Hence combination drug synergism. Medical search. Frequent questions

The current treatments for melanoma are surgery, which is performed in the early stages of the disease, and neoadjuvant treatments for advanced patients, including chemotherapy, radiotherapy, targeted therapy, immunotherapy and combination therapy [ 2 , 3 ]. (medsci.org)
Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
The data suggest that inhibitors of the Fd/FNR redox system should be avoided as ART partner drugs in ART combination therapy for treating malaria. (biorxiv.org)
Artemisinin (ART)-based combination therapy is recommended by the World Health Organization for the first-line treatment of malaria in uncomplicated Plasmodium falciparum infections. (biorxiv.org)
The effectiveness or lack of a major therapeutic effect of sphingolipid modulation by some drugs as a cancer therapy and other aspects related to their mechanism of action are discussed in this review. (frontiersin.org)
Drugs of the so-called targeted therapy operate selectively by either inhibiting receptors and ligands or molecules of the signaltransduction. (uni-marburg.de)
We demonstrated that treatment with NPD1, RvD1, and combination therapy provides high-grade neurobehavioral recovery and decreases ischemic core and penumbra volumes even when administered up to 6 h after stroke. (springer.com)
Multi-targeted drug therapy holds more promise than single-class drug regimens (Lapchak 2011 ) since some drug combinations exhibit pharmacological synergism, translating into lower doses, fewer adverse side effects, and extending the therapeutic window (Saleh et al. (springer.com)
PrimeC, NeuroSense's lead drug candidate, a combination therapy for ALS, was granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA). (prnewswire.com)
However, it is unclear whether a combination of TRAIL gene therapy and chemotherapy will have enhanced antitumor activity or can be used for the treatment of metastasis. (elsevierpure.com)
In all the cell lines tested, including a breast cancer cell line that is resistant to chemotherapy, the combination of TRAIL gene therapy and cytotoxic agents had either a synergistic or an additive effect. (elsevierpure.com)
The combination of TRAIL gene therapy and chemotherapy resulted in a further reduction of lung metastatic nodules with minimal toxicity. (elsevierpure.com)
These results suggest that a combination of TRAIL gene therapy and chemotherapy is effective in the treatment of metastatic diseases. (elsevierpure.com)
In addition, rhodomycin A rendered gefitinib-resistant lung adenocarcinoma cells more sensitive to gefitinib treatment, implying a synergistic effect of the combination therapy. (oncotarget.com)

Mechanism: pharmacodynamic synergism. (medscape.com)
Either increases toxicity of the other by pharmacodynamic synergism. (medscape.com)
tobramycin increases effects of atracurium by pharmacodynamic synergism. (medscape.com)
tobramycin increases effects of cisatracurium by pharmacodynamic synergism. (medscape.com)
tobramycin increases effects of rapacuronium by pharmacodynamic synergism. (medscape.com)

The aims of this study are to clarify the antitumor effects of TCEE on human hepatocellular carcinoma cells and also evaluate the combination drug effects with conventional chemotherapy agents, cisplatin and doxorubicin. (hindawi.com)
In combination with the chemotherapy agents, TCEE treatment further enhanced the tumor suppression efficiency of cisplatin and doxorubicin. (hindawi.com)
In contrast, the antitumor effects and related biological mechanism of TCEE as well as the combination drug effects with conventional chemotherapy agents remain unclear particularly in human hepatocellular carcinoma cells. (hindawi.com)
Furthermore, the combined drug effects of TCEE with conventional chemotherapy agents, cisplatin and doxorubicin, were also analyzed to clarify whether TCEE enhances or antagonizes the cytotoxicity of the selected chemotherapy agents in hepatocellular carcinoma cells. (hindawi.com)
Sphingolipid-targeting drugs have been tested alone or in combination with chemotherapy, exhibiting antitumor activity alone and in synergism with chemotherapy in vitro and in vivo . (frontiersin.org)

