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DengueDengue VirusSevere DengueDengue VaccinesAedesInsect VectorsAntibodies, ViralCulicidaeThailandNicaraguaAntibody-Dependent EnhancementViral Nonstructural ProteinsDisease OutbreaksVietnamFlavivirusMosquito ControlSerotypingImmunoglobulin MPuerto RicoDisease VectorsTravelBrazilEnzyme-Linked Immunosorbent AssayRNA, ViralAmericasViral Envelope ProteinsSri LankaCubaRainAntigens, ViralPolynesiaSingapore
EndemicShock syndromeSyndromeRisk of dengue feverAedesSymptomsCases of dengueAntibodiesMosquitoesKnown as dengue hemorVaccineDiagnosisAbstractPositive for dengueOutbreaksVirusesCaused by the dengue virusAcute dengueLeakageIncidenceMosquitoEpidemicsIllnessVascular permeabilitySerotypesThrombocytopeniaSecondary dengue infectionPreventionVirusOccursComplication of dengueOutbreakFebrileDENVDiseaseSecond dengueZikaInfectionsBreakbone feverPlateletsCentreWorld Health OrganAntibodyDiseasesEbola
Endemic14
  • The second reason dengue should concern health care providers in this country is the potential for encountering cases of dengue among travelers arriving from dengue-endemic areas. (cdc.gov)
  • all the rest were travelers arriving from dengue-endemic areas. (cdc.gov)
  • However, in Uttaradit, as well as in other parts of Thailand, dengue infection is endemic, with large outbreaks occurring at 2- to 3-year intervals: later epidemics have also shown an increase in the overall incidence rates. (cdc.gov)
  • A dengue vaccine called Dengvaxia has been approved for use in children and adolescents aged 9 to16 years who have had previous dengue virus infection and are living in an area where dengue is endemic. (medicinenet.com)
  • Wear a long-sleeved shirt and long trousers while visiting a dengue-endemic region. (medicinenet.com)
  • Dengue fever (DF) is endemic in numerous regions of Indonesia with primary clinical features such as high fever as well as pullout of intravascular fluid and albumin leakage, which provokes pleural effusion, hypoproteinemia, and blood hemoconcentration. (iasp-pain.org)
  • The incidence of dengue hemorrhagic fever is increasing among the adult population living in endemic areas. (medscape.com)
  • Dengue hemorrhagic fever is a variant presentation of dengue infection that occurs primarily in children 10 years living in areas where dengue is endemic. (msdmanuals.com)
  • Dengue is an endemic problem in several countries including India. (medindia.net)
  • Therefore, travelers returning from endemic areas are unlikely to have dengue fever if symptoms start more than 14 days after arriving home. (wikipedia.org)
  • Dengue infection is endemic in Thailand and Southeast Asia and thalassemia is highly prevalent in this area too. (fortunejournals.com)
  • High serum DEN-2 antibody dependent enhancing activity is a significant (relative risk = 6.2) risk factor for severe illness among children in a dengue hemorrhagic fever endemic region. (johnshopkins.edu)
  • An important difference to note, however, was that the Zika epidemic diffused in a shorter time span compared to the persisting feature of Dengue infections, which is endemic in many Asian countries. (frontiersin.org)
  • 12 months stored at 2°C to 8°C) lot of TDV in a healthy adult population in country(ies) non-endemic for dengue. (clinicaltrials.gov)
Shock syndrome10
  • DHF categories reported in this study included both DHF without shock and the dengue shock syndrome (the number of cases and deaths combined). (cdc.gov)
  • Circulatory collapse and multiorgan failure, called dengue shock syndrome, may develop rapidly 2 to 6 days after onset. (msdmanuals.com)
  • This leads to increased viral replication, a higher viral load, and a much more severe disease, resulting in DHF or even more severe dengue shock syndrome (DSS). (tanzirislambritto.com)
  • Dengue virus infection causes Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) whose pathogeneses were not clearly understood. (thescipub.com)
  • Volume replacement was studied prospectively in 208 infants with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). (tmu.edu.tw)
  • In a small proportion of cases, the disease develops into a more severe dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. (wikipedia.org)
  • People who suffer from dengue fever have no risk of death but some of them develop Dengue Haemorrhagic Fever (DHF) or Dengue Shock Syndrome (DSS) . (denguevirusnet.com)
  • Severe symptoms can indicate dengue shock syndrome (DSS) and dengue hemorrhagic fever (DHF). (medicalnewstoday.com)
  • The fatality rate was 3.3% (n = 7) and these patients died of dengue shock syndrome, while 196 (93.3%) recovered completely. (aku.edu)
  • Severe dengue was previously known as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) [ 8 ]. (hindawi.com)
Syndrome3
  • Acute kidney injury with oliguria is a prominent feature of hemorrhagic fever with renal syndrome (HFRS) seen in Hantavirus infection and may be seen in other VHFs as intravascular volume depletion becomes more pronounced. (medscape.com)
