• severe
  • Heart failure is a rare, reported consequence of severe Paget's disease (i.e. more than 40% skeletal involvement). (wikipedia.org)
  • citation needed] There have been reported cases where a polyglutamine expansion may lengthen when passed down, which often can result in an earlier age-of-onset and a more severe disease phenotype for individuals who inherit the disease allele. (wikipedia.org)
  • blindness
  • Driving Blind," a feature-length documentary, follows brothers Tod and Justin Purvis who are faced with Choroideremia, a rare genetic disease that causes blindness. (savannahnow.com)
  • During the film, the brothers go camping - an event Tod said he hadn't done in 20 years because he can't see well at night (night blindness is one of the first symptoms of the disease). (savannahnow.com)
  • In the United States the usual bureaucratic maze exists, with 8 states having mandatory reporting, about 40 having central registers of the blind, and only 13 reporting through uniform procedures to the National Institute of Neurological Diseases and Blindness (according to an unpublished survey conducted by the American Foundation for the Blind). (encyclopedia.com)
  • A major cause of congenital blindness in the United States, ophthalmia neonatorum, which is caused by gonorrhea organisms in the maternal birth canal, is now prevented by placing silver nitrate solution in all newborn infants' eyes. (thefreedictionary.com)
  • Night blindness results from a deficiency of vitamin A. See eye eye, organ of vision and light perception. (thefreedictionary.com)
  • The slowly progressing hearing loss is more problematic to adjust to than the congenital blindness for most people with Norrie disease. (wikipedia.org)
  • Many patients also exhibit nystagmus (involuntary movement of the eyes), visual disturbances, and even blindness or deafness. (wikipedia.org)
  • cataracts
  • Patients with Norrie disease may develop cataracts, leukocoria (a condition where the pupils appear white when light is shone on them), along with other developmental issues in the eye, such as shrinking of the globe and the wasting away of the iris. (wikipedia.org)
  • These progressions include the formation of cataracts, deterioration of the iris with adhesions forming between the iris and the lens or the cornea, and shallowing of the anterior chamber which may increase intraocular pressure, causing eye pain. (wikipedia.org)
  • protein
  • Many SCAs below fall under the category of polyglutamine diseases, which are caused when a disease-associated protein (i.e., ataxin-1, ataxin-3, etc.) contains a large number of repeats of glutamine residues, termed a polyQ sequence or a "CAG trinucleotide repeat" disease for either the one-letter designation or codon for glutamine respectively. (wikipedia.org)
  • Though exclusively heritable, this extremely rare disease is classified with the transmissible spongiform encephalopathies (TSE) due to the causative role played by PRNP, the human prion protein. (wikipedia.org)
  • It is also in a group of hereditary prion protein diseases or also known as TSEs. (wikipedia.org)
  • Prion diseases (transmissible spongiform encephalopathies) are rare degenerative diseases of the brain thought to be caused by a protein that converts to an abnormal form called a prion (Gambetti Pierluigi, 2013). (wikipedia.org)
  • clinical
  • the Krembil is also one of the largest research institutes in Canada focusing on human neurological disease from both a basic science and clinical research perspective. (wikipedia.org)
  • and (2) the disease may be underreported due to its clinical similarity to other diseases (Ghetti B, et al. (wikipedia.org)
  • Canine coronavirus is a gastrointestinal disease that is usually asymptomatic or with mild clinical signs. (wikipedia.org)
  • Disseminated disease occurs when the fungus has spread outside of the lungs and may include clinical signs such as lameness, pain, seizures, anterior uveitis, and localized swelling. (wikipedia.org)
  • According to a study performed in the Tucson and Phoenix area, 28% of dogs will test positive for exposure to the fungus by two years of age, but only 6% of the dogs will be ill with clinical disease. (wikipedia.org)
  • From July 1968 to August 1969 he held a clinical fellowship in neuro-ophthalmology at Bascom Palmer Eye Institute, working with Lawton Smith, MD. Dr. Bird returned to Moorfield's in August 1969 and from 1969 to 1976 held successive appointed to the Institute of Ophthalmology as lecturer, senior lecturer and reader and then from 1976 to 2006 as professor, simultaneously serving as consultant at Moorfields Eye Hospital. (wikipedia.org)
  • commonly
  • an hereditary problem, is an inability to distinguish colors, most commonly red and green. (thefreedictionary.com)
  • Paget's disease of bone (commonly known as Paget's disease or historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more bones. (wikipedia.org)
  • Paget's disease may affect any one or multiple bones of the body (most commonly pelvis, femur, and lumbar vertebrae, and skull), but never the entire skeleton, and does not spread from bone to bone. (wikipedia.org)
