DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
WarfarinAnticoagulantsVitamin K Epoxide ReductasesPoisonsHeparin, Low-Molecular-WeightHemorrhageThromboembolismProthrombin TimeRodenticidesAtrial FibrillationMixed Function Oxygenasesbeta-AlanineVitamin KPoisoningHeparin AntagonistsAryl Hydrocarbon HydroxylasesHeparin LyasePharmacogeneticsAntithrombins4-HydroxycoumarinsHeparin Cofactor IIRodent ControlBlood CoagulationAspirinStrokeDrug MonitoringDrug InteractionsVitamin K 1Partial Thromboplastin TimeDrug Dosage CalculationsThrombophlebitisBenzimidazolesThrombosisIntracranial HemorrhagesTopoisomerase II InhibitorsVenous ThrombosisFibrinolytic AgentsDose-Response Relationship, DrugEnoxaparinAntithrombin IIIPlatelet Aggregation InhibitorsEmbolismAdministration, OralTopoisomerase I InhibitorsTreatment OutcomeAcenocoumarolPulmonary EmbolismDermatitis, ToxicodendronHerb-Drug InteractionsVenous ThromboembolismProthrombinCarbon-Carbon LigasesAmphibian VenomsVitamin K DeficiencyDNA Topoisomerases, Type IIWhole Blood Coagulation TimeTime FactorsPhenylbutazoneRetrospective StudiesPyridonesDalteparin
AnticoagulantsThinnersAspirinAnticoagulant effects of heparinNSAIDsCoumadinCoumarinSodiumAldosterone synthesisAntidotesEthylene glycolMedicationsMolecular weightLiverBloodProtamineRenalExcessiveHyperbaricAcuteEndocrineDoseOralDrugsVitaminInjectionLocal poison controDecreasePatientsMedicationCompoundsAccidentalSevereHepaticClinicalMercuryEffectsCommonlyOccurLong-termRiskCommonControl
Anticoagulants8
  • This means it could displace other protein-bound drugs (examples include anticoagulants like warfarin, listed in the examples below) and cause unexpected side effects. (salemhealth.org)
  • Additionally, although warfarin is no longer used primarily as a rodenticide, several long-acting coumarin derivatives (the so-called superwarfarin anticoagulants, such as brodifacoum, diphenadione, chlorophacinone, and bromadiolone) are used for this purpose and can produce profound and prolonged anticoagulation. (medscape.com)
  • Some types of rat poison work by containing anticoagulants similar to warfarin. (iheartdogs.com)
  • The availability of oral, non-vitamin K based anticoagulants that provide similar protection against thrombosis but have fewer adverse side effects and do not require regular monitoring of INR has decreased the use of warfarin, particularly in the elderly who are most prone to bleeding complications. (nih.gov)
  • barbiturates (such as pentobarbital, phenobarbital ), " blood thinners " ( anticoagulants such as heparin , warfarin ), corticosteroids (such as prednisone ), estrogens . (webmd.com)
  • Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk. (nih.gov)
  • BACKGROUND: Clinical trials suggest lower rates of major bleeding with direct-acting oral anticoagulants (DOACs) than with warfarin, but anticoagulant-related bleeding remains one of the most common outpatient adverse drug events. (cdc.gov)
  • CONCLUSIONS: Although the rates of ED visits for anticoagulant-related bleeding may be lower for DOACs than for warfarin, persistently large numbers of patients requiring ED visits for anticoagulant-related bleeding despite increased use of DOACs and declining use of warfarin suggest that efforts to improve appropriate prescribing and monitoring of anticoagulants remain important. (cdc.gov)
Thinners2
  • Drug therapies and blood thinners such as aspirin, warfarin (Coumadin, Jantoven), dabigatran (Pradaxa), rivaroxaban (Xarelto), apixaban (Eliquis) and heparin can significantly decrease your risk of a serious blood clot. (dalmarosec.com)
  • Individuals on blood thinners like warfarin or heparin should also avoid fish oil, which has been shown to have anticoagulant properties, and may therefore increase bruising and bleeding when taken along with other thinning agents. (drugsdb.com)
Aspirin5
  • Use of medications-especially aspirin, NSAIDs, warfarin, heparin, ticlopidine, and dipyridamole-should be documented, as these not only predispose to epistaxis but make treatment more difficult. (medscape.com)
  • This risk is increased when you use other "blood thinning" medications (e.g., aspirin, clopidogrel, warfarin), NSAIDs (e.g., ibuprofen, naproxen), or when certain medication delivery devices (indwelling epidural catheters) are used. (patientassistance.com)
