• Methods: We investigated the value of using 77 breast cancer-associated single nucleotide polymorphisms (SNPs) for risk stratification, in a study of 33 673 breast cancer cases and 33 381 control women of European origin. (kb.se)
  • But there are over 300 SNPs, or single nucleotide polymorphisms, that are very common variations that are seen in more than 1% of the population that, in and of themselves, don't influence risks significantly, but in aggregate may actually have a significant effect on risk, both in women who carry genetic mutations and those who don't. (medpagetoday.com)
  • In this framework, the effect sizes of genetic markers, usually SNPs, are assumed to be independent and identical distributed random variables, and often the normal distribution (with 0-mean) is used for computational reasons. (biomedcentral.com)
  • The candidate gene approach revealed new single nucleotide polymorphisms (SNPs) in the Cholecystokinin B receptor (CCKBR) and pancreatic anionic trypsinogen (TRYP8) genes that showed strong evidence of association with feed efficiency traits. (uoguelph.ca)
  • These 807 SNPs represented a genomic heritability of 0.32 and 89% of the genetic variance of residual feed intake (RFI). (uoguelph.ca)
  • Studies have shown that unlinked single nucleotide polymorphisms (SNPs) associated with a single phenotype may be affected as a group if the phenotype undergoes differentiation [10] , [11] . (prolekarniky.cz)
  • 0.8) single-nucleotide polymorphisms (SNPs) from the genome-wide study were successfully genotyped using quantitative real time PCR in a validation study. (biomedcentral.com)
  • STUDY QUESTION: Are single-nucleotide polymorphisms (SNPs) at the interleukin 1A (IL1A) gene locus associated with endometriosis risk? (ox.ac.uk)
  • We focused on 8 single-nucleotide polymorphisms (SNPs) in 2 candidate genes important in the innate immune response to influenza infection and for which national prevalence estimates were available: the gene for tumor necrosis factor superfamily, member 2 (official symbol TNF ) and the mannose-binding lectin gene (official symbol MBL2 ). (cdc.gov)
  • Their initial analysis identified 130 suggestive single-nucleotide polymorphisms (SNPs) for African Americans and 369 suggestive SNPs for European Americans related to LTPA-related energy expenditure. (medscape.com)
  • We used detailed genomic methods to identify the genetic quantitative trait loci and the nearby putative candidate genes that have biological connections especially for immune-related activities. (usda.gov)
  • Our objective was to estimate genetic parameters and identify quantitative trait loci (QTL) for absolute T3 and/or T4 levels of piglets and fetuses challenged with Porcine reproductive and respiratory syndrome virus. (usda.gov)
  • Three significant quantitative trait loci were identified for fetal_T3 on SSC1 and SSC4, which collectively explained 10% of the genetic variation. (usda.gov)
  • In many cases, however, the identified individual loci cannot fully explain the heritability estimates, suggesting missing heritability. (nih.gov)
  • The application of genomic prediction models that take into account the effects of all individual loci may greatly enhance the elucidation of the genetic architecture of quantitative traits in plants. (nih.gov)
  • The purpose of this study was to identify 30 genetic loci underlying elevated IOP using HS rats. (nih.gov)
  • To test our hypotheses, we measured the critical thermal minimum (CT min ) and critical thermal maximum (CT max ) of 100 lines of the Drosophila Genetic Reference Panel (DGRP) and used GWAS to identify loci that explain variation in thermal limits. (frontiersin.org)
  • In genome-wide association analysis, two loci were significantly associated with PT asymmetry, including a coding polymorphism within the gene ITIH5 that is predicted to affect the protein's function and to be deleterious (rs41298373, P=2.01×10−15), and a locus that affects the expression of the genes BOK and DTYMK (rs7420166, P=7.54×10-10). (mpi.nl)
  • In conclusion, the results of our study contribute to a better understanding on the underlying genetic architecture of ET/TEF with the identification of three risk loci and candidate genes. (lu.se)
  • The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. (kb.se)
  • We applied a leaf imprinting method for rapid and non-destructive phenotyping to explore genetic variation and identify quantitative traits loci (QTL) for stomatal traits in wheat grown under greenhouse and field conditions. (biomedcentral.com)
  • In this setting, a crescent focus has been placed on the identification of genes, associated genetic polymorphisms, and multiple susceptibility loci. (scielo.br)
  • En ese sentido, existe un creciente enfoque en la identificación de genes, polimorfismos genéticos asociados y loci de susceptibilidad múltiples. (scielo.br)
  • At the same time, Genome-Wide Association Studies (GWAS) have increased discoveries of disease-associated genetic loci. (prolekarniky.cz)
  • Despite the recent explosion of knowledge regarding disease-associated loci and the genetic structure of different world populations [14] - [19] , few studies have examined population-based differences in the genetic risk factors for disease. (prolekarniky.cz)
  • The various areas that Peter M. Visscher examines in his Quantitative trait locus study include Genetic marker, Expression quantitative trait loci, Genetic linkage, Linkage and Family-based QTL mapping. (research.com)
