Hematological interleukin 3. Medical search. Frequent questions

CD123, the interleukin-3 (IL-3) receptor alpha-chain, is highly expressed in various hematological malignancies, including acute myeloid leukemia (AML). (bvsalud.org)
The dysregulation of haematopoiesis may lead to deficiencies (e.g. anaemia, leucocytopenia, thrombocytopenia) or over-production (e.g. haematological malignancies). (sysmex.es)
Dimeo F, Schwartz S, Fietz T, Wanjura T, Boning D, Thiel E: Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapy. (karger.com)
T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. (hindawi.com)
However, T cell exhaustion might lead to the possibility of immune escape of hematological malignancies. (hindawi.com)
Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
Over the last few decades, the treatment of hematological malignancies has gained tremendous headway, but these diseases still have high morbidity and mortality [ 1 - 3 ]. (hindawi.com)
Traditionally, the treatment of hematological malignancies is administrated by chemotherapy, radiotherapy, and stem cell transplantation. (hindawi.com)
In recent years, with the increased understanding of the molecular genetic basis of these malignancies, immune-targeted therapy has become a new possibility for the treatment of hematological malignancies. (hindawi.com)
It is noted that T cell has great potential for immunotherapy of hematological malignancies. (hindawi.com)
In addition, the isolation and storage of umbilical cord blood hematopoietic stem cells have been used to rebuild the immune system for the treatment of hematological malignancies and might be promising for the dynamic equilibrium expansion of functional T cells [ 12 ]. (hindawi.com)
Differential diagnoses include drug allergies and parasitic infections, solid and hematological malignancies (i.e. chronic myeloid leukemia), eosinophilic granulomatosis with polyangiitis and human T cell lymphotropic virus infection (see these terms). (orpha.net)
Apparently, the functions of neutrophils described in hematological malignancies are complex and differ from those observed in solid tumors. (biomedcentral.com)
CD123, the interleukin-3 receptor alpha chain, has been reported to be over-expressed on malignant cells in AML and other hematologic malignancies. (macrogenics.com)
Proteasome inhibition has been proposed as a therapy target for the treatment of solid and hematological malignancies. (aacrjournals.org)
The Australian SerOzNET study has investigated vaccine response in patients with haematological malignancies. (bjh.be)
it was much higher (30%) in patients with haematological malignancies. (bjh.be)
Polymorphism of CD44 influences the efficacy of CD34(+) cells mobilization in patients with hematological malignancies. (cdc.gov)
As a result, growing evidence support the role of this transcription factor in the pathogenesis number of human hematological and solid malignancies. (oncotarget.com)

To improve MRD assessment by MFC, we here evaluate the combination of human Myeloid Inhibitory C-type Lectin (hMICL, also termed C-type lectin domain family 12, member A, CLEC12A) and CD 123 (also termed interleukin-3 receptor alpha, IL3RA) in combination with CD34 and CD117 (KIT), as an MRD assay in pre-clinical and clinical testing in 69 AML patients. (elsevierpure.com)

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. (wikipedia.org)
XOMA 052 is designed to inhibit the pro-inflammatory cytokine interleukin-1 beta that is believed to be a primary trigger of pathologic inflammation in multiple diseases. (biospace.com)
c Representative ( n = 3) Human XL cytokine array output after a 24-h incubation in either mono or co-culture, cell supernatant was used for analysis. (biomedcentral.com)
Representative ( n = 3) image of cytokine array ( e ) and subsequent graphical representation ( f ) of analysis using HL++ software. (biomedcentral.com)

Human immunodeficiency virus (HIV) infection is characterized by excessive and dysregulated production of both proinflammatory and antiinflammatory interleukins, which produces various hematological changes. (ssajm.org)

Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy that relies on highly heterogeneous cytogenetic alterations. (mdpi.com)

There was also evidence of down-regulation of serum interleukin 6, a downstream nuclear factor κB effector. (aacrjournals.org)

Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation of malignant plasma cells in the bone marrow microenvironment. (confex.com)
AML is a hematological malignancy characterized by differentiation arrest and uncontrolled clonal proliferation of neoplastic precursors that prevent normal bone marrow hematopoiesis. (macrogenics.com)

Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. (cdc.gov)
The activation of macrophages leads to the production of T helper 1 (Th1) inflammatory cytokines such as tumor necrosis factor- (TNF-) α , interleukin- (IL-) 1 β , IL-6, and IL-12, whereas limited activation develops into a Th2 response (IL-4 secretion) [ 11 - 13 ]. (hindawi.com)
Genetic expressions of tumor necrosis factor (TNF-α), interleukins (IL-1β, IL-6), necrosis factor (NF-κB), and cyclooxygenase (COX-II) enzyme were studied using real-time qPCR. (iasp-pain.org)
3. Bost, T.W., Riches, D.W. and Schumacher, B. Alveolar macrophages from patients with beryllium disease and sarcoidosis express increased levels of mRNA for tumor necrosis factor alpha and interleukin-1 beta. (pacificejournals.com)

In response to transforming growth factor (TGF)-β, interferon (IFN)-β, or interleukin (IL)-35, neutrophils shift from the N1 to the N2 phenotype and support tumor progression [ 4 ]. (biomedcentral.com)
Levels of neutralising antibodies against wild-type, delta and omicron variants, S-protein IgG antibody, T-cell response by levels of interferon-g, tumour necrosis factor-a, interleukins 2/4/5/13, and epigenetic profiling of T cells were measured. (bjh.be)
interestingly, antibodies against granulocyte macrophage colony-stimulating factor, interferon, interleukin 1, and interleukin 6 in immune globulin have biologic activity in vivo. (medscape.com)

no treatment has consistently led to prolonged survival and/or hematological remission apart from an allogeneic stem cell transplant, the authors wrote. (ajmc.com)
MacroGenics plans a single-arm, registration-enabling clinical study to evaluate flotetuzumab in up to 200 patients with PIF/ER AML, with complete remission (CR) and CR with partial hematological recovery (CRh) as the primary endpoint. (macrogenics.com)

The Janus kinase (JAK)/Signal transducer and activator of transcription 3 (STAT3) pathway in MM can be both constitutively active due to autonomous mutations or activated by growth and survival factors, such as interleukin-6 (IL-6), secreted by bone marrow stromal cells and other cells within the bone marrow microenvironment. (confex.com)

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. (biomedcentral.com)

1 B cell neoplasms other than multiple myeloma including non-Hodgkin's lymphomas, and acute and chronic leukaemias might also exhibit lytic bone lesions, hypercalcaemia, and monoclonal gammopathy via the particular actions of interleukin (IL-1), IL-6, or tumour necrosis factor-α secreted by the neoplastic B cell clone, but not reported previously secondary to a primary cerebral lymphoma. (bmj.com)

The diversity of the roles that neutrophils play in the neoplastic process results from their remarkable ability to respond to many different factors and cytokines that may also alter their functions [ 3 ]. (biomedcentral.com)
This article provides a controlled evaluation of the ability of dietary supplementation with a commercially available rice bran extract modified with shitake mushroom extract (MGN-3) to support the immune function by assessing the ability of immunocytes to proliferate and produce cytokines in response to a mitogenic challenge. (biobran.org)

5. Hill, R.J., Warren, M.K. and Levin, J. Stimulation of thrombopoiesis in mice by human recombinant interleukin-6. (pacificejournals.com)

In 2011, XOMA and Servier expect to hold discussions with multiple regulatory agencies to initiate Phase 3 studies of XOMA 052 in Behcet's uveitis, a debilitating ophthalmic inflammatory condition that often leads to vision-threatening complications including blindness. (biospace.com)
Hematological parameters and systemic inflammatory indicators evaluated. (iasp-pain.org)
Ben A.P., Crofford L.J., Wilder R.L., and Hla T., (1995) Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis. (ncl.edu.tw)

Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: Evidence for decreased platelet production. (edu.pk)
Induction of growth factors [interleukin 6 (IL-6), insulin-like growth factor-1, and vascular endothelial growth factor/platelet-derived growth factor) may indirectly activate the AR and/or its downstream signaling pathways (5, 6, 7) . (aacrjournals.org)

Multiple myeloma (MM) is a lethal haematological malignancy with an incidence of 40-60 per 1,000,000 per year. (touchoncology.com)
These factors also contributed to increased chemo-resistance in multiple myeloma to established agents like Bortezomib 3 . (ijpsr.com)

NF-κB ( Nuclear Factor kappa B ) is a ubiquitous family of transcription factors involved in biological processes such as inflammation, immunity, proliferation and apoptosis [ 1 - 3 ]. (oncotarget.com)

59% female) with either solid or haematological cancers (32%) from July-November 2021. (bjh.be)
PeerJ 2021 3 9 e10678. (cdc.gov)

