synthesis
- This procedure provides a method by which nanoparticles are synthesized directly from phthalhydrazide, malononitrile and aldehydes insides of a routine protocol for the synthesis of nano particles of organic compounds in which the synthesized organic compound is transformed into nanosized particles using modern high technology, for example ultrahighpressure rapid expansion of supercritical solution, and supercritical antisolvent with enhanced mass transfer. (analchemres.org)
- Topics covered include phosphines, applications of phosphorus (III) and (V) compounds as reagents in synthesis, the chemistry of phosphorus ylides, applications of the Wittig reaction in the synthesis of heterocyclic and carbocyclic compounds, preparation ofIminophosphoranes and their synthetic applications in the aza-Wittig reaction, phospho-transfer processes leading to [P-C] bond formation, low valent phosphorus compounds and phosphorus methods in oligonucleotide chemistry. (indigo.ca)
- Dr Ranier Schobert: Applications of the Wittig reaction in the synthesis of heterocyclic and carbocyclic compounds6. (indigo.ca)
- 2.Tandem cyclizations strategy of functionalized carbodiimides, which were prepared by the aza-Wittig reaction of iminophosphoranes with isocyanates, has been developed for facile synthesis of a variety of ring-fused nitrogen-heterocyclic compounds such as imidazo-quinolines, imidazoimidazoles, imidazopyrimidines, imidazoquinazolines, imidazothiazines, pyrimidobenzothiazines, quinazolinobenzothiazines, and diazepinoquinolines. (nii.ac.jp)
- Synthesis and antimicrobial activities of novel -amino acids and heterocycles 4-(4-Acetylaminophenyl)-4-oxo-2-(5-styryl-2-thiadiazolyl compound was separated and crystallized form ethanol. (pdfmedsearch.com)
- In enzymology, the (S)-norcoclaurine synthase (EC 4.2.1.78) is an enzyme that catalyzes a biological Pictect-Spengler synthesis: Intramolecular aza Wittig reactions also afford isoquinolines. (wikipedia.org)
- Komarov earned his Doctor of Sciences degree in 2003, the title of his thesis is "Design and synthesis of model compounds: study of stereoelectronic, steric effects, reactive intermediates, catalytic enantioselective hydrogenation and dynamic protection of functional groups" He is also a scientific advisor for Enamine Ltd. and Lumobiotics GmbH. (wikipedia.org)
- The areas of scientific interests of Igor V. Komarov are medicinal chemistry and synthesis of model compounds, which can be used to obtain new knowledge in biochemistry, stereochemistry, theoretical chemistry, catalysis. (wikipedia.org)
- One of such collaborative projects was synthesis, study of stereochemistry and chemical properties of 1-aza-2-adamantanone and its derivatives. (wikipedia.org)
- Igor V. Komarov's group made a contribution to design and synthesis of light-controllable biologically active compounds - photocontrollable peptides - potential candidates for photopharmacology drugs. (wikipedia.org)
- The Kirsanov reaction is a method for the synthesis of certain organophosphorus compounds. (wikipedia.org)
- It is the most extensively studied of the aza-Cope rearrangements due to the mild conditions required to carry the arrangement out, as well as for its many synthetic applications, notably in alkaloid synthesis. (wikipedia.org)
- The Stille reaction, or the Migita-Kosugi-Stille coupling, is a chemical reaction widely used in organic synthesis which involves the coupling of an organotin compound (also known as organostannanes) with a variety of organic electrophiles via palladium-catalyzed coupling reaction. (wikipedia.org)
aromatic heterocyclic
- This chapter will mainly discuss heterocyclic compounds with relatively stable ring system and with a certain degree of aromaticity, also known as aromatic heterocyclic compound. (chemicalbook.com)
- Indole is an aromatic heterocyclic organic compound. (edu.ua)
- Igor V. Komarov started his research in the area of synthetic organic chemistry at the beginning of 1990th, working on phosphorylation of aromatic heterocyclic compounds by phosphorus(V) acid halides. (wikipedia.org)
five-membered
- The most common and also the most important heterocyclic compounds are that with five-membered or six-membered heterocyclic ring and their fused heterocyclic compounds. (chemicalbook.com)
