Hematopoietic cells oncogenes. Medical search. Frequent questions

Many human blood cells, such as red blood cells (RBCs), immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). (wikipedia.org)
Hematopoiesis involves a series of differentiation steps from one progenitor cell to a more committed cell type, forming the recognizable tree seen in the adjacent diagram. (wikipedia.org)
The CMP can then further differentiate into the megakaryocyte-erythroid progenitor cell (MEP), which goes on to make RBCs and platelets, or the granulocyte/macrophage progenitor (GMP), which gives rise to the granulocytes of the innate immune response. (wikipedia.org)
The hemangioblast theory, which posits that the RBCs and ECs derive from a common progenitor cell, was developed as researchers observed that receptor knockout mice, such as Flk1-/-, exhibited defective RBC formation and vessel growth. (wikipedia.org)
Expression of MLL-fusions enhances proliferation and blocks myeloid differentiation of hematopoietic progenitor cells, leading to their pathological accumulation. (nature.com)
Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
When stimulated to divide, they give rise to more committed, differentiated daughter cells with less proliferative potential, called "early progenitor" cells. (justia.com)
Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
Neurons that arise in the adult nervous system originate from neural stem cells and neural progenitor cells. (elifesciences.org)
Neural stem cells can also give rise to neural progenitor cells, which proliferate rapidly during their short lives and then 'differentiate' into neurons or glia. (elifesciences.org)
Consequently, neural stem and progenitor cells have usually been studied retrospectively, based on their ability to form colonies in laboratory cell cultures. (elifesciences.org)
A region of the brain called the subventricular zone contains both neural stem cells and neural progenitor cells, and is one of only two regions of the brain where neural stem cells are found in adult mammals. (elifesciences.org)
The AML that developed from these different cells of origin had different penetrance and aggressiveness when engrafted in mice, with the stem cell-derived lines being the most aggressive and the committed progenitor lines the least. (news-medical.net)
Together they identified open chromatin signatures and gene expression patterns in AML samples that may allow stem cell-derived AML to be distinguished from progenitor cell of origin AML. (news-medical.net)
These results bear out indications in human data that the stage of a progenitor cell when it becomes transformed to leukemia has an impact on its clinical progression, with earlier-stage cell of origin cancers being more aggressive. (news-medical.net)
Analysis and genetic manipulation of hematopoietic progenitor cells. (epfl.ch)
Chronic myeloid leukemia (CML) is a clonal expansion of the progenitor hematopoietic stem cells arising from the existence of the fusion BCR-ABL oncogene, that represents 15%-20% of the newly diagnosed cases of leukemia patients [ 1 - 2 ]. (jcancer.org)
Effect of Laptm4b Deletion on Hematopoietic Stem and Progenitor Cells Homeostasis in Mice]. (nih.gov)
Melinda is highly proficient in the use of in vitro and in vivo assays for normal and malignant hematopoietic stem and progenitor cells, determination of self-renewal, expansion and lineage specific differentiation capabilities, and the use of induced pluripotent stem cells for the investigation of hematopoietic disorders and leukemic progression and the testing of targeted therapeutics. (edu.au)
Committed myeloid progenitor cells and cells with long term reconstituting potential were lost from bone marrow within four days after poly injection. (biomedcentral.com)
Recent studies have isolated distinct cell populations from infantile hemangiomas that display properties equivalent to aberrant progenitor cells, suggesting that, in addition to malignant tumors, benign tumors may also contain a stem cell-like component. (medscape.com)