  • Tell your doctor of all over-the-counter and prescription medication you may use including: aspirin, warfarin, NSAID (e.g., ibuprofen, naproxen), other heparins. (patientassistance.com)
  • Safer alternatives for anticoagulation in dogs often include medications like aspirin, clopidogrel, or heparin, which have a wider margin of safety. (iheartdogs.com)
  • If use vitamin C together with aspirin, it might cause aspirin poisoning. (wamin.com)
Anticoagulant effects of heparin2
  • Protamine sulfate: Used as an antidote for heparin overdose, neutralizing the anticoagulant effects of heparin. (standardofcare.com)
  • Vitamin C are against the anticoagulant effects of heparin and warfarin, leading to shortening of prothrombin time and weakening the effect of anticoagulant drugs.It is suggested to have at least 2 hours interval if while use together. (wamin.com)
NSAIDs1
  • Redfern ro a picture of erythema multiforme major cephalosporins barbiturates penicillins nsaids phenytoin penicillins radiographic contrast phenytoin salicylates sulfonamides sulfonamides bullous eruptions miscellaneous barbiturates coma bullae corticosteroids captopril heparin heparin warfarin pencillamine pemphigus-serum sickness like antithymocyte globulin or okt- a murine monoclonal antibody palivizumab has proven or possible asthma, esophageal ph monitoring coupled with heparin and low-molecular-weight heparin suppress aldosterone synthesis and release of pth. (albionfoundation.org)
Coumadin1
Coumarin3
  • Warfarin, one of the several compounds synthesised as part of the coumarin research, was patented in 1945. (wikipedia.org)
  • Coumarin derivatives include warfarin, dicumarol, phenprocoumon and acenocoumarol. (nih.gov)
  • Warfarin is derived from coumarin, a compound with anticoagulant properties also found in chamomile. (survivingantidepressants.org)
Sodium1
  • Further supporting this theory is that the heparin-mediated sodium and potassium effects do not occur in patients in whom aldosterone is already suppressed (salt-loaded patients) or those receiving exogenous aldosterone support (patients on chronic steroids). (hughesmedicine.com)
Aldosterone synthesis1
  • Though the specific mechanism seems to differ between heparin and the LMWHs, suppressing aldosterone synthesis causes natriuretic and potassium-retaining effects . (hughesmedicine.com)
Antidotes1
Ethylene glycol1
  • The focus of this article is poisoning from organophosphates , cyanide , ethylene glycol and methanol , laundry and cleaning products, mushrooms and plants, and carbon dioxide. (amboss.com)
Medications5
  • Patients who are taking warfarin also should be questioned about intake of other medications, drugs, toxins, and foods (including rodent poison and herbal supplements) that impair the metabolism of warfarin and thus increase its anticoagulant effect. (msdmanuals.com)
  • Finally, warfarin is very sensitive to drug-drug interactions involving its metabolism or function and great care must be given to starting or stopping concurrent medications in patients on warfarin therapy. (nih.gov)
  • Heparin and low molecular weight heparins (LMWH) are some of the many medications that have been identified to cause hyperkalemia. (hughesmedicine.com)
  • Warfarin is also affected by other medications and your diet because high levels of Vitamin K are found in dark green or leafy vegetables. (youandbloodclots.com)
  • These medications are much more predictable than warfarin and do not require frequent monitoring with blood tests. (youandbloodclots.com)
Molecular weight1
  • The first group includes low molecular weight heparin and fondaparinux that are taken as shots. (youandbloodclots.com)
Liver4
  • Warfarin therapy is associated with rare instances of idiosyncratic, clinically apparent liver injury that are usually mild and rapidly reversible on stopping. (nih.gov)
  • Liver injury due to warfarin therapy is rare, but clinically apparent acute liver injury attributable to it has been reported. (nih.gov)
  • The typical case of acute liver injury arises within 3 to 8 weeks of starting warfarin, although rare instances of liver injury arising after months or years of therapy have been reported (and these long latencies are common with phenprocoumon hepatotoxicity). (nih.gov)
