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Receptor, Platelet-Derived Growth Factor alphaReceptors, ProstaglandinReceptors, Adrenergic, alphaDimerizationMolecular Sequence DataReceptors, Platelet-Derived Growth FactorAmino Acid SequenceDinoprostRecombinant ProteinsBase SequenceCell LineProtein BindingReceptor, Interferon alpha-betaRNA, MessengerSignal TransductionBinding SitesTransfectionMacrophage Inflammatory ProteinsCells, CulturedInterferon Type IInterleukin-6Corpus LuteumTumor Necrosis Factor-alphaRecombinant Fusion ProteinsProtein Structure, TertiaryGene Expression RegulationInterleukin-1DNA-Binding ProteinsTranscription FactorsReceptors, InterleukinRadioimmunoprecipitation AssayReceptors, Tumor Necrosis FactorKineticsReceptors, InterferonGene ExpressionCytokinesMacromolecular SubstancesLigandsAntigens, CDChemokine CCL4Collagen Type IMonokinesalpha 1-AntitrypsinCloning, MolecularHypoxia-Inducible Factor 1, alpha SubunitPhentolamineInterleukin-2Tumor Cells, CulturedDNA PrimersProtein SubunitsPlatelet-Derived Growth FactorChemokine CCL3Receptors, Tumor Necrosis Factor, Type IMethoxamineCell DivisionReceptors, AdrenergicBlotting, WesternReceptors, FcPolymerase Chain ReactionRetinoid X ReceptorsReceptors, Tumor Necrosis Factor, Type IIReceptors, Prostaglandin EPhosphorylationReceptors, ImmunologicMutationProtein ConformationModels, MolecularMutagenesis, Site-DirectedBinding, CompetitiveTranscription, GeneticDNAMice, Inbred C57BLSequence Homology, Amino AcidDose-Response Relationship, DrugVitreoretinopathy, ProliferativeInterleukinsReceptors, CytokineReceptors, Cell SurfaceReceptors, ChemokineFibroblastsIntegrinsNuclear ProteinsT-LymphocytesProstaglandins FPromoter Regions, GeneticBlotting, NorthernFlow CytometryCattleCell DifferentiationReceptors, Retinoic AcidProtein Structure, QuaternaryReceptors, Cytoplasmic and NuclearEnzyme ActivationElectrophoresis, Polyacrylamide GelProtein MultimerizationDown-RegulationInterleukin-12Cell MembraneInterleukin-4Interferon-gamma
Forms a heterodimeric complexCytokine receptorIsoformsLigandANTIGENAgonistBindsPathwaySubunitAdenosineFunctionalAntibodiesDistinctCytokinesEstrogen receptorStimulationTumorIL12ExtracellularTyrosineInteractionsMembraneMoleculeAllergicTranscriptionPathwaysComplexOccursSimilarlyStimulatesFamilyMiceBetaProteinFormSubunitsBindMajorDataActivationImportantNaturalMemberRelease
Forms a heterodimeric complex1
  • The apparently anomalous binding data were clarified by the fact that washed platelets (1) contained mineralocorticoid receptor and that (2) it was associated with GR. Taken together, our data suggest that platelet GR forms a heterodimeric complex with the mineralocorticoid receptor that is susceptible to differential activation by specific receptor ligands. (ashpublications.org)
Cytokine receptor1
  • Interleukin-23 receptor is a type I cytokine receptor . (wikidoc.org)
Isoforms1
  • As there is redundancy in signalling between the five PDGF ligand isoforms and three PDGF receptor isoforms, and deletion of either of the receptors in vivo produces an embryonic lethal phenotype, it is not know which ligand and receptor combinations mediate specific cellular functions. (biomedcentral.com)
Ligand7
  • Thus, the IL-17 cytokine family appears to represent a distinct ligand-receptor signaling system. (hindawi.com)
  • Dimerization of C-type lectin receptors (CLRs) or Toll-like receptors (TLRs) can alter their ligand binding ability, thereby modulating immune responses. (bvsalud.org)
  • PDGF ligand dimers bind either PDGFRα or PDGFRβ homodimers or the α/β heterodimer. (biomedcentral.com)
  • Arrows show proven in vitro ligand-receptor interactions. (biomedcentral.com)
  • There are several subtypes of melanocortin receptors, each having a distinct ligand specificity profile and tissue localization. (lookformedical.com)
  • Peroxisome proliferator-activated receptor-γ(PPARγ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors [ 10 ]. (biomedcentral.com)
  • RU486), suggesting the functional importance of the ligand-receptor complex. (ashpublications.org)
ANTIGEN3
  • Interleukin 12 (IL-12) is produced by activated antigen-presenting cells (dendritic cells, macrophages). (wikipedia.org)
  • Innate immunity is the early and relatively nonspecific response to invading pathogens, activated via the Toll-like and T-cell receptors, on antigen presenting cells and on T cells, respectively [ 1 , 2 ]. (biomedcentral.com)
  • Here we report that when mice lacking the RelA subunit of NF-κB are brought to term by breeding onto a tumor necrosis factor receptor (TNFR)1-deficient background, the mice that are born lack lymph nodes, Peyer's patches, and an organized splenic microarchitecture, and have a profound defect in T cell-dependent antigen responses. (rupress.org)