Our results indicate that DLVs represent recombinants between a common 'vector' related to a chicken endogenous virus and one of three types of cellular gene possibly involved in haematopoietic differentiation. (nature.com)
This event requires a special environment, termed the hematopoietic stem cell niche, which provides the protection and signals necessary to carry out the differentiation of cells from HSC progenitors. (wikipedia.org)
Accordingly, enforced expression of SKI induced a gene signature associated with hematopoietic stem cells and myeloid differentiation, as well as hepatocyte growth factor signaling. (edu.au)
SETD2 loss causes growth arrest and differentiation of AML cells, and leads to increased DNA damage. (nature.com)
Sequential rounds of division and differentiation give rise to an enormous amplification of cell numbers, necessary for the production of mature blood cells. (justia.com)
This process of division and differentiation is subject to regulation at many levels to control cell production. (justia.com)
Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
Overexpression of FLI1 in erythroblasts causes inhibition of differentiation and ultimately the development of pre-T cell lymphoblastic leukemia/lymphoma [ 11 ]. (biomedcentral.com)
TGF-β affects development and differentiation of human natural killer cell subsets. (sunnybrook.ca)
HEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation. (sunnybrook.ca)
Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. (jcancer.org)
Here, we determined the effect of Jiyuan oridonin A (JOA), an ent -kaurene diterpenoid compound, on the differentiation blockade in imatinib-sensitive, particularly, imatinib-resistant CML cells with BCR-ABL-T315I mutation by cell proliferation assay, apoptosis analysis, cell differentiation analysis, cell cycle analysis and colony formation assay. (jcancer.org)
We found that JOA at lower concentration significantly inhibited the proliferation of CML cells expressing mutant BCR-ABL (T315I mutation included) and wild-type BCR-ABL, which was due to that JOA induced the cell differentiation and the cell cycle arrest at G0/G1 phase. (jcancer.org)
Mechanistically, the cell differentiation mediated by JOA may be originated from the inhibition of BCR-ABL/c-MYC signaling in CML cells expressing wild-type BCR-ABL and BCR-ABL-T315I. (jcancer.org)
JOA displayed the activity of inhibiting the BCR-ABL and promoted differentiation of not only imatinib -sensitive but also imatinib -resistant cells with BCR-ABL mutation, which could become a potent lead compound to overcome the imatinib -resistant induced by inhibitors of BCR-ABL tyrosine kinase in CML therapy. (jcancer.org)
BCR-ABL oncogene encodes a BCR-ABL tyrosine kinase (TK), which triggers different downstream targets including c-Myc, STAT5 and CrkL, which participated in the control of cell differentiation, proliferation, migration and other cellular behaviors [ 3 - 5 ]. (jcancer.org)
The molecular pathways of normal myeloid differentiation, as well as the mechanisms by which oncogenes disrupt this process, remain poorly understood. (nih.gov)
A major limitation in approaching this problem has been the lack of suitable cell lines that exhibit normal, terminal, and synchronous differentiation in the absence of endogenous oncoproteins and in response to physiologic cytokines, and whose differentiation can be arrested by ectopically expressed human oncoproteins. (nih.gov)
Differentiation was normal and terminal as evidenced by morphology, cell surface markers, gene expression, and functional assays. (nih.gov)
The differentiation of the cells could be arrested by heterologous oncoproteins including AML1/ETO, PML/RARalpha, PLZF/RARalpha, Nup98/HoxA9, and other Hox proteins. (nih.gov)
These myeloid cell lines provide tools for examining the biochemical and genetic pathways that accompany normal differentiation as well as a system in which to dissect how other leukemic oncoproteins interfere with these pathways. (nih.gov)
The production of terminally differentiated cells from such cells, therefore, requires successive changes of cell fates, meaning that genes relevant for the next stage of differentiation must be switched on and genes not relevant anymore must be switched off. (amegroups.org)
The development of the hematopoietic system has long served as model to understand how changes in gene regulatory networks drive the differentiation of the various blood cell types. (amegroups.org)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

We are using this virus to study the initiating immortalizing process and switches between resting and proliferating phenotypes to better understand EBV protein - host cell interactions involved in tumorigenesis controlling the switch from cell arrest to proliferation and reprogramming of metabolism. (ki.se)
Erythroleukemia is a neoplastic proliferation of erythroid and myeloid precursors of bone marrow hematopoietic stem cells . (medscape.com)
The rate of ribosome production has far-reaching influence on the fate of the cell, and dictates its size, proliferation, and ability to translate global or specific mRNAs. (upenn.edu)
FLT3 ITD triggers the proliferation of the quiescent hematopoietic stem cell (HSC) pool but fails to directly transform HSCs. (biomedcentral.com)
SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling. (cancerindex.org)
Overexpression of SOX9 promoted NPC cell proliferation, migration and invasion. (cancerindex.org)
MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2. (sunnybrook.ca)
We examined Vav3 small interfering RNA (siRNA) effects on cell proliferation and apoptosis in docetaxel-treated LNCaP cells under chronic hypoxia (LNCaPH). (biomedcentral.com)
We examined individual and combined effects of Vav3 siRNA (si-Vav3) and docetaxel on cell growth and apoptosis under chronic hypoxia by cell proliferation, flow cytometric, DNA fragmentation, and immunoblot analyses. (biomedcentral.com)
WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)

Using inducible deletion of autophagy specifically in adult hematopoietic stem cells (HSCs) and in mice chimeric for autophagy-deficient and normal HSCs, we demonstrate that the stem cell loss is cell-intrinsic. (ox.ac.uk)