- Therefore, according to the size of the ring, heterocyclic compounds can be divided into five-membered compounds and six-membered heterocyclic compounds. (chemicalbook.com)
- According to the number of hetero atoms, five-membered compounds and six-membered heterocyclic compounds can be divided into one-hetero-atom-containing heterocyclic compounds and two-hetero-atom-containing and several-hetero-atom-containing heterocyclic compounds. (chemicalbook.com)
- The parent compound has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing ring. (wikipedia.org)
HETEROCYCLES
- This makes the DAINV reaction particularly useful in natural product syntheses, where the target compounds often contain heterocycles. (wikipedia.org)
heteroatom
- Substitution of one or more of the ring carbon atoms in the molecules of a carbocyclic compound with a heteroatom gives a heterocyclic compound. (britannica.com)
- The halogens have a standard bonding number of one, and so a heterocyclic ring containing a halogen as a heteroatom should have a formal positive charge. (wikipedia.org)
- The aza-Cope rearrangements are examples of heteroatom versions of the Cope rearrangement, which is a [3,sigmatropic rearrangement that shifts single and double bonds between two allylic components. (wikipedia.org)
- The facile nature of this rearrangement is attributed both to the fact that the cationic 2-aza-Cope is inherently thermoneutral, meaning there's no bias for the starting material or product, as well as to the presence of the charged heteroatom in the molecule, which lowers the activation barrier. (wikipedia.org)
- The presence of the ionic nitrogen heteroatom accounts for the more facile rearrangement of the cationic 2-aza-Cope rearrangement in comparison to the Cope rearrangement. (wikipedia.org)
chemistry
- Although primarily targeting a chemistry audience, the wide applicability of these compounds transcends traditional disciplines, making this text also of use to physicists, materials scientists or biologists who have interests in these areas. (wiley.com)
- The present invention belongs to the fields of organic chemistry, pharmaceutical chemistry and chemical manufacture, and provides a convenient and economical process for preparing benzo[f]quinolinones which are useful as 5α-reductase inhibitors and provides intermediate compounds for the preparation of such pharmaceuticals. (google.com)
- Advances in Heterocyclic Chemistry. (wikipedia.org)
- Rearrangements, especially those that can participate in cascade reactions, such as the aza-Cope rearrangements, are of high practical as well as conceptual importance in organic chemistry, due to their ability to quickly build structural complexity out of simple starting materials. (wikipedia.org)
heteroatoms
- The molecules of organic chemical compounds are built up from a framework or backbone of carbon atoms to which are attached hydrogen (H), oxygen, or other heteroatoms. (britannica.com)
- Other heterocyclic compounds can be envisioned similarly as derivatives of cyclopentane by substitution with other heteroatoms or of other carbocyclic compounds by substitution with nitrogen or other heteroatoms. (britannica.com)
- DAINV reactions often involve heteroatoms, and can be used to form heterocyclic compounds. (wikipedia.org)
pyridine
- and pyridine is a typical heterocyclic aromatic, or heteroaromatic, substance. (britannica.com)
- Phosphorine (IUPAC name: phosphinine) is a heavier element analog of pyridine, containing a phosphorus atom instead of an aza- moiety. (wikipedia.org)
quinoline
- Also known as 1,3-diazanaphthalene, quinazoline received its name from being an aza derivative of quinoline. (wikipedia.org)
phosphorus
- Dr R. Alan Aitken and Nazira Karodia: Applications of phosphorus (III) and (V) compounds as reagents in synthesis4. (indigo.ca)
molecule
- According to the form of the ring in the molecule, heterocyclic compounds can be divided into single-heterocyclic compounds and fused heterocyclic compounds. (chemicalbook.com)
- This is a novel and unique molecule and superior in sequence specificity to the naturally occurring antitumor compound used in man, bleomycin which cleaves DNA at a two base pair recognition site. (google.com)
