SquamousMetastasisSituPoor prognosisMalignant neoplasmDuctalTumor invasivenessProgressionTumorsLungPancreaticAnaplasticLiverPapillaryHistological typeEpithelial cellsInvasionCancersCell migrationCancerPrevalentCharacteristicsTissueHumanRecurrencePrognosisMethylationCentral Nervous SColorectal cancerAdenocarcinomasBladder CancerLiver CancerHepaticAdenocarcinomaStagingProgressionTumorMolecularProliferationNeoplastic CellsTransplantationPathogenesisCirrhosisApoptosisGlandularOvarianBiomarkersIncidenceTherapiesMalignancyHistologicalLesionsAggressiveTherapeuticCommonOccurSignificance
Squamous11
- Squamous cell carcinoma Refers to a carcinoma with observable features and characteristics indicative of squamous differentiation (intercellular bridges, keratinization, squamous pearls). (wikipedia.org)
- Adenosquamous carcinoma Refers to a mixed tumor containing both adenocarcinoma and squamous cell carcinoma, wherein each of these cell types comprise at least 10% of the tumor volume. (wikipedia.org)
- Pleomorphic carcinoma contains spindle cell and/or giant cell components, plus at least a 10% component of cells characteristic of more highly differentiated types (i.e. adenocarcinoma and/or squamous cell carcinoma). (wikipedia.org)
- Results identified elevated CR-1 expression in esophageal squamous cell carcinoma (ESCC) specimens which correlated to poor prognosis of the patients. (cusabio.com)
- A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
- The concept does not refer to neoplasms located in tissue composed of squamous elements. (lookformedical.com)
- Especially, there was an increase in Human Papillomavirus-related head and neck squamous cell carcinomas. (oncotarget.com)
- The aim of this review is to identify key data and factors about HPV-related head and neck squamous cell carcinoma in HIV-seropositive patients. (oncotarget.com)
- The development of esophageal squamous cell carcinoma (ESCC) progresses a multistage process, collectively known as precursor lesions, also called dysplasia (DYS) and carcinoma in situ (CIS), subsequent invasive lesions and final metastasis. (biomedcentral.com)
- Squamous cell carcinoma is the most common histological type of esophageal cancer in China. (biomedcentral.com)
- A multistage process has been proposed for the evolution of esophageal squamous cell carcinoma (ESCC), in which normal squamous epithelia undergo a series of histological and genetic progression towards noninvasive precursor lesions, i.e., dysplasia (DYS) and carcinoma in situ (CIS), then towards invasive cancer, and, finally towards deep invasion and metastasis to lymph nodes and other organs. (biomedcentral.com)
Metastasis1
- Anaplastic thyroid carcinoma (ATC) is an extremely malignant type of endocrine cancer frequently accompanied by extrathyroidal extension or metastasis through mechanisms that remain elusive. (biomedcentral.com)
Situ4
- Given the expression of CD44 in a wide range of cancers, the most practical application of CD44 immunostaining is its use in discriminating between urothelial transitional cell carcinoma in situ from non-neoplastic changes in the urothelium. (attogene.com)
- In terms of tumor invasiveness, 13 (92.9%) patients were invasive and one (7.1%) patient was in situ. (magiran.com)
- Erythroplasia is the clinical term for a velvety-red patch that, histologically, is a surface atypia, is usually full-thickness (carcinoma in situ), and is occasionally invasive (microinvasion) but is without keratosis. (medscape.com)
- Keratosis with atypia and carcinoma in situ are considered premalignant lesions of the oral mucosa. (medscape.com)
Poor prognosis1
- ZIP4 could promote migration, invasiveness, and suppress apoptosis in hepatocellular carcinoma, and represent a novel predictor of poor prognosis and therapeutic target for patients with HCC who undergo liver transplantation. (ijbs.com)
Malignant neoplasm5
- A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
- A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
- A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)
- Malignant neoplasm arising from the epithelium of the BRONCHI. (lookformedical.com)
- Pancreatic cancer (PC) is a malignant neoplasm with a high mortality rate. (oncotarget.com)