Bioactivity of protein post-loading was confirmed with the TF-1 cell line. (frontiersin.org)
Conditional deletion of the Bmi-1 polycomb protein depleted pre-GEPCOT and GEPCOT cells, though pre-GEPCOT cells were more dependent upon Bmi-1 for Cdkn2a ( p16 Ink4a ) repression. (elifesciences.org)
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. (cancerindex.org)
SCF R is also known as the c-kit proto-oncogene protein and as CD117. (rndsystems.com)
1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
2) Therefore, the proper control of protein levels is crucial for the cell cycle. (ukessays.com)
1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
It induces cancer-like properties when expressed in cells and can activate a protein that causes various myeloid cell disorders. (usf.edu)
Furthermore, infusion of normal bone marrow cells rescued mice from death induced by loss of THOC5/Fms interacting protein. (biomedcentral.com)
Furthermore, mechanistically depletion of THOC5/Fms interacting protein causes the down-regulation of its direct interacting partner, THOC1 which may contribute to altered THO complex function and cell death. (biomedcentral.com)
The cell lines were established by conditional immortalization of primary murine marrow progenitors with an estrogen-regulated E2a/Pbx1-estrogen receptor fusion protein. (nih.gov)
The ~200 amino acid TBC/rab GTPase-activating protein (GAP) domain is well conserved across species and has been found in a wide range of different proteins from plant adhesion molecules to mammalian oncogenes. (embl.de)
however a 45 kD protein may also be observed in some cell types using the antiserum. (bdbiosciences.com)
Because Cdc2 kinase is important for cell entry into mitosis, cyclin C's ability to regulate cell cycle progression may be attributed, in part, to modulation of Cdc2 protein expression.6 Cyclin C has a predicted molecular weight of 36 kD. (bdbiosciences.com)
Although this protein is found throughout the body, it may play a particularly important role in the production of blood cells from hematopoietic stem cells. (medlineplus.gov)
The TET2 protein appears to act as a tumor suppressor, which is a protein that prevents cells from growing and dividing in an uncontrolled way. (medlineplus.gov)
A loss of TET2 protein in hematopoietic stem cells may lead to uncontrolled growth and division of these cells. (medlineplus.gov)
The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. (cdc.gov)

Dexter observed that mesenchymal stromal cells could maintain early HSCs ex vivo, and both Lord and Gong showed that these cells localized to the endosteal margins in long bones. (wikipedia.org)
In vivo work showed that the outcomes of disease (erythroid, myeloid, or both) depend on the driving oncogene and the hematopoietic target cell in which it is aberrantly expressed. (medscape.com)
Pre-GEPCOT cells could not form neurospheres but expressed the stem cell markers Slc1a3-CreER T , GFAP-CreER T2 , Sox2 CreERT2 , and Gli1 CreERT2 and were long-lived in vivo. (elifesciences.org)
Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors. (sunnybrook.ca)

They began with five distinct, normal cell types found in the bone marrow in both mice and humans: long-term hematopoietic stem cells (HSCs), short-term HSCs, multipotent progenitors, common myeloid progenitors and granulocyte macrophage progenitors. (news-medical.net)
These patterns were also reflected in the frequency of leukemia-initiating cells in each cell line, with HSCs having the highest frequency and committed progenitors having the lowest. (news-medical.net)
Mechanistically, autophagy-deficient HSCs showed higher expression of several amino acid transporters (AAT) when compared to autophagy-competent cells, resulting in increased amino acid (AA) uptake. (ox.ac.uk)
This was followed by sustained MTOR (mechanistic target of rapamycin) activation, with enlarged cell size, glucose uptake and translation, which is detrimental to the quiescent HSCs. (ox.ac.uk)
To provide a lifelong supply of blood cells, hematopoietic stem cells (HSCs) need to carefully balance both self-renewing cell divisions and quiescence. (elsevierpure.com)

T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
Chromatin is the material in the nucleus of the cell that condenses to form chromosomes during cell division, and consists of DNA, proteins called histones and RNA. (news-medical.net)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
The course covers the regulation of gene expression, which translates the information contained in the genome into function, by adjusting the levels and activities of mRNAs and proteins to the needs of specific cells, tissues and environments. (epfl.ch)
Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. (bdbiosciences.com)
These findings provide supporting evidence that enrichment for proteins involved in pluripotency is not restricted solely to malignant tumors as is suggested by the "stem cell theory of cancer", but additionally extends to common benign vascular tumors such as hemangiomas. (medscape.com)