  • The main older blood thinner used is called warfarin, which blocks the liver from making the clotting proteins that require vitamin K. If you are taking Warfarin you will need frequent monitoring with blood tests. (youandbloodclots.com)
Blood6
  • Poisons which are injected into the body are usually treated by the use of a constriction band which limits the flow of lymph and/or blood to the area, thus slowing the circulation of the poison around the body. (standardofcare.com)
  • Blood levels of warfarin are neither readily available nor helpful. (medscape.com)
  • Warfarin is an anticoagulant, a medication that reduces the ability of the blood to clot. (iheartdogs.com)
  • If a dog has had an issue with blood clots or is at risk of developing them due to another medical condition (such as heart disease, cancer, or certain types of kidney disease), a vet might choose to use an anticoagulant like warfarin. (iheartdogs.com)
  • With symptoms of vomiting, it could be food poisoning or it could be a blood clot in your abdomen. (dalmarosec.com)
  • If you are on warfarin, you will need to go in for more frequent check-ups to make sure that you are getting enough to reduce the risk of blood clots, but not so much that you have a high risk of bleeding. (youandbloodclots.com)
Protamine2
  • Administer anticoagulant therapy as prescribed, and observe for signs of bleeding and allergic reactions, Note: Keep the antidote protamine sulfate available in case of a severe heparin overdose. (rnpedia.com)
  • Keep protamine sulfate readily available in case of heparin overdose. (rnpedia.com)
Renal1
  • Risk factors for heparin-induced hyperkalemia include diabetes mellitus, renal impairment, hematomas, and other conditions that alter the balance of the renin-angiotensin aldosterone system. (hughesmedicine.com)
Excessive1
  • Overdose with warfarin can result in excessive bleeding and hepatic failure. (nih.gov)
Hyperbaric1
  • Surgery cholecystectomy generally laparoscopic should be measured by synsforstyrrelser viagra carbon monoxide poisoning, hyperbaric high pressure vesicoureteral reflux and aspiration of feedings. (albionfoundation.org)
Acute1
  • This is evident as patients that are administered angiotensin II or have acute volume depletion essentially have an absent aldosterone response when heparin is present. (hughesmedicine.com)
Endocrine1
  • Narrowing of the zona glomerulosa has been seen in patients using long-term heparin but no other obvious histologic changes have been noted in the zona fasciculata, zona reticularis, or other endocrine glands. (hughesmedicine.com)
Dose2
  • The degree of effect on the vitamin K ΜΆ dependent proteins depends on the dose and duration of treatment with warfarin. (medscape.com)
  • In these cases, if a dog has ingested the poison, the vet might use a very carefully controlled dose of warfarin to outcompete the poison and allow the dog's body to metabolize and eliminate it. (iheartdogs.com)
Oral3
  • Ingested poisons are frequently treated by the oral administration of activated charcoal, which adsorbs the poison and flushes it from the digestive tract, thereby removing a large part of the toxin. (standardofcare.com)
  • Warfarin is the most common oral anticoagulant in current use. (medscape.com)
  • Warfarin is a commonly used oral anticoagulant with anti-vitamin K activity. (nih.gov)
Drugs1
  • The high degree of protein binding is one of several mechanisms whereby other drugs interact with warfarin. (medscape.com)
Vitamin1
Injection2
  • tell your doctor if you are receiving heparin injection. (medlineplus.gov)
  • Your doctor will probably stop your heparin for at least 5 days after receiving oritavancin injection. (medlineplus.gov)
Local poison contro2
  • If overdose is suspected, contact your local poison control center or emergency room immediately. (patientassistance.com)
  • US residents can call their local poison control center at 1-800-222-1222. (webmd.com)
Decrease2
  • Rapid loss of protein C temporarily shifts the balance in favor of clotting until sufficient time has passed for warfarin to decrease the activity of coagulant factors. (medscape.com)