- Aza-Cope rearrangements are generally classified by the position of the nitrogen in the molecule (see figure): The first example of an aza-Cope rearrangement was the ubiquitous cationic 2-aza-Cope Rearrangement, which takes place at temperatures 100-200 °C lower than the Cope rearrangement due to the facile nature of the rearrangement. (wikipedia.org)
carbocyclic
- such substances often are referred to as carbocyclic or alicyclic compounds. (britannica.com)
intramolecular
- Isoindolines can be prepared by 1,2-addition of a nucleophile onto a bifunctional ε-benzoiminoenoates followed by intramolecular aza-Michael reaction. (wikipedia.org)
nitrogen atoms
- CAACs were first developed by Guy Bertrand at UCSD as an alternative to traditional N-heterocyclic carbenes which contain two nitrogen atoms with in the structure typically derived from imidazole. (wikipedia.org)
indole
- The indole structure can be found in many organic compounds like the amino acid tryptophan and in tryptophan-containing protein, in alkaloids, and in pigments. (edu.ua)
Wittig
- Dr I O'Neil and Dr J.M. Southern: Preparation and reactions of Iminophosphoranes and their synthetic applications in the aza-Wittig reaction7. (indigo.ca)
precursors
- N-bridge head heterocyclic compound used as precursors possess high site reactivity susceptible to be attack by either Electrophile/ Nucleophile in the substitution/addition reactions which give high stability nature for the dyes formed [ 17 ]. (tsijournals.com)
- Substituted indoles are structural elements of (and for some compounds the synthetic precursors for) the tryptophan-derived tryptamine alkaloids like the neurotransmitter serotonin, and melatonin. (edu.ua)
Ligands
- The study of catalysis was carried out using model compounds: functionalized camphor- and tartaric acid-derived chiral ligands were synthesized such as monophosphines, diphosphines, and then Rhodium(I) complexes with them. (wikipedia.org)
- Current research is investigating the use of these ligands in organometallic compounds as catalysts and into developing new derivatives of CAACs such as bicyclic CAACs. (wikipedia.org)
moiety
- To explore the possibility of electrostatic interactions, the use of molecular electrostatic potentials (MEP) were employed with model compound 34 (replacing the phenyltropane moiety with a methyl group). (wikipedia.org)
Reaction
- This tandem aza-Cope/Mannich reaction is characterized by its mild reaction conditions, diastereoselectivity, and wide synthetic applicability. (wikipedia.org)
- Thermodynamically, the general 2-aza-Cope rearrangement does not have a product bias, as the bonds broken and formed are equivalent in either direction of the reaction, similar to the Cope rearrangement. (wikipedia.org)
quinazoline
- Quinazoline is a organic compound with the formula C8H6N2. (wikipedia.org)
Thus
- Thus, in general DEAD is an aza-dienophile and dehydrogenating agent, converting alcohols to aldehydes, thiols to disulfides and hydrazo groups to azo groups. (wikipedia.org)
- Thus, heterocyclic compounds play an important role in organic compounds especially in organic medicines. (chemicalbook.com)
- Thus the cationic-aza-Cope rearrangement proceeds more quickly than more concerted processes such as the Cope rearrangement. (wikipedia.org)
aromaticity
- Structural studies by electron diffraction reveal that phosphorine is a planar aromatic compound with 88% of the aromaticity of that of benzene. (wikipedia.org)
preparations
- Special attention is given to the implementation, preparations and applications of polynuclear heterocyclic cyanine to show the various aspects in order to satisfy the great demand in industrial and various biological fields. (tsijournals.com)
carbon atoms
- When one of the carbon atoms of cyclopentane is replaced with an atom of nitrogen, the compound pyrrolidine, a chemical relative of pyrrole , is produced. (britannica.com)
- Nonaromatic unsaturated compounds are highly reactive-that is, they readily undergo additions of atoms or groups of atoms to the carbon atoms of their double bonds, giving each carbon four substituents. (britannica.com)
- Heterocyclic compounds are a class of compounds that consist of carbon atoms and non-carbon atoms altogether forming a cyclic skeletal structure. (chemicalbook.com)