  • In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
  • The cases reveal a spectrum of neurological findings in dengue infection and include dengue haemorrhagic encephalitis, acute disseminated encephalomyelitis (ADEM), reversible splenial lesion syndrome (RESLES), intracranial haematoma, and posterior reversible encephalopathy syndrome (PRES), with a focus on the relevant imaging features. (ajol.info)
Risk of dengue fever2
  • A person is at risk of dengue fever if they live or travel in an area where dengue occurs and mosquitoes that can carry it live. (medicalnewstoday.com)
  • Population density, water supply, and the risk of dengue fever in Vietnam: Cohort study and spatial analysis. (oamjms.eu)
Aedes14
  • 10) Adding to the concern of indigenous dengue transmission is the recent establishment in the United States of another known dengue vector, Aedes albopictus, which was probably imported in shipments of tires from Asia. (cdc.gov)
  • The Aedes mosquito, mainly Aedes aegypti and, to a lesser extent, Aedes albopictus, plays a crucial role in transmitting the dengue virus, which causes Dengue Hemorrhagic Fever. (tanzirislambritto.com)
  • Dengue Haemorrhagic Fever is an infection transmitted by Aedes or common house mosquitoes and it is usually found in tropical regions especially South East Asia and Pacific Islands. (eliteplusmagazine.com)
  • Dengue is spread by several species of female mosquitoes of the Aedes genus, principally Aedes aegypti. (wikipedia.org)
  • Dengue fever, or breakbone fever, results from a viral infection carried by Aedes mosquitoes. (medicalnewstoday.com)
  • Vertical transmission in Aedes aegypti and Aedes albopictus is considered a maintenance mechanism for dengue virus (DENV) during unfavorable conditions and may be implicated in dengue outbreaks. (nature.com)
  • Hidayati R, Kesumawati U, Manuwoto S, Boer R, Koesmayono Y. Kebutuhan satuan panas untuk fase perkembangan pada nyamuk Aedes aegypti (Diptera: Culicidae) dan periode inkubasi ekstrinsik virus dengue. (oamjms.eu)
  • Dengue is a viral disease it is transmitted by the infective bite of the Aedes Aegypti mosquito. (apollohospitals.com)
  • It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . (hindawi.com)
  • Dengue fever is an infectious disease caused by dengue virus that comes from the bite of Aedes aegypti mosquito. (answers.com)
  • Dengue is a flu-like viral disease that is spread by the bite of an infected mosquito (Aedes mosquito). (answers.com)
  • Dengue is a viral infection transmitted by Aedes aegypti mosquitoes. (starbulletin.com)
  • When the Zika epidemic spread through the American continent and then later to Africa and Asia in 2015, researchers compared the characteristics of the Zika infection to Dengue, considering both these viruses were transmitted primarily through the same vector, the Aedes aegypti female mosquitoes. (frontiersin.org)
  • Dengue is a disease transmitted by mosquitoes, with the primary vector being the Aedes Aegypti mosquito. (frontiersin.org)
Symptoms16
  • On August 27, 2005, Tamaulipas State Health Services reported to TDSHS that an outbreak of dengue fever in the border state had grown to 1,251 cases that met the Mexico case definition (i.e., fever and at least two of the following symptoms: headache, myalgia, arthralgia, and rash). (cdc.gov)
  • Fever, thrombocytopenia, and hemoconcentration are the classical symptoms of dengue hemorrhagic fever observed in adult, pediatric, and obstetric populations. (medscape.com)
  • It causes high fever and the typical flu-like symptoms seen in dengue and leads to severe bleeding, blood plasma leakage, and low platelet count. (tanzirislambritto.com)
  • What are Dengue Haemorrhagic Fever's symptoms? (eliteplusmagazine.com)
  • Typically, people infected with dengue virus are asymptomatic (80%) or have only mild symptoms such as an uncomplicated fever. (wikipedia.org)
  • The characteristic symptoms of dengue are sudden-onset fever, headache (typically located behind the eyes), muscle and joint pains, and a rash. (wikipedia.org)
  • For typical dengue, other treatment is purely concerned with relief of the symptoms (symptomatic). (denguevirusnet.com)
  • Patients may receive paracetamol preparations to deal with these symptoms if dengue is suspected. (denguevirusnet.com)
  • Symptoms range of dengue fever from mild to severe. (medicalnewstoday.com)
  • This article looks at the symptoms and causes of dengue fever and who is at risk. (medicalnewstoday.com)
  • Symptoms of dengue fever will depend on the severity of the disease. (medicalnewstoday.com)
  • Around 75% of people with dengue fever will not experience symptoms. (medicalnewstoday.com)
  • Treatment for dengue involves managing the symptoms. (medicalnewstoday.com)
  • The signs and symptoms of dengue fever are similar to some other diseases such as influenza and malaria . (medicalnewstoday.com)
  • Haematological parameters are an important clue and should be tested when a patient presents with symptoms suggestive of dengue fever. (aku.edu)
