ApoptosisRenalPapillary thyroid cTumorOncogenicProgressionProteinsAlterationsMalignantOccurrenceMalignancyTumorsGlioblastomaCancerCellsTranscriptionSpecificOral squamous cell carcProto-oncogeneIntrahepatic cholangiocarcinomaGastric cancerKRASSerineTumorAdenocarcinomaPrognosisMutationsMetastaticBRAFAdditionallyChromatinProliferation2024TranscriptionPathwaysMitochondrialProteinLiverCancersGeneBreast cancerChromosomeChromosomalGeneticDistinctPatientsClinicalHumanLungModelsCommonEarlyActiveTreatment
Apoptosis1
- The 'cancer platform' concept proposes that most oncogenic molecules also have the inherent ability to activate tumor suppressor genes or pathways through oncogene-induced apoptosis or senescence, thus limiting their oncogenic effects in a homeostatic fashion. (biomedcentral.com)
Renal4
- Here, in Part I, we describe areas where major inroads were initially achieved by targeting angiogenesis (central to the biology of renal cell carcinoma and hepatocellular cancer) and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in gastrointestinal stromal tumors (GIST) and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
- Renal cell carcinoma (RCC) incidence has increased over the past two decades. (hindawi.com)
- Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
- For instance, RUNX2 is involved in the progression of various tumor types, such as osteosarcoma, renal cell carcinoma, gastric cancer and breast cancer ( 15 - 20 ). (spandidos-publications.com)
Papillary thyroid c1
- CREB3L1 knockdown dramatically attenuated invasion of ATC cells, whereas overexpression of CREB3L1 facilitated the invasion of papillary thyroid carcinoma (PTC) cells. (biomedcentral.com)
Tumor7
- Current concepts suggest that a limited number of molecular alterations involving oncogene activation and tumor suppressor inhibition are responsible for initiation of cancer. (biomedcentral.com)
- utilizes a combination of high-resolution comparative genomic hybridization, short hairpin RNA inhibition of target genes at the locations of focal genomic deletions, and a primed cell mosaic mouse model to identify novel tumor suppressors in hepatocellular carcinoma. (biomedcentral.com)
- Here we analyzed the impact of EGFRvIII on the profile of glioma EVs using isogenic tumor cell lines, in which this oncogene exhibits a strong transforming activity. (cancer-genetics.org)
- Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. (frontiersin.org)
- Commonly these markers are individual genetic changes, such as driver mutations affecting oncogenes or tumor suppressor genes, or copy-number alterations thereof. (nature.com)
- Wnt signaling is highly oncogenic to mammalian epithelia, and indeed comprises one of the main sources of human tumor initiation identified to date. (wisc.edu)
- By altering membrane transport in the early secretory pathway, TFG fusion proteins may modulate cargo export, potentially enhancing the secretion of growth factors that help to sustain a rich tumor microenvironment. (wisc.edu)
Oncogenic3
- Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). (cancer-genetics.org)
- For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
- During the course of their studies, members of the Audhya laboratory demonstrated that two oncogenic fusion proteins, TFG-NTRK1 and TFG-ALK, created by distinct chromosomal translocation events, localize to subdomains of the endoplasmic reticulum (sites of COPII vesicle formation) and dramatically upregulate ERK activity. (wisc.edu)
Progression1
- Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). (hindawi.com)
Proteins1
- Nano-flow cytometry revealed that the EV output from individual glioma cell lines was highly heterogeneous, such that only a fraction of vesicles contained specific proteins (including EGFRvIII). (cancer-genetics.org)
Alterations1
- These subpopulations, present within the highly genotoxic inflammatory environment typical of chronic liver disease, are then at especial risk of acquiring additional genetic and epigenetic alterations that predispose them to carcinogenesis. (biomedcentral.com)
Malignant2
- Anaplastic thyroid carcinoma (ATC) is an extremely malignant type of endocrine cancer frequently accompanied by extrathyroidal extension or metastasis through mechanisms that remain elusive. (biomedcentral.com)
- Anaplastic thyroid carcinoma (ATC) is a rare but extremely malignant thyroid - cancer subtype. (biomedcentral.com)
Occurrence1
