Insulin ResistanceInsulinLiverGlucose Clamp TechniqueFatty LiverBlood GlucoseReceptor, InsulinGlucoseHyperinsulinismInsulin Receptor Substrate ProteinsGluconeogenesisGlucose Tolerance TestDiabetes Mellitus, Type 2ObesityGlucose-6-PhosphataseDietary FatsAdipose TissueFatty Acids, NonesterifiedTriglyceridesGlucose IntoleranceFastingParasympathectomyHyperglycemiaDiet, High-FatHypoglycemic AgentsProtein Kinase C-epsilonSignal TransductionLipid MetabolismHepatocytesC-PeptideMice, Inbred C57BLGlucokinaseMuscle, SkeletalEndoplasmic Reticulum StressGlycogenMice, KnockoutHomeostasisFructoseBody WeightGlucagonMetabolic Syndrome XDrug ResistanceBody CompositionLeptinLipogenesisFatty AcidsRats, Sprague-DawleyProto-Oncogene Proteins c-aktThiazolidinedionesPhosphoenolpyruvate Carboxykinase (GTP)DiglyceridesPhosphorylationEnergy MetabolismDrug Resistance, MicrobialMicropore FiltersAdiponectinDrug Resistance, BacterialOligonucleotides, AntisenseDiet TherapyDiacylglycerol O-AcyltransferaseRats, WistarHepatic ArteryInsulin-Like Growth Factor Binding Protein 1Insulin-Secreting CellsDietAdipocytesMice, ObeseGlycerolGene Expression RegulationRNA, MessengerTime FactorsLipidsHypothalamusDisease Models, AnimalDrug Resistance, NeoplasmIslets of LangerhansMice, TransgenicBody Mass IndexHepatic VeinsGene ExpressionResistinCells, CulturedGlucose Transporter Type 4Reverse Transcriptase Polymerase Chain ReactionGlycogenolysisRats, ZuckerInsulin, Long-ActingDrug Resistance, MultipleInsulin AntibodiesVascular ResistanceBlotting, WesternMetforminDisease ResistanceDiabetes Mellitus, ExperimentalOxidation-ReductionJNK Mitogen-Activated Protein KinasesAdiposityInsulin AntagonistsHormones, EctopicProtein Tyrosine Phosphatase, Non-Receptor Type 1