LiversCold ischemiaLipidTransplantationApoptosisHepatocellularSteatosisFibrosisAutophagyMitochondriaAbstractDysfunctionTissueOrgansInflammatoryReducesEndothelialMyocardial infarctionIschemicHypothermiaGraft functionReconstructionSwineClinicalMechanismRoleMiceSinusoidalDemonstratesInnate immunityConclusionPathwaysOcclusionVascularLungHypoxiaDeprivationDamageTherapeuticSurgical proceduresAcute KidneyEffectsIncreases
Livers6
- Bosentan, a novel endothelin receptor antagonist, was infused directly into the portal vein prior to cold ischemia and immediately on reperfusion, in five porcine livers. (duke.edu)
- Livers treated with NMP combined with BMMSCs showed better liver function, relieved histopathological damage, reduced oxidative stress injury and ferroptosis, and the mechanism of reduction was associated with downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ levels. (medscimonit.com)
- BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. (medscimonit.com)
- Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia-reperfusion injury. (wanfangdata.com.cn)
- Induction of autophagy reduces ischemia/reperfusion injury in steatotic rat livers [J].2017,216. (wanfangdata.com.cn)
- Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice [J].2011,141(6). (wanfangdata.com.cn)
Cold ischemia1
- In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
Lipid2
- Following hepatic I/R, the levels of hepatic lipid peroxidation and serum alanine aminotransferase increased, while the ratio of hepatic glutathione (GSH):oxidized GSH was reduced, which was effectively attenuated by pretreatment with GP. (spandidos-publications.com)
- Autophagy prevents NAFLD and AFLD progression through enhanced lipid catabolism and decreasing hepatic steatosis, which is characterized by the accumulation of triglycerides and increased inflammation. (hindawi.com)
Transplantation11
- Ischemia/reperfusion (I/R) is a predominant cause of hepatic injury, which is of clinical significance following liver surgery, hemorrhagic shock and liver transplantation ( 1 ). (spandidos-publications.com)
- Ischemia/reperfusion injury (IRI) represents the major problem in clinical liver transplantation. (houstonmethodist.org)
- Ischaemic reperfusion (I/R) occurs during surgical procedures, including hepatic resection and liver transplantation (LT) [ 1 ]. (ijbs.com)
- This suggests that hepatic ischemia-reperfusion injury may play a critical role in the pathogenesis of AKI after liver transplantation. (birmingham.ac.uk)
- The aim of this single-center study was to determine if hepatic ischemia-reperfusion injury, estimated by peak peri-operative serum amino-transferase (AST), is associated with AKI following donation after brain death (DBD) liver transplantation. (birmingham.ac.uk)
- Hepatic ischemia-reperfusion (I/R) injury is a common complication in liver transplantation. (nanostring.com)
- Acetaminophen (APAP) poisoning is one of the leading causes of acute hepatic failure and liver transplantation is often the only lifesaving alternative. (mdpi.com)
- The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)
- Geha JA, Geha JD, O'Mahony CA, Cotton RT, Galván TN, Rana A, Goss JA " Reconstruction of the Replaced Right Hepatic Artery Using Donor Iliac Arterial Y-Graft in Orthotopic Liver Transplantation . (bcm.edu)
- Spectral Doppler ultrasonographic waveform of the right hepatic artery in a 60-year-old man, 8 years after orthotopic liver transplantation. (medscape.com)
- A-1: Magnetic resonance angiogram in a transplantation patient with hepatic artery thrombosis. (medscape.com)
Apoptosis3
- It has been demonstrated that I/R-induced hepatic injury is initially triggered by reactive oxygen species (ROS), which induce oxidative damage and apoptosis, an important mechanism for cell death following hepatic I/R injury ( 2 ). (spandidos-publications.com)
- Trim8 knockout relieved hepatocyte injury triggered by I/R. Silencing of Trim8 expression alleviated hepatic inflammation responses and inhibited apoptosis in vitro and in vivo . (ijbs.com)
- Specifically, she is interested in the GLP- 1 receptor and its role in hepatic steatosis, apoptosis and autophagy in the setting of ischemia reperfusion injury. (choa.org)