- The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. (lookformedical.com)
Malignancy1
- Ovarian cancer (OC) is a highly lethal gynecological malignancy. (stanford.edu)
Tumors2
- Hepatocellular carcinoma (HCC) one of the most common digestive system tumors, threatens the tens of thousands of people with high morbidity and mortality world widely. (biomedcentral.com)
- However in women with a higher body mass index, these ERa positive tumors are larger at the time of diagnosis and are more clinically aggressive. (wisc.edu)
Glioblastoma1
- Despite this aggressive treatment, median survival of glioblastoma patients is only about 15 months, and recurrence remains almost inevitable ( 1 , 2 ). (frontiersin.org)
Cancer3
- DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53. (cancerindex.org)
- Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most common cause of death from cancer [ 1 ]. (biomedcentral.com)
- Exosomes are vesicles with a bilayer membrane structure formed by a series of regulatory processes, such as "endocytosis-fusion-exclusion" of most cells (including T cells, platelets, and cancer cells), with a diameter of about 50-150 nm [ 10 ]. (ijbs.com)
Cells1
- CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia. (u-tokyo-hemat.com)
Transcription1
- For example, Cirs-7 is derived from a highly conserved single exon, also known as antisense transcription of cerebellar degeneration-related protein 1 (CDR1as), which can regulate miR-7 through adsorption, thus reducing the inhibition of miR-7 on its target [ 19 ]. (biomedcentral.com)
Specific1
- Circular RNAs (circRNAs) are a type of RNAs that are more abundant, specific, and highly organized, compared to other types of RNAs. (ijbs.com)
Oral squamous cell carc1
Proto-oncogene1
- designed for the detection of rearrangements involving the chromosomal region 7q34 harboring the BRAF (B-Raf proto-oncogene, serine/threonine kinase, a.k.a. (pragostem.cz)
Intrahepatic cholangiocarcinoma2
- Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are devastating primary liver cancers with increasing prevalence in many parts of the world. (biomedcentral.com)
- Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) are two types of primary liver cancer (PLC) with increasing incidence worldwide and high death rate. (biomedcentral.com)
Gastric cancer1
- COTE1 was recently described as an oncogene in hepatocellular carcinoma and gastric cancer. (bvsalud.org)
KRAS1
- In addition, our results suggest a new method for blocking the signal from the oncogene KRAS by targeting TfR in LAC. (cusabio.com)
Serine1
- The results show that SEELA mediated cis-activated transcription of the nearby oncogene Serine incorporate 2 ( SERINC2 ) by directly binding to the K31 amino acid (aa) of histone H4. (biomedcentral.com)
Tumor8
- While the DNAJB1-PRKACA fusion is clearly known to be the driver of FLC, and essential for the growth and survival of FLC tumor cells, there have been other suggestions that this fusion gene alone if not enough for the complete transformation to a robust FLC-like cancer. (fibrofoundation.org)
- in this case, at least one additional genetic change was required to yield aggressive tumor growth. (fibrofoundation.org)
- Glioblastoma (GB) is the most common and highly malignant brain tumor characterized by aggressive growth and resistance to alkylating chemotherapy. (biomedcentral.com)
- These cellular processes are self-sufficiency in growth signals (oncogene addiction), insensitivity to growth-inhibitory signals (loss of tumor suppressors), evading programmed cell death (anti-apoptosis), limitless replication potential (aberrant cell cycle), sustained angiogenesis, and invasion/metastasis. (medscape.com)
- Many oncogenes (RAS, PI3K, KIT) and tumor suppressors (P53, RB, PTEN) are frequently mutated in different human malignancies. (medscape.com)
- High throughput genome sequencing of tumor DNA has elucidated low-frequency mutations in several genes that are highly likely to drive oncogenesis. (medscape.com)
- The absence of an aggressive screening program may be one explanation of why, in Western countries such as the USA, 75 % of patients with upper GI cancers are diagnosed with locally advanced tumor categories and with correspondingly lower survival rates [ 5 ]. (springeropen.com)
- Ewing sarcoma (EWS), a highly aggressive pediatric tumor, is driven by EWS- FLI1 , an oncogenic transcription factor that remodels the tumor genetic landscape. (aabioetica.org)
Adenocarcinoma3
- Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland. (nih.gov)
- Malignant C40367 Acinic Cell Breast Carcinoma A breast adenocarcinoma characterized by the presence of serous (acinic cell) differentiation. (nih.gov)
- On the other hand, there has been a shift of distal gastric carcinomas to the proximal area of subcardial adenocarcinoma of the esophago-gastral junction (AEG Type III) and cardia localization (AEG Type II) over an 80-year period. (springeropen.com)
Prognosis3
- High COTE1 expression was significantly correlated with aggressive clinical features and predicted poor prognosis of ICC patients. (bvsalud.org)
- MLL -rearranged leukemia, caused by Mixed Lineage Leukemia ( MLL ) gene translocation-induced expression of the MLL fusion protein, has the worst prognosis and is the most aggressive among leukemia subtypes [ 22 ]. (biomedcentral.com)
- mutations represent the great majority of RAS mutations in patients with cutaneous melanoma and are associated with a poor prognosis and more aggressive clinical course than patients without NRAS mutations (e.g. (globaltechbiz.com)
Mutations3
- A major goal is to determine whether the introduction of additional mutations in cells containing the DNAJB1-PRKACA fusion can generate biological features more closely resembling fully transformed FLC cancer cells. (fibrofoundation.org)
- When this occurs, CRAF remains constitutively activated which leads to MEK/ERK activation.8C10 The most common mutation, accounting for 70C88% of all mutations, is a substitution of glutamic acid for valine at amino acid 600 (V600E).7,11 Other mutations in occur less frequently and include V600K, V600R, V600M, non-V600 alterations and fusions. (globaltechbiz.com)
- Table 1: Classification of BRAF mutations oncogene subtypes (K-, H-, N) are seen in up T0901317 to a quarter of patients with melanoma, are typically mutually exclusive of BRAFV600 mutations, and are seen in all subtypes of patients of melanoma except uveal. (globaltechbiz.com)
Metastatic1
- The interaction of anti-microtubular drugs paclitaxel and vinblastine was earlier demonstrated as anticancer drugs in aggressive metastatic tumors. (springeropen.com)
BRAF1
- Colorectal carcinoma or melanoma patients with BRAF V600E mutation were found to acquire resistance to MEK and BRAF inhibitors through amplification of the mutated BRAF gene. (pragostem.cz)
Additionally1
- Additionally, hepatocellular carcinoma (HCC) patients with VEGFA gain responded better to a multi-kinase inhibitor (sorafenib) that blocks, i.a., receptors of the VEGFA protein, resulting in improved survival of the patients. (pragostem.cz)
Chromatin1
- Chromatin-bound SEELA strengthens the interaction between chromatin and histone modifiers to promote histone recognition and oncogene transcription. (biomedcentral.com)
Proliferation2
- Our data, for the first time, illustrate that COTE1 is an oncogene in ICC pathogenesis, and the ectopic COTE1 expression promotes ICC proliferation and invasion via Beclin1-dependent autophagy inhibition. (bvsalud.org)
- The extracellular matrix (ECM) is a highly dynamic structure that surrounds the above-mentioned cells and affects their proliferation and cell-cell communication via the transmission of mechanical signals and cell adhesion [ 6 ] . (encyclopedia.pub)
20241
- HN - 2024 (1973) BX - Acetic Phosphatase BX - Acylphosphate Phosphohydrolase BX - CAP Phosphatase BX - Carbamyl Phosphate Phosphatase MH - Aflatoxin Poisoning UI - D000096702 MN - C25.723.680.131 MS - Poisoning by AFLATOXINS most often associated with NAUSEA, abdominal pain, hepatotoxicity, immunosuppression, HEPATOCELLULAR CARCINOMA and sometimes death. (nih.gov)
Transcription1
- This study shows that lnc-eRNAs are epigenetically activated by cancer-initiating oncoproteins and uncovers a cis-activating mechanism of oncogene transcription control based on lnc-eRNA-mediated epigenetic regulation of enhancer activity, providing insights into the critical roles of lnc-eRNAs in cancer initiation and progression. (biomedcentral.com)
Pathways1
- Effective targeting of aberrant-oncogene addicted and nonaddicted pathways with rational combinations of targeted therapies directed to the hallmarks of cancer will be the key to cure. (medscape.com)
Mitochondrial2
- Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. (cusabio.com)
- When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. (cusabio.com)
Protein2
