Intravascular hemolysisAntibodySerumPhagocytosisHemolytic anemiaExtravascularELISAAntibodiesBovinePremature destructionLaboratoryDestructionBiomechanicalKininChronicPrevalenceAntiglobulinHemoglobinuriaActivateSerologicalGuineaImmunoglobulinAcuteAssayViralInvestigationsClinicalOccurElderlyConfirmatoryIncreasesTypePositiveResultsInterpretationNegativeLevelPatientImportantDaysAgentEfficientSamplesSystemPatientsStudies
Intravascular hemolysis7
- Paroxysmal cold hemoglobinuria (PCH) is an autoimmune hemolytic anemia featured by complement-mediated intravascular hemolysis after cold exposure. (wikipedia.org)
- As a weak, biphasic antibody, it absorbs to the P antigen in the cold temperature as in the periphery in the primary phase, and fixes complement on recirculation to the core temperature in the secondary phase, resulting in intravascular hemolysis. (wikipedia.org)
- The purposes of laboratory investigations are to: Confirm the presence of intravascular hemolysis in terms of metabolic products of red cells and hematopoietic response. (wikipedia.org)
- For intravascular hemolysis, the laboratory parameters include increased serum free hemoglobin, lactate dehydrogenase, unconjugated bilirubin, and reduced haptoglobin. (wikipedia.org)
- The hematopathological findings can reflect both the presence of intravascular hemolysis and the underlying immunological process. (wikipedia.org)
- Unlike cold agglutinin disease, in which affected RBCs are removed via extravascular phagocytosis, paroxysmal cold hemoglobinuria involves intravascular hemolysis. (medscape.com)
- Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis). (lecturio.com)
Antibody3
- To demonstrate a 4-fold rise in rubella-specific IgG antibody, a serum sample should be obtained as soon as possible during the acute phase of infection and tested for rubella-specific IgG antibody. (medscape.com)
- In warm antibody hemolytic anemia, hemolysis occurs primarily in the spleen and is not due to direct lysis of RBCs. (msdmanuals.com)
- Blood-based biomarker testing may help identify patients who are candidates for early antibody treatment. (questdiagnostics.com)
Serum8
- Each serum sample was subjected to the three tests and the results obtained were recorded and the test outcomes were cross-classified to estimate the sensitivity and specificity of the tests using Bayesian model. (hindawi.com)
- An aliquot of this serum should be frozen and stored for repeat testing later. (medscape.com)
- Then, a second serum specimen is collected at 2-3 weeks and tested in the same laboratory at the same time with the first serum sample. (medscape.com)
- It involves the cooling of the patient's serum to 4°C to allow the absorption of anti-P autoantibodies to the red cells, followed by warming to 37°C to activate complement fixation and hemolysis. (wikipedia.org)
- Indirect DL test with addition of ABO-compatible P antigen-positive blood can be performed in case the direct DL test is negative, since the complement in the original serum may be consumed and result in false negative. (wikipedia.org)
- Complement, also known as alexin, cytase, or addiment, is generally defined as the portion of fresh blood serum or plasma which is not increased on immunization and which, when added to certain sensitized cells, combines with these sensitized cells and, under appropriate conditions, results in their destruction or death. (datapdf.com)
- Blood, serum, and urine samples are tested on Mondays, Wednesdays, and Thursdays with a turnaround time of 5 days. (tamu.edu)
- The Sensitivity Of Hsv Pcr Csf reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (apoptosises.com)
Phagocytosis3
- Description: Description of target: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. (apoptosises.com)
- Levels of immunoglobulin G (IgG) subclasses and C1q fixation in response to Plasmodium falciparum merozoite antigens (erythrocyte-binding antigen [EBA] 175RIII-V, merozoite surface protein 2 [MSP-2], and MSP-142) and opsonic phagocytosis of merozoites were measured in a multinational trial assessing the efficacy of artesunate therapy across 11 Southeast Asian sites. (ox.ac.uk)
- The prevalence of IgG3, complement-fixing antibodies, and merozoite phagocytosis vary according to transmission intensity, are associated with faster parasite clearance, and may be sensitive surrogates of an augmented clearance capacity of infected erythrocytes. (ox.ac.uk)
Hemolytic anemia4
- Once the clinical suspicion of autoimmune hemolytic anemia is made, direct antiglobulin test (DAT) or direct Coombs' test is the first line of investigation to confirm the presence of warm autoantibodies. (wikipedia.org)
- Autoantibodies that bind to the erythrocyte membrane leading to premature erythrocyte destruction (hemolysis) characterize autoimmune hemolytic anemia. (medscape.com)
- Autoimmune hemolytic anemia Hemolytic Anemia Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). (lecturio.com)
- Hemolytic Anemia (AIHA) is hemolysis or premature Premature Childbirth before 37 weeks of pregnancy (259 days from the first day of the mother's last menstrual period, or 245 days after fertilization). (lecturio.com)
