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  • heteroatom
  • Substitution of one or more of the ring carbon atoms in the molecules of a carbocyclic compound with a heteroatom gives a heterocyclic compound. (britannica.com)
  • The halogens have a standard bonding number of one, and so a heterocyclic ring containing a halogen as a heteroatom should have a formal positive charge. (wikipedia.org)
  • The aza-Cope rearrangements are examples of heteroatom versions of the Cope rearrangement, which is a [3,sigmatropic rearrangement that shifts single and double bonds between two allylic components. (wikipedia.org)
  • The facile nature of this rearrangement is attributed both to the fact that the cationic 2-aza-Cope is inherently thermoneutral, meaning there's no bias for the starting material or product, as well as to the presence of the charged heteroatom in the molecule, which lowers the activation barrier. (wikipedia.org)
  • The presence of the ionic nitrogen heteroatom accounts for the more facile rearrangement of the cationic 2-aza-Cope rearrangement in comparison to the Cope rearrangement. (wikipedia.org)
  • chemistry
  • Although primarily targeting a chemistry audience, the wide applicability of these compounds transcends traditional disciplines, making this text also of use to physicists, materials scientists or biologists who have interests in these areas. (wiley.com)
  • The present invention belongs to the fields of organic chemistry, pharmaceutical chemistry and chemical manufacture, and provides a convenient and economical process for preparing benzo[f]quinolinones which are useful as 5α-reductase inhibitors and provides intermediate compounds for the preparation of such pharmaceuticals. (google.com)
  • Advances in Heterocyclic Chemistry. (wikipedia.org)
  • Rearrangements, especially those that can participate in cascade reactions, such as the aza-Cope rearrangements, are of high practical as well as conceptual importance in organic chemistry, due to their ability to quickly build structural complexity out of simple starting materials. (wikipedia.org)
  • Ligands
  • The study of catalysis was carried out using model compounds: functionalized camphor- and tartaric acid-derived chiral ligands were synthesized such as monophosphines, diphosphines, and then Rhodium(I) complexes with them. (wikipedia.org)
  • Current research is investigating the use of these ligands in organometallic compounds as catalysts and into developing new derivatives of CAACs such as bicyclic CAACs. (wikipedia.org)
  • moiety
  • To explore the possibility of electrostatic interactions, the use of molecular electrostatic potentials (MEP) were employed with model compound 34 (replacing the phenyltropane moiety with a methyl group). (wikipedia.org)
  • Reaction
  • This tandem aza-Cope/Mannich reaction is characterized by its mild reaction conditions, diastereoselectivity, and wide synthetic applicability. (wikipedia.org)
  • Thermodynamically, the general 2-aza-Cope rearrangement does not have a product bias, as the bonds broken and formed are equivalent in either direction of the reaction, similar to the Cope rearrangement. (wikipedia.org)
  • preparations
  • Special attention is given to the implementation, preparations and applications of polynuclear heterocyclic cyanine to show the various aspects in order to satisfy the great demand in industrial and various biological fields. (tsijournals.com)
  • synthetic
  • In general, synthetic methods and physical and chemical properties of the saturated and the partly unsaturated heterocyclic compounds closely resemble those for their acyclic (noncyclic, or open-chain) analogs . (britannica.com)
  • The 1- and 3-aza-Cope rearrangements have high activation barriers and limited synthetic applicability, accounting for their relative obscurity. (wikipedia.org)
  • To maximize its synthetic utility, the cationic 2-aza-Cope rearrangement is normally paired with a thermodynamic bias toward one side of the rearrangement. (wikipedia.org)
  • derivatives
  • to give the corresponding furanone, imidazolo[2,3-b]1,3,4- thiadiazole, 1,3,4-thiadiazolopyrimidine and pyridazinone 4-(4-Acetylaminophenyl)-4-oxo-2-(5-(4-chlorophenyl)-2- derivatives, respectively with an aim to obtain some thiadiazolyl amino)butanoic acid(4) interesting heterocyclic compounds with non-mixing and mixing system. (pdfmedsearch.com)
  • Compounds with an intermediate number of double bonds are named as the hydrogenated derivatives of the mancude ring. (wikipedia.org)
  • relates
  • The present invention relates to a compound represented by formula 1, an organic optoelectronic element comprising the same, and a display device comprising the organic optoelectronic element. (sumobrain.com)