Drug combinations are increasingly important in disease treatments, for combating drug resistance, and for elucidating fundamental relationships in cell physiology. (embopress.org)
Further studies indicated that mismatched drug exposure profiles likely permitted induction of phenotypic clarithromycin resistance and subsequent loss of synergism. (uzh.ch)
nonetheless, mutations of Fd gene ( fd ) may modulate ART resistance and Fd would be an important target for antimalarial drugs. (biorxiv.org)
This low survival may result from the metastasis of cancer cells and arising resistance to drugs. (oncotarget.com)
it exposes patients to drug complications without any benefit and contributes to bacterial resistance. (msdmanuals.com)

4 Here ibrutinib demonstrated the strongest synergism with venetoclax, whereas cisplatin appeared the most antagonistic ( Figure 1B and C, Online Supplementary Figure S1B ). (haematologica.org)
The effects of pirfenidone alone and in combination with cisplatin on human patient-derived CAF cell lines and non-small cell lung cancer (NSCLC) cell lines were examined. (biomedcentral.com)
However, co-culture in vitro experiments and co-implantation in vivo experiments showed that the combination of low doses of cisplatin (10 μM) and low doses of pirfenidone (0.5 mg/mL), in both CAFs and tumors, lead to increased cell death and decreased tumor progression, respectively. (biomedcentral.com)
Furthermore, the combination of cisplatin and pirfenidone in NSCLC cells (A549 and H157 cells) leads to increased apoptosis and synergistic cell death. (biomedcentral.com)
Our studies reveal for the first time that the combination of cisplatin and pirfenidone is active in preclinical models of NSCLC and therefore may be a new therapeutic approach in this disease. (biomedcentral.com)
Cisplatin is a platinum-based chemotherapeutic drug that has been used as the standard of care in late stages of NSCLC in combination with paclitaxel, vinorelbine, gemcitabine, docetaxel, pemetrexed, or irinotecan [ 20 ]. (biomedcentral.com)

Since all terms of MEE and CIE are dimensionless relativity ratio thus generally applicable regardless in vitro, in animals and in clinical trials, or physical states, resulting in econo-green bioresearch and new drug evaluation and bio-development. (wikipedia.org)
In vitro, 1599 synergized with 11 drugs from 6 antibiotic classes. (uzh.ch)
These studies highlight the importance of validating in vitro synergism and the challenge of matching drug exposures to obtain a synergistic outcome in vivo. (uzh.ch)
This study supports evidence in literature pointing to a certain activity of these drugs and at the same time emphasizes the different sensibility of human ovarian cancer cell lines to targeted therapeutics in vitro. (uni-marburg.de)
Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
Synergy with no overlapping toxicities has been demonstrated for the combination of irinotecan ( Camptosar, CPT-11) and gemcitabine (Gemzar) in vitro. (cancernetwork.com)

Avoid or Use Alternate Drug. (medscape.com)

Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)

Analogous studies in a murine syngeneic tumor model using surrogate antibodies demonstrated significant synergy between LAG-3 and PD-1 blockade-combination treatment led to a marked improvement in therapeutic efficacy, increased T-cell proliferation, IFNγ production, and elicited durable immunologic memory upon tumor rechallenge. (aacrjournals.org)
Such drug interactions are crucial for treatment efficacy, but their underlying mechanisms remain largely unknown. (embopress.org)
The observed synergy was tested against clinical isolates confirming synergy with Clarithromycin, Doxycycline and Clindamycin, combinations of which were taken forward for in vivo efficacy determination. (uzh.ch)
We employed combinatorial drug screening to identify synergistic combination partners to enhance the efficacy of venetoclax in T-PLL patients. (haematologica.org)
The synergistic interaction of curcumin and piperine was further confirmed by the efficacy of the combination in LPS-stimulated RAW 264.7 macrophage cells. (biomedcentral.com)
Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin. (uchicago.edu)