Ductal2
- An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST. (lookformedical.com)
- Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic neoplasm with high metastatic potential and poor clinical outcome. (biomedcentral.com)
Tumor invasiveness1
- Studies have suggested that the CD44-hyaluronate interaction is central to tumor invasiveness. (attogene.com)
Progression1
- However, the role of DRAM2 in the progression of human neoplasms is still unknown. (cancerindex.org)
Tumors3
- These tumors are referred to as anaplastic or undifferentiated carcinomas. (wikipedia.org)
- Very rarely, tumors may contain individual components resembling both carcinoma and true sarcoma, including carcinosarcoma and pulmonary blastoma. (wikipedia.org)
- Digestive system tumors including esophageal cancer, colorectal cancer, gastric cancer, pancreatic cancer, hepatic cancer, cholangiocarcinoma, and gallbladder carcinoma are associated with significantly high mortality and morbidity rates [ 1 ]. (ijbs.com)
Lung1
- It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
Pancreatic1
Anaplastic4
- Anaplastic carcinoma Refers to a heterogeneous group of high-grade carcinomas that feature cells lacking distinct histological or cytological evidence of any of the more specifically differentiated neoplasms. (wikipedia.org)
- There are a large number of rare subtypes of anaplastic, undifferentiated carcinoma. (wikipedia.org)
- An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
- Anaplastic thyroid carcinoma (ATC) is a rare but extremely malignant thyroid - cancer subtype. (biomedcentral.com)
Liver1
- Alcohol-related liver disease is the most prevalent chronic liver disease worldwide, accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths. (springer.com)
Papillary1
- CREB3L1 knockdown dramatically attenuated invasion of ATC cells, whereas overexpression of CREB3L1 facilitated the invasion of papillary thyroid carcinoma (PTC) cells. (biomedcentral.com)
Histological type1
- It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer. (lookformedical.com)
Epithelial cells2
- Carcinoma is a malignancy that develops from epithelial cells. (wikipedia.org)
- It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
Invasion3
- Knockdown of Cripto-1 inhibits the proliferation, migration, invasion, and angiogenesis in prostate carcinoma cells. (cusabio.com)
- A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
- A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. (lookformedical.com)
Cancers1
- Some of the more well known include the lesions containing pseudo-sarcomatous components: spindle cell carcinoma (containing elongated cells resembling connective tissue cancers), giant cell carcinoma (containing huge, bizarre, multinucleated cells), and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). (wikipedia.org)
Cell migration1
- Specific suppression of ZIP4 reduced cell migration and invasiveness, whereas ZIP4 overexpression caused increases in cell migration and invasiveness. (ijbs.com)
Cancer6
- Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal, mesodermal or ectodermal germ layer during embryogenesis. (wikipedia.org)
- Corrigendum to "RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin" [J. Funct. (tmu.edu.tw)
- Carcinomas, malignancies of epithelial tissue, account for 80 to 90 % of all cancer cases since epithelial tissues are most abundantly found in the body from being present in the skin to the covering and lining of organs and internal passageways, such as the gastrointestinal tract. (solutionpharmacy.in)
- Since the pioneering use of 131 I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using 177 Lu-labeled somatostatin analogs or in the treatment of advanced prostate cancer using prostate-specific membrane antigen-directed radionuclide therapy. (snmjournals.org)
- Investigating the relationship between KIN17 and neoplasms will provide a vital theoretical basis for KIN17 to serve as a diagnostic and prognostic biomarker for cancer patients and as a potential target for cancer therapy. (spandidos-publications.com)