  • After being bitten by a mosquito carrying the virus, the incubation period ranges from three to 15 (usually five to eight) days before the signs and symptoms of dengue appear. (answers.com)
Cases of dengue8
  • In August 2005, health authorities in the neighboring state of Tamaulipas, Mexico, reported an ongoing dengue outbreak with 1,251 cases of dengue fever, including 223 cases (17.8%) of DHF. (cdc.gov)
  • Hundreds of thousands of cases of dengue and DHF are reported each year in tropical regions of the Americas, Africa, Asia and Oceania. (cdc.gov)
  • From 1980 through 1987, 879 632 cases of dengue were reported to the Pan American Health Organization from countries in the American region. (cdc.gov)
  • 13-15) From 1980 through 1989, 1457 suspected and 276 confirmed cases of dengue in the continental United States and Hawaii were reported to the Centers for Disease Control. (cdc.gov)
  • Although the incidence of hemorrhagic dengue in United States travelers abroad is low,(13,15) clinicians in this country may encounter severe cases of dengue, particularly among immigrants from areas with a high incidence of DHF. (cdc.gov)
  • During the week, a total of 1,587 positive cases of Dengue fever have been re- ported. (who.int)
  • Officials say that a total of 71 cases of dengue have been reported from across the capital this week alone. (medindia.net)
  • Between 0.5% and 5% of cases of dengue fever become severe. (medicalnewstoday.com)
Antibodies9
  • However, the antibodies attacking one strain don't attack other strains of the dengue virus. (medicinenet.com)
  • In ADE, antibodies from a first dengue infection fail to neutralize a second dengue virus of a different serotype during re-infection. (tanzirislambritto.com)
  • When a person is infected with the dengue virus for the first time, the immune system responds by producing antibodies specific to that serotype. (tanzirislambritto.com)
  • For instance, infants born to dengue-immune mothers are at a higher risk of severe disease due to the presence of maternal antibodies, which can enhance viral infection. (tanzirislambritto.com)
  • Platelets and endothelial cells are bound by the cross-reactive anti-dengue virus antibodies such as anti-NS1 or anti-prM antibodies. (thescipub.com)
  • Dengue antibodies can be neutralizing and therefore protective, or they can be enhancing and increase the risk of dengue hemorrhagic fever. (johnshopkins.edu)
  • GMTs of neutralizing antibodies for each of the 4 dengue serotypes were measured by microneutralization test 50% [MNT50]. (clinicaltrials.gov)
  • Seropositivity rate was defined as the percentage of participants being seropositive, derived from titers of dengue- neutralizing antibodies. (clinicaltrials.gov)
  • Nineteen national-level public health laboratories performed routine dengue diagnostic assays on a proficiency testing panel consisting of two modules: one containing commercial serum samples spiked with cultured dengue viruses for the detection of nucleic acid and non-structural protein 1 (NS1) (Module A) and one containing human serum samples for the detection of anti-dengue virus antibodies (Module B). A review of logistics arrangements was also conducted. (who.int)
Mosquitoes3
  • These mosquitoes are highly adaptive to the human environment, coupled with increasing urbanization and inadequate vector control, which has led to a surge in dengue transmission in urban and semi-urban settings. (tanzirislambritto.com)
  • The elevation is an important factor that can affect the presence of dengue vector mosquitoes. (oamjms.eu)
  • High population density contributes to dengue transmission by increasing the contact between infected mosquitoes and human hosts. (oamjms.eu)
Known as dengue hemor1
  • Secondary dengue viral infection can produce capillary leakage associated with increased mortality known as dengue hemorrhagic fever (DHF). (utmb.edu)
Vaccine9
  • There is an effort to produce the vaccine but currently Dengue vaccine has not been proved officially effective. (eliteplusmagazine.com)
  • Two types of dengue vaccine have been approved and are commercially available. (wikipedia.org)
  • A vaccine for dengue fever has been approved and is commercially available in a number of countries. (denguevirusnet.com)
  • In 2019, the Food and Drug Administration (FDA) approved a vaccine for children ages 9-16 years who have had dengue in the past and live in areas where dengue is common. (medicalnewstoday.com)
  • In May 2019 , the FDA approved the first dengue vaccine. (medicalnewstoday.com)
  • To date, there is no effective vaccine or specific antiviral therapy for dengue. (hindawi.com)
  • He chairs a multinational board of counselors for a Pediatric Dengue Vaccine Initiative that is working on developing dengue fever vaccines. (starbulletin.com)
  • Together, this information appraises the current understanding of both Zika and Dengue infections, providing insights for future vaccine design approaches against both viruses. (frontiersin.org)