  • Genome-wide association studies have identified more than 100 genetic loci for SLE susceptibility across populations, with most of the genetic risk shared across borders and ethnicities. (medscape.com)
  • In addition, we discuss reports on the interactions of OXT and AVP receptor genes and genes involved in other pathways (such as those of dopamine, serotonin, and reelin), as well as research that has shed some light on the impact of gene polymorphisms on the volume, connectivity, and activation of specific neural structures, differential receptor expression, and plasma levels of the OXT and AVP peptides. (frontiersin.org)
  • Chromosomal abnormalities, HLA phenotypes, and polymorphisms of various genes have been associated with acne. (springer.com)
  • It is believed that 75-80% of the heritability of Graves disease is caused by likely associated genes, variants, and polymorphisms. (medscape.com)
  • developmental language disorders are genetic and is therefore caused (at least in part) by the genes passed on from parents to children. (brookes.ac.uk)
  • Although there is strong evidence for the role of a genetic component in language disorder, we do not know which genes contribute to this disorder or how the inheritance of language problems work. (brookes.ac.uk)
  • Twin and family studies and newly evolving genetic approaches start to give us a glimpse as to which genes and (interacting) environmental influences are shaping our brains. (news-medical.net)
  • Polygenic risk scores or polygenic scores (PS) analyse an individual's genome, aggregating thousands of genes, to estimate genetic tendency towards particular traits and diseases. (bmj.com)
  • In Aim 3, we will confirm causal genes using an established knockin CAG-LSL-Cas9 rat model on the WMI/WLI genetic background. (hhs.gov)
  • This review highlights the genes and genetic polymorphisms currently studied, identified as influential in the genesis of IS, such as MMP-3, IL-6, type I collagen, and vitamin D and estrogen receptors. (scielo.br)
  • La presente revisión destaca los genes y polimorfismos genéticos actualmente estudiados, identificados como influyentes en la génesis de la EI, como los genes MMP-3, IL-6, colágeno tipo 1 y receptores de vitamina D y de estrógeno. (scielo.br)
  • And so it's felt in 2021 that we've probably identified most, if not all, of the highly penetrant and moderately penetrant genes, and the remaining mystery of heritability is probably largely explainable by this genomic combination of single nucleotide polymorphisms. (medpagetoday.com)
  • The polymorphisms within genes CCKBR and TRYP8 were associated with pancreas mass and pancreatic exocrine secretion. (uoguelph.ca)
  • Polymorphisms of candidate genes in diverse pathways have been associated with LV mass. (biomedcentral.com)
  • The present study was carried out with the objective to determine the polymorphism of CYP19 (promoter) and ER1 genes and their possible association with cystic ovarian disease in HF crossbred cows. (ijlr.org)
  • We compared the prevalence of 8 polymorphisms in the tumor necrosis factor and mannose-binding lectin genes among 105 children and young adults with fatal influenza with US population estimates and determined in subanalyses whether these polymorphisms were associated with sudden death and bacterial co-infection among persons with fatal influenza. (cdc.gov)
  • Limited analysis of 2 genes important to the innate immune response found no association between genetic variants and fatal influenza infection. (cdc.gov)
  • Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)
  • Studies in twins have estimated an influence of heritability on leisure-time physical activity (LTPA) in the range of 35% to 83%, and recent work has identified several potentially relevant genes. (medscape.com)
  • These results provide further insight into genetic susceptibility to breast cancer and will improve the use of genetic risk scores for individualized screening and prevention. (kb.se)
  • Gastrointestinal infections can be life threatening, but not much is known about the host's genetic contribution to susceptibility to gastrointestinal infections or the latter's association with psychiatric disorders. (escholarship.org)
  • The SNP heritability of susceptibility to gastrointestinal infections ranged from 3.7% to 6.4% on the liability scale. (escholarship.org)
  • We furthermore provide a functional basis for the association by showing a possible link to decreased brain tissue CDKN2B expression and substantiate that genetic susceptibility differs between low- and high-grade astrocytoma. (escholarship.org)
  • Polygenic risk score analyses based on the 21 susceptibility variants demonstrate varying cumulative contribution of common risk alleles among different patient subgroups, as well as genetic associations with cardiac electrical traits and disorders in the general population. (cdc.gov)
  • Analyzing the impact of human migration on genetic disease susceptibility is critical to the understanding of complex disease. (prolekarniky.cz)
  • Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. (who.int)
  • Polymorphism occurs both at a specific level with heritable variation in the overall morphological design of individuals as well as in certain specific morphological or physiological traits within a species. (wikipedia.org)
