• Stem Cell-Derived Hepatocytes
  • This promising advance in the development of cell-based therapies to treat liver failure resulting from injury or disease relied on the development of scalable, reproducible methods to produce stem cell-derived hepatocytes in bioreactors, as described in an article in Stem Cells and Development , a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. (medindia.net)
  • The researchers "developed a system for mass manufacture of stem cell derived hepatocytes in numbers that would be useful for clinical application," creating possibilities for future "immune matched cell based therapies," says Hay. (medindia.net)
  • cytochrome
  • Paine A (1990).The maintenance of cytochrome P$%) in rat hepatocyte cultures: Some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P450 system.Chem-biol Interact. (springer.com)
  • protein
  • 2-Cyanoethylene oxide accumulated in the hepatocyte incubations but did not appear to contribute extensively to alkylation of GSH or protein. (aacrjournals.org)
  • The ability of nonprotein thiols to modulate rates of protein synthesis was investigated in isolated rat hepatocytes. (springer.com)
  • Hepatocyte growth factor has been shown to interact with the protein product of the c-Met oncogene, identified as the HGF receptor (HGFR). (wikipedia.org)
  • Both overexpression of the Met/HGFR receptor protein and autocrine activation of Met/HGFR by simultaneous expression of the hepatocyte growth factor ligand have been implicated in oncogenesis. (wikipedia.org)
  • eosinophilic
  • Histologically, multifocal to coalescing areas of many hepatocytes contained large cytoplasmic vacuoles filled with pale eosinophilic homogeneous material and rare fine basophilic granules. (hindawi.com)
  • Metabolism
  • Rooda S.J.E., van Loon M.A.C., Visser T.J. (1986) Metabolism of rT 3 by Isolated Rat Hepatocytes. (springer.com)
  • In order to establish the relative contributions of the various pathways leading to activated and detoxicated products, we examined AN metabolism in isolated Fischer 344 rat hepatocytes as a model. (aacrjournals.org)
  • Hepatocytes have the ability to metabolize, detoxify, and inactivate exogenous compounds such as drugs, (drug metabolism), and insecticides, and endogenous compounds such as steroids. (wikipedia.org)
  • In addition, pharmaceutical industry has heavily relied on the use of hepatocytes in suspension or culture to explore mechanisms of drug metabolism and even predict in vivo drug metabolism. (wikipedia.org)
  • bile
  • hepatocyte (hip- at -oh-syt) n. the principal cell type in the liver: a large cell with many metabolic functions, including synthesis, storage, detoxification, and bile production. (encyclopedia.com)
  • functional
  • Massoud Vosough and coauthors demonstrate a large-scale, integrated manufacturing strategy for generating functional hepatocytes in a single suspension culture grown in a scalable stirred bioreactor. (medindia.net)
  • primary
  • All primary hepatocyte products are pre-screened and extensively characterized, which provides researchers with the data necessary to select lots which are well-suited to their research needs. (corning.com)
  • Primary hepatocytes are commonly used in cell biological and biopharmaceutical research. (wikipedia.org)
  • mice
  • Furthermore, the morphological and ultrastructural changes of hepatocytes derived from RTV-treated mice have been observed. (sigmaaldrich.com)
  • Under the electron microscope, chromatin margination, mitochondrial cristae disappearance, karyopyknosis and cytoplasmic vacuolization can be observed in the hepatocytes of mice treated with ritonavir. (sigmaaldrich.com)
  • sinusoids
  • Hepatocytes are organised into plates separated by vascular channels (sinusoids), an arrangement supported by a reticulin (collagen type III) network. (wikipedia.org)
  • These surfaces are the place where the exchange of substances between the hepatocytes and the sinusoids occurs. (wikipedia.org)
  • The intercellular surfaces are the ones that are between two adjacent hepatocytes and they are not in contact with sinusoids or canaliculi. (wikipedia.org)
  • cellular
  • The 24-hour incubation with EGCG in concentrations of 10 μ mol/L and higher led to signs of cellular injury and to a decrease in hepatocyte functions. (hindawi.com)
  • These are simple surfaces specialized in the cellular adherence and in the communication between hepatocytes through gap junctions. (wikipedia.org)
  • cell
  • Liver homeostasis is achieved by the removal of diseased and damaged hepatocytes and their coordinated replacement to maintain a constant liver cell mass. (biomedsearch.com)
  • The hepatocyte is a cell in the body that manufactures serum albumin, fibrinogen, and the prothrombin group of clotting factors (except for Factors 3 and 4). (wikipedia.org)