  • The vaccine being tested in this study is tetravalent dengue vaccine (TDV). (clinicaltrials.gov)
Diagnosis10
  • Health-care providers along the U.S. border with Mexico should be vigilant for DHF and familiar with its diagnosis and management to reduce the number of severe illnesses and deaths associated with outbreaks of dengue fever. (cdc.gov)
  • On June 28, the woman was hospitalized in Matamoros with a diagnosis of probable dengue fever and urinary tract infection. (cdc.gov)
  • Combined with the dengue virus RNA amplification test, it can provide a diagnosis within the first 1 to 7 days of illness. (msdmanuals.com)
  • WHO (1997) Dengue Hemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. (scirp.org)
  • The presumptive clinical diagnosis of dengue fever was supported by deranged haematological parameters followed by confirmatory serological testing. (aku.edu)
  • Haemoconcentration, leucopenia and thrombocytopenia in the presence of haemorrhagic manifestations and strong clinical background can give important clues in reaching a diagnosis of dengue fever. (aku.edu)
  • Clinical diagnosis of Dengue is conducted by laboratory testing on human serum and plasma tested for DENV SubT and dengue NS-1 (DENG NS-1), dengue IgG and IgM to confirm the presence of infection. (answers.com)
  • Despite revised clinical classifications of dengue infections by the World Health Organization, the wide spectrum of the manifestations of dengue illness continues to pose challenges in diagnosis and patient management for clinicians. (frontiersin.org)
  • Contribution: The present case series emphasises the importance of understanding the relevant imaging findings and potential aetiopathogenesis of neurological involvement in dengue infected patients in order to make the correct diagnosis for effective treatment and improved outcome. (ajol.info)
  • 1,2 Dengue presentation is broad and non-specific, which may confound clinical diagnosis. (who.int)
Abstract1
  • abstract = "A retrospective observational study of dengue fever was performed, including 210 patients (male:female ratio 1.6:1, ages 6-74 y, mean 29.7 y) attending the Aga Khan University Hospital, Karachi from January 2001 to December 2006. (aku.edu)
Positive for dengue2
  • Of those, 122 tested positive for dengue infection. (starbulletin.com)
  • Patients positive for dengue on serology and with neurological manifestations were analysed and included in the present case series and brief review. (ajol.info)
Outbreaks8
  • This report summarizes the results of that investigation, which determined that the percentage of DHF cases associated with dengue fever outbreaks at the Texas-Tamaulipas border has increased. (cdc.gov)
  • 1) Outbreaks of the more severe form of dengue, DHF, occurred in Cuba in 1981 (2) and in Venezuela in 1989. (cdc.gov)
  • 9) Outbreaks of indigenous dengue transmission occurred in Texas in 1980 and again in 1986. (cdc.gov)
  • In Thailand, Dengue Haemorrhagic Fever is regarded as a severe epidemic that usually outbreaks during rainy season. (eliteplusmagazine.com)
  • This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil. (hindawi.com)
  • The Hawaii dengue experience is another example of how readily pathogens can cross great expanses of ocean to cause outbreaks in new territory," state and federal officials said in May 2005 in a paper reviewing the outbreak. (starbulletin.com)
  • In the Western Pacific Region, dengue outbreaks occur yearly in multiple countries, driven by a complex interplay of virus, vector and host biology, climatic and socioeconomic factors as well as international travel and trade. (who.int)
  • In 2013, outbreaks resulted in 44 098 dengue cases in the Lao People's Democratic Republic, 39 222 cases in Malaysia, 10 548 cases in New Caledonia and 22 170 cases in Singapore. (who.int)
Viruses7
  • Dengue and dengue hemorrhagic fever (DHF) result from infection by any of four serotypes of dengue viruses. (cdc.gov)
  • The PRNT requires live dengue viruses for the test and is labor-intensive and expensive. (msdmanuals.com)
  • Viral hemorrhagic fevers (VHFs) are a group of febrile illnesses caused by RNA viruses from several viral families. (medscape.com)
  • Hemorrhagic fever viruses have an affinity for the vascular system, leading initially to signs such as flushing, conjunctival injection, and petechial hemorrhages, usually associated with fever and myalgias. (medscape.com)
  • Enzyme-linked immunosorbent assay-format microneutralization test for dengue viruses. (ajtmh.org)
  • Four different viruses can cause dengue fever. (medicalnewstoday.com)
  • Meanwhile, the cross-reactivity of CD8+ and CD4+ T cells response to Dengue and Zika viruses provide important clues for further development of potential treatments. (frontiersin.org)
Caused by the dengue virus3
Acute dengue7
  • Treatment of acute dengue is supportive and includes giving fluid either by mouth or intravenously for mild or moderate disease. (wikipedia.org)