synthetic
- In general, synthetic methods and physical and chemical properties of the saturated and the partly unsaturated heterocyclic compounds closely resemble those for their acyclic (noncyclic, or open-chain) analogs . (britannica.com)
- The 1- and 3-aza-Cope rearrangements have high activation barriers and limited synthetic applicability, accounting for their relative obscurity. (wikipedia.org)
- To maximize its synthetic utility, the cationic 2-aza-Cope rearrangement is normally paired with a thermodynamic bias toward one side of the rearrangement. (wikipedia.org)
derivatives
- to give the corresponding furanone, imidazolo[2,3-b]1,3,4- thiadiazole, 1,3,4-thiadiazolopyrimidine and pyridazinone 4-(4-Acetylaminophenyl)-4-oxo-2-(5-(4-chlorophenyl)-2- derivatives, respectively with an aim to obtain some thiadiazolyl amino)butanoic acid(4) interesting heterocyclic compounds with non-mixing and mixing system. (pdfmedsearch.com)
- Compounds with an intermediate number of double bonds are named as the hydrogenated derivatives of the mancude ring. (wikipedia.org)
relates
- The present invention relates to a compound represented by formula 1, an organic optoelectronic element comprising the same, and a display device comprising the organic optoelectronic element. (sumobrain.com)
- The invention furthermore relates to processes for the preparation of the compounds of the formulae Ia and Ib, their use and pharmaceutical compositions comprising them. (patentsencyclopedia.com)
reactions
- Aromatic compounds, though having double bonds, are extremely stable and do not readily undergo the addition reactions characteristic of other unsaturated compounds. (britannica.com)
- In 1878, the structure of piperidine was still unknown, and A. W. Hofmann made attempts to add hydrogen chloride or bromine to it in the belief that the compound possessed unsaturation (i.e. he performed standard alkene classification test reactions). (wikipedia.org)
- Phosphorine undergoes electrophilic substitution reactions like ordinary aromatic compounds: bromination, acylation, and so on. (wikipedia.org)
amino
- For example, heterocyclic structure exists in chlorophyll in plants, hemoglobin in animal blood, alkaloids and glycosides as the active ingredient in herbs, some antibiotics and vitamins, certain composition of amino acids in protein and bases in nucleotide. (chemicalbook.com)
- The isoquinoline ring in these natural compound derives from the aromatic amino acid tyrosine. (wikipedia.org)
- In 1950, Horowitz and Geissman reported the first example of the 2-aza-Cope rearrangement, a surprising result in a failed attempt to synthesize an amino alcohol. (wikipedia.org)
parent compound
- The parent compound for unsaturated ring systems is the one containing the maximal number of non-cumulated double bonds (known as the mancude ring system). (wikipedia.org)
Furthermore
- Furthermore, N-Bridgehead heterocyclic cyanine dyes have a wide range of potential applications in fluorescent compounds, DNA-binding dyes [ 19 ] and organic materials [ 20 ]. (tsijournals.com)
pathway
- These results indicate that in some cellular context, the cell sensitivity to PRIMA-1 could depend on the abolition of a gain-of-function activity of the mutated p53, through a protein degradation pathway specifically induced by this compound. (biomedsearch.com)
cycloaddition
- 1,2-Cycloaddition of 1-Aza-1,3-dienes. (paperplane.io)
- Formation of 3,5-disubstituted pyridines via [4 + cycloaddition/cycloelimination of enamines to 1-aza-1,3-butadiene intermediates including ( 1 ) is known (eq 9). (paperplane.io)
oxygen
- For example, "oxa" (for oxygen) always comes before "aza" (for nitrogen) in a name. (wikipedia.org)
structural formula
- Diethyl azodicarboxylate, conventionally abbreviated as DEAD and sometimes as DEADCAT, is an organic compound with the structural formula CH3CH2O2CN=NCO2CH2CH3. (wikipedia.org)
methyl
- These dyes have many vital general applications this back to their higher stability which can be used as bioactive compounds such as the N-methyl-Daspartate antagonists [ 18 ]. (tsijournals.com)
- While polymerization of imine ( 1 ) is not reported, analogous N -alkylmethacroleinimines such as N -cyclohexyl-3-methyl-1-aza-1,3-butadiene are known to polymerize by anionic catalysts but not by cationic or radical initiators. (paperplane.io)
