• Interaction of hepatocyte growth factor with heparan sulfate. (wikipedia.org)
  • We demonstrated that a risk variant for Crohn's disease, hepatocyte growth factor activator (HGFAC) Arg509His (R509H), disrupted a damage-sensing pathway connecting the coagulation cascade to growth factors that drive the differentiation of wound-associated epithelial (WAE) cells and production of a localized retinoic acid (RA) gradient to promote fibroblast-mediated tissue remodeling. (bvsalud.org)
  • GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)
  • Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. (biomedcentral.com)
  • Fucan represents a family of water soluble, SP rich in sulfated l -fucose, extracted from extracellular matrix of these weeds (Li et al. (springer.com)
  • Through integration of single-cell transcriptomics and spatial transcriptomics, we demonstrated that WAE cells generated RA in a spatially restricted region of the wound site and that mucosal fibroblasts responded to this signal by producing extracellular matrix and growth factors. (bvsalud.org)
  • The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. (wikipedia.org)
  • FGF2 , also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene . (wikidoc.org)
  • Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated basic FGF, Heparin-binding growth factor-2, and Endothelial cell growth factor-2. (wikidoc.org)
  • Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1 , [13] RPL6 [14] and ribosomal protein S19 . (wikidoc.org)
  • In this study we used phosphorylation of the transcription factor cAMP response element-binding protein as a functional readout to identify cells responding to EGF and FGF-2. (beauty104.com.tw)
  • Specifically, we showed that HGFAC R509H was activated by thrombin protease activity but exhibited impaired proteolytic activation of the growth factor macrophage-stimulating protein (MSP). (bvsalud.org)
  • Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. (wikidoc.org)
  • Removal of the sulfate residues leads to a protein which has a more globular structure and provides less protection for the tissues from the intestinal contents. (simplymimi.net)
  • SPARC (secreted protein,acidic and rich in cysteine) is a matricellular glycoprotein that regulates cell-cell and cell-matrix interactions, cellular proliferation and differentiation, and the expression of genes encoding extracellular matrix components. (silverchair.com)
  • Moreover, at molecular level, each heparan sulfate proteoglycan (HSPG) consists of a core protein linked to one or more linear heparan sulfate (HS) chains composed of alternating D-glucosamine and uronic acids, leading to N - or O -sulfated glycan [ 5 ]. (biomedcentral.com)
  • VEGFA, commonly referred to as VEGF, is an essential growth factor for vascular endothelial cells and regulates endothelial cell permeability, proliferation, migration, and fenestration formation. (cusabio.com)
  • The signaling complex at the cell surface is believed to be a ternary complex formed between two identical FGF ligands, two identical FGFR subunits and either one or two heparan sulfate chains. (beauty104.com.tw)
  • Before birth, the functional units of the brain, 'neurons', are laid down on a scaffolding network of sulfated carbohydrate chains. (simplymimi.net)
  • Upon an electrochemical switch, growth factor presentation was reversed, which initiated cellular differentiation along the neuronal lineages. (5dok.org)
  • A wide array of chemical substances can influence cell growth and differentiation. (beauty104.com.tw)
  • The winged-helix transcription factor Foxd3 suppresses intemeuron differentiation and promotes neural crest cell fate. (forexsignalx.com)
  • in this manner we show that fibrotic matrices clearly promote transforming growth factor-β-independent myofibroblast differentiation compared with normal matrices. (atsjournals.org)
  • [3] [5] FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules. (wikidoc.org)
  • They then further fractionated the extract using acidic and basic pH and isolated two slightly different forms that were named 'acidic fibroblast growth factor' (FGF1) and 'basic fibroblast growth factor' (FGF2). (beauty104.com.tw)
  • Not long after FGF1 and FGF2 were isolated, another group isolated a pair of heparin -binding growth factors which they named HBGF-1 and HBGF-2, whilst a third group isolated a pair of growth factors that caused proliferation of cells in a bioassay containing blood vessel endothelium cells which they called ECGF-1 and ECGF-2. (beauty104.com.tw)