Anemia may cause shortness of breath, cardiovascular complication, poor performance status, impairment of cognitive, and fatigue in lymphoma patients [3]. (waocp.com)
The most common type of anemia in patients with lymphoma is anemia of chronic disease, followed with secondary anemia due to marrow involvement, iron deficiency anemia (IDA), vitamin B-12 deficiency, and hemolytic anemia [3]. (waocp.com)
In developing countries, majority of the lymphoma patients had high prevalence of anemia with bone marrow involvement as one of the causative factors and most of them were diagnosed with advanced stages of disease [3]. (waocp.com)
Patients were administered vaccines, and blood samples were taken for analysis at 0 and 3-4 weeks post-dose 1, 2, 3 and 4, respectively. (bjh.be)
Cancer cachexia is characterized by a decrease in body weight and food consumption and occurs in 80% of patients with progressive cancer, causing at least 20% of cancer-related deaths [ 1 - 3 ]. (oncotarget.com)
This study described hematological changes in HIV-positive patients in Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. (ssajm.org)
All 88 patients were evaluated for full blood count and CD4 + T-cell count as well as interleukins 6 and 10 assays. (ssajm.org)
Une étude a été menée dans des unités de soins intensifs en chirurgie pour adultes de l'hôpital universitaire de Zagazig, (Égypte) auprès de 25 patients atteints de septicémie, de 27 patients atteints d'une septicémie sévère et de 28 témoins. (who.int)
SCD patients with fever, severe anaemia or pancytopenia should be investigated for early diagnosis and prompt treatment of IAH, which is a life- threatening haematological emergency for which transfusion therapy alone may not suffice. (bvsalud.org)

However, in 82As2 cells, LIF production was significantly increased by stimulation with TLR5, which was suppressed by an inhibitor of interleukin-1 receptor-associated kinase-1/4, which are important factors in the TLR5 signaling pathway. (oncotarget.com)
Constitutive p50/p65 activity is observed in a large variety of hematological as well as solid tumors [ 6 - 8 ], as a result of an aberrant expression of p50/p65, deletions of the IκBα inhibitor gene or an increased IKK activity [ 9 - 13 ]. (oncotarget.com)

Nuclear factor-κB (NF-κB) is closely linked to prolonged survival rate due to interleukin and growth factor indipendce from the bone marrow. (ijpsr.com)
As 2 O 3 (ATO) acts directly on MM cells at relatively low concentrations, which effects survival and apoptosis of MM cell lines U-266 and RPMI-8226. (ijpsr.com)

similar to IL-6-null mice (see Additional information [2]), these mice exhibit impaired humoral and mucosal immunity, and like leukemia inhibitory factor (LIF)-deficient females (see Additional information [3]) were infertile. (biomedcentral.com)
Impaired immune and acute-phase responses in interleukin-6-deficient mice. (biomedcentral.com)
After 55 days, infected diabetic mice exhibited fewer leukocytes in both peritoneal lavage fluid (PeLF) and bronchoalveolar lavage fluid and reduced secretion of interleukin- (IL-) 6 in lungs. (hindawi.com)

Humoral and cellular immune response to Sars-CoV-2 wild-type and variants of concern following 3-dose vaccination in a large cohort of adults with cancer: The SerOzNET study. (bjh.be)

At the doses of 500 mg/Kg ( ≤ .05) and 1000 mg/Kg ( ≤ .001), IGE significantly reduced TNF-α, interleukins, and COX-II mRNA expression. (iasp-pain.org)

It is the second most common hematological malignancy responsible for around 15% to 20% percent of deaths of all hematological cancer and around 2% of deaths from all cancers 2 . (ijpsr.com)

5(3): zcad048, 2023 Sep. (bvsalud.org)

However, in roughly 3/4 of cases, pathogenesis remains unknown, now defining idiopathic HES. (orpha.net)

Likewise, in the early stages of prostate cancer, the growth of cancerous prostatic epithelial cells is often androgen dependent (3) . (aacrjournals.org)
In RPMI-8226 cells evident activation of caspase 3 by ATO was seen. (ijpsr.com)
Blood Cells Mol Dis 2008;40(3):339-46. (hepcidinanalysis.com)
The 2 2 and 3 subunits are only weakly recognized in additional cells, including mind (Wallner et al. (health-e-nc.org)

Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)