  • To disentangle the genetic architecture of such traits, natural variation within species can be explored by studying genotype-phenotype relationships. (nih.gov)
  • We analyzed 349 Arabidopsis accessions and found extensive variation and high heritabilities for different morphological traits. (nih.gov)
  • In conclusion, our study identified that common genetic variation indeed influences the common substrate, but that these variants do not directly translate to increased disease risk. (nature.com)
  • Recent findings have shown, that variation in total gray and white matter volume of the adult human brain is primarily (70-90%) genetically determined [Baare et al, 2001] and in a recent magnetic resonance imaging (MRI) brain study with 45 monozygotic and 61 dizygotic 9-year-old twin-pairs, and their 87 full siblings also high heritabilities have been found [Peper et al, in preparation]. (news-medical.net)
  • However, the extent to which standing genetic variation in thermal tolerance alleles influence dynamic stress responses vs. preparatory processes is unknown. (frontiersin.org)
  • Genetic variation in thermal tolerance is well-documented (e.g. (frontiersin.org)
  • Maria Martinez interconnects LRRK2, Meta-analysis, Disease, Imputation and Genetic variation in the investigation of issues within Genome-wide association study. (research.com)
  • Her studies in Genome-wide association study integrate themes in fields like Exome, Computational biology, Genetic variation and Candidate gene. (research.com)
  • CONCLUSIONS: Common genetic variation has an important role in the etiology of schizophrenia and PPI impairments. (hofstra.edu)
  • Whereas genome-wide association studies (GWAS) represent the primary tool for determining the genetic basis of a phenotype/trait of interest, quantifying the contribution of genetic factors to the variation of a phenotype plays in addition an important role in many studies. (biomedcentral.com)
  • Although limited from the computational perspective due to the extremely high-dimensional data in GWAS, high-dimensional linear regression is a natural model for GWAS in modelling the whole-genome level contributions of genetic variation. (biomedcentral.com)
  • Therefore, the main objective of this work was to identify genetic markers responsible for genetic variation in feed efficiency traits as well as to understand the molecular basis of feed efficiency traits. (uoguelph.ca)
  • This process has enabled researchers to characterize worldwide genetic variation and has provided information regarding migrations that founded entire populations [2] , [3] . (prolekarniky.cz)
  • His Genetics and Genetic variation, Quantitative trait locus, Linkage disequilibrium, Human height and Gene investigations all form part of his Genetics research activities. (research.com)
  • His Heritability, Genetic variation, Genetic architecture, Gene and Linkage disequilibrium investigations are all subjects of Genetics research. (research.com)
  • His is doing research in Gene, Heritability, Quantitative trait locus, Genetic variation and Genome, both of which are found in Genetics. (research.com)
  • In contrast, definite identification of the actual genetic variation which is directly responsible for the observed association in the initial GWAS oppose major difficulties due to the presence of strong local linkage disequilibrium. (univ-lyon1.fr)
  • Recent candidate gene studies [ 13 - 16 ], as well as genome-wide association studies [ 17 - 25 ], have identified polymorphisms that account for a portion of the variation in blood lipid levels. (cdc.gov)
  • To assess genetic variation among racial and ethnic groups in the U.S. population, we need genetic information from a large, well-designed, and population-based U.S. survey, such as the Third National Health and Nutrition Examination Survey (NHANES III) that includes the three major race/ethnic groups. (cdc.gov)
  • Competing causes of mortali- or all of the animal species tested genetic variation, health status, life ty may prevent the development of experimentally. (who.int)
  • High heritability estimates for acne in twins were reported [6, 7]. (springer.com)
  • Twin studies have also shown that genetic effects vary regionally within the brain, with high heritabilities of frontal lobe volumes (90-95%), moderate estimates in the hippocampus (40-69%), and environmental factors influencing several medial brain areas. (news-medical.net)
  • Single nucleotide polymorphism (SNP)-heritability estimates indicate a strong polygenic influence. (cdc.gov)
  • These estimates have a very different interpretation also qualitatively and they disagree most likely because they are based on different statistical models of heritability. (biomedcentral.com)
  • We conducted a hypothesis-generating pilot study to examine if host genetic variants were associated with fatal influenza virus infection by comparing prevalence of selected host genetic variants among children and young adults who died of influenza with population-based prevalence estimates. (cdc.gov)
  • Power RA, Pluess M. Heritability estimates of the big five personality traits based on common genetic variants. (medlineplus.gov)
  • An ectotherm's thermal tolerance is determined by both fixed genetic factors and plastic changes in behavior, morphology, physiology, and gene expression. (frontiersin.org)