  • Some of these factors (ie, acidic and basic fibroblast growth factors, interleukin 1 [IL-1], and vascular endothelial growth factor [VEGF]) have been identified and isolated from cornea and tears. (medscape.com)
  • bFGF is a more potent angiogenic factor than VEGF ( vascular endothelial growth factor ) or PDGF ( platelet-derived growth factor ). (beauty104.com.tw)
  • Widespread transduction of cardiac and skeletal muscle has been achieved in adult mouse by intravenous administration of rAAV6 vector supplemented with vascular endothelium growth factor (VEGF) (Gregorevic et al. (justia.com)
  • Proteins that act both at the cell surface and intracellularly will be discussed in this thesis, with particular emphasis on the fibroblast growth factors. (beauty104.com.tw)
  • These proteins were found to be identical to the acidic and basic FGFs described by Gospodarowicz and coworkers. (beauty104.com.tw)
  • Sulfate is essential in forming the mucin proteins which line the gut walls. (simplymimi.net)
  • Mucin proteins, which line the gastrointestinal tract, are sulfated glyco-proteins which control adhesion/lubrication of gut contents and absorption of nutrients (2). (simplymimi.net)
  • This reduced sulfation of mucin proteins may underlie the relatively common finding of Candida infections in the gut, since the slight negative charges on Candida cells would lead to their repulsion by the negatively charged sulfate groups on normal mucins. (simplymimi.net)
  • After treatment with CaG, a total of 152 genes were down-regulated, including nuclear RNA export factor (Nxf3) and hyaluronan proteoglycan link protein1 (Hapln1). (biomedcentral.com)
  • Like other FGF family members, basic fibroblast growth factor possess broad mitogenic and cell survival activities, and is involved in a variety of biological processes, including embryonic development , cell growth , morphogenesis , tissue repair , tumor growth and invasion. (wikidoc.org)
  • It has been hypothesized that, during both wound healing of normal tissues and tumor development, the action of heparan sulfate -degrading enzymes activates bFGF, thus mediating the formation of new blood vessels , a process known as angiogenesis . (wikidoc.org)
  • GAGs also exert anti-cancer effects by altering structures of various tumor cells through sulfated modifications, including chondroitin sulfate (CS) and dermatan sulfate (DS). (biomedcentral.com)
  • Hence, altering expression of CS and heparan sulfate (HS) on surface of tumor cells is a potential molecular strategy to prevent malignant transformation and tumor metastasis [ 2 ]. (biomedcentral.com)
  • As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. (wikidoc.org)
  • PF4 is chemotactic for neutrophils , fibroblasts and monocytes , and interacts with a splice variant of the chemokine receptor CXCR3 , known as CXCR3B. (wikidoc.org)
  • OMIM 253010), based on a deficiency of different lysosomal enzymes-N-acetylgalactosamine-6-sulfate sulfatase (GALNS) and β-galactosidase, respectively. (medscape.com)
  • It is interesting that Helicobacter pylori, which can colonise the stomach, only does so when it has produced a sulfatase enzyme to de-sulphate the gastric mucins (6). (simplymimi.net)
  • The human platelet factor 4 kills malaria parasites within erythrocytes by selectively lysing the parasite's digestive vacuole. (wikidoc.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Horse Transforming Growth Factor Beta 1 (TGFb1) in serum, platelet-poor plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (stemcellcharter.org)
  • In addition to temporal changes in growth factor presentation, mechanical stiffness of tissues is also dynamically altered over time. (5dok.org)
  • It was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase . (wikidoc.org)
  • This can either occur by cell surface receptor interactions, as in the case with peptide growth factors, or by interactions with intracellular molecules, as in the case with steroid hormones. (beauty104.com.tw)
  • Human keratinocytes and fibroblasts adhered to the alkali-treated collagen via the collagen receptor integrin alpha2beta1. (lookformedical.com)
  • Sulfate is needed to start the cascade of digestive enzymes released from the pancreas. (simplymimi.net)
  • Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs (Olsen et al. (beauty104.com.tw)
  • Sulfate is essential for many biological processes. (simplymimi.net)
  • The process of sulfation involves adding on a sulfate residue, which has two negative charges, to a biological molecule. (simplymimi.net)