The reported synergism of the precursor spectinomycin with other antibiotics prompted us to examine whether spectinamides sensitize M. tuberculosis to other antibiotics not traditionally used in the treatment of tuberculosis to potentially expand therapeutic options for MDR/XDR Tuberculosis. (uzh.ch)
Methods Demographic, clinical and pharmacological variables, including tacrolimus whole blood concentrations obtained from therapeutic drug monitoring and data from dense-sampling pharmacokinetic profiles, were recorded in 26 paediatric patients with biliary atresia who underwent liver transplantation between 2016 and 2021. (unav.edu)
Therefore, searching for new molecular targets and drug combinations is critical for the development of effective therapeutic options. (aacrjournals.org)
The most clinically important interactions involve drugs with a low therapeutic ratio (ie, toxic levels are close to therapeutic levels). (msdmanuals.com)

Clove, guava and lemongrass exhibit the highest synergism rate with antimicrobial drugs. (pakalertpress.com)
Renal papillary necrosis (RPN) is kidney damage characterized by coagulative necrosis of the renal medullary pyramids and papillae, brought on by several associated conditions and toxins that exhibit synergism toward the development of ischemia. (medscape.com)

These drugs are bacteriostatic, meaning they inhibit the growth of the bacteria but do not kill them. (americanaquariumproducts.com)
Sulfa drugs arrest cell growth by inhibiting the synthesis of folic acid, a component required for growth by bacteria. (americanaquariumproducts.com)
Antibacterial drugs are derived from bacteria or molds or are synthesized de novo. (msdmanuals.com)
Technically, "antibiotic" refers only to antimicrobials derived from bacteria or molds but is often (including in THE MANUAL) used synonymously with "antibacterial drug. (msdmanuals.com)
For serious infections, combinations of antibiotics are often necessary because multiple species of bacteria may be present or because combinations act synergistically against a single species of bacteria. (msdmanuals.com)

For this reason sulfa drugs are not toxic to animal cells. (americanaquariumproducts.com)
Sulfa drugs are among the oldest in the medicine, the first being a sulfonamide was trade named Prontosil dating back to experiments by Bayer in 1932. (americanaquariumproducts.com)

The combination was additive, meaning that the experimental effect did not deviate in a statistically significant manner from the null reference model (or additive surface) of the combined effect. (manchester.ac.uk)
Body burden of the two solvents in combination was not additive. (cdc.gov)

In vivo experiments using xenograft and SCID-hu models of MM demonstrated a significant antitumor effect of the GSI/ABT-737 combination as compared to the effect of Notch or Bcl-2/Bcl-xL inhibitors alone. (aacrjournals.org)

Gemcitabine (Gemzar) and irinotecan (CPT-11, Camptosar) are active cytotoxic drugs against pancreatic cancer. (cancernetwork.com)
The synergism was independent of TLR-4 expression in pancreatic cancer cells. (rcsi.com)

The most potent extracts was tested along with gemcitabine using our established drug combination analysis. (rcsi.com)

However, it is unclear whether lycopene can act as an adjuvant to increase the anti-metastatic activity of anticancer drugs. (frontiersin.org)

The objective of this review was to analyze the results from preclinical and clinical trials of these drugs for the treatment of cancer. (frontiersin.org)
Aslthough all these drugs have produced good results in preclinical studies of multiple cancers, the outcomes of clinical trials have not been similar. (frontiersin.org)
The first 2 pairs were also enriched among pairs discovered using gene expression data and are supported by molecular interactions in drug-protein networks and preclinical and epidemiologic evidence. (sutterhealth.org)