- Here, Western blot and qRT-PCR analysis revealed that TPX2 at both mRNA and protein levels was up-regulated in bladder carcinoma tissues compared to their paired adjacent normal tissues. (cancerindex.org)
- Microvesicles loaded with MCs encoding a thymidine kinase (TK)/nitroreductase (NTR) fusion protein produced prolonged TK-NTR expression in mammary carcinoma cells. (regenerativemedicine.net)
Liver4
- The team will also determine whether introduction of the fusion gene and other genetic changes into normal ductal organoids gives more complete FLC-like transformation than in liver organoids. (fibrofoundation.org)
- Therefore, one of the aims of this proposal is to engineer normal liver cells in culture to express the DNAJB1-PRKACA gene fusion. (fibrofoundation.org)
- Hepatocellular carcinoma (HCC), abbreviated as liver cancer, is one of the most common cancers in clinics. (biomedcentral.com)
- Over the last 15 years, the NF-κB pathway has emerged as a critical driver of tumorigenesis, independent of mutant oncogene status, in sarcomas, as well as pancreas, prostate, head and neck, liver, and breast cancer. (justia.com)
Cancers3
- VEGFA gene amplifications occur in colorectal cancers and result in a highly aggressive disease. (pragostem.cz)
- Human cancers arise via a multistep mutagenic process reflective of genetic and epigenetic changes that drive progressive transformation of normal cells into highly malignant counterparts. (medscape.com)
- Since the identification of Helicobacter pylori (H. pylori) , the incidences in gastric cancers have decreased worldwide, but there are reports of increases in esophageal squamous cell carcinomas (ESCC) as well as of adenocarcinomas of the esophago-gastral junction [ 5 ]. (springeropen.com)
Gene3
- In previous work, these investigators "knocked-in" the DNAJB1-PRKACA fusion gene into organoids. (fibrofoundation.org)
- reveal drivers of FLC that act in coordination with the fusion gene, which could lead to the discovery and design of new therapeutic approaches. (fibrofoundation.org)
- The GABARAP gene has been described to be highly expressed in endocrine tissues while the GABARAPL1 gene is predominantly expressed in the central nervous system but they both are underexpressed in a large variety of cancer cell lines [ 5 ]. (biomedcentral.com)
Breast cancer2
Chromosome1
- 7. The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl-1, int-2 and hst loci. (nih.gov)
Chromosomal1
- We show that these lnc-eRNAs are broadly activated in MLL -rearranged leukemia ( MLL leukemia), an aggressive leukemia caused by a chromosomal translocation, through a mechanism by which the HOXA cluster initiates enhancer activity, and the epigenetic reader BRD4 cooperates with the coregulator MLL fusion oncoprotein to induce transcriptional activation. (biomedcentral.com)
Genetic1
Distinct1
- Leukemia sensitivity to these two agents was highly associated with MRD although with distinct patterns and only in B cell ALL. (cdc.gov)
Patients1
Clinical1
- Sarcomatoid component occurs in various epithelial malignancies and is associated with an aggressive disease course and poor clinical outcome. (nih.gov)
Human2
- 16. Amplification of oncogenes in human cancer cells. (nih.gov)
- Human INT1 has been found to be very similar to mouse INT1, thus most revealing the highly conserved nature of this pathway across species [3]. (chemdiv.com)
Lung2
- Generally, NRG1 rearrangements in lung adenocarcinomas of never smokers were found to result in the fusion of CD74 to the EGF-like domain of NRG1. (pragostem.cz)
- A carcinoma originating in the lung and the most common lung cancer type in never-smokers. (nih.gov)
Models1
- In this study, delivery vehicles comprised of microvesicles loaded with engineered minicircle (MC) DNA that encodes prodrug converting enzymes were developed as a cancer therapy in mammary carcinoma models. (regenerativemedicine.net)
Common1
- Hepatocellular carcinoma (HCC) one of the most common digestive system tumors, threatens the tens of thousands of people with high morbidity and mortality world widely. (biomedcentral.com)
Early1
- RAB5A is required for the fusion of plasma membranes and early endosomes. (betalifesci.com)
Active1
- Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. (betalifesci.com)
Treatment1
- In addition, the first patient was enrolled in the pivotal study of lorlatinib, which we are co-developing with Pfizer, for the treatment of c-ros oncogene 1 (ROS1)-positive advanced NSCLC. (cstonepharma.com)