The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. (justia.com)
We have developed model systems whereby we can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice. (stanford.edu)
Unlike some other tissues, it has not been possible to identify or purify neural stem cells directly from the tissue. (elifesciences.org)
In the present study, up-regulation of SOX9 was observed in both NPC tissues and different NPC cells. (cancerindex.org)
Furthermore, Cox regression analyses conducted on four cancers, including Head and Neck squamous cell carcinoma (HNSC), Kidney renal clear cell carcinoma (KIRC), Stomach adenocarcinoma (STAD), and Uterine Corpus Endometrial Carcinoma (UCEC), revealed strong correlation between viral composition/abundance in tissues and patient survival. (bvsalud.org)

The Paralkar Lab has identified that key hematopoietic and leukemic transcription factors bind to rDNA and regulate rRNA transcription, and we are interested in understanding how the binding of cell-type-specific transcription factors regulates the activity of Polymerase I and the transcription of rRNA in normal hematopoiesis, and how this regulation is co-opted in leukemia to drive abundant ribosome biogenesis. (upenn.edu)
Multifunctional growth factor which regulates both cell growth and cell motility. (bvsalud.org)

Research in the Paralkar Lab spans the spectrum from human patient sample studies and mouse models to cutting-edge molecular biology tools, high-throughput sequencing approaches, and novel computational algorithms, all with the goal of gaining insight into how the transcription of coding genes and noncoding ribosomal DNA genes is regulated in hematopoietic stem cells, myeloid progenitors, and in leukemia. (upenn.edu)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
The identification of neural crest specification genes expressed in the neural plate of basal chordates, in addition to the discovery of pigmented migratory cells in ascidians, has challenged this hypothesis. (biomedcentral.com)
A remarkable proportion of the new neural crest genes encode soluble ligands that control neural crest precursor specification into each cell lineage, including pigmented, neural, glial, and skeletal derivatives. (biomedcentral.com)
We propose that the evolution of the neural crest is linked not only to the recruitment of ancestral regulatory genes but also to the emergence of signaling peptides that control the increasingly complex lineage diversification of this plastic cell population. (biomedcentral.com)
The course covers in detail molecular mechanisms of cancer development with emphasis on cell cycle control, genome stability, oncogenes and tumor suppressor genes. (epfl.ch)
ETS family members transcription factors control the appearance of oncogenes, tumor suppressor genes, and various other genes linked to vessel development, invasion, and metastasis, and expression of the elements correlates with poor survival [7C10] often. (columbiagypsy.net)
The review highlights the discovery of oncogenes and suppressor tumor genes, underlining the crucial role of these achievements in cancer diagnosis and therapies. (jcancer.org)
10 Genes that, when activated, contribute to the carcinogenesis are generally termed proto-oncogenes. (bmj.com)
The mutated forms of these genes are referred to as oncogenes. (bmj.com)

In particular, using the tetracycline regulatory system, we have generated a conditional model system for MYC-induce hematopoietic tumors. (stanford.edu)
How do tumors escape dependence on oncogenes? (stanford.edu)
However, little is known about the mechanisms underlying the activation of this proto-oncogene in tumors. (biomedcentral.com)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
The "stem cell theory of cancer" states that a subpopulation of cells with stem cell-like properties plays a central role in the formation, sustainment, spread, and drug resistant characteristics of malignant tumors. (medscape.com)

Her lab worked with a mouse model of acute myeloid leukemia (AML) driven by expression of MLL-AF9, a fusion oncogene formed by a chromosome translocation between human chromosomes 9 and 11. (news-medical.net)
IL27R is a cytokine receptor identified as a novel oncogene from an acute myeloid leukemia patient. (usf.edu)
Prognostic impact of pre-transplant chromosomal aberrations in peripheral blood of patients undergoing unrelated donor hematopoietic cell transplant for acute myeloid leukemia. (cdc.gov)

The EBV cell line models allow comparison of non-malignant versus malignant phenotypes of human cancer in vitro (lymphoblastoid cell lines, LCL vs Burkitt´s lymphoma cell line, BL). (ki.se)
[ 2 ] It has become clear that AITL is a clonal T-cell disorder involving deregulation of B-cells and endothelial cells against a background involving a unique malignant microenvironment. (medscape.com)
The Paralkar Lab has developed customized genomes and computational pipelines to map datasets to rDNA, and we are interested in developing advanced tools to map and interpret the genetic and epigenetic profiles of rDNA in normal and malignant cells. (upenn.edu)
In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
A dermatology work-up was initiated, and the síndrome de Sézary initial diagnosis of malignant T-cell neoplasm was confirmed. (bvsalud.org)
subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)