Agonist1
  • However, while prednisolone (1-10 μM) reduced adenosine diphosphate (ADP, 4 μM) and thromboxane A 2 receptor agonist U46619 induced platelet aggregation (up to 75%), dexamethasone had no effect. (ashpublications.org)
Binds1
  • citation needed] IL-12 binds to the IL-12 receptor, which is a heterodimeric receptor formed by IL-12Rβ1 and IL-12Rβ2. (wikipedia.org)
Pathway3
  • An extensive review and visualization of IL-12 signaling can be found at the peer-reviewed pathway database Reactome: Interleukin-12 family IL-12 is linked with autoimmunity. (wikipedia.org)
  • KEGG pathway analysis showed that in the early stage of TGF-ß1 induction (TGF-ß1 treatment for 6 h), the changes in Hippo, TGF-ß and Wnt signaling pathways were observed, while in the late stage of TGF-ß1 induction (TGF-ß1 treatment for 24 h), the changes of extracellular matrix-receptor interaction, focal adhesion and adherens junction were mainly enriched. (bvsalud.org)
  • The biosynthesis of noscapine in P. somniferum begins with chorismic acid , which is synthesized via the shikimate pathway from erythrose 4-phosphate and phosphoenolpyruvate . (cloudfront.net)
Subunit4
  • Interleukin-23 ( IL-23 ) is a heterodimeric cytokine composed of an IL12B ( IL-12p40 ) subunit (that is shared with IL12 ) and the IL23A ( IL-23p19 ) subunit. (wikidoc.org)
  • The protein encoded by this gene is a subunit of the receptor for IL-23 . (wikidoc.org)
  • An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. (lookformedical.com)
  • HIF-1 is also a heterodimeric transcription factor, consisting of the oxygen dependent alpha subunit and the constitutively expressed beta subunit. (biomedcentral.com)
Adenosine3
Functional2
  • [1] A functional receptor for IL-23 (the IL-23 receptor ) has been identified and is composed of IL-12R β1 and IL-23R . (wikidoc.org)
  • Here, we report for the first time that human platelets contain the glucocorticoid receptor (GR) as identified by a combination of biochemical and functional techniques. (ashpublications.org)
Antibodies4
  • Initially, all antibodies are of the first form, attached to the surface of a B cell - these are then referred to as B-cell receptors (BCR). (wikipedia.org)
  • [4] Soluble antibodies are released into the blood and tissue fluids , as well as many secretions . (wikipedia.org)
  • In this study, we used PDGFR-specific neutralising antibodies to dissect out receptor-specific signalling events in fibroblasts in vitro , to further understand key cellular processes involved in wound healing and tissue repair. (biomedcentral.com)
  • Neutralising antibodies against PDGFRs were shown to block signalling through PDGFRα and PDGFRβ receptors, reduce human PDGF-AA and PDGF-BB-induced collagen gel remodelling in dermal fibroblasts, and reduce migration stimulated by all PDGF ligands in human dermal and lung fibroblasts. (biomedcentral.com)
Distinct3
  • ACKR1 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. (guidetomalariapharmacology.org)
  • Although stimulation of PDGFRα and PDGFRβ evokes similar signal transduction cascades, in vitro studies suggest distinct requirements for specific pathways to initiate particular receptor-mediated functions. (biomedcentral.com)
  • The strategy underlying these CD4 based therapies, i.e. blocking the interaction between gp120 and the CD4 receptor, encompasses advantages distinct from current HAART regimens. (justia.com)
Cytokines1
  • IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35. (wikipedia.org)
Estrogen receptor3
  • Taken together with the fact that 60-70% of human breast cancers are estrogen receptor-alpha positive[ 7 ], the evidence suggests an etiological significance of estrogen in breast cancer initiation and progression. (biomedcentral.com)
  • Estrogen mediates its effects by binding to its cognate estrogen receptor(s), either estrogen receptor alpha (ERα) or estrogen receptor beta (ERβ), leading to ER dimerization and association with various co-factors. (biomedcentral.com)
  • The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily that encompasses, among others, estrogen receptor and peroxisome proliferators-activated receptor. (ashpublications.org)
Stimulation1
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. (wikipedia.org)
Tumor1
IL121
  • IL12 is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). (wikipedia.org)
Extracellular1
  • Each PDGF receptor has five extracellular immunoglobulin-like domains and two intracellular tyrosine kinase domains. (biomedcentral.com)
Tyrosine3
  • Platelet-derived growth factors (PDGFs) acting via their tyrosine kinase receptors are major mitogens for many cell types of mesenchymal origin, including fibroblasts and vascular smooth muscle cells (VSMCs)[ 1 - 4 ]. (biomedcentral.com)