  • Plasma samples taken from initial clinical presentation of acute dengue infection were subjected to proteomics analyses using ELISA and a recently developed biofluid analysis platform. (utmb.edu)
  • Efficacy of rupatadine in reducing the incidence of dengue haemorrhagic fever in patients with acute dengue: A randomised, double blind, placebo-controlled trial. (ox.ac.uk)
  • BACKGROUND: Rupatadine was previously shown to reduce endothelial dysfunction in vitro, reduced vascular leak in dengue mouse models and to reduce the extent of pleural effusions and thrombocytopenia in patients with acute dengue. (ox.ac.uk)
  • Therefore, we sought to determine the efficacy of rupatadine in reducing the incidence of dengue haemorrhagic fever (DHF) in patients with acute dengue. (ox.ac.uk)
  • METHODS AND FINDINGS: A phase 2, randomised, double blind, placebo controlled clinical trial was carried out in patients with acute dengue in Sri Lanka in an outpatient setting. (ox.ac.uk)
  • CONCLUSIONS: Rupatadine appeared to be safe and well tolerated and showed a trend towards a reducing proportion of patients with acute dengue who developed DHF. (ox.ac.uk)
Leakage3
  • 100,000/mm 3 , evidence of bleeding [hematuria and fecal occult blood] and plasma leakage) were consistent with World Health Organization (WHO) criteria for DHF ( Box ) ( 2 ), dengue was not diagnosed at the Brownsville hospital. (cdc.gov)
  • A 24-year-old primigravid Sundanese woman presented to our intensive care unit due to acute pulmonary edema secondary to massive plasma leakage caused by severe dengue. (medscape.com)
  • SD is defined by an increase in vascular permeability ("plasma leakage"), hemorrhagic manifestations, and decreased platelet counts near the time of defervescence, which may progress to clinical hypotension and shock [ 6 , 9 - 11 ]. (hindawi.com)
Incidence5
  • The incidence of dengue hemorrhagic fever (DHF) has experienced rapid development throughout the world in recent decades. (oamjms.eu)
  • This study aimed to determine the correlation between elevation and population density with the incidence of dengue in Kendari City in 2014-2018. (oamjms.eu)
  • Epidemiology of dengue in Nepal: History of incidence, current prevalence and strategies for future control. (oamjms.eu)
  • The incidence of dengue in Brazil has been frequently high, and the number of cases in the country has at some point in time represented up to 60% of the dengue reported cases worldwide. (hindawi.com)
  • Dengue fever, the most common arboviral tropical disease, has shown a rapid increase in incidence over the last few decades. (ajol.info)
Mosquito9
  • Dengue fever is a mosquito-transmitted disease caused by any of four closely related virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4) of the genus Flavivirus . (cdc.gov)
  • To sum up, the cause of DHF is multi-factorial, involving not only the dengue virus and its serotypes but also the human immune response, the vector mosquito species, and various ecological factors. (tanzirislambritto.com)
  • In April, the WHO issued a warning that climate change could trigger a worldwide surge in mosquito-borne diseases, including dengue, Zika, and Chikungunya. (medindia.net)
  • For most people, the best way to prevent dengue fever is to take steps to avoid mosquito bites. (medicalnewstoday.com)
  • The A aegypti mosquito is a known transmitter of dengue fever and yellow fever. (medscape.com)
  • Dengue is the most important reemerging mosquito-borne viral disease worldwide. (hindawi.com)
  • The mosquito becomes a vector after it has bitten an dengue infected carrier - usually another Human. (answers.com)
  • Eggs of the dengue fever mosquito, Aede aegypti. (starbulletin.com)
  • Dengue is a mosquito-borne viral infection associated with significant morbidity and mortality caused by any of four closely related virus serotypes (DENV-1,-2,-3 and -4), all of which circulate in the World Health Organization (WHO) Western Pacific Region. (who.int)
Epidemics11
  • One of the earliest, if not the first, dengue epidemics described in the medical literature occurred in Philadelphia in 1780. (cdc.gov)
  • 5-7) Dengue epidemics were reported in various parts of the south- eastern United States through the 19th and 20th centuries, (6) most recently in Louisiana in 1945. (cdc.gov)
  • Dengue-like epidemics occurred in Egypt and on Java in 1779, but these may actually have been caused by chikungunya virus. (cdc.gov)
  • 7) Dengue or dengue-like epidemics were reported through- out the 19th and early 20th centuries in the Americas, southern Europe, North Africa, the Middle East, Asia and Australia and on various islands in the Indian Ocean, South and Central Pacific and the Caribbean. (cdc.gov)
  • 7) Deaths occurred during dengue epidemics in Australia in 1897 and in Greece in 1928, when over 1000 deaths were reported. (cdc.gov)
  • 17) Hemorrhagic manifestations, including gastrointestinal hemorrhage, were described during dengue epidemics in Texas and Louisiana in 1922. (cdc.gov)
  • The lethal type was first recognized in the 1950s when dengue epidemics spread out in the Philippines and Thailand. (eliteplusmagazine.com)