3 2 Under physiological hypoxia, low oxygen levels lead to reduced activity of succinate dehydrogenase (SDH), which metabolizes succinate, and other oxygen-dependent enzymes in the electron transport chain, causing succinate accumulation. (haematologica.org)
6 3 In fact, one of the first pieces of evidence for a role of succinate in cancer development was provided by the discovery of pseudohypoxia, which refers to activation of hypoxia signaling pathways under normal oxygen levels. (haematologica.org)

Interleukin-10 gene polymorphism in bone marrow transplant recipients. (cdc.gov)
Influence of ABCB1, CYP3A4*18B and CYP3A5*3 polymorphisms on cyclosporine A pharmacokinetics in bone marrow transplant recipients. (cdc.gov)

It is assumed that interleukin 6 in the liver activates the homologue of the human longevity gene mINDY expression via binding to its IL-6-receptor, which is associated with activation of the transcription factor STAT3 (which binds to the binding site in the mIndy promoter) and thereby rise of citrate uptake and hepatic lipogenesis. (wikipedia.org)
[ 3 ] IVIGs are sterile, purified IgG products manufactured from pooled human plasma and typically contain more than 95% unmodified IgG, which has intact Fc-dependent effector functions and only trace amounts of immunoglobulin A (IgA) or immunoglobulin M (IgM). (medscape.com)

Growth factors include for example erythropoietin (EPO), thrombopoietin (TPO), interleukins (e.g. (sysmex.es)

Binding of a tumor antigen via the scFv activates the T cell in a major histocompatibility-independent manner which leads to a cytotoxic response [ 3 ]. (nature.com)

The aim of this study was to evaluate the effect of 12 weeks aerobic training and oral green tea extract on cardiac caspase-3 expression in aged male rats. (ac.ir)
Immunohistochemistry method was used to measure the expression of caspase-3. (ac.ir)
Results: The results show that caspase-3 expression was significantly lower in exercise group (18%), supplement group (13%) and exercise + supplement group (43%), than the control group (p≤0.05). (ac.ir)
HSP70 reduces caspase activation (mainly caspase-3) and suppresses mitochondrial damage and nuclear fragmentation. (biomedcentral.com)

This study examines the efficacy of Biobran/MGN-3 against SARS-CoV-2. (biobran.org)

In this study, five treatments including field sanitation (T 1 ), pheromone-based attract and kill strategy (T 2 ), protein-based bait method (T 3 ), combination of all three methods (T 4 ) and control (T 5 ) were evaluated against B. dorsalis infestation in citrus during 2015 and 2016. (researcherslinks.com)
The study participants from the main group received a dietary supplement containing Siberian fir terpenes, limonene, alpha-linolenic acid, and vitamin E-1 capsule 3 times a day for 90 days. (frontiersin.org)

AML is a highly heterogeneous hematological disease and is the second most common form of leukemia. (mdpi.com)

1999). 2 Subunit manifestation is especially abundant in ovaries, whereas 3 shows the (S,R,S)-AHPC hydrochloride highest manifestation in the pancreas and testis. (health-e-nc.org)

Interleukin-6 receptor antagonists (IL-6RAs) and steroids are emerging immunomodulatory therapies for severe and critical coronavirus disease (COVID-19). (biomedcentral.com)

Several studies have shown promise in targeting prosurvival BCL2 family members with BCL2 homology domain 3 (BH3) mimetics in MM. (confex.com)
Although the exact origin of SARS-CoV-2 is not known, it is understood that its viral structure is 96.2% similar to CoV-RaTG13, which mainly affects bats and is 79.5% like SARS-CoV than the other presented forms of the coronavirus family 1-3 . (bvsalud.org)

Anatomy46

Organisms10

Diseases10

Chemicals and Drugs131

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes33

Disciplines and Occupations1

Information Science3

Health Care2

Malignancies20

Termed interleukin-3 recept1

Cytokine4

Various hematological1

Acute myeloid1

Serum interleukin1

Malignancy characterized2

Tumor necros4

Interferon3

Remission2

Activator of transcription1

Signal transducer1

Tumour1

Cytokines2

Recombinant1

Inflammatory3

Platelet2

Multiple Myeloma2

Proliferation1

20212

Patients9

Inhibitor2

Survival2

Mice3

Immune1

MRNA1

Cancers1

20231

Pathogenesis1

Cells4

Diseases1

Levels2

Bone2

Human2

Growth1

Antigen1

Caspase4

Efficacy1

Study2

Second most common1

Subunit1

Disease1

Family2