  • This study aimed to examine the contribution of genotypes of DNA double-strand break repair gene X-ray repair cross complementing protein 3 (XRCC3) and its polymorphisms to asthma risk in the Taiwanese. (iiarjournals.org)
  • Her Genetics study is mostly concerned with Genetic linkage, Allele, Gene mapping, Candidate gene and Gene. (research.com)
  • Her work on Single-nucleotide polymorphism, Gene, Genotyping and Molecular genetics as part of general Genetics study is frequently linked to HMG-CoA reductase, bridging the gap between disciplines. (research.com)
  • The polymorphism in CYP19 and ER1 gene was detected using PCR-RFLP using PvuII and BglI restriction enzymes, respectively. (ijlr.org)
  • 2014) explored genetic polymorphism of exon 2 of CYP19 gene and its association with ovarian activity in Egyptian buffaloes using PCR-SSCP and sequencing analysis. (ijlr.org)
  • The aim of this study was to identify and characterize the genetic polymorphism in promoter region of CYP19 gene by RFLP analysis and to elucidate the relationship between polymorphism in CYP19 gene and COD in HF crossbred cattle. (ijlr.org)
  • Instead, many (perhaps thousands) of common gene variations (polymorphisms) combine to influence individual characteristics of temperament. (medlineplus.gov)
  • Univariate and multivariable linear regression and within-gene haplotype trend regression were used to test for genetic associations assuming an additive mode of inheritance for each of the three major race/ethnic groups in the United States (non-Hispanic white, non-Hispanic black, and Mexican American). (cdc.gov)
  • In follow-up analyses, rs17076061 was not robustly associated with psychiatric disease, and no overlap was found between the broader genetic architecture of the common substrate and genetic risk for major depressive disorder, bipolar disorder, or schizophrenia. (nature.com)
  • Using publicly available genome-wide association statistics from large-scale studies, we saw no significant genetic correlations of PT asymmetry with autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia, educational attainment or intelligence. (mpi.nl)
  • BACKGROUND: Prepulse inhibition (PPI) of the startle reflex has been suggested as a candidate endophenotype for schizophrenia research, as it shows high heritability and has been found deficient in schizophrenia spectrum disorders. (hofstra.edu)
  • Overall, these data support the idea that PPI is a valid endophenotype that can be used to explore the genetic architecture of schizophrenia. (hofstra.edu)
  • His Genome-wide association study study combines topics from a wide range of disciplines, such as Schizophrenia, Polymorphism, Disease, Locus and Genetic architecture. (research.com)
  • Here, genomic prediction models revealed different genetic architectures for the morphological traits. (nih.gov)
  • Preparative yield, amylose/amylopectin content, and phosphorylation of potato tuber starch are starch-related traits studied at the genetic level. (peerj.com)
  • We investigated a possible genetic association between ADHD and narcolepsy traits in the Hamamatsu Birth Cohort for mothers and children (HBC study) ( n = 876). (nature.com)
  • In this first study to decifer genetic relationships between wheat stomatal traits and yield in response to water deficit, no significant correlations were observed among yield and stomatal traits under field conditions. (biomedcentral.com)
  • The reproduction and production traits are closely connected in cattle and therefore the genetic improvement of the reproduction traits is important for the efficient way of lactogenesis and lactopoesis. (ijlr.org)
  • Generally, low numbers of genetic marker (AFLP, RFLP) significantly influencing the reproduction traits have been detected, because most of them are characterized by low heritability. (ijlr.org)
  • In addition, we examined the polygenicity of EA/TEF and found that EA/TEF is less polygenic than other complex genetic diseases. (lu.se)
  • We concluded that IS remains a complex disease with a polygenic background and that genetic polymorphisms are intrinsically related to this condition. (scielo.br)
  • More than three hundred publications describing results of GWAS studies have now been published providing a better view on the mechanism by which genetic diversity may modulate human phenotype and disease risk. (univ-lyon1.fr)
  • This mapping strategy is supported by the high heritability, large effect size of strain on phenotypes, and existing whole genome sequencing data for the WMI and WLI strains ( ~100x coverage per strain, with ~4,400 high confidence polymorphisms between strains). (hhs.gov)
  • Seasonal polyphenism in Eurema hecabe Environmental polymorphism, where genetic heritability plays no role, is often termed polyphenism. (wikipedia.org)
  • A large twin study demonstrated that 81 % of the variance of the disease was attributed to additive genetic effects, whereas the remaining 19 % was attributed to unique, unshared environmental factors [10]. (springer.com)
  • Remarkably, at age 14 years, facial acne in girls was less influenced by genetic factors than in boys and was significantly influenced by common environmental factors [12]. (springer.com)
  • Genetic and environmental influences on acne in adolescent twins. (springer.com)
