Hematopoietic. Medical search. Frequent questions

By homing, transplanted hematopoietic cells are able to travel to and engraft (establish residence) in the bone marrow. (wikipedia.org)

Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
Hematopoietic stem cell transplantation (HSCT) is a broad term that covers the transplantation of blood progenitor/stem cells from any source. (drugdiscoverynews.com)
The year 2020 marked the 30th anniversary of the Nobel Prize in Medicine awarded to E. Donnall Thomas for the development of allogeneic hematopoietic stem cell transplantation (allo-HSCT) to treat hematologic malignancies and other blood disorders. (broadinstitute.org)
Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
There is a paucity of data examining the tolerance and outcome of hematopoietic stem cell transplantation (HSCT) for relapse after tositumomab/iodine-131 tositumomab. (cancernetwork.com)
There is a paucity of data examining the tolerance andoutcome of hematopoietic stem cell transplantation (HSCT) for relapse aftertositumomab/iodine-131 tositumomab. (cancernetwork.com)
The potential role of elastin in patients with myeloid leukemia treated with hematopoietic stem cell transplantation (HSCT) has not been investigated so far. (medscimonit.com)
This study aimed to know the perceptions and experiences of family companions facing illness and transplantation of hematopoietic stem cells (HSCT) in light of the theory of anticipatory grief. (bvsalud.org)

In this research we describe a previously unknown set of molecular inputs that are required to make hematopoietic stem cells during embryonic development. (ca.gov)
They appear to make hematopoietic stem cells more responsive to differentiation, but the exact mechanism is not clear. (medscape.com)

Various chemokines and receptors are involved in the homing of hematopoietic stem cells. (wikipedia.org)

HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
HSCs specifically are defined by their ability for self-renewal and to reconstitute the entire hematopoietic system following transplantation. (stemcell.com)
Haematopoietic stem cells (HSCs) are a self-renewing population of cells that continuously replenish all blood and immune cells during the lifetime of an individual. (ca.gov)
Bone marrow hematopoietic stem cells (HSCs) are vital for the maintenance of hematopoiesis. (irbbarcelona.org)
In inbred mice housed in gnotobiotic facilities, the top of the hematopoietic hierarchy is occupied by dormant HSCs, which reversibly exit quiescence during stress. (irbbarcelona.org)
Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. (biorxiv.org)
Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) and potential alternative for bone marrow transplantation for patients who lack human leukocyte antigen (HLA)-matched donors. (wjgnet.com)
However, sustained engraftment of the expanded cells was not observed after transplantation, suggesting ineffective expansion of hematopoietic stem cells with long-term repopulating activity (LTR-HSCs). (confex.com)
Hematopoietic stem cells (HSCs) enable hematopoietic stem cell transplantation (HCT) through their ability to replenish the entire blood system. (lu.se)

Stem and progenitor cell commitment processes have been subject to intense experimental studies over the last decade with some emphasis on embryonic and hematopoietic stem cells. (lu.se)
This review outlines current protocols and cell markers used in flow cytometric analysis of hematopoietic stem and progenitor cell populations . (bvsalud.org)

Allogeneic hematopoietic stem cell (HSC) is a curative treatment used for many hematologic malignancies and congenital or acquired anomalies of hematopoiesis. (pasteur.fr)
Examples of secondary immunodeficiency include HIV infection, hematopoietic malignancies, treatment with radiation, and treatment with immunosuppressive drugs. (cdc.gov)
Our study demonstrated that persistent use of statins is associated with a lower overall cancer risk and particularly the risk of incident hematopoietic malignancies. (cdc.gov)

We examined hematopoietic stem cells at four stages of differentiation, lineage-committed progenitors, and mature myeloid and lymphoid cells. (nih.gov)
With this method, we will provide the first in vivo description of the human hematopoietic tree and identify new progenitors and key molecular factors involved in human hematopoiesis. (europa.eu)
Endothelial progenitors should be devoid of hematopoietic markers and able to form vessels both in vitro and in vivo . (hindawi.com)
In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
The in vitro effect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. (bmj.com)

Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)
Effect of race on outcomes after allogeneic hematopoietic cell transplantation for severe aplastic anemia. (aamds.org)

Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. (hindawi.com)
Gene editing of the erythroid-specific BCL11A enhancer in hematopoietic stem and progenitor cells (HSPCs) from sickle cell disease (SCD) patients induces fetal hemoglobin (HbF) without detectable toxicity as assessed by mouse xenotransplant. (physiciansweekly.com)
Notch activation in human CD34+ hematopoietic stem/progenitor cells (HSPCs) by treatment with Delta1 ligand has enabled clinically relevant ex vivo expansion of short-term HSPCs. (confex.com)

Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
I found that rRNA transcription was downregulated during hematopoietic differentiation in both human leukemia cell line and mouse hematopoietic stem cells. (nii.ac.jp)
In response to the inhibition of rRNA transcription, nucleolar protein MYBBP1A was translocated from the nucleolus to the nucleoplasm and interacted with c-Myc, which is one of the master regulator of hematopoietic differentiation. (nii.ac.jp)
I also found that hematopoietic differentiation was sufficiently induced by specific suppression of rRNA transcription using actinomycin D or siRNA for TIF-IA. (nii.ac.jp)
These results suggest that the downregulation of rRNA transcription accelerates cellular differentiation at least in hematopoietic cells. (nii.ac.jp)
These factors are glycoproteins that act on hematopoietic cells by binding to specific cell surface receptors and stimulating proliferation, differentiation, commitment, and some end cell functional activation. (medscape.com)
Specific niches within the bone marrow are discussed, as are metabolic processes that contribute to stem cell self-renewal and differentiation, as well as the role of hematopoietic stem cells outside of the bone marrow at physiologic steady state . (bvsalud.org)