  • Regarding to WHOs, before 1970, there were only 9 countries experiencing severe dengue epidemics. (eliteplusmagazine.com)
  • However, even though São Paulo is the most populous city in the Americas and has experienced major dengue epidemics, natural vertical transmission had never been detected in this area before. (nature.com)
  • Despite the fact that São Paulo, the capital of the state, is the most populous city in Brazil and Latin America 22 and in recent years has experienced major dengue epidemics, such as those in 2014 and 2015 23 , natural vertical transmission has never been detected in the city 15 . (nature.com)
  • HO CHI MINH CITY, VIETNAM » Dengue fever epidemics are sweeping through Asia with cases doubling this year over last year in Vietnam and travelers warned to take preventive measures. (starbulletin.com)
Illness6
  • 14,18,19) Nevertheless through the first half of the 20th century, dengue was generally described as a self-limited, nonfatal febrile illness, with occasional hemorrhagic manifestations such as petechiae, epistaxis, gingival bleeding and menorrhagia, that only rarely resulted in more severe or fatal outcomes. (cdc.gov)
  • Here, we report a case of dengue fever complicated with spontaneous splenic rupture in a 22-year-old man with thalassemia presenting acute febrile illness and left upper quadrant pain. (fortunejournals.com)
  • Its presentation can range from asymptomatic illness to acute-onset viral hepatitis and hemorrhagic fever. (medscape.com)
  • Dengue Fever is a severe, flu-like illness. (apollohospitals.com)
  • Symptomatic infections vary from a mild, flu-like illness known as dengue fever (DF) to a life-threatening form called severe dengue (SD) [ 8 ]. (hindawi.com)
  • Knowledge about the pathogenesis of dengue infection is limited, but both viral and immune host factors appear to be associated with severe illness [ 26 ]. (hindawi.com)
Vascular permeability3
  • The primary defect in patients with viral hemorrhagic fever (VHF) is that of increased vascular permeability. (medscape.com)
  • In vitro studies reveal these cytokines lead to shock and increased vascular permeability, the basic pathophysiologic processes most often seen in viral hemorrhagic fever infection. (medscape.com)
  • Although the pathophysiology of dengue infection is complex and incompletely understood, severe dengue infection can be differentiated from milder forms by the presence of increased vascular permeability. (medscape.com)
Serotypes5
Thrombocytopenia1
  • Patients with World Health Organization-defined clinical criteria plus thrombocytopenia ( ≤ 100,000/mcL [≤ 100 x 10 9 /L]) or hemoconcentration (Hct increased by ≥ 20%) are presumed to have the disease (see the Centers for Disease Control and Prevention's Dengue Virus: Clinical Guidance ). (msdmanuals.com)
Secondary dengue infection2
  • this was interpreted as indicative of a secondary dengue infection ( 1 ). (cdc.gov)
  • She tested positive for both immunoglobulin G and immunoglobulin M dengue serology indicating she had secondary dengue infection, which placed her at risk for an exaggerated cytokine response as was evident clinically. (medscape.com)
Prevention5
  • It also aimed to determine the residents' a) knowledge on Dengue Hemorrhagic Fever and its prevention, b) perceived susceptibility to risk, and c) preventive practices against Dengue Hemorrhagic Fever. (edu.ph)
  • Furthermore, this study aimed to determine the relationship between the residents' knowledge on Dengue Hemorrhagic Fever and its prevention and preventive practices when their perceived susceptibility to risk is controlled. (edu.ph)
  • Moreover, there was no significant relationship between personal characteristics in terms of age and sex and the level of knowledge on Dengue Hemorrhagic Fever and its prevention and on their perceived susceptibility to risk. (edu.ph)
  • The relationship between the level of knowledge of the residents on Dengue Hemorrhagic Fever and its prevention and their perceived susceptibility to risk was found to be highly correlated and significant at 0.05 level. (edu.ph)
  • No significant relationship was also found between knowledge on Dengue Hemorrhagic Fever and its prevention and preventive practices of the residents when their perceived susceptibility to risk was controlled. (edu.ph)
Virus24
  • Four strains of the dengue virus may cause DF. (medicinenet.com)
  • If your body gets infected by a different version of the dengue virus, it may trick the antibody to attack it. (medicinenet.com)
  • Dengue hemorrhagic fever, which has also been called Philippine, Thai, or Southeast Asian hemorrhagic fever, frequently requires prior infection with the dengue virus. (msdmanuals.com)
  • dengue virus-antibody immune complexes trigger release of vasoactive mediators by macrophages. (msdmanuals.com)
  • Titers in acute and convalescent phase serum samples can reliably establish dengue virus infection and may indicate the specific dengue virus type involved. (msdmanuals.com)