Hepatocellular2
- Hepatocellular damage was assessed through hepatic venous levels of sorbitol dehydrogenase and lactate dehydrogenase. (duke.edu)
- Using a 90-min lobar warm ischemia model, wild type (WT), TLR4 KO/mutant and TLR2 KO mice were first assessed for the severity of hepatocellular damage at 6 h postreperfusion. (houstonmethodist.org)
Steatosis2
- Numerous preclinical models have depicted the impact of I/R injury and hepatic parenchymal quality (steatosis, age) on increased cancer growth in the injured liver. (123dok.net)
- 5% of hepatocytes displaying steatosis in the absence of significant ethanol intake and metabolic disease or toxic injury. (medscape.com)
Fibrosis3
- Gypenoside (GP), the predominant component of Gynostemma pentaphyllum, exhibits a therapeutic effect on chronic hepatic injury, fibrosis and fatty liver disease via its anti-inflammatory and anti‑oxidant activity. (spandidos-publications.com)
- Furthermore, GP exhibits a therapeutic effect on chronic hepatic injury, fibrosis, as well as fatty liver disease, which were induced by a high fat, high cholesterol diet and alcohol in mice ( 5 , 8 ). (spandidos-publications.com)
- [ 8 ] In adolescents with NAFLD, a direct relationship between the degree of hypoxemia and severity of hepatic fibrosis was noted. (medscape.com)
Autophagy3
- In this study, we show that one CaMK member, CaMKIV, is protective in hepatic I/R by activating the prosurvival pathway of autophagy in hepatocytes. (usuhs.edu)
- Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. (wanfangdata.com.cn)
- Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury. (wanfangdata.com.cn)
Mitochondria1
- Management of reperfusion injury is based on protecting mitochondria. (standardofcare.com)
Abstract1
- Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
Dysfunction4
- Despite accumulating evidence regarding its mechanisms and potential therapeutic approaches, hepatic I/R is still a leading cause of organ dysfunction, morbidity, and resource utilization, especially in those patients with underlying parenchymal abnormali-ties. (123dok.net)
- Hepatic I/R is an important cause of liver damage and is also the underlying cause of graft dysfunction in marginal organs. (ijbs.com)
- Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. (wanfangdata.com.cn)
- Lack of myocardial reperfusion in the presence of a patent coronary artery is referred to as a no-reflow phenomenon and is attributed to microvascular dysfunction. (standardofcare.com)
Tissue3
- Hepatic vascular resistance and liver tissue blood flow, as measured by thermistor flow probes, were determined following reperfusion. (duke.edu)
- In our experiment, adult SD rat model of acute lung injury was established by injecting lipopolysaccharide (LPS) into treachea, and life signs and dry-wet ratio of pulmonary tissue were closely observed. (researchsquare.com)
- Cannabidiol (CBD) protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response of oxidative and nitrative stress, and thereby cell death and tissue injury, but independent from classical CB1 and CB2 receptors. (standardofcare.com)
Organs1
- HBOT could obviously enhance aterial oxygen level, increase partial pressure of oxygen and improve ischemia in various organs or tissues, decrease acid metabolites and hasten functional recovery of various organs. (researchsquare.com)
Inflammatory4
- In addition, certain pro-inflammatory chemokines and cytokines are key during the initial period of reperfusion, whereas the late period of hepatic injury is neutrophil-mediated ( 3 ). (spandidos-publications.com)
- I/R injury, through the liberation of radical oxygen species and the activation of inflammatory pathways, induces cellular injury and mi-crocirculatory damage, which translate to organ dysfunc-tion, morbidity, and increased health care costs [7, 8]. (123dok.net)
- Activation of Kupffer cells and neutrophils leads to release of inflammatory cytokines and free radicals, which further aggravate liver injury [ 4 , 5 ]. (ijbs.com)
- Sterile inflammatory insults, such as ischemia-reperfusion (I/R) injury, result from pathogenic factors, including damage-associated molecular pattern signaling, activation of innate immunity, and upregulation of proinflammatory cytokines. (usuhs.edu)