This leads to mobilization of hematopoietic stem cells to the peripheral blood. (drugs.com)
The hematopoietic stem cells (CD34+ cells) are collected from the peripheral blood and used for autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma . (drugs.com)
Hematopoietic stem cells produce all types of blood cells so autologous transplantation restores normal production of the blood cells. (drugs.com)
Complementary oligonucleotides capable of hybridizing to 181 miRNAs were immobilized on a membrane and probed with radiolabeled RNA derived from low molecular weight fractions of total RNA from several different hematopoietic and neuronal cells. (nih.gov)
This is the first report of systematic miRNA gene profiling in cells of the hematopoietic system. (nih.gov)
As expected, miRNA expression patterns were very different between hematopoietic and non-hematopoietic cells, with further subtle differences observed within the hematopoietic group. (nih.gov)
We assayed telomerase activity in single cells of the hematopoietic and immune systems. (nih.gov)
Among bone marrow hematopoietic stem cells, 70% exhibited detectable telomerase activity. (nih.gov)
An infectious retrovirus vector has been used to transfer a bacterial gene encoding resistance to the neomycin analogue G418 into pluripotent haematopoietic stem cells present in explanted murine bone marrow tissue. (nature.com)
Subsequent transplantation of the cells into lethally irradiated mice results in engraftment of the animals with donor haematopoietic tissue containing the bacterial gene. (nature.com)
Test the activities of the vectors in hematopoietic stem cells from healthy donor in culture and by growing in immune deficient mice. (ca.gov)
Test the activities of the vectors in hematopoietic stem cells from patients with severe AT in culture that produces red blood cells. (ca.gov)
While murine hematopoiesis has been considered as resolved science, recent results using barcoding, which allows the tracing of single cells in vivo, clearly show that the topology of the murine hematopoietic tree needs revisions. (europa.eu)
This knowledge will allow us to test whether cells with different origins have different functions, a key question in immunology in particular during infection and inflammation, and it will help design ways of therapeutically manipulating the hematopoietic system. (europa.eu)
Retroviral gene transfer to primitive normal and leukemic hematopoietic cells using clinically applicable procedures. (jci.org)
Clinical uses of gene transfer to bone marrow transplants require the establishment of a reproducible method for infecting large numbers of very primitive hematopoietic cells at high efficiency using cell-free retrovirus-containing media. (jci.org)
Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)
PLX-R18 cells, derived from mesenchymal-like cells collected from donated placentas, are designed to release a combination of therapeutic proteins to jumpstart the regeneration of a poorly functioning hematopoietic system. (drugdiscoverynews.com)
Hematopoietic stem cells in the bone marrow give rise to red blood cells and immune cells . (fightaging.org)
In this study, we observed that the expression of pseudouridine (Ψ) synthase 10 is increased in aged hematopoietic stem and progenitor cells (HSPC) and enforced protein of Ψ synthase 10 (PUS10) recapitulates the phenotype of aged HSC, which is not achieved by its Ψ synthase activity. (haematologica.org)
Hematopoietic stem cells (HSC) generate all of the blood cells throughout their life-span. (haematologica.org)
A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. (ca.gov)
Hematopoietic stem cells are an important population of cells that continuously produce and replace red blood and immune system cells during life. (ca.gov)
Understanding how hematopoietic stem cells are made during embryonic development is important because it could teach us how to make such cells in the laboratory, and possibly allow circumvention of donor immune compatibility issues. (ca.gov)
Eventually these findings may help us discover the complete set of molecular controls necessary for making hematopoietic stem cells. (ca.gov)
Bone marrow stem cells are targets for benzene-induced cytotoxicity and DNA damage that could result in changes to the genome of these progenitor cells, thereby leading to hematopoietic disorders and cancers. (rti.org)
Human bone marrow CD34(+) hematopoietic progenitor cells (HPC) were exposed in vitro to 1,4-BQ to assess cytotoxicity, genotoxicity, and DNA damage responses and the molecular mechanisms associated with these events. (rti.org)
One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)
Therefore, the cells we used should be considered as hematopoietic precursors of myeloid angiogenic cells and are referred as PACs. (hindawi.com)
How are hematopoietic stem cells born during the development of the vertebrate embryo? (uctv.tv)
00:39 police is these are hematopoietic stem cells. (yale.edu)
BCL11A enhancer edited hematopoietic stem cells persist in rhesus monkeys without toxicity. (physiciansweekly.com)
Most clusters could be computationally assigned to a defined hematopoietic subpopulation, including progenitor cells (clusters 0 to 4) and a single transcriptionally defined HSC population (cluster 5). (confex.com)
Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. (uzh.ch)
Cellular activation through pattern recognition receptors induces interferon production in a wide variety of hematopoietic and nonhematopoietic cell types, including dendritic cells, fibroblasts, hepatocytes, and cells of neuronal origin. (uzh.ch)
The relative contribution of hematopoietic and nonhematopoietic cells to the overall interferon response is an important issue which has not been fully addressed. (uzh.ch)
We found that during systemic cytopathic virus infection, hematopoietic cells were essential for production of IFN-I, inhibition of viral spread to peripheral organs, and limiting cell damage. (uzh.ch)
In a model of autoimmune diabetes induced by noncytopathic virus infection, hematopoietic cell-derived IFN-I was essential for CD8(+) T cell-dependent cytotoxicity in pancreatic beta-islet cells and induction of diabetes. (uzh.ch)
Identification of Gene Expression-Based Prognostic Markers in the Hematopoietic Stem Cells of Patients With Myelodysplastic Syndromes. (stembook.org)
Hematopoietic stem cells and extramedullary hematopoiesis in the lungs. (bvsalud.org)
Hematopoietic stem cells are key players in hematopoiesis as the body maintains a physiologic steady state , and the signaling pathways and control mechanisms of these dynamic cells are implicated in processes from inflammation to cancer . (bvsalud.org)
Although the bone marrow is commonly regarded as the site of hematopoiesis and hematopoietic stem cell residence, these cells also circulate in the blood and reside in extramedullary tissues , including the lungs . (bvsalud.org)
Flow cytometry is an invaluable tool in evaluating hematopoietic stem cells , revealing their phenotypes and relative abundances in both healthy and diseased states. (bvsalud.org)
Hematopoiesis in the lungs is a new and emerging concept, and discovering ways in which the study of lung -resident hematopoietic stem cells can be translated from murine models to patients will impact clinical treatment . (bvsalud.org)

We used oligonucleotide arrays to analyze miRNA expression in the murine hematopoietic system. (nih.gov)

