• A phase I clinical trial in humans with prostate cancer designed to study the effects of high dose silibinin found 13 grams daily to be well tolerated in patients with advanced prostate cancer with asymptomatic liver toxicity (hyperbilirubinemia and elevation of alanine aminotransferase) being the most commonly seen adverse event. (wikipedia.org)
  • HABP/VABP Patients: The most frequently reported adverse reactions occurring in greater than or equal to 5% of patients treated with RECARBRIO were alanine aminotransferase increased, aspartate aminotransferase increased, anemia, diarrhea, hypokalemia, and hyponatremia. (nih.gov)
  • Liver function tests, especially alanine aminotransferase (ALT) and aspartate aminotransferase (AST), should be monitored. (medscape.com)
  • At the end of the treatment period, haematological parameters (red blood cell count, white blood cell count, platelet count, packed cell volume and haemoglobin concentration) and biochemical parameters (alkaline phosphatase (ALP), alanine aminotransaminase (ALT) and aspartate aminotransaminase (AST)) were determined. (researchgate.net)
  • For practical purposes, anemia is considered when one or more of the following are decreased: hemoglobin concentration, hematocrit, or RBC count. (medscape.com)
  • The patient's complete blood cell (CBC) count should be monitored for the hemoglobin/hematocrit to maintain a high threshold for transfusion. (medscape.com)
  • In patients who develop diabetes mellitus, the usual parameters, such as hemoglobin A1C (HbA1C) and glucose, should be monitored. (medscape.com)
  • Canagliflozin has dose-dependent pharmacokinetics, and research in laboratory animals demonstrated high oral bioavailability (85%) and rapid effects in lowering glycosylated hemoglobin (HbA1c) values. (docksci.com)
  • The most common adverse events reported during clinical trials with fenofibrate (≥ 2% and at least 1% greater than placebo) were abnormal liver tests, increased AST, increased ALT, increased CPK, and rhinitis ( 6.1 ). (nih.gov)
  • Hemoglobin, white blood cell, absolute neutrophil, or platelet count outside the local laboratory-defined limits of normal. (who.int)
  • 0.05, 0.01) red blood cell count, white blood cell count, packed cell volume, haemoglobin concentration and platelet count. (researchgate.net)
  • This is a randomized, parallel-group, double-blind, placebo-controlled, multi-center, phase II study in which patients, treating physicians, and the associated clinical staff as well as the sponsor clinical team are blinded. (biomedcentral.com)
  • The first study into the potential ergogenic effects of inosine involved nine "highly trained" endurance runners in a double-blind, placebo-controlled, crossover study. (tigerfitness.com)
  • Control interventions assessed were placebo, oral antidiabetic drugs, or insulin. (bmj.com)
  • However, there is increasing evidence that placebo interventions also affect end-organ functions regulated by the autonomic nervous system (ANS). (pdgfrsignals.com)
  • The findings indicate that several autonomic organ functions can indeed be altered by verbal suggestions delivered during placebo and nocebo interventions. (pdgfrsignals.com)
  • Median overall survival was 65.3 weeks (48.7-infinity) for (223)Ra and 46.4 weeks (32.1-77.4) for placebo (p=0.066, log rank). (researchgate.net)
  • We conducted a cross-sectional study in 216 type 2 diabetic patients with a hemoglobin A 1c of 8.3 ± 1.7% and a median diabetes duration of 9.0 years. (biomedcentral.com)
  • Due to its immunomodulatory, iron chelating and antioxidant properties, this herb has the potential to be used in beta-thalassemia patients who receive regular blood transfusions and suffer from iron overload. (wikipedia.org)
  • AIMS/INTRODUCTION: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have shown beneficial effects on cardiometabolic risk factors (hemoglobin A1c, body mass index, systolic blood pressure) in patients with type 2 diabetes mellitus. (bvsalud.org)
  • We compared combined cardiometabolic effects of SGLT2i on hemoglobin A1c, body mass index and systolic blood pressure versus dipeptidyl peptidase-4 inhibitors (DPP4i) in Japanese patients with type 2 diabetes mellitus. (bvsalud.org)
  • Hypersensitivity Reactions: Hypersensitivity reactions have been reported in patients receiving beta lactam drugs. (nih.gov)
  • Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to four intravenous injections of (223)Ra (50 kBq/kg, 33 patients) or placebo (31 patients), given every 4 weeks. (researchgate.net)
  • Fifty patients are randomly assigned in a 1:1 ratio to receive either 300 mg secukinumab or placebo subcutaneously at baseline, weeks 1, 2 and 3, and every 4 weeks from week 4. (biomedcentral.com)
  • The primary endpoint is the proportion of patients in sustained remission until week 28 in the secukinumab group compared to the proportion of patients in the placebo group. (biomedcentral.com)
  • The trial design allows the first placebo-controlled data collection on the efficacy and safety of secukinumab in patients with GCA. (biomedcentral.com)
  • Overall, the proportion of patients with hemoglobin levels within ±1.0 g/dL of baseline increased over the course of the study from 39% (Weeks 2-13) to 54% (Weeks 18-25). (biomedcentral.com)