- [ 6 ] He noted the cancer-producing potential of the pipe-smoker's palate (leukokeratosis), and, in 1870, he clearly implied that oral ichthyosis (white keratotic plaque) was a significant precursor to lingual carcinoma. (medscape.com)
Prevalent1
Characteristics1
- OBJECTIVE: To summarize the clinical characteristics of children with adrenocortical carcinoma (ACC) and preliminarily explore the indications for and efficacy of neoadjuvant chemotherapy in certain patients. (bvsalud.org)
Tissue2
- When cells in some area of the body duplicate without control, the excess of tissue develops called tumor or neoplasm. (solutionpharmacy.in)
- Ability of neoplasms to infiltrate and actively destroy surrounding tissue. (lookformedical.com)
Human1
- Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas. (journalsmededu.pl)
Recurrence1
- Hepatocellular carcinoma (HCC) recurrence after orthotopic liver transplantation (OLT) is potential cause for the poor outcome. (nih.gov)
Prognosis3
- In this study, we observed that the lncRNA-activated by TGF-β (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. (nih.gov)
- Hepatocellular carcinoma (HCC) is an aggressive, chemo resistant neoplasm with poor prognosis and limited treatment options. (frontiersin.org)
- Their majority is superficial at diagnosis (non-muscle-invasive bladder carcinoma, NMIBC), presenting good prognosis upon surgical resection and localized therapies. (biomedcentral.com)
Methylation2
- Applications to several DNA methylation datasets from the Cancer Genome Atlas (TCGA) project and DNA methylation data on hepatocellular carcinoma (HCC) from the Columbia University Medical Center (CUMC) suggest that the proposed NEpiC algorithm identifies more cancer-related genes and generates better replication results. (nih.gov)
- The histone H3 modifica tion could play an important role in MUC2 gene expression, possibly affecting DNA methylation in pan creatic neoplasm. (hdac-assay.com)
Central Nervous S1
- Meningiomas are frequent central nervous system neoplasms, which despite their predominant benignity, show sporadically malignant behavior. (neurorgs.net)
Colorectal cancer1
- The observation that the level of COX-2 expression correlated negatively with the histological malignant grade and/or tumor size, has been reported for colorectal cancer and hepatocellular carcinoma. (medscape.com)
Adenocarcinomas2
- In this study we demonstrate that, after intramuscular injection in chickens, it induces hepatocellular carcinomas of the liver and adenocarcinomas of the kidney. (nih.gov)
- Adenocarcinomas , with the main criterion being invasiveness. (patholines.org)
Bladder Cancer2
- Urothelial carcinoma is the most common pathologic type of bladder cancer, and muscle-invasive bladder cancer (MIBC) is a commonly occurring disease with a high mortality rate despite comprehensive treatment ( 2 - 7 ). (spandidos-publications.com)
- Urothelial carcinomas constitute the most common bladder cancer type. (biomedcentral.com)
Liver Cancer3
- 1 Barcelona Clinic Liver Cancer Group, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Catalonia, Spain. (nih.gov)
- CC is the second most common primary liver cancer after hepatocellular cancer [ 1 , 2 ]. (gastrores.org)
- A recent meta-analysis of 16 articles involving 19 cohorts of subjects with liver cancer (i.e., hepatocellular carcinoma) found a linear relationship between the amount of alcohol consumed and the risk of liver cancer compared with nondrinkers (Turati et al. (nih.gov)
Hepatic2
- The role of hepatic resection in the treatment of hepatocellular cance" by S. Roayaie, G. Jibara et al. (hofstra.edu)
- This mode of action is supported by the observation that even a one year exposure to PPARα agonists was insufficient to cause an increase in the incidence of hepatic neoplasms in PPARα knock-out mice. (biomedcentral.com)
Adenocarcinoma2
- Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland. (nih.gov)
- Malignant C40367 Acinic Cell Breast Carcinoma A breast adenocarcinoma characterized by the presence of serous (acinic cell) differentiation. (nih.gov)
Staging1
- [ 102 ] For adrenal carcinoma staging, the 2009 European Network for the Study of Adrenal Tumors (ENSAT) TNM system is recommended over the AJCC system. (medscape.com)
Progression1