Extravascular2
- Hemolysis is extravascular. (msdmanuals.com)
- The hemolysis occurs largely in the extravascular mononuclear phagocyte system of the liver and spleen. (msdmanuals.com)
ELISA6
- Test evaluation in the absence of a gold standard test was conducted for the diagnosis and screening of bovine brucellosis using three commercially available tests including RBPT, CFT, and I-ELISA in National Animal Health Diagnostic and Investigation Center (NAHDIC) Ethiopia. (hindawi.com)
- The objective of this studywas to evaluate diagnostic performance and discriminative ability of Rose Bengal Plate Test (RBPT), complement fixation test (CFT), and indirect enzyme linked immunosorbent assay (I-ELISA) tests used for screening and confirmatory diagnosis of bovine brucellosis in Ethiopia using Bayesian method. (hindawi.com)
- Among all the serologic tests available, ELISA is the most widely used because it is relatively inexpensive, technically easy to perform, rapid, and very sensitive. (medscape.com)
- The same serologic testing methods (ELISA, IFA, LA, HI, CF) discussed for postnatal rubella can be used to detect specific antibodies in congenital infection. (medscape.com)
- Results from IS 711 real-time PCR were compared to those obtained by bacterial isolation, Rose Bengal Test (RBT), competitive ELISA (c-ELISA) and indirect ELISA (i-ELISA). (biomedcentral.com)
- Serological tests showed different sensitivities [RBT 15.6%, c-ELISA 7.5% and i-ELISA 5.5%] and only 2% of blood samples were positive with all three tests, which makes interpretation of the serological results very difficult. (biomedcentral.com)
Antibodies4
- the higher the temperature (ie, the closer to normal body temperature) at which these antibodies react with the RBC, the greater the hemolysis. (msdmanuals.com)
- Detection of antibodies to Corynebacterium pseudotuberculosis, the causative agent of caseous lymphadenitis, by synergistic hemolysis inhibition. (tamu.edu)
- Detection of antibodies to Coxiella burnetii, the causative agent of Q fever, by complement fixation. (tamu.edu)
- This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY. (lookformedical.com)
Bovine2
- Previous studies carried out in Ethiopia on bovine brucellosis using Rose Bengal and complement fixation tests described higher prevalence in intensive and semi-intensive dairy farms than extensive farms [ 1 , 7 , 8 ]. (hindawi.com)
- This study is one of a kind in the context of field diagnostic test evaluation for bovine brucellosis in Ethiopia which has significant importance for disease surveillance and future control endeavors. (hindawi.com)
Premature destruction1
- Hemolysis is defined as premature destruction and hence a shortened RBC life span. (msdmanuals.com)
Laboratory3
- The laboratory diagnosis of rubella can be made either though serologic testing or by viral culture. (medscape.com)
- Actual reporting of test results depends on the full battery of tests requested, day of the week/time of day samples arrive at the testing laboratory, and the quantity/quality of samples submitted. (tamu.edu)
- Laboratory tests show that both B- and T-Lymphocytes counts are very low. (pdfcoffee.com)
Destruction1
- Data accumulated over a number of years from several sources indicate that complement plays a major r81e in the destruction of certain microorganisms, The bacteriologist and immunologist have made important strides in the elucidation of the biological significance of complement. (datapdf.com)
Biomechanical2
- Biomechanical forces, pointed shoes and fixation with or haemolysis. (solepost.com)
- Supplemental medial small fragment fixation adds stability to distal femur fixation: A biomechanical study. (stanford.edu)
Kinin1
- O 1h of infusion and efficient treatment but, because of the end of complement, kinin, and pericardial friction rub or anaemia at positions 264 and stool for urine. (tei2020.com)
Chronic1
- Urine tests may show elevated hemoglobinuria and hemosiderinuria in chronic cases. (wikipedia.org)
Prevalence1
- The prevalence of positive CSF IgM tests increases by about 10% per day after illness onset and reaches 70-80% by the end of the first week. (basicmedicalkey.com)
Antiglobulin2
- Testing with polyspecific and IgG-specific antiglobulin agents is usually negative, and that with C3-specific agent may be positive. (wikipedia.org)
- The direct antiglobulin (direct Coombs) test establishes the diagnosis and may suggest the cause. (msdmanuals.com)
Hemoglobinuria1
- Parenteral hemoglobinuria caused by rapid hemolysis of erythrocytes, potassium chlorate, lead poisoning (PB), etc. (kingfish-media.com)
Activate1
- Enzymes that activate one or more COMPLEMENT PROTEINS in the complement system leading to the formation of the COMPLEMENT MEMBRANE ATTACK COMPLEX, an important response in host defense. (lookformedical.com)
Serological2
- Serological tests are widely used to conduct several epidemiological studies and diagnostic purposes, but there is no perfect serological test [ 14 , 15 ]. (hindawi.com)
- Sera from 126 domestic pigs were tested: 29 pigs were Brucella infected, 80 were non-infected and 17 were confirmed to be false positive serological reactors (FPSR). (bvsalud.org)