  • 4] Environmental and epigenetic factors may play a role in the pathogenesis of this disease (eg, initiation, progression, development), but the interaction among genetic, epigenetic, and immunologic factors remains unclear. (medscape.com)
  • Elevated intraocular pressure (IOP) is influenced by environmental and genetic factors. (nih.gov)
  • While the causes of most birth defects remain unknown, there are likely to be combinations of genetic and environmental risk factors involved. (cdc.gov)
  • and (5) heritability estimated on dam components is hD2=0.46, which implies that the maternal effect (genetic and environmental) is an important factor in this type of behaviour.It is concluded that there is an additive genetic, and therefore, hereditary factor for dominant-aggressive behaviour in the English Cocker Spaniel. (researchgate.net)
  • Estimation of the genetic and environmental contributions to baseline startle and PPI showed a substantial single nucleotide polymorphism heritability for 120-millisecond PPI stimuli. (hofstra.edu)
  • However, deviations from genetic drift are expected when environmental changes occur due to migration [13] . (prolekarniky.cz)
  • Host genetic factors, moreover, may modify the response to these environmental challenges and are responsible for developmental vascular instability. (medscape.com)
  • Dr. Nir Enyon from Victoria University's Institute of Sport, Exercise and Active Living, in Melbourne, Australia, told Reuters Health by email, "PA is complex and is influenced by environmental factors but also from genetic factors that we currently can't control. (medscape.com)
  • Although a large body of research, ranging from rodents to humans, has reported on the effects of OXT and AVP administration on affiliative and trust behaviors, and has highlighted the genetic contributions of OXT and AVP receptor polymorphisms to both social behaviors and to diseases related to social deficits, the consequences of peptide administration on psychiatric symptoms, and the impact of receptor polymorphisms on receptor function, are still unclear. (frontiersin.org)
  • This review summarizes findings on the associations between OXT and AVP receptor polymorphism, social behavior, and psychiatric diseases. (frontiersin.org)
  • PRS can also be used to examine the genetic association between two different diseases or phenotypes. (nature.com)
  • In the late 1990s, 1 the development of preimplantation genetic diagnosis (or PGD) made it possible to test in vitro fertilised (IVF) embryos for known genetic diseases and select only unaffected embryos for implantation. (bmj.com)
  • We calculated the genetic risk of 102 diseases in 1,043 unrelated individuals across 51 populations of the Human Genome Diversity Panel. (prolekarniky.cz)
  • Additionally, they have included only a modest number of diseases, populations, or genetic samples. (prolekarniky.cz)
  • Finding the missing heritability of complex diseases. (research.com)
  • There is mounting evidence that common polymorphism will only explain a small fraction of the heritability of common diseases. (univ-lyon1.fr)
  • Polymorphism is the appearance of forms or "morphs" differing in color and number of attributes within a single species. (wikipedia.org)
  • Animals were genotyped using 60 K Illumina or 650 K Affymetrix single nucleotide polymorphism (SNP) panels. (usda.gov)
  • Genome-wide association studies that link phenotypes to thousands of single nucleotide polymorphism markers are nowadays common practice for such analyses. (nih.gov)
  • The top single-nucleotide polymorphism (SNP) rs17076061 was associated with the common substrate at genome-wide significance and replicated, explaining 1.2% of the common substrate variance. (nature.com)
  • Genotyping-by-sequencing was used to obtain ~3.5M single nucleotide polymorphisms from each 32 individual. (nih.gov)
  • We also analyzed the genetic EA/TEF architecture beyond the single marker level, which revealed an estimated single-nucleotide polymorphism (SNP)-based heritability of around 37% ± 14% standard deviation. (lu.se)
  • We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2-5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. (kb.se)
  • Her primary area of study in Single-nucleotide polymorphism is in the field of Imputation. (research.com)
  • Her study in Single-nucleotide polymorphism focuses on SNP in particular. (research.com)
  • Her work on SNP as part of general Single-nucleotide polymorphism research is often related to Plasma cell differentiation, thus linking different fields of science. (research.com)
  • Her scientific interests lie mostly in Genome-wide association study, Genetic association, Parkinson's disease, Meta-analysis and Single-nucleotide polymorphism. (research.com)
  • In his study, Gerontology is strongly linked to Cognition, which falls under the umbrella field of Single-nucleotide polymorphism. (research.com)
  • His Single-nucleotide polymorphism research integrates issues from Genome, Cognition and Allele frequency. (research.com)
  • His Single-nucleotide polymorphism research is multidisciplinary, incorporating perspectives in Body mass index and Confounding. (research.com)
  • Alzheimer's disease (AD) is notable for having substantial heritability unaccounted for by single nucleotide polymorphism alleles. (ibm.com)
  • In these studies, upwards of a million single-nucleotide polymorphisms are typed in each individual. (medscape.com)