Reduces1
- These results indicate that administration of bosentan before and after ischemia/reperfusion reduces hepatic circulatory disturbances, diminishes endothelial cell damage, and augments hepatic graft function. (duke.edu)
Endothelial1
- Hepatic I/R injury is characterized by endothelial and Kupffer cell swelling, vasoconstriction, leukocyte infiltration, and platelet aggregation in sinusoids [ 3 ]. (ijbs.com)
Myocardial infarction1
- In myocardial infarction aims to provide early, full and sustained restoration of antegrade flow at the epicardial level and to achieve adequate reperfusion at the myocardial level. (standardofcare.com)
Ischemic2
- Putative pathophysiological mechanisms linking I/R injury and liver cancer recurrence include an increased implantation of circulating cancer cells in the ischemic liver and the upregulation of proliferation and angiogenic factors following the ischemic insult. (123dok.net)
- Excessive glutamate release and the overexcitation of glutamate receptors has been identified as a central mediator in the pathophysiology of the neuronal injury associated with ischemic stroke and head trauma ( Choi, 1987 ). (jneurosci.org)
Hypothermia1
- Hypothermia minimizes a patient's production of deadly free radicals during reperfusion. (standardofcare.com)
Graft function1
- Scholars@Duke publication: Bosentan, an endothelin antagonist, augments hepatic graft function by reducing graft circulatory impairment following ischemia/reperfusion injury. (duke.edu)
Reconstruction1
Swine1
- Methods: This preclinical study evaluated the use of beta-blockers during induction of anesthesia in a swine model of liver ischemia-reperfusion injury (metoprolol and control groups). (journalcra.com)
Clinical5
- Conclusion: The use of beta-blockers does not have a clinical impact on attenuating liver ischemia reperfusion injury. (journalcra.com)
- Although limited, there is growing clinical evidence that I/R injury and liver quality are associated with the risk of post-sur-gical cancer recurrence. (123dok.net)
- I/R is a common pathological disorder leading to acute liver injury, a potentially life-threatening clinical condition with high morbidity, mortality, and prolonged patient hospitalization. (ijbs.com)
- In the present study, the team was able to show that Liproxstatin-1 suppresses ferroptosis both in human kidney cells, Gpx4 deletion-induced acute renal failure and in a pre-clinical model of hepatic ischemia reperfusion injury. (sciencedaily.com)
- To investigate the effects of hydrogen-rich saline (HRS) combined with hyperbaric oxygen (HBO) on acute lung injury (ALI) and its clinical significance. (researchsquare.com)
Mechanism3
- To the best of our knowledge, the role of GP in hepatic I/R injury and the underlying molecular mechanism, have not yet been investigated. (spandidos-publications.com)
- In conclusion, this study highlights the importance of cross talk between HO-1 and TLR system in the mechanism of hepatic IRI. (houstonmethodist.org)
- The nature and severity of abdominal injuries vary widely depending on the mechanism and forces involved, thus generalizations about mortality and need for operative repair tend to be misleading. (msdmanuals.com)
Role8
- We evaluated the role of an endothelin antagonist in hepatic ischemia/reperfusion injury. (duke.edu)
- Purpose: Beta-blockers show promise in the attenuation of ischemia reperfusion during cardiac surgery, however its role on injury during liver surgery is not known. (journalcra.com)
- This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery, using a ''bench-to-bedside'' approach. (123dok.net)
- The aim of this study is to explore the role of Trim8 in hepatic I/R injury. (ijbs.com)
- In conclusion, our study demonstrates that Trim8 deficiency plays a protective role in hepatic I/R injury by inhibiting the activation of TAK1-dependent signalling pathways. (ijbs.com)
- A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver Ischemia/Reperfusion Injury. (nih.gov)
- 29256408 ). N-Acetyltryptophan has also been shown to have a role in preventing hepatic ischemia-reperfusion injury. (hmdb.ca)
- The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury [J].2015,78. (wanfangdata.com.cn)
