• heteroatom
  • Substitution of one or more of the ring carbon atoms in the molecules of a carbocyclic compound with a heteroatom gives a heterocyclic compound. (britannica.com)
  • The halogens have a standard bonding number of one, and so a heterocyclic ring containing a halogen as a heteroatom should have a formal positive charge. (wikipedia.org)
  • The aza-Cope rearrangements are examples of heteroatom versions of the Cope rearrangement, which is a [3,sigmatropic rearrangement that shifts single and double bonds between two allylic components. (wikipedia.org)
  • The facile nature of this rearrangement is attributed both to the fact that the cationic 2-aza-Cope is inherently thermoneutral, meaning there's no bias for the starting material or product, as well as to the presence of the charged heteroatom in the molecule, which lowers the activation barrier. (wikipedia.org)
  • The presence of the ionic nitrogen heteroatom accounts for the more facile rearrangement of the cationic 2-aza-Cope rearrangement in comparison to the Cope rearrangement. (wikipedia.org)
  • Reaction
  • This tandem aza-Cope/Mannich reaction is characterized by its mild reaction conditions, diastereoselectivity, and wide synthetic applicability. (wikipedia.org)
  • Thermodynamically, the general 2-aza-Cope rearrangement does not have a product bias, as the bonds broken and formed are equivalent in either direction of the reaction, similar to the Cope rearrangement. (wikipedia.org)
  • derivatives
  • to give the corresponding furanone, imidazolo[2,3-b]1,3,4- thiadiazole, 1,3,4-thiadiazolopyrimidine and pyridazinone 4-(4-Acetylaminophenyl)-4-oxo-2-(5-(4-chlorophenyl)-2- derivatives, respectively with an aim to obtain some thiadiazolyl amino)butanoic acid(4) interesting heterocyclic compounds with non-mixing and mixing system. (pdfmedsearch.com)
  • Compounds with an intermediate number of double bonds are named as the hydrogenated derivatives of the mancude ring. (wikipedia.org)
  • Current research is investigating the use of these ligands in organometallic compounds as catalysts and into developing new derivatives of CAACs such as bicyclic CAACs. (wikipedia.org)
  • moiety
  • To explore the possibility of electrostatic interactions, the use of molecular electrostatic potentials (MEP) were employed with model compound 34 (replacing the phenyltropane moiety with a methyl group). (wikipedia.org)
  • Mannich
  • The most common and synthetically useful strategy couples the cationic 2-aza-Cope rearrangement with a Mannich cyclization, and is the subject of much of this article. (wikipedia.org)
  • ligands
  • The study of catalysis was carried out using model compounds: functionalized camphor- and tartaric acid-derived chiral ligands were synthesized such as monophosphines, diphosphines, and then Rhodium(I) complexes with them. (wikipedia.org)
  • amino
  • In 1950, Horowitz and Geissman reported the first example of the 2-aza-Cope rearrangement, a surprising result in a failed attempt to synthesize an amino alcohol. (wikipedia.org)
  • wherein
  • Bifunctional molecules having a DNA intercalator or DNA groove binder linked to ethylene diamine tetraacetic acid such as compounds having the formula: ##STR1## wherein R is methyl or ethyl. (google.com)
  • pathway
  • These results indicate that in some cellular context, the cell sensitivity to PRIMA-1 could depend on the abolition of a gain-of-function activity of the mutated p53, through a protein degradation pathway specifically induced by this compound. (biomedsearch.com)
  • synthetic
  • In general, synthetic methods and physical and chemical properties of the saturated and the partly unsaturated heterocyclic compounds closely resemble those for their acyclic (noncyclic, or open-chain) analogs . (britannica.com)
  • The 1- and 3-aza-Cope rearrangements have high activation barriers and limited synthetic applicability, accounting for their relative obscurity. (wikipedia.org)
  • To maximize its synthetic utility, the cationic 2-aza-Cope rearrangement is normally paired with a thermodynamic bias toward one side of the rearrangement. (wikipedia.org)
  • oxygen
  • For example, "oxa" (for oxygen) always comes before "aza" (for nitrogen) in a name. (wikipedia.org)
  • A photosensitizer is a chemical compound that can be promoted to an excited state upon absorption of light and undergo intersystem crossing (ISC) with oxygen to produce singlet oxygen. (wikipedia.org)
  • processes
  • Thus the cationic-aza-Cope rearrangement proceeds more quickly than more concerted processes such as the Cope rearrangement. (wikipedia.org)
  • molecule
  • This is a novel and unique molecule and superior in sequence specificity to the naturally occurring antitumor compound used in man, bleomycin which cleaves DNA at a two base pair recognition site. (google.com)
  • Aza-Cope rearrangements are generally classified by the position of the nitrogen in the molecule (see figure): The first example of an aza-Cope rearrangement was the ubiquitous cationic 2-aza-Cope Rearrangement, which takes place at temperatures 100-200 °C lower than the Cope rearrangement due to the facile nature of the rearrangement. (wikipedia.org)
  • acid
  • The process comprises oxidizing a feed stream comprising at least one oxidizable compound to generate a crude carboxylic acid slurry co. (sumobrain.com)
  • Thus
  • Thus, in general DEAD is an aza-dienophile and dehydrogenating agent, converting alcohols to aldehydes, thiols to disulfides and hydrazo groups to azo groups. (wikipedia.org)
  • catalysis
  • In particular, photoredox catalysis employs small quantities of a light-sensitive compound that, when excited by light, can mediate the transfer of electrons between chemical compounds that otherwise would react more slowly or not at all. (wikipedia.org)
  • respectively
  • Hantzsch-Widman nomenclature is named after the German chemist Arthur Hantzsch and the Swedish chemist Oskar Widman, who independently proposed similar methods for the systematic naming of heterocyclic compounds in 1887 and 1888 respectively. (wikipedia.org)
  • double bonds
  • The parent compound for unsaturated ring systems is the one containing the maximal number of non-cumulated double bonds (known as the mancude ring system). (wikipedia.org)
  • involves
  • The initial step involves the deprotonation of 2,6-disopropylaniline with lithium diisopropylamide to give a aza-allyl anion. (wikipedia.org)
  • parent
  • Hantzsch-Widman nomenclature, also called the extended Hantzsch-Widman system, is a type of systematic chemical nomenclature used for naming heterocyclic parent hydrides having no more than ten ring members. (wikipedia.org)
  • methods
  • Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are de. (sumobrain.com)
  • Ring
  • The aza-allyl anion then induces the ring opening of 1,2-epoxy-2-methylpro-pane leading to a lithium alkoxide. (wikipedia.org)
  • materials
  • CV measurements and theoretical calculations demonstrate that the frontier molecular orbital levels of these compounds are suitable as donor materials in solar cells when combined with C 60 as the acceptor. (rsc.org)