Since clinical trials involving ibudilast have shown no adverse side effects and the drug readily penetrates the blood brain barrier, treatment of GBM with this combination is clinically achievable. (nature.com)
Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. (medscape.com)
abstract = "The strategy of combining antifungal drugs in a treatment regimen may improve the outcome of invasive candidiasis. (manchester.ac.uk)
Our methods provide a way in which some of the complex issues surrounding antifungal combination treatment can be addressed. (manchester.ac.uk)
Via flow cytometry in both cell lines a clear transformation of cell cycle induced by treatment with the drugs could be demonstrated, but these effects seem to be rather a single effect of flavopiridol. (uni-marburg.de)
It is known that adjuvant is defined as a substance that helps and enhances the effect of a drug or treatment ( 19 ). (frontiersin.org)
EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including disease-specific gene expression and drug-protein interactions, provide mechanistic understanding. (sutterhealth.org)
A clinical study to evaluate of the combination of AHCC plus PLD in the treatment of ovarian cancer is being pursued. (researchgate.net)
Since Pseudomonas & Aeromonas are common causes of opportunistic fin rot in fish (assuming the causes of this opportunity are negated), this drug or a combination that includes it may be a good alternative treatment. (americanaquariumproducts.com)
Anti-fibrotic drugs such as pirfenidone have been developed for the treatment of idiopathic pulmonary fibrosis. (biomedcentral.com)
In 2011, pirfenidone was the first drug approved in Europe for the treatment of idiopathic pulmonary fibrosis [ 18 ] following its approval in the United States in 2014. (biomedcentral.com)
PrimeC's upgraded formulation, which is a unique extended-release tablet, designed to maximize the synergism between the compounds, is now being evaluated in a Phase IIb clinical trial, PARADIGM, for the treatment of ALS. (prnewswire.com)
Become a scientist she did, and along the way she synthesized and co-developed two of the first successful drugs for the treatment of leukemia (thioguanine and mercaptopurine), as well as azathioprine (Imuran), an agent to prevent the rejection of kidney transplants and to treat rheumatoid arthritis. (cuny.edu)
Drug combination treatment study was performed using ruxolitinib and the indole analog. (eurekaselect.com)

To uncover the causes of drug interactions, we developed a systematic approach based on precise quantification of the individual and joint effects of antibiotics on growth of genome-wide Escherichia coli gene deletion strains. (embopress.org)
We found that drug interactions between antibiotics representing the main modes of action are highly robust to genetic perturbation. (embopress.org)
Rare violations of this principle exposed recurring cellular functions controlling drug interactions. (embopress.org)
In particular, we found that polysaccharide and ATP synthesis control multiple drug interactions with previously unexplained mechanisms, and small molecule adjuvants targeting these functions synthetically reshape drug interactions in predictable ways. (embopress.org)
These results provide a new conceptual framework for the design of multidrug combinations and suggest that there are universal mechanisms at the heart of most drug interactions. (embopress.org)
Rare violations of this principle expose cellular functions that control drug interactions and can be targeted by small molecules to alter drug interactions in predictable ways. (embopress.org)
Drug interactions between antibiotics are highly robust to genetic perturbations. (embopress.org)
Rare violations of this principle expose cellular functions that control drug interactions. (embopress.org)
Diverse drug interactions are controlled by recurring cellular functions, including LPS synthesis and ATP synthesis. (embopress.org)
METHOD: We applied Group Lasso INTERaction NETwork (glinternet), an overlap group lasso penalty on a logistic regression model, with pairwise interactions to identify variables and interacting drug pairs associated with reduced 5-year mortality using EHRs of 9945 breast cancer patients. (sutterhealth.org)

Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
These findings will assist the development of anti-tumour drugs to treat lung cancer. (oncotarget.com)

This robustness is encapsulated in a general principle of bacterial growth, which enables the quantitative prediction of mutant growth rates under drug combinations. (embopress.org)

CONCLUSIONS: This is a proof-of-concept study demonstrating that a combination of complementary data sources, such as EHRs and gene expression, can corroborate discoveries and provide mechanistic insight into drug synergism for repurposing. (sutterhealth.org)

it is probable that antifungal drug synergism can be utilised. (auckland.ac.nz)
Once manuka honey was determined as the most efficient non-peroxide antifungal honey, the antifungal drug synergies with the potential synergists were analysed in a presence of catalase (2 mg/ml) against T. rubrum and C. albicans. (auckland.ac.nz)

Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. (medscape.com)

Ibudilast showed modest anti-proliferative activity however, when combined with TMZ, significant synergism was observed, resulting in cell cycle arrest and apoptosis. (nature.com)

