• genetic
  • These genetic disorders represent an important health care threat in tropical low income countries due to the high prevalence of hemoglobin variants in these areas. (biomedcentral.com)
  • This new finding is critical: understanding how hemoglobin levels are controlled at a genetic level has significant public health implications for people of all ages in developing and developed countries", explains Dr John Chambers, from the Department of Epidemiology and Public Health at Imperial College London and one of the lead authors of the study. (redorbit.com)
  • The new research adds to our understanding of the multiple causes of problems with hemoglobin levels, which include an iron-deficient diet, chronic diseases such as cancer, and genetic associations, such as the one described in this paper. (redorbit.com)
  • major
  • Despite that limitation, the Radical-7 may provide a useful new tool for monitoring hemoglobin levels during major surgery in children, with the potential to reduce the frequency of blood samples. (iars.org)
  • The aggregation is reversed by oxygenation, and can be inhibited by addition of organic phosphates or the corresponding major haemoglobin fraction in a stoichiometric ratio of 1:1. (biochemj.org)
  • study
  • The present study analyzed the frequency of the most common hemoglobin variants in an asymptomatic afro-descendent population using capillary electrophoresis. (biomedcentral.com)
  • Newswise - San Francisco, CA. (December 4, 2012) - For children undergoing brain surgery, a new technology allows noninvasive, continuous monitoring of blood hemoglobin levels, according to a study in the December issue of Anesthesia & Analgesia , official journal of the International Anesthesia Research Society (IARS). (iars.org)
  • The study included a total of 119 paired SpHb and direct hemoglobin measurements. (iars.org)
  • A gene with a significant effect on regulating hemoglobin in the body has been identified as part of a genome-wide association study, which looked at the link between genes and hemoglobin level in 16,000 people. (redorbit.com)
  • levels
  • Spectrophotometric hemoglobin (SpHb) assessment using the Radical-7 Pulse CO-Oximeter can be a useful 'trend monitor' for hemoglobin levels during neurosurgery in children, report Dr Yong-Hee Park of Seoul National University Hospital and colleagues. (iars.org)
  • The results showed that SpHb was fairly accurate in estimating hemoglobin levels during surgery. (iars.org)
  • Changes in hemoglobin levels can also affect our susceptibility to diseases like malaria, which infect the red blood cells" says Professor Kooner, from the National Heart and Lung Institute at Imperial College London and the study's chief investigator. (redorbit.com)
  • In the future, the finding could lead to new treatments for people suffering from chronic problems with hemoglobin levels not linked to iron in the diet. (redorbit.com)
  • Designing a drug that enhances TMPRSS6 activity could augment hemoglobin in people such as cancer and kidney failure patients, who suffer from chronically low levels. (redorbit.com)
  • A different drug that blocked TMPRSS6 enzyme production might bring down high hemoglobin levels", adds Dr Chambers. (redorbit.com)
  • difference
  • value is 0.17 pH unit, which corresponds to a difference of 1.20 positive charges between the oxy and deoxy states of the tetrameric haemoglobin. (biochemj.org)
  • values
  • values of mutant or chemically modified haemoglobins carrying an abnormality at the N - or C -terminus of the α-chains are decreased by 30% compared with the ΔpI value measured in haemoglobin A 0 . (biochemj.org)