  • Moreover, DHF occurs when a person is infected with the dengue virus for the second time. (tanzirislambritto.com)
  • The increasing spread of the dengue virus worldwide and the high fatality rate of DHF make this disease a significant global health concern. (tanzirislambritto.com)
  • Once a dengue virus enters the human body, it takes refuge in the white blood cells and replicates while the cells perform their normal functions. (tanzirislambritto.com)
  • Interestingly, it's not the first infection with the dengue virus that usually causes DHF but rather a subsequent infection with a different dengue serotype. (tanzirislambritto.com)
  • DHF and DSS are also influenced by various other factors, such as the strain and serotype of the dengue virus, age, genetic predisposition, and the individual's immune status. (tanzirislambritto.com)
  • An aberrant immune over-activation after dengue virus infection not only impair the immune response to clear the virus, but also result in overproduction of cytokines that affect monocytes, endothelial cells, and hepatocytes, as well as the abnormal production of autoantibodies to platelet and endothelial cells. (thescipub.com)
  • A molecular mimicry occurs between platelets/endothelial cells and dengue virus antigens. (thescipub.com)
  • Dengue virus-induced vasculopathy and coagulopathy are involved in the pathogenesis of hemorrhage, and the unbalance between coagulation and fibrinolysis activation increases the likelihood of severe hemorrhage in DHF/DSS. (thescipub.com)
  • This theory of transient hemophagocytic activity in immunopathogenesis of DHF/DSS can account for specific characteristics of clinical, pathologic, and epidemiological observations in dengue virus infection. (thescipub.com)
  • Advertising opportunities on Dengue Virus Net include standard size banners as well as text ads. (denguevirusnet.com)
  • You can also make a donation by PayPal and support the Dengue Virus Net website. (denguevirusnet.com)
  • Dengue virus can develop properly based on certain regional conditions. (oamjms.eu)
  • Serum specimens collected during a prospective study of dengue infections among schoolchildren in Bangkok were tested for their ability to enhance dengue 2 (DEN-2) virus growth in human monocytes in vitro. (johnshopkins.edu)
  • Dengue virus infection is more and more acknowledged as one of the world's major escalating problems. (scirp.org)
  • The name of the microorganism is the dengue virus. (answers.com)
  • Dengue virus (DENV) is an enveloped, single-stranded RNA virus belonging to the Flaviviridae family. (frontiersin.org)
  • The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
  • Detection of ongoing/recent dengue virus infection by both molecular (RT-PCR) and serological methods (IgM) was available in 15/19 participating laboratories. (who.int)
  • Further comprehensive diagnostic testing for dengue virus and other priority pathogens in the Region will be assessed during future rounds. (who.int)
Occurs1
Complication of dengue1
Outbreak6
  • To characterize this dengue outbreak, the Texas Department of State Health Services (TDSHS), Mexican health authorities, and CDC conducted a clinical and epidemiologic investigation. (cdc.gov)
  • Patient with Ebola hemorrhagic fever during 1976 outbreak in Zaire demonstrating palatal petechiae and hemorrhage. (medscape.com)
  • Health officials in Guwahati, Assam, are reporting a new outbreak of dengue fever, which has so far claimed three lives over the last eight days while many more have been hospitalized. (medindia.net)
  • Dengue fever outbreak in Lucknow: The cumulative count of dengue cases in Lucknow has now reached 1,308. (medindia.net)
  • note = "Funding Information: The y 2006 witnessed an outbreak of dengue fever in the city of Karachi. (aku.edu)
  • Hawaii's first dengue fever outbreak in 56 years in 2001-2002 was traced to a resident who had visited French Polynesia during a dengue epidemic. (starbulletin.com)
Febrile2
  • The early history of dengue is clouded by the similarity of its clinical picture to that of other febrile illnesses. (cdc.gov)
  • A total of 574 DNA samples were genotyped, including 176 DF, 135 DHF, 143 other non-dengue febrile illnesses (OFI) and 120 population controls. (johnshopkins.edu)
DENV2
  • Nevertheless, the involved DENV type and the host genetic makeup may explain some differences in clinical manifestations observed, since genetic polymorphisms appear to provide protection or predispose to more severe forms of dengue [ 27 ]. (hindawi.com)
  • however, a new model using high doses of DENV has recently been shown to develop hemorrhagic signs after infection. (mdpi.com)
Disease13
  • Therefore, persons can acquire a second dengue infection from a different serotype, and second infections place them at greater risk for dengue hemorrhagic fever (DHF), the more severe form of the disease ( 1 ). (cdc.gov)
  • Dengue Branch and the Division of Vector Borne Infectious Diseases, Centers for Disease Control, CID, Fort Collins, CO. Duane J. Gubler, Sc.D and Edward B. Hayes, MD. (cdc.gov)