To this topic, lycopene had been demonstrated to have synergism from the combination of oxaliplatin in a human ovarian cancer cell line ( 20 ), suggesting that the adjuvant property on the anticancer of lycopene. (frontiersin.org)

When drugs are combined, their individual effects on cells may be amplified or weakened. (embopress.org)
The effects of acute exposure to toluene (108883) and methyl -ethyl- ketone (78933) (MEK) singly and in combination were investigated. (cdc.gov)
The potential CNS-side effects of the curcumin and piperine combination were also assessed using LABORAS automated home-cage behavioral analysis. (biomedcentral.com)
Furthermore, the curcumin-piperine combination had no effects on mouse spontaneous locomotor behaviors in LABORAS automated home cage monitoring. (biomedcentral.com)
Overall, the present study demonstrates strong antinociceptive synergism between curcumin and piperine in mouse models with no potential CNS side effects, suggesting its possible use in clinical trials. (biomedcentral.com)
Drug synergistic effects were observed when cells were stimulated to proliferate through both the IL3 and TpoR pathways. (eurekaselect.com)
A combination of Citricidal (grapefruit seed extract) and geranium oil showed the greatest anti-bacterial effects against MRSA . (pakalertpress.com)
In recent decades, the use of natural products for pharmacological purposes has witnessed a significant increase worldwide due mainly to attempts to minimize the side effects caused by synthetic drugs 1 . (bvsalud.org)

The 90-60 rule notes that approximately 90% of infections treated based on C&S are likely to respond, where as 60% will respond even if drugs noted as resistant are selected. (vin.com)
Among the most problematic concern is the fact that determination and interpretation of minimum inhibitory concentrations (MIC and MIC BP ) are based on assumed plasma drug concentrations (PDC), yet infections generally are located in extracellular fluid (ECF) and occasionally intracellular. (vin.com)
I generally reserved stronger treatments such as the AAP Yellow Powder/Kanamycin combination for later or full blown infections (which were more common with "fish doctor" calls, not my regular clients). (americanaquariumproducts.com)
Cultures and antibiotic susceptibility testing are essential for selecting a drug for serious infections. (msdmanuals.com)

Rapid molecular identification and typing methods that may be useful include 16S rRNA gene sequencing, random amplified polymorphic DNA and a combination polymerase chain reaction-restriction fragment length polymorphism analysis ( 39 , 116 ). (antimicrobe.org)

Twenty-four candidate compounds were selected based on their clinical approval status, literature data, and mechanisms of drug action. (haematologica.org)

We probed putative mechanisms and demonstrated clinical feasibility and activity of a putative combination by treating two patients with active, r/r-T-PLL. (haematologica.org)

Garlic and tea have antibacterial activity against Klebsiella , as well as drug resistant strains of Saphylococci, Enterococci and Psedomonas aeruginosa . (pakalertpress.com)
Honeydew and manuka honey has strong antimicrobial activity against multi-drug resistant pathogens . (pakalertpress.com)
By using folk knowledge, and by seeking scientific proof concerning this knowledge, it is possible to find substances that are both effective and less toxic to human health, and which are able to combat microorganisms that are commonly resistant to conventional drugs. (bvsalud.org)

We identified differentially expressed genes from 14 case-control human breast cancer gene expression datasets and integrated them with drug-protein networks. (sutterhealth.org)

Using a well-validated pharmacodynamic murine model of invasive candidiasis, we defined the effect of the combination of amphotericin B deoxycholate (AmB) and 5-fluorocytosine (5FC) by use of the Greco model of drug interaction. (manchester.ac.uk)
Synergism between curcumin and piperine has been found in several animal models but not in periodontal disease and diabetes, and the antinociceptive interaction is still unknown. (biomedcentral.com)

Also, other drugs can increase or decrease levels of antibiotics. (msdmanuals.com)
Synergism is usually defined as a more rapid and complete bactericidal action from a combination of antibiotics than occurs with either antibiotic alone. (msdmanuals.com)