- Bifunctional molecules having a DNA intercalator or DNA groove binder linked to ethylene diamine tetraacetic acid such as compounds having the formula: ##STR1## wherein R is methyl or ethyl. (google.com)
acid
- The process comprises oxidizing a feed stream comprising at least one oxidizable compound to generate a crude carboxylic acid slurry co. (sumobrain.com)
methods
- Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are de. (sumobrain.com)
- Hantzsch-Widman nomenclature is named after the German chemist Arthur Hantzsch and the Swedish chemist Oskar Widman, who independently proposed similar methods for the systematic naming of heterocyclic compounds in 1887 and 1888 respectively. (wikipedia.org)
formula
- The present invention provides a compound with a structure represented by general formula I or a pharmaceutically acceptable salt thereof, a preparation method for the compound or the salt, and a use of the compound or the pharmaceutical. (sumobrain.com)
- A compound represented by general formula (1): (in formula (1), A shows a C6-30 divalent aromatic group for forming an aromatic ring, or the like, and the plurality of R1 each independently show a hydrogen atom or the like), tetracarb. (sumobrain.com)
- Isoindoline is a heterocyclic organic compound with the molecular formula C8H9N. (wikipedia.org)
catalysis
- In particular, photoredox catalysis employs small quantities of a light-sensitive compound that, when excited by light, can mediate the transfer of electrons between chemical compounds that otherwise would react more slowly or not at all. (wikipedia.org)
applications
- Aza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. (analchemres.org)
- These compounds present many different avenues of research into therapeutic applications, particularly in addiction treatment. (wikipedia.org)
chemical
- Hantzsch-Widman nomenclature, also called the extended Hantzsch-Widman system, is a type of systematic chemical nomenclature used for naming heterocyclic parent hydrides having no more than ten ring members. (wikipedia.org)
- Phenyltropanes (PTs) are a family of chemical compounds originally derived from structural modification of cocaine. (wikipedia.org)
- Dimers of phenyltropanes, connected in their dual form using the C2 locant as altered toward a carboxamide structural configuring (in contrast and away from the usual inherent ecgonine carbmethoxy), as per Frank Ivy Carroll's patent inclusive of such chemical compounds, possibly so patented due to being actively delayed pro-drugs in vivo. (wikipedia.org)
involves
- The initial step involves the deprotonation of 2,6-disopropylaniline with lithium diisopropylamide to give a aza-allyl anion. (wikipedia.org)
useful
- The most common and synthetically useful strategy couples the cationic 2-aza-Cope rearrangement with a Mannich cyclization, and is the subject of much of this article. (wikipedia.org)
common
- Naming heterocyclic compounds is complicated because of the existence of many common names in addition to the internationally agreed-upon systematic nomenclature . (britannica.com)
- Some common heterocyclic compounds have retained names that do not follow the Hantzsch-Widman pattern. (wikipedia.org)
- Less common are the 1-aza-Cope rearrangement and the 3-aza-Cope rearrangement, which are the microscopic reverse of each other. (wikipedia.org)
structure
- Bisbenzylisoquinolinium compounds are compounds similar in structure to tubocurarine. (wikipedia.org)
class
- N-Bridgehead heterocyclic cyanine dyes are an important class of dyes which characterized by the presence unit of aza-heterocyclic compound the nature of nitrogen atom inside the ring. (tsijournals.com)
similar
- With similar properties of congeneric open-chain compounds, they will be discussed in corresponding chapters. (chemicalbook.com)
important
- Many natural heterocyclic compounds in animals and plants play an important physiological role in the body. (chemicalbook.com)
Major
- for more information, see below Major classes of heterocyclic compounds . (britannica.com)
nature
- There are many kinds and a large number of heterocyclic compounds widely distributed in nature. (chemicalbook.com)