Breakpoint Cluster Region-Abelson kinase (BCR-Abl) is a driver oncogene that causes chronic myeloid leukemia and a subset of acute lymphoid leukemias. (uib.no)

Developmental progression of fetal HEB(-/-) precursors to the pre-T-cell stage is restored by HEBAlt. (sunnybrook.ca)
Cell cycle progression was also affected. (frontiersin.org)
Cyclins contain a conserved amino acid sequence motif, the cyclin box, which allows their binding to cdks to form active complexes that regulate progression of the cell cycle. (bdbiosciences.com)
Cyclin C may play a dual role within the cell in its ability to regulate both cell cycle progression as well as gene transcription. (bdbiosciences.com)

As the embryo requires rapid oxygenation due to its high mitotic activity, these islands are the main source of red blood cell (RBC) production via fusing endothelial cells (ECs) with the developing embryonic circulation. (wikipedia.org)
Fli-1, a known person in the ETS transcription aspect family members, is also the mark of insertional activation by Friend murine leukemia trojan (F-MuLV) and it is preferentially portrayed in vascular endothelial cells and hematopoietic tissue [6]. (columbiagypsy.net)

Subsequently, bioactivity assays were evaluated in vitro using the TF-1 tyrosine receptor kinase A (Trk-A) expressing cell line. (frontiersin.org)
Cytomegalovirus-Specific CD8+ T-Cells With Different T-Cell Receptor Affinities Segregate T-Cell Phenotypes and Correlate With Chronic Graft-Versus-Host Disease in Patients Post-Hematopoietic Stem Cell Transplantation. (ki.se)
Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals. (sunnybrook.ca)
Versican G3 promotes mouse mammary tumor cell growth, migration, and metastasis by influencing EGF receptor signaling. (sunnybrook.ca)
MST1R (RON) is a trans-membrane receptor tyrosine kinase (RTK), which is part of the c-MET proto-oncogene family. (frontiersin.org)
Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)

The disorder is now classified as angioimmunoblastic T-cell lymphoma (AITL). (medscape.com)
AITL is a type of peripheral T-cell lymphoma (PTCL) that is clinically characterized by high fever and generalized lymphadenopathy. (medscape.com)
AITL-type dysplasia with an oligoclonal T-cell pattern has frequently been shown to progress into AITL-type lymphoma. (medscape.com)
Evidence exists that angioimmunoblastic T-cell lymphoma (AITL) develops in a serial fashion. (medscape.com)
[ 6 ] The lymphomatous infiltrate in some bone marrow specimens from these AITL patients contained numerous small or scattered large B cells, and these cells resembled either benign lymphoid aggregates or T-cell-rich large B-cell lymphoma, respectively. (medscape.com)
DJ34-mediated c-Myc depletion occurred in a wide range of tumor cell types, including lymphoma, lung, glioblastoma, breast cancer, and several forms of leukemia, with primary LSCs being particularly sensitive to DJ34. (uib.no)
In addition to increased B-cell lymphoma 2 (Bcl-2) phosphorylation through JNK signaling in response to docetaxel, si-Vav3 enhanced docetaxel-induced apoptosis, as characterized by the accumulation of sub-G1 phase cells and DNA fragmentation, through Bcl-xL/Bcl-2-associated death promoter (Bad) dephosphorylation, resulting in increased caspase-9, caspase-3, and cleaved poly(ADP-ribose) polymerase activation. (biomedcentral.com)
Krenacs et al have suggested that the phenotype of neoplastic cells in angioimmunoblastic T-cell lymphoma appears consistent with the phenotype of activated follicular B-helper T cells. (medscape.com)
Dunleavy et al noted that overexpression of the chemokine CXCL13 and vascular endothelial growth factor-A in angioimmunoblastic T cell lymphoma suggests that it may be derived from follicular helper T cells. (medscape.com)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
NK-cell lineages all of which are further incidence of leukaemia and lymphoma, and radiodiagnosis physician (for imag- classified as distinct entities including it is important to investigate whether ing). (who.int)
Cutaneous T-cell lymphoma is a general term from mycosis fungoides or occur spontane- to identify non-Hodgkin's T-cell lymphomas ously, although some authors now consider that primarily affect the skin. (bvsalud.org)