The safety profile of venetoclax following allogeneic hematopoietic stem cell transplantation in patients with chronic lymphocytic leukemia appears to be comparable with other reports in clinical trials. (cancernetwork.com)

These factors may regulate myeloid versus lymphoid balance with age, and can potentially mitigate the long-term deleterious effects of inflammation that lead to hematopoietic pathologies. (biorxiv.org)
Physiologic aging in both humans and mice leads to permanent changes in LT-HSC function, such as myeloid-biased hematopoietic output ( Akunuru and Geiger, 2016 ). (biorxiv.org)

Hematopoietic and lymphoid systems. (medlineplus.gov)

No significant alteration of hematopoietic homeostasis and HSC function is observed in young Pus10-/- mice, while aged Pus10-/- mice exhibit mild alteration of hematopoietic homeostasis and HSC function. (haematologica.org)

Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)

Aging of the hematopoietic system promotes various blood, immune, and systemic disorders and is largely driven by hematopoietic stem cell (HSC) dysfunction. (fightaging.org)
Indications for hematopoietic cell transplantation and immune effector cell therapy: Guidelines from the American Society for Transplantation and Cellular Therapy. (msdmanuals.com)

In this webinar, CFC assay expert Dr. Jackie Damen will describe how customized hematopoietic CFC assays can be applied to assist you in the successful development of your small molecule compounds and biologics. (stemcell.com)

An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)

We test these hypotheses by measuring pathogen replicative fitness as within-host viral loads from the onset of infection to the beginning of virus clearance, using the rhabdovirus infectious hematopoietic necrosis virus (IHNV) in salmonid fish. (usgs.gov)
These data suggest that during systemic viral infection primarily hematopoietic cell-derived IFN-I controls viral replication and viral-induced disease. (uzh.ch)

Hematopoietic stem cell mobilizer binds to the CXCR4 chemokine receptor and inhibits the binding of its ligand, stromal cell-derived factor-1-alpha (SDF-1-alpha). (drugs.com)
Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
Hematopoietic cell transplantation improved survival among high-risk genetic subgroups of patients with myelodysplastic syndrome, a recent study found. (curetoday.com)
Hematopoietic cell transplant is currently the only known cure for myelodysplastic syndrome. (curetoday.com)
The current treatment for incomplete hematopoietic recovery includes administration of factors stimulating white and red blood cell growth, such as granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin. (drugdiscoverynews.com)
60 Years Young: The Evolving Role of Allogeneic Hematopoietic Stem Cell Transplantation in Cancer Immunotherapy. (broadinstitute.org)
Products listed include human and murine Dendritic Cell Cytokine Packages and Hematopoietic Stem Cell Expansion Cytokine Packages. (peprotech.com)
Reduced intensity hematopoietic stem cell transplantation for myelofibrosis in accelerated-phase. (physiciansweekly.com)
The outcome of hematopoietic stem cell transplantation for AP myelofibrosis has not been evaluated yet. (physiciansweekly.com)
T cell responses after hematopoietic stem cell transplantation for aggressive relapsing-remitting multiple sclerosis. (stembook.org)
Under immunosuppression conditions, all infectious foci can be activated and, for this reason, all active infections in hematopoietic stem cell pre-transplant patients must be eradicated prior to transplant so as to prevent or reduce the risk of systemic complications in these patients. (bvsalud.org)
Aim: Present a case report of dental care provided to a non-Hodgkin lymphoma patient with an urgent need for hematopoietic stem cell transplant. (bvsalud.org)
Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. (cdc.gov)

Genetic dissection of mesodermal commitment to the hematopoietic fates. (ca.gov)

It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)

Chronic human exposure to benzene has been linked to several hematopoietic disorders, including leukemia and lymphomas. (rti.org)

Transplanted hematopoietic cells1

HSCT8

Make hematopoietic stem2

Homing of hematopoietic stem1

HSCs9

Progenitor cell2

Malignancies3

Progenitors5

Allogeneic hematopoietic-cell3

HSPCs4

Differentiation7

Cells44

Murine hematopoietic1

Transplantation in patients1

Myeloid2

Lymphoid1

Mice1

Toxicity1

Immune2

Assays1

Myeloablative1

Infection2

Cell13

Genetic1

Clinical1

Leukemia1