  • For this purpose, heritability is a crucial quantity [ 1 , 2 ] and it is defined (in the narrow-sense) as the proportion of the variance of a phenotype explained by the (additive) genetic factors. (biomedcentral.com)
  • Since heritability is a concept detailing the additive variance of a trait which is in a certain sense based on a statistical model, heritability estimation is consequently dependent on the specified model [ 12 ]. (biomedcentral.com)
  • We have constructed an ML pipeline, which we call RubricOE, comprised of linear kernel support vector machines, using feature ranking based on heritability estimated by variance predicted by linear ridge regression, and with multiple layers of cross validation to identify "stable sets" of the most strongly predictive features that remain consistent across all the training/test and validation splits. (ibm.com)
  • Common genetic variants explain 15%of the variance in neuroticism. (illinois.edu)
  • The genetic basis for elevation in lipid levels is not well understood, but substantial heritability has been demonstrated in twin [ 9 ] and family-based [ 10 - 12 ] studies, which have estimated that approximately 43% to 83% of the variance in blood lipid and lipoprotein levels is attributable to genetic factors. (cdc.gov)
  • In Aim 1, we will use a reduced complexity mapping strategy to identify the causal genetic factors for oxycodone and stress response phenotypes. (hhs.gov)
  • MRI can provide intermediate or endo-phenotypes that can be used to assess the genetic architecture of such disorders. (biorxiv.org)
  • 2006]. For the genetic analyses, structural equation modeling and voxel-based morphometry were used. (news-medical.net)
  • The purpose of this study was to determine if the variability observed in this behavioural characteristic has an additive genetic component and if so, to estimate heritability (h2). (researchgate.net)
  • In this paper, we propose a generic strategy for heritability inference, termed as "boosting heritability" , by combining the advantageous features of different recent methods to produce an estimate of the heritability with a high-dimensional linear model. (biomedcentral.com)
  • Boosting heritability uses in particular a multiple sample splitting strategy which leads in general to a stable and accurate estimate. (biomedcentral.com)
  • A complementary hypothesis posits that a substantial part of this heritability is due to many, genetically independent, rare mutations, a proposition that has recently gained experimental support. (univ-lyon1.fr)
  • 163 In Lepidoptera, polymorphism can be seen not only between individuals in a population but also between the sexes as sexual dimorphism, between geographically separated populations in geographical polymorphism and also between generations flying at different seasons of the year (seasonal polymorphism). (wikipedia.org)
  • The difference between the two experiments could result from sampling variations and from differences in the genetic structure of the two populations possibly including both heterosis and additive effects as well as their interaction in the first experiment. (gse-journal.org)
  • Genetic diversity across different human populations can enhance understanding of the genetic basis of disease. (prolekarniky.cz)
  • Adaptation to new environments may have caused genetic risk differences across many human populations. (prolekarniky.cz)
  • His studies in Heritability integrate themes in fields like Demography, Genetic correlation, Missing heritability problem and DNA methylation. (research.com)
  • The risk of developing SLE is at least in part genetic, but it is a complex genetic illness with no clear mendelian pattern of inheritance. (medscape.com)
  • These results indicate that there are genetic differences in the resistance to visceral infection by S. enteritidis in these commercial egg-laying flocks, and suggest that these differences are at least partly due to genetic polymorphism in the NRAMP1 region. (gse-journal.org)
  • This situation allows differences in the genetic basis of disease to build naturally via genetic drift. (prolekarniky.cz)
  • Conclusion: Age at cannabis initiation appears to be moderately heritable in western countries, and individual differences in onset can be explained by separate but correlated genetic liabilities. (eur.nl)
  • Future studies replicating these findings would be warranted to elucidate the genetic vulnerability for daytime sleepiness in individuals with ADHD. (nature.com)
  • Among AD patients, early onset (EOAD) vs. late onset (LOAD) show different impacts in memory and language vs. motor and atypical AD symptoms, as well as familial heritability in EOAD. (ibm.com)
  • This species, and others in its genus, have been extensively studied for understanding the genetic basis for polymorphism and Batesian mimicry. (wikipedia.org)
  • Another twin study revealed that heritability of acne on the back was very high [12]. (springer.com)
  • Genetic control of sebum excretion and acne - a twin study. (springer.com)
  • In our study involving 54 monozygotic and 58 dizygotic twin pairs and their 34 singleton siblings, verbal, and performal intelligence were found to share a common genetic origin with an anatomical neural network involving the frontal, occipital, and parahippocampal gray matter and connecting white matter of the superior occipitofrontal fascicle, and the corpus callosum [Hulshoff Pol et al. (news-medical.net)