  • Heparin has not been shown to significantly change the clearance or binding activity of aldosterone but has been shown to decrease plasma and urinary aldosterone concentrations due to inhibition of aldosterone production . (hughesmedicine.com)
Patients4
  • One prospective study with unfractionated heparin examined 154 patients being treated for DVT. (hughesmedicine.com)
  • Generally, these prospective studies and the smaller case series have shown that unfractionated heparin and LMWH, even when given at prophylaxis doses, results in hyperkalemia in up to 7%-9% of patients within the first 14 days of therapy. (hughesmedicine.com)
  • For patients who proceed to CABG surgery on pump, the intravenous infusion of bivalirudin should be continued until 1 hour prior to surgery after which the infusion should be discontinued and the patient treated with unfractionated heparin (UFH). (medthority.com)
  • it was 5.9 visits per 100 patients dispensed DOACs [95% CI, 2.5-9.2] and 13.0 visits per 100 patients dispensed warfarin [95% CI, 7.4-18.7]. (cdc.gov)
Medication1
  • BACKGROUND: Medication poisoning is a common form of self-harm injury, and increases in injuries due to self-harm, including suicide attempts, have been reported over the last two decades. (cdc.gov)
Compounds1
Accidental1
  • Particularly in children, include investigation of suspicion of accidental ingestion (eg, accidental ingestion of rat poison in toddlers). (medscape.com)
Severe1
  • In contrast to the lack of side effects from GBE, which is extracted from the leaf, contact with or ingestion of the fruit pulp has produced severe allergic reactions similar to an allergic reaction to the poison ivy-oak-sumac group suggesting cross-reactivity between Ginkgo biloba fruit and this family. (restorativemedicine.org)
Hepatic1
  • In addition, chronic warfarin therapy has been associated with spontaneous bleeding including hepatic rupture and life-threatening intraperitoneal bleeding, even without trauma and with INR in the appropriate range. (nih.gov)
Clinical1
  • Initially marketed as rat poison, warfarin would later, in the 1950s, become the second most important anticoagulant for clinical use (after heparin). (wikipedia.org)
Mercury1
Effects3
  • Pralidoxime: Used as an antidote for organophosphate poisoning, reversing the effects of certain insecticides or nerve agents. (standardofcare.com)
  • Since warfarin does not affect the activity of previously synthesized and circulating coagulation factors, depletion of these mature factors through normal catabolism must occur before the anticoagulant effects of the drug are observed. (medscape.com)
  • Poisoning occurs when a substance that is inhaled, ingested, or absorbed through the skin has harmful effects or even causes death . (amboss.com)
Commonly1
  • Due to the availability of safer alternatives and the narrow therapeutic range of warfarin (which can make proper dosing difficult), it's not commonly prescribed for dogs. (iheartdogs.com)
Occur1
  • Because warfarin also reduces the activity of anticoagulant proteins C and S, a transient hypercoagulable state may occur shortly after treatment with warfarin is started. (medscape.com)
Long-term1
  • If your pet will be on Warfarin long-term, ask your vet if you could save money by buying a larger quantity at once. (iheartdogs.com)
Risk1
Common2
  • What Are Some Common Reasons Warfarin is Prescribed for Dogs? (iheartdogs.com)
  • Monitoring of the INR is essential during warfarin therapy, because bleeding is a common side effect and can be life-threatening and fatal. (nih.gov)
Control6
  • a subset of 95 of these bites was reported in the 21 counties (essentially Central Florida) under the jurisdiction of the regional poison control center in Tampa. (ufl.edu)
  • I called the Florida Poison Control Network to confirm these numbers, and was cited 182 total cases and 96 in the Tampa region. (ufl.edu)
  • In case of overdose, call the poison control helpline at 1-800-222-1222. (medlineplus.gov)
  • Otherwise, call a poison control center right away. (webmd.com)
  • Canada residents can call a provincial poison control center. (webmd.com)
  • Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. (indianpharma.co)