Hematological affects leukemia. Medical search. Frequent questions

The pharmacokinetics of rasburicase were evaluated in both pediatric and adult patients with leukemia, lymphoma or other hematological malignancies. (wikipedia.org)
Its two lead molecules, TTI-622 and TTI-621, block the signal-regulatory protein α (SIRPα)-CD47 axis, which is emerging as a key immune checkpoint in hematological malignancies. (pfizer.com)
TTI-622 and TTI-621 are novel SIRPα-Fc fusion proteins that are currently in Phase 1b/2 development across several indications, with a focus on hematological malignancies. (pfizer.com)
Acute myeloid leukemia (AML) is a heterogeneous group of aggressive hematological malignancies commonly associated with treatment resistance, high risk of relapse, and mitochondrial dysregulation. (nature.com)
DNA methylation is common in hematological malignancies. (hindawi.com)
In general, the male population is more affected by hematological malignancies. (sld.cu)
Therapeutic antibodies blocking "don't eat me" signals exhibited potent preclinical and early clinical efficacy against solid tumors and hematological malignancies. (aap.com.au)
These pre-clinical data support the further development and evaluation of ATG-031 in the Phase I, multicenter, dose escalating clinical trial in patients with solid tumors and hematological malignancies. (aap.com.au)
Hematological malignancies are the kinds of cancer affecting blood, bone marrow and lymph nodes. (medgadget.com)
The group has focused on patients with hematological cancers, particularly acute myeloid leukemia (AML), since standard therapies for the advanced forms of these malignancies have a limited effect and the outcome is invariably poor. (impactlab.com)
The aim of this review is to summarize the PD-1 and PD-L1 biological functions and their alterative expression in hematological malignancies. (biomedcentral.com)
The role of PD-1 and PD-L1 in T-cell immune suppression and the potential for immunotherapy via blocking PD-1 and PD-L1 in hematological malignancies are also reviewed. (biomedcentral.com)
Leukemia, particularly aggressive refractory hematological malignancies unresponsive to upfront therapy, remains a difficult condition to treat. (biomedcentral.com)
Hematological malignancies are defined by their underlying genetic alterations, many of which are used to diagnose patients to classify them to different risk groups that dictate the therapy given. (avhandlingar.se)
In particular, flubendazole has shown significant anti-tumor effects in animal models of hematological malignancies, including lymphoma and leukemia. (fenbenmed.com)
Apparently, the functions of neutrophils described in hematological malignancies are complex and differ from those observed in solid tumors. (biomedcentral.com)
To ensure a wider access to clozapine therapy, which is the most effective antipsychotic drug, our results suggest that patients and caregivers should be informed about early signs of hematological malignancies, just as they are currently encouraged to monitor early signs of agranulocytosis ," wrote Jari Tiihonen, M.D., of the Karolinska Institutet and colleagues. (psychnews.org)
Invasive fungal rhinosinusitis (IFRS) generally occurs in immunocompromised patients, i.e. those with haematological malignancies or undergoing chemotherapy or allogeneic haematopoietic transplantation, patients with AIDS, and in poorly controlled diabetic patients undergoing immunosuppressive therapy 4 . (actaitalica.it)
The oncogene activation of FLT3 in hematological malignancies is mainly manifested through internal tandem duplication which may result in a poor prognosis [ 8 ]. (hindawi.com)
However, no exhibited amplification of FLT3 on dmins has been reported in hematological malignancies. (hindawi.com)
Later, many cases have been reported in heart, kidney, and bone marrow transplant recipients and patients with hematological malignancies. (medscape.com)
This is probably due to underdiagnosis and underreporting of this disease in patients with hematological malignancies or solid organ transplantation. (medscape.com)
SETBP1 variants occur as somatic mutations in several hematological malignancies such as atypical chronic myeloid leukemia and as de novo germline mutations in the Schinzel-Giedion syndrome. (nih.gov)
In summary, this work unveils a SETBP1 function that directly affects gene transcription and clarifies the mechanism operating in myeloid malignancies and in the Schinzel-Giedion syndrome caused by SETBP1 mutations. (nih.gov)
In hematological malignancies, exosome-mediated expulsion of a number of key proteins and micro RNAs, resulting in influence of major tumor-related pathways. (bbrc.in)
Furthermore, exosomes contain a great variety of bioactive molecules and are emerging as rich reservoirs of hematological tumor-specific biomarkers for the detection and therapeutics.This comprehensive review highlights the advancements in understanding of the pathogenesis of exosomes secretion and the consequence onhematological malignancies development. (bbrc.in)
Xia B, Li M, Yang R, Wang X, Shun C, Zhang Y. The Central Roles of Exosomes in Hematological Malignancies: A New Frontier Review. (bbrc.in)
Hematological malignancies, which include lymphoid, myeloid, histiocytic, and mast cell neoplasms, are a heterogeneous group of diseases of diverse incidence, pathogenesis and prognosis (Kornblau et al . (bbrc.in)
1998). The prognosis of hematological malignancies patients diverges greatly, largely depending on thepathological types of the patient (Li et al . (bbrc.in)
Mucorales growths are the most widely recognized parasites found in hematological malignancies, hematopoietic immature microorganism transplantation, and strong organ transplantation after Aspergillus [3]. (fortuneonline.org)
Pediatric radiation therapy survivors incur risk for radiation-induced hematological malignancies related to red bone marrow (RBM) dose. (appliedradiationoncology.com)
This finding suggests that further study is warranted with a larger sample set that is more uniformly distributed in age and sex to assess the impact on clinical or research studies of the risk of subsequent hematological malignancies for survivors of childhood radiation therapy. (appliedradiationoncology.com)
Excess-radiation-induced hematological malignancies (eg, acute myeloid leukemia) have been observed in survivors of pediatric radiation therapy. (appliedradiationoncology.com)
The purpose of this study was to assess the effect of chronic inhalation exposure to mixtures of nitrous - oxide (10024972) (NO) and halothane (151677) (HT) on the reticuloendothelial malignancies in rats. (cdc.gov)
Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies. (lu.se)
Neoplastic meningitis is a complication of solid and hematological malignancies. (medscape.com)
The NCI group has published a recent update of one of their studies, with an additional 10 years of follow-up, and it continues to suggest a possible link between formaldehyde exposure and mortality due to lymphohematopoietic malignancies, particularly myeloid leukemia (Beane Freeman, Blair et al. (who.int)