Guinea2
- Existing views on the chemical nature and the functions of each component of guinea pig complement are summarized. (datapdf.com)
- It is the purpose of this review to consider complement as a chemical system composed of multiple components and to summarize, in the light of recent advances, existing views on the chemical nature and the function of each ofthe components of guinea pig ~omplement. (datapdf.com)
Immunoglobulin1
- Limited fragmentation of pig Ig[immunoglobulin]M anti-Salmonella with pepsin gave a 12S product which agglutinated Salmonella almost as efficiently as the original IgM, but the complement [C] fixing ability of the complexes was substantially lowered. (eurekamag.com)
Acute1
- False-positive rubella IgM test results have been reported in persons with other viral infections (eg, acute Epstein-Barr virus [EBV], infectious mononucleosis , cytomegalovirus [CMV] infection , parvovirus B19 infection) and in the presence of rheumatoid factor (RF). (medscape.com)
Assay1
- the assay systems include : viral infectivity, complement fixing activity, particle counts, radial diffusion titre and single radial haemolysis titre. (liverpool.ac.uk)
Viral1
- Congenital rubella in infants and children is diagnosed by viral isolation or by serologic testing. (medscape.com)
Investigations1
- Although chemists and physicists have been reluctant to enter into investigations on complement, the need of a closer cooperation between these workers and the immunologists is desirable, since the application of exact physical and chemical methods to this problem gives promise that it may be eventually solved. (datapdf.com)
Clinical2
- Complement your expertise with clinical consultations from Quest. (questdiagnostics.com)
- Table 164-5 highlights specific diagnostic test results in encephalitis that can be useful in clinical decision making. (basicmedicalkey.com)
Occur1
- Positive tests may occur in patients with a CSF pleocytosis due to other causes. (basicmedicalkey.com)
Elderly1
- Narrow fixations, eg starting school is elderly are any mental retardation, cerebral hemispheres. (tei2020.com)
Confirmatory1
- Donath-Landsteiner test is the confirmatory test for PCH. (wikipedia.org)
Increases1
- Zinsser states that complement fixation in the study of which increases for sterility and to accept the molecule. (memphiscfc.com)
Type2
- A new type of screening protocol was tested and evaluated. (9pdf.co)
- CD16 and CD56 are markers for NK Cells *Rx for Mycoplasma pneumonia (cold agglutinins) mentioned in stem Erythromycin, Tetracycline *Guy had occult blood in stool and fibrosis in kidney Polyarteritis Nodosa *What type of HSN reaction is the PPD test for TB Type IV HSN Rx *ADH hormone 2nd messenger adenylyl cyclase / cAMP *Pt. (pdfcoffee.com)
Positive2
- Sera from 49 wild boar were tested: 18 were positive and 31 were negative. (bvsalud.org)
- Measurement of drugs in samples that have been determined to be positive by other TVMDL tests. (tamu.edu)
Results2
- Log into MyQuest ® to book or reschedule a lab visit, view test results, and more. (questdiagnostics.com)
- Fees charged to animal owners by veterinarians may exceed test prices shown herein, reflecting the time, expertise, and expense necessary to collect the sample, ship it in an appropriate manner, interpret results, and provide treatment advice. (tamu.edu)
Interpretation1
- Complement your expertise with ours to improve test selection and interpretation. (questdiagnostics.com)
Negative1
- The CSF HSV PCR test may be negative in the first 72 h of symptoms of HSV encephalitis. (basicmedicalkey.com)
Level2
- The complement level is usually low. (wikipedia.org)
- C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. (lookformedical.com)
Patient1
- Using 2019 data, we compared patient demographic and lifestyle risk factors using 2 test for biologic prescriptions and corticosteroids with or without biologics prescriptions. (cdc.gov)
Important2
- Subsequent studies resulted in the practical use of complement in important diagnostic tests (complement fixation). (datapdf.com)
- A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. (lookformedical.com)
Days2
Agent1
- as it is an excellent thera- peutic agent, then followed by tests. (memphiscfc.com)
Efficient1
- Complexes probably need to be formed by molecules having at least 2 intact subunits before efficient C fixation takes place. (eurekamag.com)
Samples1
- A total of 278 sera samples from five dairy herds were collected and tested. (hindawi.com)
System2
- The three test-one population Bayesian model was modified and applied using WinBug software with the assumption that the dairy herds have similar management system and unknown disease status. (hindawi.com)
- Received March 4 , 1943 Complement is considered to be a chemical system composed of multiple components. (datapdf.com)
Patients1
- Both tests should be performed in patients with suspected VZV CNS disease. (basicmedicalkey.com)
Studies1
- Case studies report benefit from treatment with rituximab or the complement inhibitor eculizumab. (medscape.com)