Mice6
- In the present study, a hepatic I/R‑injury model was successfully established using C57BL/6 mice. (spandidos-publications.com)
- Therefore, in the present study the protective effects of GP against I/R-induced hepatic injury in mice was studied. (spandidos-publications.com)
- In contrast, tin protoporphyrin-mediated HO-1 inhibition restored hepatic damage in otherwise IRI-resistant TLR4 mutant/KO mice. (houstonmethodist.org)
- CoPP-induced HO-1 overexpression ameliorated hepatic damage in IRI-susceptible TLR2 KO mice, comparable with WT controls, and concomitantly diminished TLR4 levels. (houstonmethodist.org)
- Trim8 gene knockout mice and primary hepatocytes were used to construct hepatic I/R models. (ijbs.com)
- The results indicated that Trim8 was significantly upregulated in liver of mice subjected to hepatic I/R injury. (ijbs.com)
Sinusoidal1
- 21]Peralta,C.,Jiménez-Castro,M.B.,Gracia-Sancho,J.. Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu [J].2013,59(5). (wanfangdata.com.cn)
Demonstrates1
- In conclusion, hepatic ischemia-reperfusion injury demonstrates a strong relationship with peri-operative AKI in DBD liver transplant recipients. (birmingham.ac.uk)
Innate immunity1
- Hepatic IRI represents a case for innate immunity in which HO-1 modulates proinflammatory responses that are triggered via TLR4 signaling, a putative HO-1 repressor. (houstonmethodist.org)
Conclusion2
- In conclusion, the present study indicated that GP effectively protected against I/R-induced hepatic injury via its anti-oxidative and anti-apoptotic bioactivity. (spandidos-publications.com)
- In conclusion, on top of its harmful early impact on organ function, I/R injury is linked to increased tumor growth. (123dok.net)
Pathways2
- Tao Q, Tianyu W, Jiangqiao Z, Zhongbao C, Xiaoxiong M, Long Z, Jilin Z. Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways. (ijbs.com)
- Mechanistically, our study suggests that Trim8 deficiency may elicit hepatic protective effects by inhibiting the activation of transforming growth factor β-activated kinase 1 (TAK1)-p38/JNK signalling pathways. (ijbs.com)
Occlusion2
- Subsequent angiography confirmed occlusion at the hepatic arterial anastomosis. (medscape.com)
- Magnetic resonance angiogram of the recipient celiac axis depicts complete occlusion of the hepatic artery. (medscape.com)
Vascular1
- Excess release and over-expression of immflammatory mediators and related immflammatory cytokines could stimulate excess immflammatory reaction, resulting in damage to alvelar-cappilary membrane and increased vascular permeability and ultimately acute lung injury (ALI) [ 5 - 7 ] . (researchsquare.com)
Lung2
- Lung injury is one of the most serious injuries that are difficult to handle and is a leading cause of death in patients with thoracic trauma [ 1 , 2 ] . (researchsquare.com)
- Lung ischemia reperfusion injury: A bench-to-bedside review [J].2013,17(1). (wanfangdata.com.cn)
Hypoxia1
- Hypoxia associated with OSA leads to hypoxia-reoxygenation with ischemia- reperfusion injury . (medscape.com)
Deprivation1
- Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
Damage1
- Qi et al ( 9 ) reported that GP protected against DNA damage in neurons in I/R-induced cerebral injury. (spandidos-publications.com)
Therapeutic2
- Therefore, developing effective preventive and therapeutic strategies for I/R-induced hepatic injury is required. (spandidos-publications.com)
- Therapeutic strategies tackling I/R injury could not only improve post-surgical organ function, but also allow a reduction in the risk of cancer recurrence. (123dok.net)
Surgical procedures1
- the liver, I/R injury is at the source of poor outcomes after surgical procedures such as hepatectomy and liver trans-plantation [7]. (123dok.net)
Acute Kidney1
- Donation after cardiac death liver transplant recipients have an increased frequency of acute kidney injury (AKI). (birmingham.ac.uk)
Effects1
- We evaluated whether siRNA targeting maternal hepatic angiotensinogen (Agt) could ameliorate symptoms of preeclampsia without adverse placental or fetal effects in 2 rodent models. (jci.org)
Increases1
- Reperfusion increases free radical production. (standardofcare.com)