A year later, Choi showed that blast cells derived from embryonic stem (ES) cells displayed common gene expression of both hematopoietic and endothelial precursors. (wikipedia.org)
HEBAlt enhances the T-cell potential of fetal myeloid-biased precursors. (sunnybrook.ca)
Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of red blood cell and white blood cell precursors. (msdmanuals.com)

Our laboratory investigates how oncogenes initiate and sustain tumorigenesis. (stanford.edu)
How do oncogenes initiate tumorigenesis? (stanford.edu)
PyV-induced tumorigenesis in laboratory animals, by simian virus 40 (SV40) or by multiple human PyVs, such as JC virus (JCV), is used extensively as a cell transformation model. (cdc.gov)

In 1978, after observing that the prototypical colony-forming stem cells were less capable at replacing differentiated cells than bone marrow cells injected into irradiated animals, Schofield proposed that a specialized environment in the bone marrow allows these precursor cells to maintain their cellular reconstitution potential. (wikipedia.org)
2021). The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells . (essex.ac.uk)
Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism. (ox.ac.uk)
In the developing embryo, TFs regulating the assembly/disassembly of transcriptional complexes and ultimately gene expression, are directed by complex extrinsic signalling processes which connect all cells within a multi-cellular organism to their environment. (amegroups.org)

Stem cells represent a very small percentage of bone marrow cells, and are normally quiescent. (justia.com)
In contrast, pre-GEPCOT cells were quiescent, expressed higher Glast, and lower EGFR and PlexinB2. (elifesciences.org)
Neural stem cells have long lives, much of which they spend in a quiescent state. (elifesciences.org)
term pre-GEPCOT cells (based on an acronym of the markers used to isolate the cells), were long-lived and quiescent, but they lacked the ability to form colonies in culture. (elifesciences.org)
Adult stem cells are long-lived and quiescent with unique metabolic requirements. (ox.ac.uk)

There are 2 types of hematopoiesis that occur in humans: Primitive hematopoiesis - blood stem cells differentiate into only a few specialized blood lineages (typically isolated to early fetal development). (wikipedia.org)
Morphological recognition of main hematopoietic lineages. (epfl.ch)

[ 1 ] Patients usuallly present with nonspecific signs and symptoms from the anemia, thrombocytopenia, and leukopenia resulting from the replacement of bone marrow by leukemic cells (see Presentation ). (medscape.com)
The leukemic cells in erythroleukemia often carry complex karyotypes and mutations in oncogenes known to be associated with AML. (medscape.com)
rRNA transcription rates vary dramatically between different normal cell types in the hematopoietic tree, and leukemic cells have characteristic prominent nucleoli, indicating robust ribosome synthesis. (upenn.edu)
Although tyrosine kinase inhibitors provide an effective treatment for these diseases, they generally do not kill leukemic stem cells (LSCs), the cancer-initiating cells that compete with normal hematopoietic stem cells for the bone marrow niche. (uib.no)

AITL is mainly derived from CD2 + CD3 + CD4 + CD5 + CD7 - mature T-helper cells with varying expression and partial loss of detectable CD4. (medscape.com)
Using the tet system, we have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation. (stanford.edu)
In addition, SCF R expression has also been reported in several human tumor cell lines (1,2). (rndsystems.com)
In non-small cell lung cancer, the FLI1 expression score is associated with the stage of SCLC. (biomedcentral.com)
This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)
The stimulus for the change of cell fate originates from extrinsic signals which set a cascade of intracellular processes in motion that eventually terminate at the genome leading to changes in gene expression and the development of alternate gene regulatory networks. (amegroups.org)
Like many cyclins, the expression of cyclin C oscillates throughout the cell cycle, with a peak observed during G1 phase. (bdbiosciences.com)

Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
Historically, the most effective treatment for XSCID has been bone marrow transplantation, [i.e. hematopoietic stem cell transplantation (HSCT)], where a patient receives healthy blood-forming cells from a matched sibling donor, or a half-matched parental donor. (stjude.org)