  • The disease in dogs can affect the lungs and skin, but more commonly the eye and central nervous system. (wikipedia.org)
  • These examples are not considered infectious diseases because they do not satisfy Koch's postulates - for example Staphylococcus intermedius, a commonly isolated bacteria from skin infections in dogs, would not cause pyoderma when introduced to a healthy dog. (wikipedia.org)
  • Ringworm
  • Treatment for localized ringworm is not always necessary as the disease is self-limiting, but the cliinical course can be shortened by using topical miconazole or clotrimazole. (wikipedia.org)
  • lesions
  • BVMD typically becomes noticeable in children and is represented by the buildup of lipofuscin (lipid residuals) lesions in the eye. (wikipedia.org)
  • The disease in dogs is usually nodular skin lesions of the head and trunk. (wikipedia.org)
  • sickle
  • Inform your doctor if there are painful or prolonged erection in your history, you currently suffer with kidney diseases, stomach ulcers, blood cell problems such as sickle cell anemia, leukemia, or myeloma. (arfamed.com)
  • Before starting to take Cialis Super Active discuss with your doctor if you have allergy to any component of the pill, painful or prolonged erection in your history, kidney diseases, stomach ulcers, blood cell problems such as sickle cell anemia, leukemia, or myeloma. (doc-heal.com)
  • Involvement
  • Rarely, skull involvement may lead to compression of the nerves that supply the eye, leading to vision loss. (wikipedia.org)
  • cornea
  • However, an affected baby may have a normally sized eye globe and inconspicuous iris, anterior chamber, cornea and intraocular pressure. (wikipedia.org)
  • In the last stage of Norrie disease, the globes appear small and sunken in (phthisis bulbi) and the cornea appears to be milky. (wikipedia.org)
  • asymptomatic
  • Mild or early cases of Pagets are asymptomatic, and so most people are diagnosed with Paget's disease incidentally during medical evaluation for another problem. (wikipedia.org)
  • disorders
  • Hyperkinesia is a state of excessive restlessness which is featured in a large variety of disorders that affect the ability to control motor movement, such as Huntington's disease. (wikipedia.org)
  • This is a partial list of human eye diseases and disorders. (wikipedia.org)
  • movements
  • In evaluating the individual with a suspected form of hyperkinesia, the physician will record a thorough medical history including a clear description of the movements in question, medications prescribed in the past and present, family history of similar diseases, medical history including past infections, and any past exposure to toxic chemicals. (wikipedia.org)
  • humans
  • In humans the eye is of the camera type, with an iris diaphragm and variable focusing, or accommodation. (thefreedictionary.com)
  • Some of these diseases are unique to dogs or closely related species, while others are found in other animals, including humans. (wikipedia.org)
  • Rocky Mountain spotted fever* is a rickettsial disease that occurs in dogs and humans. (wikipedia.org)
  • Certain infectious diseases are a concern from a public health standpoint because they are zoonoses (transmittable to humans). (wikipedia.org)
  • problems
  • The World Health Organization publishes a classification of known diseases and injuries, the International Statistical Classification of Diseases and Related Health Problems, or ICD-10. (wikipedia.org)
  • International Statistical Classification of Diseases and Related Health Problems. (wikipedia.org)
  • brain
  • He sees the diseases of an aging population - in the brain, spine, bones, joints and eyes - being cured, easing an enormous burden on patients, their families and the healthcare system. (wikipedia.org)
  • nervous
  • From January 1964 to December 1967 he served his ophthalmic residency at Moorfields Eye Hospital, then worked from December 1967 to June 1968 as senior registrar at the Royal London Hospital and the National Hospital for Nervous Diseases. (wikipedia.org)
  • males
  • Developmental delay or learning difficulties are present in about 30 to 50% of males who have Norrie disease. (wikipedia.org)
  • heart
  • More recently, the American Heart Association did a presentation on how aging Americans can fight heart disease through a variety of connective technologies ranging from Facebook to senior-specific outlets such as online patient portals. (hannahhomecare.net)
  • abnormal
  • For example, bowing of a femur affected by Paget's may distort overall leg alignment, subjecting the knee to abnormal mechanical forces and accelerating degenerative wear. (wikipedia.org)
  • loss
  • in the strictly scientific sense, the permanent and irreversible loss of vision in both eyes, the inability to distinguish light from darkness. (thefreedictionary.com)
  • Paget's disease affecting the skull may lead to loss of hearing in one or both ears due to compression of the nerves in the inner ear. (wikipedia.org)