  • There were non-significant reductions in Body weight and BMI in the L_K56, H_K56, VL_K56 groups, whereas increases were observed in the placebo and VH_K56 groups compared with baseline values. (biomedcentral.com)
  • In fact, when the runners consumed the placebo, researchers noted that their time to exhaustion was BETTER than when they took the inosine supplement, suggesting that inosine supplementation IMPAIRS PERFORMANCE. (tigerfitness.com)
  • The results suggest that supplementation with different doses of Lacticaseibacillus paracasei K56 has certain effect on reducing body fat and glycosylated hemoglobin, especially at a dose of 10 9 CFU/day. (biomedcentral.com)
  • count, packed cell v olume, haemoglobin concentration and platelet co unt. (researchgate.net)
  • Although males have higher hemoglobin values, they also have higher rates of advanced CKD. (medscape.com)
  • selleck compound interaction was noted for glycerol (p = 0.0006), with values higher for supplement compared to placebo at 30, 60, and 90 minutes post ingestion Thymidylate synthase (p (bcl-2protein.com)
  • A condition main effect was noted for systolic blood pressure (p = 0.04), with values increasing from 117 ± 2 mmHg to 123 ± 2 mmHg with the dietary supplement, while remaining unchanged for placebo. (bcl-2protein.com)
  • Amiodarone has been found to have higher efficacy and lower relapse rates compared to placebo and rate-control medications [ 1 ]. (journalmc.org)
  • It is designed to evaluate efficacy and safety of secukinumab compared to placebo in combination with an open-label prednisolone taper regimen. (biomedcentral.com)
  • Inhibition of amyloid-beta fibril formation in the presence of A beta(1-42), evaluated by Thioflavin T fluorescence, demonstrated comparable or improved activity to a previously reported pentapeptide-based fibrillogenesis inhibitor, iA beta 5p. (pdgfrsignals.com)
  • placebo effects, this article provides an anatomical framework of the autonomic system and then critically reviews the relevant placebo studies in the field, thereby focusing on gastrointestinal, cardiovascular and pulmonary functions. (pdgfrsignals.com)
  • The patient initially presented with atrial flutter, which was controlled with beta blockers but was switched to amiodarone after 2 weeks when he developed atrial fibrillation with the rapid ventricular response. (journalmc.org)
  • Twenty-three men and women (aged 18-35 years old) supplemented with KS or a placebo (PLA) twice per day for 6 weeks in a randomised, double-blinded, PLA-controlled design. (insulinresistance.org)
  • One small 2021 study in Frontiers in Nutrition observed 30 participants taking either 250 milligrams of NMN or a placebo daily for 12 weeks and concluded that NMN users may experience mild side effects including abdominal pain, diarrhea, gas and upper respiratory health issues Okabe K, Yaku K, Uchida Y, et al. (decadethirty.com)
  • The results showed that the L_K56 group had significant decreases in percent body fat ( p = 0.004), visceral fat area ( p = 0.0007), total body fat mass ( p = 0.018), trunk body fat mass ( p = 0.003), waist circumference ( p = 0.003), glycosylated hemoglobin( p = 0.002) at the end of the study compared with baseline. (biomedcentral.com)
  • For many subjectively experienced outcomes, such as pain and depression, rather large placebo effects have been reported. (pdgfrsignals.com)
  • It is suggested that the placebo effects on autonomic organ functions are best explained by the model of 'implicit affordance', which assumes that placebo effects are dependent on 'lived experience' rather than on the conscious representation of expected outcomes. (pdgfrsignals.com)
  • Peginesatide doses were titrated to maintain hemoglobin levels within ±1.0 g/dL from baseline. (biomedcentral.com)
  • Standard therapies for CKD-associated anemia are erythropoiesis-stimulating agents (ESAs), which have been shown to increase and maintain hemoglobin (Hb) levels leading to a decreased need for red blood cell transfusions [ 3 ]. (biomedcentral.com)
  • Figure 2 Plasma epinephrine (A) and norepinephrine (B) data for 10 men consuming Meltdown ® and placebo in a randomized cross-over design. (bcl-2protein.com)
  • Each subject consumed with an inosine supplement (6g per day for 2 days) or placebo. (tigerfitness.com)
  • Moreover, cohorts that used an erythropoiesis-stimulating agent-free interval did not have the substantial initial increase in hemoglobin levels that was seen in those cohorts that did not use such an interval. (biomedcentral.com)
  • Total kilocalorie expenditure during the 30 minute collection period was 29.6% greater (p = 0.02) for the dietary supplement compared to placebo (Figure 4A). (bcl-2protein.com)
  • Greater norepinephrine AUC for Meltdown® compared to placebo (p = 0.03). (bcl-2protein.com)
  • Vitamin B6 , helps the formation of hemoglobin, the synthesis of antibodies. (aloeverashop.gr)
  • Essentially HMB has anabolic benefits, so helps with muscular repair and development, whilst Beta-Alanine assists with the development of top-end power and lactic acid tolerance. (torqfitness.co.uk)