The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. (edu.au)
In line, many MLL-fusions can act as potent oncogenes in cell line models and animal models of leukemia 4 . (nature.com)
AITL has been reported to occur concurrently with plasma cell leukemia. (medscape.com)
Every cancer starts with a single cell, and Jackson Laboratory (JAX) researchers have found a precise and reliable way -- whole-genome profiling of open chromatin -- to identify the kind of cell that leads to a given case of leukemia, a valuable key to cancer prognosis and outcome. (news-medical.net)
Among the ETS family members, Friend leukemia virus integration 1 ( FLI1 ) was first identified as a proto-oncogene activated by proviral integration in F-MuLV-induced erythroleukemias [ 4 ]. (biomedcentral.com)
and early trials resulted in vector-induced leukemia in 25% of patients due to insertion of the gene-carrying retrovirus near an oncogene. (stjude.org)
Somatic TET2 gene mutations are also associated with certain types of cancer of blood-forming cells (leukemia) and a disease of the blood and bone marrow called myelodysplastic syndrome. (medlineplus.gov)
is a hematopoietic stem cell defect in which the fibrosis is a result of mutations in the JAK2 (Janus kinase 2), CALR (calreticulin), or MPL (myeloproliferative leukemia virus oncogene). (msdmanuals.com)
RUNX1-positive leukemia cells in preclinical models. (lu.se)

Using a CRISPR Cas9-guided immunoprecipitation assay, we identify a circular RNA in the FLI1 promoter chromatin complex, consisting of FLI1 exons 4-2-3, referred to as FECR1.Overexpression of FECR1 enhances invasiveness of MDA-MB231 breast cancer cells. (biomedcentral.com)
Interrupting Vav3 signaling enhances docetaxel-induced apoptosis in LNCaP cells under chronic hypoxia by inhibiting the PI3K/Akt, ERK, and AR signaling pathways. (biomedcentral.com)

These studies and others supported the idea that bone cells create the HSC niche, and all the research that elucidated this specialized hematopoietic microenvironment stemmed from these landmark studies. (wikipedia.org)
Specifically, the concepts of tumour heterogeneity, oncogene addiction, non-oncogene addiction, tumour initiating cells, tumour microenvironment, non-coding sequences and DNA damage response will be reviewed. (bmj.com)

In the absence of doxycycline, tTA dimers bind specifically to a concatamer of seven tetO sequences (7X tet-o) and activate oncogene transcription from the minimal TATA promoter. (stanford.edu)
While the inflammatory transcription factor nuclear factor of activated T-cells 2 ( NFAT2 , NFATC1 ) is overexpressed in AML, it is unknown whether it plays a role in FLT3 ITD -induced HSC transformation. (biomedcentral.com)
PU.1 prevented excessive HSC division and exhaustion by controlling the transcription of multiple cell-cycle regulators. (elsevierpure.com)
We also highlight recent studies identifying the cis -regulatory elements such as enhancers at the global level and explain how their developmental activity is regulated by the cooperation of cell-type specific and ubiquitous transcription factors with extrinsic signals. (amegroups.org)

This condition is characterized by scar tissue (fibrosis) in the bone marrow, the tissue that produces blood cells. (medlineplus.gov)
Decreased functional hematopoietic tissue due to bone marrow infiltration is the main cause of anemia. (msdmanuals.com)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)

We particularly study Epstein-Barr Virus (EBV)-infection, which can also be used as a model to study early steps in in vitro transformation, viral genetic switches, non-genetic variation and cancer cell metabolism. (ki.se)
Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature. (sunnybrook.ca)

Context-dependent regulation of hematopoietic lineage choice by HEBAlt. (sunnybrook.ca)

1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
To profile the open chromatin in these distinct AML samples, and compare them to open chromatin patterns in normal cells, Trowbridge collaborated with Duygu Ucar, Ph.D., an assistant professor at JAX who develops computational models to study gene regulation including chromatin structure. (news-medical.net)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
More recently, cyclins are being shown to have additional functions not restricted to cell cycle regulation. (bdbiosciences.com)
Group 3 cyclins (G1, G2 and I) may play a role distinct from either cell cycle or transcriptional regulation. (bdbiosciences.com)

Some gene mutations are acquired during a person's lifetime and are present only in certain cells. (medlineplus.gov)
Somatic mutations in the TET2 gene are associated with polycythemia vera, a disorder characterized by uncontrolled blood cell production. (medlineplus.gov)

To clarify the molecular basis of si-Vav3- and docetaxel-induced apoptosis, we analyzed alterations in phosphatidylinositol 3-kinase (PI3K)/Akt, extracellular signal-regulate kinase (ERK), c-jun N-terminal kinase (JNK), and AR pathways using kinase inhibitors in LNCaPH cells. (biomedcentral.com)

This report describes clonal, granulocyte-macrophage colony-stimulating factor-dependent myeloid cell lines that exhibit these properties. (nih.gov)