- 17. Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression. (nih.gov)
Tumor1
- Background and Objective: Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor of the digestive system worldwide. (bvsalud.org)
Molecular3
- Understanding the underlying molecular pathogenesis leading to hepatocellular carcinoma is a prerequisite to develop new drugs that will hamper or block the steps of these pathways. (xiahepublishing.com)
- As hepatocellular carcinoma has higher arterial vascularization than normal liver, this could be a good target for novel molecular therapies. (xiahepublishing.com)
- We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
Proliferation2
- 8. Expression of Syk in invasive breast cancer: correlation to proliferation and invasiveness. (nih.gov)
- of medical indications ceased disease development in both CFA-CIA and PIA, decreased joint and bone tissue damage, and inhibited FLS proliferation and invasiveness. (ecologicalsgardens.com)
Neoplastic Cells1
- The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. (nih.gov)
Transplantation1
- A subset of patients with hepatocellular carcinoma (HCC) beyond Milan criteria might obtain acceptable survival outcomes after liver transplantation. (nih.gov)
Pathogenesis1
- The pathogenesis of sporadic pancreatic neuroendocrine neoplasms (PNENs) is poorly understood. (deepdyve.com)
Cirrhosis2
- Digital image analysis of the distribution of proliferating cell nuclear antigen in hepatitis C virus-related chronic hepatitis, cirrhosis, and hepatocellular carcinoma. (shengsci.com)
- Current guidelines recommend surgical resection as the primary treatment for a single hepatocellular cancer (HCC) with Child's A cirrhosis, normal serum bilirubin, and no clinically significant portal hypertension. (hofstra.edu)
Apoptosis1
- Cyclo-oxygenase-2 induction leads to angiogenesis, immunosuppression and inhibition of apoptosis in neoplasms, mediated at least in part by PG. (medscape.com)
Glandular1
Ovarian1
- Glypican-3 (GPC3) is specifically expressed in ovarian clear cell carcinoma (OCCC), hepatocellular carci-noma (HCC), and melanoma and lung cancer. (deepdyve.com)
Biomarkers1
- Background Hepatitis C virus (HCV) infection is a main contribution to the increase in hepatocellular carcinoma (HCC) incidence and patients' death recently, but prognostic biomarkers for HCV-related HCC remain rarely reported. (researchsquare.com)
Incidence1
- Hepatocellular carcinoma (HCC) is the sixth most frequent neoplasia (749,000 new cases/year), with a constantly increasing worldwide incidence and about 745,000 deaths/year. (xiahepublishing.com)
Therapies1
Malignancy2
- Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide. (biomedcentral.com)
- Hepatocellular carcinoma (HCC) represents the sixth most common cancer and the third leading cause of mortality for malignancy in the world[ 1 ]. (biomedcentral.com)
Histological1
- Anaplastic carcinoma Refers to a heterogeneous group of high-grade carcinomas that feature cells lacking distinct histological or cytological evidence of any of the more specifically differentiated neoplasms. (wikipedia.org)
Lesions1
- Some of the more well known include the lesions containing pseudo-sarcomatous components: spindle cell carcinoma (containing elongated cells resembling connective tissue cancers), giant cell carcinoma (containing huge, bizarre, multinucleated cells), and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). (wikipedia.org)
Aggressive1
- HCC is an aggressive, chemo resistant neoplasm with complex etiology and high metastatic potential. (frontiersin.org)
Therapeutic1
- However, little is known about glycolytic function and therapeutic value of NDRG2 in hepatocellular carcinoma (HCC). (referencecitationanalysis.com)
Common2
- A history of cigarette smoking is the most common cause of large cell carcinoma. (wikipedia.org)
- Type 2 neurofibromatosis (NF2) is an autosomal dominant condition related to a mutation on chromosome 22q12 and is a common condition related to elevated risk for developing meningiomas, among other neoplasms (4). (neurorgs.net)
Occur1
- Carcinomas occur when the DNA of a cell is damaged or altered and the cell begins to grow uncontrollably and become malignant. (wikipedia.org)