Acute leukemia (AL) is a critical hematological malignancy with increasing incidence year by year [ 1 ]. (hindawi.com)
Acute myeloid leukemia (AML) is a hematological malignancy affecting different organ systems including the eye. (dovepress.com)
Chemotherapy is still the current standard treatment for hematological malignancy and febrile neutropenia is a common complication of chemotherapy in most patients [ 1 ]. (biomedcentral.com)
OBJECTIVE: Acute myeloid leukemia (AML) is a hematological malignancy that frequently affects elderly population. (northclinist.com)
This hematological malignancy mainly affects the elderly population (those aged over 65), which usually presents a high rate of therapeutic failure and an unfavorable prognosis. (bvsalud.org)
however, patients who used clozapine for five years or more were about three times as likely as patients who had never used clozapine to be diagnosed with a hematological malignancy. (psychnews.org)
During the 17-year follow-up, 37 deaths were due to hematological malignancy among patients exposed to clozapine versus three deaths from agranulocytosis, the authors noted. (psychnews.org)
M]ental health clinicians should be vigilant for signs and symptoms of hematological malignancy in patients treated with clozapine. (psychnews.org)
BPDCN is a very rare and aggressive hematological malignancy that is derived from plasmacytoid dendritic cell precursors. (cellectis.com)

Rasburicase is approved for use by the U.S. Food and Drug Administration (and European counterparts) for the prevention and treatment of tumor lysis syndrome (TLS) in people receiving chemotherapy for hematologic cancers such as leukemias and lymphomas. (wikipedia.org)
See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
The most commonly diagnosed blood cancers are non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute myeloid leukemia, acute lymphoblastic leukemia and multiple myeloma. (medgadget.com)
Overall, our results suggest that berberine, curcumin and picroliv were able to suppress the progression of leukemia induced by FMuLv and further support their chemopreventive potential against virally induced cancers. (oldcitypublishing.com)
A functional precision medicine study conducted in Finland demonstrates that treatment selection based on results from drug sensitivity testing of patients' cells can be clinically useful in patients with aggressive hematological cancers. (impactlab.com)
Here we provide an overview of the most prominent CSC markers, focusing on solid cancers (lung, stomach, liver, breast, and colorectal cancers) and hematological cancers (acute and chronic myeloid leukemia). (atlasantibodies.com)
Hematological cancers (blood cancers) arise in the blood-forming tissues, such as bone marrow, lymph nodes, and lymphatic system. (atlasantibodies.com)
Acute (AML) and chronic (CML) myeloid leukemia are cancers of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. (atlasantibodies.com)
People who take the antipsychotic clozapine for more than five years may be at a slightly increased risk of developing blood cancers such as leukemia or lymphoma compared with people who take other antipsychotics, a report in The Lancet Psychiatry has found. (psychnews.org)

Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
There was a significant improvement in survival of Acute Myeloid Leukemia, Chronic Lymphoid leukemia, CML and ALL, the latter approximately with 90% cure rate in children. (sld.cu)
In leukemias, a clone of malignant cells may arise at any stage of maturation, that is, in the lymphoid, myeloid, or pluripotential stage. (medscape.com)
Acute leukemia is a group of diseases affecting either the lymphoid or myeloid lineage in hematopoiesis, resulting in acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). (avhandlingar.se)

For examples include acute lymphoblastic leukemia, chronic lymphocytic leukemia, lymphomas and multiple myeloma. (medgadget.com)
Since these tissues are all intimately connected through both the circulatory and the immune system, a disease affecting one system will often affect the other as well, making myeloproliferation (leukemias) and lymphoproliferation (lymphomas) closely related and often overlapping conditions. (atlasantibodies.com)
It occurs in 4% to 15% of solid tumors and up to 20% of lymphomas and leukemias, and it is associated with significant morbidity and short survival rates (range, several weeks to 8 months). (medscape.com)

Acute myeloid leukemia (AML) is a malignant disorder of the hematopoietic stem cells characterized by abnormal proliferation of myeloid blast cells in the bone marrow and blood, preventing them from further differentiating into the specialized cells of the bone marrow and thus causing pancytopenia. (dovepress.com)
Chronic myeloid leukemia (CML) is a clonal expansion of the progenitor hematopoietic stem cells arising from the existence of the fusion BCR-ABL oncogene, that represents 15%-20% of the newly diagnosed cases of leukemia patients [ 1 - 2 ]. (jcancer.org)

The purpose of this review is to present and evaluate the medical literature regarding the early ophthalmological manifestations of acute myeloid leukemia. (dovepress.com)
11 The purpose of this review is to present and evaluate the medical literature on the early ophthalmological manifestations of acute myeloid leukemia, which physicians should be aware of for an earlier and more efficient diagnosis and treatment. (dovepress.com)
PubMed, Embase, and Science Direct databases were searched with the keywords [(Acute Myeloid Leukemia) OR (AML)] AND (Ophthalmic Manifestations). (dovepress.com)
or exp Ophthalmology/)] AND (acute myeloid leukemia.mp. (dovepress.com)
As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
Hematologic Malignancie market report is segmented on the basis of type, therapy and by regional & country level.Based upontype, Hematologic Malignancie market is classified intoLeukemia, Acute Lymphocytic Leukemia, Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Lymphoma,Multiple Myeloma and Others. (medgadget.com)
A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia. (cancerindex.org)
Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have a dismal outcome. (cancerindex.org)
The researchers tested the effects of more than 500 candidate drugs on the patient cells from 186 patients with relapsed adult acute myeloid leukemia (AML), a disease characterized by poor prognosis. (impactlab.com)
METHODS: Forty one patients with chronic myeloid leukemia treated with asciminib from 2018 to 2022 were reviewed and analyzed for the efficacy and tolerability of asciminib using real-world experience data. (bvsalud.org)
We systematically investigate functional and molecular measures of stemness in patients with acute myeloid leukemia (AML) using a cohort of 121 individuals. (bvsalud.org)
3) The effect of hematological growth fucoxanthin on severe myeloid leukemia HL-60 cell line. (zspharmac.com)
Chronic myeloid leukemia (CML) is characterized by the uncontrolled proliferation of hematopoietic cells carrying the Philadelphia chromosome (Ph), the product of reciprocal translocation between chromosomes 9 and 22, t(9;22)(q34.1;q11.2). (touchoncology.com)
CSCs were first identified in hematological cancer such as acute myeloid leukemia in the late '90s when scientists isolated a subpopulation of leukemia cells that expressed the surface marker CD34 but not CD38. (atlasantibodies.com)
Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. (jcancer.org)
Consequently, various DC-based antitumor therapeutic strategies have been developed, particularly vaccines, and have been intensively investigated specifically in the context of acute myeloid leukemia (AML). (bvsalud.org)
The frequencies of dmin in acute myeloid leukemia (AML) range from 0.3% to 2.8% [ 4 ]. (hindawi.com)
Nasdaq: CLLS), a biopharmaceutical company focused on developing immunotherapies based on gene edited CAR T-cells (UCART), has received an Investigational New Drug (IND) approval from the U.S. Food and Drug Administration (FDA) to conduct Phase 1 clinical trials with UCART123, the Company's most advanced, wholly owned TALEN® gene-edited product candidate, in patients with acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). (cellectis.com)
In the current study, we used the genome and transcriptome data from The Cancer Genome Atlas-Acute Myeloid Leukemia (TCGA-AML) cohort. (mdpi.com)
Based on feedback from the FDA, Celyad finalized the EPITHINK protocol, which is evaluating the synergetic effect of the concurrent administration of CYAD-01 (CAR-T NKG2D) with a standard of care 5-azacytidine (AZA) in treatment-naïve Acute Myeloid Leukemia (AML) or myelodysplastic syndrome (MDS) patients who are not candidates for intensive therapy. (prohostbiotech.com)
Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD. (lu.se)
A rearrangement (translocation) of genetic material between chromosomes 9 and 22 causes a type of cancer of blood-forming cells called chronic myeloid leukemia. (medlineplus.gov)
The Working Group was not aware of any good rodent models that simulate the occurrence of acute myeloid leukemia in humans. (who.int)
Therefore, on the basis of the data available at this time, it was not possible to identify a mechanism for the induction of myeloid leukemia in humans. (who.int)