  • Sulfation can activate or inactivate a wide range of biological compounds and any aberration in the supply of sulfate can have potentially serious consequences. (simplymimi.net)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Milk Fat Globule EGF Factor 8 (MFGE8) in serum, plasma, cell lysates and other biological fluids. (elisareagents.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Milk Fat Globule EGF Factor 8 (MFGE8) in samples from serum, plasma, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (elisareagents.com)
  • Description: A sandwich ELISA kit for detection of Milk Fat Globule EGF Factor 8 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (elisareagents.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Milk Fat Globule EGF Factor 8 (MFGE8) in samples from serum, plasma, tissue homogenates or other biological fluids. (elisareagents.com)
  • Description: A sandwich ELISA kit for detection of Transforming Growth Factor Beta 3 from Horse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (stemcellcharter.org)
  • It thus promotes angiogenesis , the growth of new blood vessels from the pre-existing vasculature. (beauty104.com.tw)
  • The underlying molecular mechanisms and the responsible pathogenic factors leading to these changes in outflow resistance remain unknown. (arvojournals.org)
  • However, this pathway is often sub-optimal and many people benefit from sulfate supplementation. (simplymimi.net)
  • Principally, sulfation is a major inactivation pathway for catecholamines such as the neurotransmitter dopamine, about 80% of which is sulfated in man (1). (simplymimi.net)
  • Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit Introduction: The event of SARS-CoV-2 serological assessments is very large. (elisastrip.com)
  • Adminstration with these GAGs increased survival time and decreased melanoma sizes in mice, in accordance with their inhibitory effects on cell growth ratio of melanoma B16F10. (biomedcentral.com)
  • Immunostaining with an affinity-purified mouse antibody reveals that Eph is highly targeted to axons and growth cones of developing neurons within the VNC. (sdbonline.org)
  • We used conjugated polymers to develop a novel neural stem cell culture substrate with anchored growth factors to promote cell self-renewal. (5dok.org)
  • In 1974, the GALNS enzyme and its deficiency were discovered and identified using oligosaccharide substrate prepared from C6S containing N-acetylgalactosamine-6-sulfate. (medscape.com)
  • To better address how ECM influences fibroblast phenotype in a disease-specific manner, we developed a culture system using acellular human normal and fibrotic lungs. (atsjournals.org)
  • For this reason my coworkers and I had used high pressure as a factor which is ca- pable of modulating the enzyme catalytic activity both in micelle free solutions and in micellar system. (forexsignalx.com)
  • sPLA 2 s contain 6 to 8 disulphide bonds, a highly conserved His/Asp catalytic dyad, and a Ca 2+ -binding loop [ 1 ]. (ijbs.com)
  • We further dissected this WAE cell-fibroblast signaling circuit in vitro using a genetically tractable organoid coculture model. (bvsalud.org)
  • Considering the immense biomedical prospects of sulfated polysaccharides, the profound and emerging functional properties published in recent times will be discussed here with experimental evidences. (springer.com)
  • However, FGFs 11-14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functional differences compared to the FGFs. (beauty104.com.tw)
  • the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. (wikidoc.org)
  • However, even in late gestation, mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. (biomedcentral.com)
  • In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)
  • [ 8 ] This is especially present in patients with a history of aphakia, extended wear, poor compliance, low oxygen permeable CLs, long-term CL wear (many years), and poor follow-up care. (medscape.com)
  • Statistical data have shown that the amount of this factor is significantly increased in the AH of approximately 50% of patients with POAG. (arvojournals.org)
  • low levels of sulfate are found in plasma and synovial fluid from patients with rheumatoid arthritis. (simplymimi.net)
  • Low plasma sulfate has been found in patients with irritable bowel disease. (simplymimi.net)
  • Of these, AAV1, 6, 8, and 9 recombinant vectors have been reported to result in higher transgene expression level in muscle than rAAV2 vector (Wang et al. (justia.com)