• anemia
  • Beta thalassemia intermedia describes the disease in individuals who have moderate anemia that only requires blood transfusions intermittently, if at all. (encyclopedia.com)
  • Individuals with hemoglobin H disease can experience events of hemolytic anemia - anemia caused by the rapid breakdown of the red blood cells. (encyclopedia.com)
  • It may result in a mild anemia, reduced mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH). (thalassemiapatientsandfriends.com)
  • Some with HbH have moderate anemia that does not require transfusions and some become transfusion dependent because their hemoglobin level is too low to maintain good health. (thalassemiapatientsandfriends.com)
  • Thalassemia should be looked for in all children showing persistent or progressive anemia, hepatosplenomegaly and the characteristic facies. (hubpages.com)
  • Microcytic hypochromic anemia unresponsive to Iron therapy and the presence of numerous target cells and other evidence of hemolysis are strongly suggestive of thalassemia. (hubpages.com)
  • Possible causes include alpha thalassemia, iron deficiency , sideroblastic anemia , anemia of chronic disease and lead poisoning . (symptoma.com)
  • It may also reappear in adults when the bone marrow is overactive, as in disorders such as pernicious anemia, multiple myeloma, and invasive (metastatic) cancer affecting bone marrow. (encyclopedia.com)
  • mild
  • There may be mild reductions in red cell mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH). (thalassemiapatientsandfriends.com)
  • Mild cases of thalassemia that cause no clinical disturbance or profound laboratory findings may be simply monitored, without any treatment. (symptoma.com)
  • The patients with HbE β thalassaemia who had co-inherited α thalassaemia all showed an extremely mild phenotype and reduced levels of HbF and there was a highly significant paucity of α(+) thalassaemia in these patients compared with the normal population. (ox.ac.uk)
  • transfusion
  • Patients generally need a few transfusion sessions throughout their lives, as hemoglobin levels fluctuate between the values of 7 to 10 g/dL. (symptoma.com)
  • patients
  • Contrary to that, only half of the patients with thalassemia have an augmented RDW. (symptoma.com)
  • 13 in patients that have inherited thalassemia . (symptoma.com)
  • Hemoglobin abnormalities usually need supportive care in patients with HbB disease. (symptoma.com)
  • Patients with alpha thalassemia must be closely monitored to detect a possible iron deficiency , for which they may be treated with iron supplements if necessary, although this treatment does not lead to improved blood test results. (symptoma.com)
  • Also, a Phase 1 clinical trial for in utero hematopoietic stem cell transplantation for alpha thalassemia major is recruiting prenatally diagnosed patients to investigate safety and feasibility. (wikipedia.org)
  • variants
  • Even within a species, different variants of hemoglobin always exist, although one sequence is usually a "most common" one in each species. (wikipedia.org)
  • In other words, the researchers discovered two versions of hemoglobin: the [Hb-Hopand S variants. (wikipedia.org)
  • Membrane
  • These alpha globin inclusions lead to impairment of erythoid cell replication, membrane function, migration from bone marrow and red cell survival. (hubpages.com)