  • The invention furthermore relates to processes for the preparation of the compounds of the formulae Ia and Ib, their use and pharmaceutical compositions comprising them. (patentsencyclopedia.com)
  • reactions
  • Aromatic compounds, though having double bonds, are extremely stable and do not readily undergo the addition reactions characteristic of other unsaturated compounds. (britannica.com)
  • In 1878, the structure of piperidine was still unknown, and A. W. Hofmann made attempts to add hydrogen chloride or bromine to it in the belief that the compound possessed unsaturation (i.e. he performed standard alkene classification test reactions). (wikipedia.org)
  • Phosphorine undergoes electrophilic substitution reactions like ordinary aromatic compounds: bromination, acylation, and so on. (wikipedia.org)
  • amino
  • For example, heterocyclic structure exists in chlorophyll in plants, hemoglobin in animal blood, alkaloids and glycosides as the active ingredient in herbs, some antibiotics and vitamins, certain composition of amino acids in protein and bases in nucleotide. (chemicalbook.com)
  • The isoquinoline ring in these natural compound derives from the aromatic amino acid tyrosine. (wikipedia.org)
  • In 1950, Horowitz and Geissman reported the first example of the 2-aza-Cope rearrangement, a surprising result in a failed attempt to synthesize an amino alcohol. (wikipedia.org)
  • parent compound
  • The parent compound for unsaturated ring systems is the one containing the maximal number of non-cumulated double bonds (known as the mancude ring system). (wikipedia.org)
  • pathway
  • These results indicate that in some cellular context, the cell sensitivity to PRIMA-1 could depend on the abolition of a gain-of-function activity of the mutated p53, through a protein degradation pathway specifically induced by this compound. (biomedsearch.com)
  • cycloaddition
  • 1,2-Cycloaddition of 1-Aza-1,3-dienes. (paperplane.io)
  • Formation of 3,5-disubstituted pyridines via [4 + cycloaddition/cycloelimination of enamines to 1-aza-1,3-butadiene intermediates including ( 1 ) is known (eq 9). (paperplane.io)
  • methyl
  • These dyes have many vital general applications this back to their higher stability which can be used as bioactive compounds such as the N-methyl-Daspartate antagonists [ 18 ]. (tsijournals.com)
  • While polymerization of imine ( 1 ) is not reported, analogous N -alkylmethacroleinimines such as N -cyclohexyl-3-methyl-1-aza-1,3-butadiene are known to polymerize by anionic catalysts but not by cationic or radical initiators. (paperplane.io)
  • Bifunctional molecules having a DNA intercalator or DNA groove binder linked to ethylene diamine tetraacetic acid such as compounds having the formula: ##STR1## wherein R is methyl or ethyl. (google.com)
  • acid
  • The process comprises oxidizing a feed stream comprising at least one oxidizable compound to generate a crude carboxylic acid slurry co. (sumobrain.com)
  • methods
  • Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are de. (sumobrain.com)
  • Hantzsch-Widman nomenclature is named after the German chemist Arthur Hantzsch and the Swedish chemist Oskar Widman, who independently proposed similar methods for the systematic naming of heterocyclic compounds in 1887 and 1888 respectively. (wikipedia.org)
  • catalysis
  • In particular, photoredox catalysis employs small quantities of a light-sensitive compound that, when excited by light, can mediate the transfer of electrons between chemical compounds that otherwise would react more slowly or not at all. (wikipedia.org)
  • chemical
  • Hantzsch-Widman nomenclature, also called the extended Hantzsch-Widman system, is a type of systematic chemical nomenclature used for naming heterocyclic parent hydrides having no more than ten ring members. (wikipedia.org)
  • Phenyltropanes (PTs) are a family of chemical compounds originally derived from structural modification of cocaine. (wikipedia.org)
  • Dimers of phenyltropanes, connected in their dual form using the C2 locant as altered toward a carboxamide structural configuring (in contrast and away from the usual inherent ecgonine carbmethoxy), as per Frank Ivy Carroll's patent inclusive of such chemical compounds, possibly so patented due to being actively delayed pro-drugs in vivo. (wikipedia.org)
  • involves
  • The initial step involves the deprotonation of 2,6-disopropylaniline with lithium diisopropylamide to give a aza-allyl anion. (wikipedia.org)
  • useful
  • The most common and synthetically useful strategy couples the cationic 2-aza-Cope rearrangement with a Mannich cyclization, and is the subject of much of this article. (wikipedia.org)