  • Dengue hemorrhagic fever (DHF) has been recognized as a disease of young children in the past. (cdc.gov)
  • Dengue fever, a milder disease manifestation, was not included. (cdc.gov)
  • People are now alert with Dengue Haemorrhagic Fever after it was announced in all media channels last night that one of Thai superstars is in coma from this disease and receiving the treatment in Ramathibodi Hospital. (eliteplusmagazine.com)
  • Dengue fever is a viral infectious disease. (css.ch)
  • Dengue is considered the most serious re-emergent viral disease transmitted by arthropods, with approximately 390 million infections worldwide each year, 7% of which occur in Brazil 1 , 2 . (nature.com)
  • Dengue Haemorrhagic Fever (DHF) is a more severe form of disease, which may cause death. (apollohospitals.com)
  • The problem with dengue is it's never considered to be a high-priority disease," said Dr. Duane Gubler, Hawaii infectious disease specialist, who is working with Vietnamese health officials on dengue control programs. (starbulletin.com)
  • Mothers are trained through mass media how to recognize dengue disease and take their children to the hospital. (starbulletin.com)
  • Dengue is a major public health concern, affecting almost 400 million people worldwide, with about 70% of the global burden of disease in Asia. (frontiersin.org)
  • This review discusses similarities between Dengue and Zika infections, comparing their disease transmissions and vectors involved, and both the innate and adaptive immune responses in these infections. (frontiersin.org)
  • Finally, a summary of the immune biomarkers that have been reported for dengue and Zika viral infections are discussed which may be useful indicators for future anti-viral targets or predictors for disease severity. (frontiersin.org)
Second dengue1
  • Some researchers have found that when the average number of annual dengue infections declines, the chance of persons acquiring dengue infections declines, resulting in delays in the age when a person has experienced the first, then second, dengue infection ( 4 ). (cdc.gov)
Zika1
  • Consideration of the genetic identity of both the Dengue and Zika flaviviruses as well as the cross-reactivity of relevant T cells along with the actions of CD4+ cytotoxic cells in these infections are also presented. (frontiersin.org)
Infections3
  • Sumi A, Telan EF, Chagan-Yasutan H, Piolo MB, Hattori T, Kobayashi N. Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines. (oamjms.eu)
  • and 9 dengue antibody positive serum specimens from children who subsequently developed severe symptomatic secondary dengue infections, 8 of which were clinically diagnosed as dengue hemorrhagic fever. (johnshopkins.edu)
  • The majority (~75%) of infections in humans are asymptomatic, but a small proportion of symptomatic patients develops severe dengue characterized by rapid progression into shock, severe bleeding and/or multiorgan impairment, which leads to death if unattended or mismanaged. (who.int)
Breakbone fever1
  • An alternative name for dengue, "breakbone fever", comes from the associated muscle and joint pains. (wikipedia.org)
Platelets1
  • In Philippines dengue patients use tawa-tawa herbs and sweet potato tops juice to increase the platelets counts and revived the patients. (denguevirusnet.com)
Centre1
  • d WHO Collaborating Centre for Arbovirus Reference and Research (Dengue/Severe Dengue), Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. (who.int)
World Health Organ2
  • From 1981 through 1986, 796 386 cases of DHF and 9774 deaths caused by dengue were reported to the World Health Organization (WHO) from countries in Southeast Asia. (cdc.gov)
  • The objective of this programme was to assess dengue diagnostic proficiency among national-level public health laboratories in the World Health Organization (WHO) Western Pacific Region. (who.int)
Antibody2
  • With both genotypes, MDDCs revealed an increase in viral replication following the addition of anti-IP-10 neutralizing antibody.Conclusions/Significance:The rs4804803 SNP in the CD209 promoter contributed to susceptibility to dengue infection and complication of DHF. (johnshopkins.edu)
  • All included patients proved dengue IgM antibody positive. (aku.edu)
Diseases4
  • Hemorrhagic diseases are caused by bleeding, or they result in bleeding (hemorrhaging). (medlineplus.gov)
  • 220 897 dengue fever cases, and 25 064 Rift Valley fever cases among arboviruses or vector-borne diseases reported in 2020. (who.int)
  • He said dengue is the biggest threat in Vietnam of the many communicable diseases, including SARS and HIV, and more government help is needed for biocontrol. (starbulletin.com)
  • About half the patients have dengue fever or other infectious diseases, they said. (starbulletin.com)
Ebola1
  • Hepatic involvement varies with the infecting organism and is at times seen with Ebola, Marburg, RVF, Crimean-Congo hemorrhagic fever (CCHF), and yellow fever. (medscape.com)