  • Tyrosine can undergo a PLP -mediated transamination to form 4-hydroxyphenylpyruvic acid (4-HPP), followed by a TPP -mediated decarboxylation to form 4-hydroxyphenylacetaldehyde (4-HPAA). (cloudfront.net)
  • Tyrosine can also be hydroxylated to form 3,4-dihydroxyphenylalanine (DOPA), followed by a PLP-mediated decarboxylation to form dopamine . (cloudfront.net)
Interactions1
  • From that we are to coupled sites and inactivated receptors, docking both interactions as viable including climates and used sine download proteins. (evakoch.com)
Membrane2
Molecule3
  • Results published in the Journal of Allergy and Clinical Immunology from a study where mice that were bred to be allergic to peanuts, interleukin-12 has been shown to not be present, suggesting that the molecule normally stops allergies to food from developing. (wikipedia.org)
  • This protein pairs with the receptor molecule IL-12Rβ1 ( IL12RB1 ), together forming the IL-23 receptor complex, and both are required for IL-23 signaling. (wikidoc.org)
  • The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. (lookformedical.com)
Allergic1
  • IL-17F is expressed in activated CD4 + T cells, basophils, and mast cells, three important cell types involved in allergic airway inflammation [ 3 ]. (hindawi.com)
Transcription1
  • Validation in a cell model showed that TGF-ß1 induced expression of 9 transcription factors (encoded by Snai1, Irf8, Bhlhe40, Junb, Arid5a, Vdr, Lef1, Myc, Tcf7), while the expression levels of the other 4 genes did not significantly change after TGF-ß1 treatment. (bvsalud.org)
Pathways1
  • The receptor for IL-17F is the heterodimeric complex of IL-17RA and IL-17RC, and IL-17F activates many signaling pathways. (hindawi.com)
Complex1
  • The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (CD3 COMPLEX). (edu.au)
Occurs1
  • tightly you dissipate your download, contribute the nursing of it, and bind in with your triphosphatase endocytosis promoter and bilayer pore( the activation Early occurs to the endocytic 4 products of your source phosphorylation). (evakoch.com)
Similarly2
  • Similarly, the IL-17 receptor family (IL-17RA-RE) is not related to any of the other known cytokine receptors [ 2 ]. (hindawi.com)
  • 4 Similarly, conventional clinical doses of prednisone do not impair platelet function or enhance primary hemostasis in healthy subjects, as measured by the bleeding time. (ashpublications.org)
Stimulates2
  • IL-2 stimulates the expression of two IL-12 receptors, IL-12R-β1 and IL-12R-β2, maintaining the expression of a critical protein involved in IL-12 signaling in NK cells. (wikipedia.org)
  • Alpha-MSH stimulates the synthesis and distribution of MELANIN in MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. (lookformedical.com)
Family1
Mice1
  • The present study shows that carrageenan induces a trend of slightly increased spontaneous pain sensitivity in PTPH1-KO mice compared to WT (wild-type) littermates, but no differences in cytokine release, induced pain perception and cellular infiltration have been detected between the two genotypes in this mouse model. (biomedcentral.com)
Beta3
  • Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses. (lookformedical.com)
  • Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). (edu.au)
  • The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS. (lookformedical.com)
Protein2
  • The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis. (wikipedia.org)
  • However, the complement C5a receptor 2 may act as a decoy receptor for C5a, as it has no reported G protein signalling capacity. (guidetomalariapharmacology.org)
Form2
  • The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
  • ACTH (1-13) is amidated at the C-terminal to form ACTH (1-13)NH2 which in turn is acetylated to form alpha-MSH in the secretory granules. (lookformedical.com)
Subunits2
Bind1
  • Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. (lookformedical.com)
Major1
  • One of two major pharmacologically defined classes of adrenergic receptors. (lookformedical.com)
Data1
Activation1
  • transiting of such constituent c receptor type VIa regions in kinase during activation. (evakoch.com)
Important1
  • Support is lent to this idea by the observation that a receptor for IL-12 is important for IFNγ production by lymphocytes. (wikipedia.org)
Natural1
  • Moreover, this variant is a natural antagonist for the wild-type IL-17F. (hindawi.com)
Member1
  • prolonged activity oxidation highly with CREBP1 and EP300 induces blood of GZMB( granzyme B), which is continual for the C-terminal member of CD8+ types( Maekawa et al. (evakoch.com)
Release1
  • CB 2 receptor on eosinophils mainly mediates anti-inflammatory and immunomodulatory actions e.g. downregulation of pro-inflammatory mediator release. (guidetomalariapharmacology.org)