Many patients with chronic leukemias are asymptomatic. (medscape.com)
Some chronic leukemias enter a blast phase where the clinical manifestations are similar to the acute leukemias. (medscape.com)

Our present research is aimed at studying the abnormal expression of GRHL2 and the association of methylation in patients with acute leukemia and its relationship with prognosis. (hindawi.com)
We analyzed the significant correlation between the expression level of GRHL2 with clinicopathological features and patients' prognosis in acute leukemia using the corresponding statistical methods. (hindawi.com)
Increased expression and methylation level of GRHL2 are closely associated with the prognosis and malignant phenotype of acute leukemia patients and play an irreplaceable role in the occurrence and development of patients with acute leukemia. (hindawi.com)
1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia. (cancerindex.org)
A diagnosis of neoplastic meningitis is generally suggestive of advanced disease, and the overall prognosis is affected by controlling leptomeningeal disease. (medscape.com)

A study by Wang et al found that when they studied the landscape of somatic mutations in chronic lymphocytic leukemia, pre-mRNA splicing was an important cellular process. (medscape.com)
Genomic characterization of mouse leukemias unveiled de novo signaling mutations in several mice harboring only a KMT2A-R, emphasizing the importance of such mutations in KMT2A-R leukemogenesis. (avhandlingar.se)
Genes controlled by SETBP1 such as MECOM are significantly upregulated in leukemias containing SETBP1 mutations. (nih.gov)
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. (lu.se)
Missense mutations in SH2D1A identified in patients with X-linked lymphoproliferative disease differentially affect the expression and function of SAP. (lu.se)
PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. (lu.se)

It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
Moreover, oral mucositis induces pediatric patients to reduce food intake, which affects their nutritional status and makes them less responsive to treatment 4-5 . (bvsalud.org)

This study aimed to evaluate the efficacy of fenbendazole in enhancing the anti-tumor effect of standard chemotherapy drugs in patients with NB. (fenbenmed.com)

Long-term clozapine use has a higher effect on mortality due to lymphoma and leukemia than due to agranulocytosis," Tiihonen and colleagues wrote. (psychnews.org)

Leukemias are a group of heterogeneous neoplastic disorders of white blood cells. (medscape.com)
Nevertheless, the identification of novel additional molecular alterations is of great interest, opening to new prognostic and therapeutic strategies for such heterogeneous hematological disease. (cancerindex.org)

It is believed that the occurrence of leukemia is the result of genetic and epigenetic changes in protooncogene and tumor suppressor genes [ 8 ]. (hindawi.com)
Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (atlasgeneticsoncology.org)
Recently, it has been reported by many workers that the potential functions of exosomes contributed to various aspects of hematological tumorigenesis, particularly with a focus on the exosome-mediated tumor progression, metastasis, drug resistance and immune escape by altering the function of receiver cells via diverse exosomal cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs) (Whiteside and Boyiadzis, (2017). (bbrc.in)

Examples of hematologic cancer include leukemia, lymphoma, and multiple myeloma. (atlasantibodies.com)

Taken together, the work included in this thesis highlights the major impact that specific genetic alterations have on leukemogenesis, and how their autonomous and non-autonomous cooperation influence clonal evolution, disease phenotype, and molecular profiles of the leukemia. (avhandlingar.se)
We analyzed both the phenotype and activity of neutrophils isolated from the spleens of TCL1 leukemia-bearing mice. (biomedcentral.com)
Additionally, we show that Treg depletion and IL-10 neutralization induce changes in the leukemia microenvironment, partially restoring the "healthy" phenotype of neutrophils. (biomedcentral.com)