3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)

Every type of cell has a characteristic chromatin structure that includes closed chromatin, which is tightly wound around nucleosomes and is relatively inactive, and open chromatin, looser stretches of the material that interact with regulatory elements encoded in DNA. (news-medical.net)
Trowbridge hypothesized that analyzing open chromatin in bulk tumor cells could provide a possible improved method to identify cancer cell of origin because of the cell-type specificity of chromatin structure. (news-medical.net)

CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)

Collectively our results demonstrate that SKI is an important regulator of hematopoietic stem cell activity and its overexpression leads to myeloproliferative disease. (edu.au)
Primary Myelofibrosis Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, splenomegaly, and anemia with nucleated and teardrop-shaped red blood cells. (msdmanuals.com)
Polycythemia Vera Polycythemia vera is a chronic myeloproliferative neoplasm characterized by an increase in morphologically normal red cells (its hallmark), but also white cells and platelets. (msdmanuals.com)

We find that NFATC1 governs FLT3 ITD -driven precursor cell expansion and transformation, causing a fully penetrant lethal AML. (biomedcentral.com)
Thus, although PyV-induced oncogenesis in laboratory animals has been a prolific model for the study of the cell cycle and cell transformation, natural infections rarely result in tumor formation, so the steps in cell transformation after natural infection are being revealed more slowly. (cdc.gov)

True stem cells are both pluripotent-that is they can give rise to all cell types-and capable of self-renewal. (justia.com)

Other cell types derived from hematopoietic stem cells include platelets and erythrocytes. (justia.com)
These stem cells are located within the bone marrow and have the potential to develop into red blood cells, white blood cells, and platelets. (medlineplus.gov)
Platelets are the blood cells involved in blood clotting. (medlineplus.gov)

Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. (justia.com)
In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. (justia.com)
Thus we considered the hematopoietic system and found that seven days after poly injection, the number of blood cells in peripheral blood decreased drastically. (biomedcentral.com)

Satellite cells and skeletal muscle regeneration . (inrs.ca)

Dr. Multani has extensive expertise in the field of Human and Mammalian Cytogenetics, and specializes in the evaluation of genetic instability and complex chromosomal rearrangements in cancer cells, telomere dysfunction, characterization of embryonic stem cells, and authentication of cell lines. (mdanderson.org)

But existing methods to identify cell of origin from bulk tumor cell samples have been unsuccessful. (news-medical.net)

The Vav family of Rho/Rac guanosine nucleotide exchange factors comprises three members in mammalian cells. (biomedcentral.com)

Trilineage hematopoietic hyperplasia and plasmacytosis were other changes noted by Grogg et al. (medscape.com)

Current bioinformatic pipelines for high-throughput studies like whole genome sequencing, RNA-seq, ChIP-seq, and single cell RNA-seq are limited in their ability to map repetitive elements of the genome like ribosomal DNA. (upenn.edu)

The neural crest is a transient population of embryonic cells that originate at the boundary between neural plate and dorsal ectoderm. (biomedcentral.com)
However, all developmental processes originate from pluripotent precursor cell types. (amegroups.org)
The best available evidence suggests that glioblastomas originate from cells that give rise to glial cells. (bmj.com)

Knowledge to date on secondary malignancy following hematopoietic cell transplantation for sickle cell disease. (cdc.gov)

Anatomy39

Organisms15

Diseases20

Chemicals and Drugs89

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes60

Technology, Industry, Agriculture1

Information Science3

Named Groups2

Health Care1

Progenitor24

Differentiation26

Proliferation12

Adult hematopoietic stem1

Protein19

Vivo4

HSCs5

Proteins6

Tissues5

Regulates2

Genes10

Tumors5

Acute myeloid3

Malignant6

Chronic myeloid1

Progression4

Endothelial cells2

Receptor6

Lymphoma12

Precursors3

Tumorigenesis3

Cellular4

Quiescent5

Lineages2

Leukemic4

Expression7

Bone marrow transpla2

Leukemia9

Enhances2

Microenvironment2

Transcription4

Tissue3

Vitro2

Lineage1

Regulation5

Mutations2

Kinase1

Myeloid cell1

Initiate and sustain1

Chromatin2

CD1171

Myeloproliferative3

Transformation2

Self-renewal1

Platelets3

Peripheral3

Skeletal1

Embryonic stem1

Tumor cell1

Mammalian1

Hyperplasia1

Genome1

Originate3

Transplantation1