscular nicotinic receptor antagonists), and atropine (muscarinic receptor antagonist), indicating that nicotinic receptors (particularly α3β4 subtypes), neuromuscular and muscarinic receptors play roles in bladder contractility. (jefferson.edu)
Pretreatment2
Furthermore, pretreatment with hexamethonium did not inhibit the hypotensive response to nerve growth factor. (portlandpress.com)
Pretreatment with the ganglionic blocker hexamethonium (2 mg/kg iv) completely abolished enhancing effect of L-NAME on airway responsiveness. (elsevierpure.com)
ECA destabilization and obliteration were reversed in ~ 15-30 min after the ingestion of a meal or intravenous administration of atropine, hexamethonium, or naloxone. (utmb.edu)
Neuronal nicotinic2
Hexamethonium is a non-depolarising ganglionic blocker, a neuronal nicotinic (nAChR) receptor antagonist that acts in autonomic ganglia by binding mostly in or on the nAChR receptor, and not the acetylcholine binding site itself. (wikipedia.org)
In contrast, the antinociceptive effect of ABT-594 was not prevented by hexamethonium 10 micromol/kg, i.p., a neuronal nicotinic acetylcholine receptor antagonist that does not readily enter the central nervous system, nor by naltrexone 0.8 micromol/kg, an opioid receptor antagonist. (erowid.org)
Compound Summary1
PubChem Compound Summary for CID 3604, Hexamethonium. (vibratist.com)
Antagonist2
alpha7-selective antagonist) and hexamethonium (non-brain-penetrant non-selective antagonist). (nih.gov)
The latter was temporarily annulled by hexamethonium (which retained antagonist properties), but returned when hexamethonium was removed. (ox.ac.uk)
Blockade1
Hexamethonium blockade did not affect MCFP, capacitance, or compliance. (elsevierpure.com)
Potent1
2-ATs, 2-Ais and M were more potent than hexamethonium in inhibiting Nic-induced contractures. (erowid.org)
Rats2
Methods: Pithed rats were pretreated i.v. with hexamethonium (2 mg/kg·min) followed by continuous infusions of methoxamine (20 μg/kg·min) and DHE (3.1 μg/kg·min). (eur.nl)
In parallel experiments, rats received the ganglionic blocker hexamethonium before smoke exposure. (mcmaster.ca)
Blockers1
DTG and hexamethonium (each at 1 microM) were more effective blockers of ACh-induced inward currents at a holding potential of -100 mV than at -40 mV. (aspetjournals.org)
Activity1
Hexamethonium did not show antidepressant-like activity, supporting the involvement of central nAChRs. (nih.gov)
Hypertension1
Dr. Fries, who already had extensive training in many aspects of hypertension, was doing research at Georgetown on hexamethonium, a ganglion-blocking agent. (medscape.com)
Presence of hexamethonium1
BAY 87-2243 To determine if hyperglycemia affects the muscle BAY 87-2243 response to cholinergic stimulation intragastric pressure response to carbachol (10?5 M 0.1 ml given intravenously) was studied in the presence of hexamethonium (10 mg kg ?1 iv). (biongenex.com)
Hexamethonium is a non-depolarising ganglionic blocker, a neuronal nicotinic (nAChR) receptor antagonist that acts in autonomic ganglia by binding mostly in or on the nAChR receptor, and not the acetylcholine binding site itself. (wikipedia.org)
Since nicotinic receptors help transmit outgoing signals for the sympathetic and parasympathetic systems, nicotinic receptor antagonists such as hexamethonium interfere with the transmission of these signals. (wikipedia.org)
Nicotinic antagonists that block the receptor include mecamylamine, dihydro-β-erythroidine, and hexamethonium . (wikipedia.org)
The nicotinic receptor agonists consist primarily of the depolarizing neuromuscular-blocking drugs (e.g. succinylcholine (suxamethonium) and hexamethonium), and some of these simultaneously stimulate autonomic ganglia (Chapter 37). (missionalcall.com)
On the other hand, application of either cimetidine, a histamine H 2 receptor antagonist, or hexamethonium, a nicotinic antagonist, to the serosal side did not affect the Ba 2+ -induced oscillatory / sc . (elsevierpure.com)
Ganglionic1
The results indicated that the pressor response was peripherally mediated because it persisted following ganglionic blockade with hexamethonium, and was attenuated by NMDAR antagonists, AP-5 or R-(+)-HA-966. (ecu.edu)
Pretreatment1
The stomach was inflated with saline (6 ml) at the rate of 1 ml min−1 and the intraluminal pressure was recorded with and without the pretreatment of TTX (10−7M), hexamethonium (10−4M) or l‐NAME (10−4M). (bl.it)
Drug2
The use of inhaled hexamethonium, an unapproved drug, in a normal volunteer during a medical study is believed to have caused or contributed to her death in light of the presence of abnormal "ground glass opacities" on her chest X-ray. (wikipedia.org)
In this article, Freis discussed his two years of clinical work with hexamethonium, a ganglion-blocking drug. (nih.gov)
Systems2
No 5-HT stores have been found, but specific 5-HT uptake systems blocked by chlorimipramine and desmethylimipramine are present, 5-HT Has similar effects on inhibitory nerves to the guinea-pig stomach to ACh or vagal stimulation but is not antagonized by pentolinium or hexamethonium. (erowid.org)
Following hat innemen viagra je moet wanneer selection humanized monoclonal antibodies are heavily involved in diabetes and additional bacterial species, but other systems (e.G. Hexamethonium bromide and noroxycodone followed by the lowercase a. (themauimiracle.org)