The objective was to define the mechanism of the growth inhibition of active hexose correlated compound (AHCC) alone and evaluate its activity in combination with pegylated liposomal doxorubicin (PLD). (researchgate.net)
Although drugs within each class share structural and functional similarities, they often have different pharmacology and spectra of activity. (msdmanuals.com)
Whether chosen according to culture results or not, drugs with the narrowest spectrum of activity that can control the infection should be used. (msdmanuals.com)

Synergy was assessed with the combination index method using Calcusyn software. (biomedcentral.com)

The median-effect equation (MEE) of the mass-action law (MAL) was delivered by Chou in 1976 through the derivation of over 300 rate equations of enzyme dynamics, patten analysis, combination analysis, followed by mathematical induction and deduction. (wikipedia.org)
Pharmacogenetic Analysis of the Model-Based Pharmacokinetics of Five Anti-HIV Drugs: How Does This Influence the Effect of Aging? (ncsu.edu)

Venetoclax was used in pairwise combinations ( Figure 1A ) in primary T-PLL samples with a mean post-thawing viability of 93% and mean purity of 94% ( Table 1 ). (haematologica.org)

An old standby that is still useful and can be used in combination with Malachite Green (especially effective in combination with MG at ½ strength when treating Ich in scale less fish) or Acriflavin (do not combine with copper sulfate). (americanaquariumproducts.com)

Moreover, curcumin is considered a safe compound and authorized as a GRAS compound (generally recognized as safe) by US FDA (United States Food and Drug Administration) [ 7 ]. (biomedcentral.com)

Synergistic drug combos from EHR & gene expression. (sutterhealth.org)
Synergistic drug combinations from electronic health records and gene expression. (sutterhealth.org)
Lastly, we determined whether synergistic drug pairs found in the EHRs were enriched among synergistic drug pairs from gene-expression data using a method similar to gene set enrichment analysis. (sutterhealth.org)

This study focuses on the neuroprotective bioactivity of docosanoid mediators: Neuroprotectin D1 (NPD1), Resolvin D1 (RvD1), and their combination in experimental stroke. (springer.com)

The combination of AHCC with PLD demonstrated a 64.1% reduction in tumor growth compared to the untreated group (p value = 0.03) and a 31.2% improvement in tumor response with combination regimen compared to PLD alone. (researchgate.net)

Nirmatrelvir/ritonavir is contraindicated with drugs that are highly dependent on CYP3A for clearance and for which elevated concentrations are associated with serious and/or life-threatening reactions. (medscape.com)
In combination, synergism may be schedule dependent. (cancernetwork.com)

Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions. (medscape.com)
Because activated fibroblasts in inflammatory conditions have similar characteristics as cancer-associated fibroblasts (CAFs) and CAFs contribute actively to the malignant phenotype, we believe that anti-fibrotic drugs have the potential to be repurposed as anti-cancer drugs. (biomedcentral.com)

For example, in the "test tube", the organism is exposed to the same conditions, including drug concentrations throughout the incubation period, a situation which does not occur in the patient. (vin.com)

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Disciplines and Occupations1

Therapy14

Pharmacodynamic synergism5

Chemotherapy5

Resistance5

Cisplatin6

Vitro6

Avoid or Use Alternate Drug1

Metastasis1

Efficacy6

Therapeutic4

Exhibit2

Bacteria5

Sulfa drugs2

Additive2

Antitumor1

Pancreatic cancer2

Gemcitabine1

Anticancer drugs1

Preclinical3

Treatment14

Interactions10

Lung2

Quantitative1

Complementary1

Antifungal2

Coadministration1

Apoptosis1

Ovarian cancer1

Effects8

Infections4

Molecular1

Compounds1

Mechanisms1

Resistant3

Datasets1

Interaction2

Antibiotics2

Activity3

Synergy1

Effect2

Pairwise1

Strength1

Generally1

Gene3

Mediators1

Regimen1

Dependent2

Malignant2

Concentrations1