  • One recent study conducted in Japan demonstrated that the relative risk of narcolepsy in affected first-degree family members is 10- to 40-fold higher than in the general population, suggesting that genetic factors play an important role in this disease 12 . (nature.com)
  • The NBDPS was a multisite, population-based, case-control study of genetic and non-genetic risk factors for major structural birth defects that included women with deliveries between 1997 and 2011. (cdc.gov)
  • In this proposal, we aim to conduct a genetic mapping study to identify genetic factors influencing oxycodone-motivated behaviors and vulnerability to stress, a major risk factor of opioid use disorder. (hhs.gov)
  • Her Heritability study combines topics in areas such as Missing heritability problem and Genetic architecture. (research.com)
  • Her Comorbidity study incorporates themes from Heritability, Genetic heterogeneity, Clinical psychology and Risk factor. (research.com)
  • The study of heritability estimation with fixed-effect models has been started relatively recently and it has not yet gained a wide-spread attention. (biomedcentral.com)
  • This study estimated the heritability of age at first cannabis use and identified associations with genetic variants. (eur.nl)
  • His Genome-wide association study study incorporates themes from Biobank, Bioinformatics, Disease, Computational biology and Genetic architecture. (research.com)
  • His research in Genetic association focuses on subjects like Demography, which are connected to Observational study. (research.com)
  • Cases and controls were selected from the extremes of the LV mass index distribution from 906 individuals in the Family Blood Pressure Program (FBPP) - Hypertension Genetic Epidemiology Network (HyperGEN) Study. (biomedcentral.com)
  • In addition, the study shows that neuroticism is influenced by many genetic variants of small effect that are either common or tagged by common variants. (illinois.edu)
  • The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. (cdc.gov)
  • Dr. Simin Liu from Brown University, in Providence, Rhode Island, and colleagues examined the role of genetic factors in affecting LTPA in their genome-wide analysis of data from the Women's Health Initiative, the Jackson Heart Study and the Framingham Heart Study. (medscape.com)
  • This analysis represents a large-scale attempt to characterize genetic risk differentiation in the context of migration. (prolekarniky.cz)
  • METHODS: Meta-analysis of 3 population-based genome-wide association studies comprising 4069 children with glioma and 8778 controls of multiple genetic ancestries. (escholarship.org)
  • The association was driven by low-grade astrocytoma (P-value of 3.815e-9) and exhibited unidirectional effects across all 6 genetic ancestries. (escholarship.org)
  • Her Genetic association research incorporates themes from Genetic heterogeneity and Heritability. (research.com)
  • Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (research.com)
  • Her Genetic association research includes themes of Quantitative trait locus, Comorbidity and Heritability. (research.com)
  • His work carried out in the field of Genetic association brings together such families of science as SNP, Computational biology and Receiver operating characteristic. (research.com)
  • His research in Genetic association intersects with topics in Body mass index and Population stratification. (research.com)
  • Generally, genetic association studies do not account for the heritability. (ibm.com)
  • However, to our knowledge, no published studies have examined the association between specific host genetic variants and severe influenza disease outcomes. (cdc.gov)
  • However, conflicting findings are common among genetic association studies. (cdc.gov)
  • Twin studies of disease heritability based on medical records: application to acne vulgaris. (springer.com)
  • The risk allele was associated with reduced ABO expression, providing, for the first time, genetic evidence to support previous studies linking the O blood group to gastrointestinal infections. (escholarship.org)
  • Several studies show evidence that the genetic component is determinant to the development of IS. (scielo.br)
  • These developments have paved the way for studies investigating the effects of migration on the genetic basis of disease [4] - [6] . (prolekarniky.cz)
  • The correct diagnosis of a cleft anomaly is fundamental for treatment, for further genetic and etiopathological studies, and for preventive measures correctly targeting the category of preventable orofacial clefts. (medscape.com)
  • In our lab, we are trying to identify genetic factors that might play a role in these disorders. (brookes.ac.uk)
  • Shared genetic factors have been suggested to link PT asymmetry to these disorders. (mpi.nl)
  • Anxiety disorders appear to be caused by an interaction of biopsychosocial factors, including genetic vulnerability, which interact with situations, stress, or trauma to produce clinically significant syndromes. (health.am)
  • Genetic factors significantly influence risk for many anxiety disorders. (health.am)
  • Evidence continues to accumulate to suggest important roles for inflammation and genetic factors in the process of atherosclerosis and specifically in stroke. (medscape.com)
