• genotype
  • The aim of the study is to analyze treatments available for patients infected with genotype (G) 3 hepatitis C virus (HCV) in Poland at the beginning of the interferon (IFN)-free era and evaluate the efficacy and safety of different therapeutic options administered in a real-world setting. (bioportfolio.com)
  • polymerase
  • Negative-sense viral RNA is complementary to mRNA and thus must be converted to positive-sense RNA by an RNA-dependent RNA polymerase before translation. (wikipedia.org)
  • One of these includes RNA-dependent RNA polymerase (RNA replicase), which copies the viral RNA to form a double-stranded replicative form. (wikipedia.org)
  • Diseases
  • This viral family includes a diverse array of pathogens affecting humans and animals, including hepatitis C, dengue, and many other diseases important to public health. (healthmap.org)
  • Despite the fact that this killed whole virus strategy is widely exercised to prevent diseases like polio, influenza, cholera, mumps, rabies, typhoid fever and hepatitis A in the past, it failed to receive any serious attention in the effort to develop vaccines against HIV for various scientific, economical and technical reasons. (wikipedia.org)
  • Other epidemics of viral diseases that depend on large concentrations of people, such as mumps, rubella and polio, also first occurred at this time. (wikipedia.org)
  • He was one of the most prodigious scientists in many areas of infectious diseases in man and animals, the ecology of pathogens, epidemiology and public health[1- (wikipedia.org)
  • The Transvaal Department of Agriculture in the (then) Union of South Africa had just established a large, special Institute devoted to research in public health and farm animal diseases, the latter being important for the economy of the country. (wikipedia.org)
  • protein
  • Entry into the host cell is achieved by attachment of the viral envelope protein E to host receptors, which mediates clathrin-mediated endocytosis. (wikipedia.org)
  • Novel viral RNA is then transferred to the cytoplasm for translation and subsequent protein synthesis. (wikipedia.org)
  • The capsid is enveloped by a lipid bilayer that contains three forms of envelope proteins: small (S) proteins, intermediated (M) proteins, and large (L) proteins, and these proteins have different surface antigenes domains which contribute the viral infectivity: L protein (Pre S1, Pre S2, S), M protein (Pre S2, S), S protein (S). In figure 1, showing the simplified structure of HBV particles. (wikipedia.org)
  • influenza
  • Taribavirin is as active against influenza as ribavirin in animal models, with slightly less toxicity, so it may also eventually replace ribavirin as an anti-influenza agent. (wikipedia.org)
  • double-stranded
  • Reverse transcriptase, a viral enzyme that comes from the virus itself after it is uncoated, converts the viral RNA into a complementary strand of DNA, which is copied to produce a double-stranded molecule of viral DNA. (wikipedia.org)
  • humans and animals
  • Members of this group include the rotaviruses, renowned globally as the most common cause of gastroenteritis in young children, and picobirnaviruses, renowned worldwide as the most commonly occurring virus in fecal samples of both humans and animals with or without signs of diarrhea. (wikipedia.org)
  • immune responses
  • Over the past few years, hydrodynamic gene delivery (HGD) with naked DNA has drawn increasing interest in both research and potential clinic applications due to its high efficiency and low risk in triggering immune responses and carcinogenesis in comparison to viral vectors. (frontiersin.org)
  • Researchers reported that the therapeutic vaccine induced robust cellular immune responses in animal tests recently conducted. (wikipedia.org)
  • AIDS
  • Gladstone Institutes is an independent and nonprofit biomedical research organization whose focus is to better understand, prevent, treat and cure cardiovascular, viral and neurological conditions such as heart failure, HIV/AIDS and Alzheimer's disease. (wikipedia.org)
  • molecule
  • The positive-sense RNA molecule then acts as viral mRNA, which is translated into proteins by the host ribosomes. (wikipedia.org)
  • Valeant is testing the drug as a treatment for chronic hepatitis C. Note on formulas: The carboxamidine group of this molecule is somewhat basic, and therefore this drug is also known and administered as the hydrochloride salt (with a corresponding .HCl chemical formula and different ChemID / PubChem number). (wikipedia.org)
  • virion
  • The term virion (plural virions), which dates from 1959, is also used to refer to a single, stable infective viral particle that is released from the cell and is fully capable of infecting other cells of the same type. (wikipedia.org)
  • About the viral entry, several proteins have been identified as possible virus receptors, and studies show that the binding of virion with receptors can be neutralized by anti-PreS1 antibodies. (wikipedia.org)
  • Sequence
  • Sequence analysis of viral nucleic acids revealed the presence of a virus related to HCV, which was named canine hepacivirus (CHV). (virology.ws)
  • cytoplasm
  • Viral RNA was detected in the cytoplasm of hepatocytes in canine liver, but whether CHV is hepatotropic (replicates in liver cells) in dogs is not known. (virology.ws)
  • transmission
  • An antibody that "masks" these cells, targeting alpha-4-beta-7 integrin, can reduce the risk of viral transmission in a non-human primate model. (healthcanal.com)
  • loads
  • Viral loads can change on their own without obvious reason and are not significant to whether or not to treat. (medhelp.org)
  • Higher than usual viral loads have been associated with severe idiopathic inflammatory myopathies, cancer and lupus. (wikipedia.org)
  • Increased viral loads in cases of congenital mannose-binding lectin deficiencies have been reported. (wikipedia.org)
  • proteins
  • The minus-strand is linked to the viral reverse transcriptase and can encode all the known viral proteins, but the plus-strain cannot encode viral proteins. (wikipedia.org)
  • Outbreak
  • While Zika's varied manifestations - ranging from a complete lack of clinical disease to (potential) birth defects - are sensationalized in the media, an outbreak with this constellation of clinical signs is not unprecedented in the animal kingdom. (healthmap.org)
  • Treatment
  • Thats a first for me, as a matter of fact a lower viral load to start treatment with can have better odds of clearing Hep-C....... What kind of doctor is telling you this? (medhelp.org)
  • AT-2 chemical treatment is used because it does not affect the viral structure and immunogens. (wikipedia.org)
  • pregnant
  • Clinically, it is comparable to hepatitis A, but in pregnant women, the disease is more often severe and is associated with a clinical syndrome called fulminant liver failure. (wikipedia.org)
  • load
  • Dr just called to tell me that she had misinformed me yesterday about my viral load (which she had insisted hadn't been run) but apparently the RNA was run. (medhelp.org)
  • in Oct the viral load was '0' and as of last week it is 43,000. (medhelp.org)
  • and that viral load isn't necessarily indicative of the progressio of the disease. (medhelp.org)
  • Yes your viral load can change by the day, not sure what she is talking about it being to low to treat. (medhelp.org)
  • Research
  • Stem-cell transplantation improves muscles in MD animal model, UT Southwestern research. (bio-medicine.org)
  • 1997. The Essentiality of Tree Shrews Application and E xperimental Animalization in Biomedicine Research [C]//The Proceedings of Yunnan Strain Animals & Plants Industry and Market Developing Seminar, Kunming, Yunnan Science & Technology Press, 78-80. (zoores.ac.cn)
  • 2008. The progress of tree shrew as animal models for hepatitis research [J]. Chin J Comp Med , 18 (2): 59-62. (zoores.ac.cn)
  • patients
  • Although it does not appear to cause symptoms of hepatitis on its own, it is often found in patients with liver disease. (wikipedia.org)
  • Initially found in Japanese patients with hepatitis of unknown cause, TTV was detected in various populations without proven pathology, including blood donors. (wikipedia.org)