  • Overall, the findings "suggest that human LTPA may be regulated by the genetic factors through 1) homeostasis and neural reward system, both of which are under the constant control of the nervous system, (and) 2) the structural and metabolic constraints exerted on the capacity to actually perform LTPA," the researchers conclude. (medscape.com)
  • Here, we investigated the hypothesis that the common substrate serves as an intermediate phenotype to detect genetic risk variants relevant for psychiatric disease. (nature.com)
  • After correction for covariates, the heritability of the common substrate was estimated at 0.50 (standard error 0.18). (nature.com)
  • Similarly, it was unresolved whether there is a common genetic origin of focal gray matter and white matter structures with intelligence. (news-medical.net)
  • To explore the common genetic origin of focal gray matter and white matter areas with intelligence, cross-trait/cross-twin correlations were obtained in which the focal gray matter and white matter densities of each twin are correlated with the psychometric intelligence quotient of his/her cotwin. (news-medical.net)
  • Both rare and common genetic variants have been associated with ADHD. (nature.com)
  • Our results provide new insight into the genetic architecture of the brain with relevance to complex neurological and psychiatric disorders, as well as brain development and aging. (biorxiv.org)
  • This is known as a complex genetic disorder. (brookes.ac.uk)
  • Although SLE is generally a complex genetic illness, there are several examples of mutations that can produce a monogenetic form of the illness. (medscape.com)
  • Due to its 24 complex, multifactorial nature, genetic predisposition is not completely understood thus, there is an urgent 25 need for additional investigations into the genetic regulation of IOP. (nih.gov)
  • Working closely with other collaborators active in this field, we aim to identify specific genetic variants that cause this predisposition and to investigate the kinds of biological processes that they take part in. (brookes.ac.uk)
  • Even if you have a biological or genetic predisposition to low levels of PA, we can always find a PA program that will work for you," Dr. Enyon said. (medscape.com)
  • Research in my lab centres around genetic contributions to speech, language and Communication Disorders (SLCDs). (brookes.ac.uk)
  • And the ancestry was not determined by self-reported ancestry, but actually by genomic or genetic ancestry. (medpagetoday.com)
  • Phenotypic and genetic correlations of piglet_T3 levels with weight gain (0-42 DPI) were 0.26 ± 0.03 and 0.67 ± 0.14, respectively. (usda.gov)
  • Identification of Genetic Alterations, as Causative Genetic Defects in Long QT Syndrome, Using Next Generation Sequencing Technology. (cdc.gov)
  • Another example is the genetic polymorphism of larval developmental rates seen in the Phengaris rebeli, in which there exist slow-developing larvae (SDL) (75% of the total P. rebeli larval population) and fast-developing larvae (FDL) (25% of the total P. rebeli larvae population). (wikipedia.org)
  • Materials and Methods: Associations of seven XRCC3 genotypes, namely rs1799794, rs45603942, rs861530, rs3212057, rs1799796, rs861539 and rs28903081, with the risk of asthma were investigated among 198 patients with asthma and 453 non-asthma controls by polymerase chain reaction-restriction fragment length polymorphism genotyping methodology. (iiarjournals.org)
  • Existing methods for estimating heritability are most often based on random-effect models, typically for computational reasons. (biomedcentral.com)
  • However, to our knowledge, a systematic numerical comparison of these different methods for estimating heritability has not been made yet. (biomedcentral.com)
  • Methods: A twin-based heritability analysis using 8055 twins from three cohorts was performed. (eur.nl)
  • Molecular techniques like detection of DNA-level polymorphism by restriction fragment length polymorphism (RFLP), AFLP, SNP and a number of molecular markers are in frequent use to improve animal performance from one generation to next generation (Khare & Khare, 2017). (ijlr.org)
  • However, the genetic control of T3 and T4 levels during infection is not completely understood. (usda.gov)
  • The combination of pregnancy exposure information, genetic data, detailed clinical information about the birth defects, and family histories is a unique resource. (cdc.gov)
  • Absence of Family History and Phenotype-Genotype Correlation in Pediatric Brugada Syndrome: More Burden to Bear in Clinical and Genetic Diagnosis. (cdc.gov)
  • Brugada syndrome: clinical and genetic findings. (cdc.gov)
  • GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer. (ucsf.edu)
  • The heritability of opioid addiction has been estimated to be approximately 0.5 in humans. (hhs.gov)
  • We found that genetic risk for type 2 diabetes and pancreatic cancer decreased as humans migrated toward East Asia. (prolekarniky.cz)
  • Evidence is accumulating that brain structure is under considerable genetic influence [Peper et al. (news-medical.net)
  • However, empirical evidence for genetic risk stratification is lacking. (kb.se)
  • Sheppard found that the polymorphism is maintained by selective mating: each genotype preferentially mates with other morphs. (wikipedia.org)
  • His Heritability research includes elements of Minor allele frequency and Statistics. (research.com)