Acute myelogenous leukemia (AML) is a group of neoplastic disorders of the hematopoietic precursor cells of the bone marrow. (medscape.com)
The HaeMa laboratory in Mannheim covers a broad range of hematological diagnostics for detecting diseases and disorders affecting the blood cells - from reactive changes to leukemias. (jenoptik.com)
In this study, clinical characteristics were retrospectively reviewed and their correlation with outcome was evaluated to identify prognostic factors in patients with hematological disorders and IFS. (biomedcentral.com)
1993). Leukemia and Other Related Hematological Disorders Among Danish Patients Exposed to Thorotrast. (cdc.gov)

Ophthalmic manifestations of leukemia are more frequent with acute than chronic leukemia and can affect all intraocular structures. (dovepress.com)

Acute leukemia is an aggressive cancer with multiple subtypes. (ugent.be)

Leukemia 2007(6): 1303-5 [ PubMed abstract ]. (lu.se)
Leukemia 2006(6): 1155-8 [ PubMed abstract ]. (lu.se)

The presence of an activating mutation affected the leukemias transcriptional profiles by further enhancing transcriptional programs previously associated with KMT2A-Rs. (avhandlingar.se)
Here, we determined the effect of Jiyuan oridonin A (JOA), an ent -kaurene diterpenoid compound, on the differentiation blockade in imatinib-sensitive, particularly, imatinib-resistant CML cells with BCR-ABL-T315I mutation by cell proliferation assay, apoptosis analysis, cell differentiation analysis, cell cycle analysis and colony formation assay. (jcancer.org)
Clonal duplication of a germline PTPN11 mutation due to acquired uniparental disomy in acute lymphoblastic leukemia blasts from a patient with Noonan syndrome. (lu.se)

It is also called as hematological disease. (medgadget.com)
A retrospective study of hospitalized patients with hematological disease was conducted at National Taiwan University Hospital between January 1995 and December 2009. (biomedcentral.com)
Invasive fungal sinusitis (IFS) is a rare disease largely attributable to Aspergillus and Mucor in patients with stem cell transplants and hematological disease [ 9 ]. (biomedcentral.com)
In addition, PD-1/PD-L1 interactions contribute to functional T-cell impairment, which fails to elicit minimal residual disease and may be related to leukemia relapse. (biomedcentral.com)
Microscopic analysis of stained blood slides is crucial method for identification of hematological disease. (discoveryjournals.org)
Genomic amplification of FLT3 has not been reported in hematological disease. (hindawi.com)
BPDCN is a disease of bone marrow and blood cells but also often affects skin and lymph nodes. (cellectis.com)
The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. (lu.se)
Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation. (cdc.gov)

To understand the effect of these compounds in the initiation and progression of leukemia we did a series of analysis, which include hematological and biochemical parameters, histopathological evaluations of the liver and the spleen and expression analysis of selected genes such as Bcl-2, p53, p45 NFE2 , Raf-1, Erk-1, IFNgamma receptor and erythropoietin in spleen. (oldcitypublishing.com)
Indeed, neutrophils are able to support leukemia progression through mechanisms that mimic the cooperation of neutrophils with healthy regulatory B cells [ 6 ]. (biomedcentral.com)
The progression of chronic lymphocytic leukemia (CLL) is strongly associated with the modification of diverse immune cell populations to create a niche appropriate for the proliferation and survival of leukemic B cells. (biomedcentral.com)

Acute lymphocytic leukemia (ALL) is a malignant clonal disorder of the bone marrow lymphopoietic precursor cells. (medscape.com)

Only one new report from an original epidemiology study in relation to leukemia induction by formaldehyde has been published since the last review. (who.int)

Kinetics and Risk Factors of Relapse after Allogeneic Stem Cell Transplantation in Children with Leukemia: A Long-Term Follow-Up Single-Center Study. (cdc.gov)
69 Years with Acute Myelogenous Leukemia: On Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. (cdc.gov)

AML affects the ocular system through direct infiltration of tissues, secondary to hematological abnormalities, or in the form of chloroma or myeloid sarcoma in the brain or orbit consequently leading to a variety of manifestations depending on the ocular tissue involved. (dovepress.com)

However, it does indicate quite convincingly that if the unique phytochemical molecules found in grapeseed extract can be delivered to leukemia cells with sufficient potency, they may play an important role in cancer cells destroying themselves, thereby protecting the whole organism from runaway cancer. (infiniteunknown.net)
Fucoxanthin has excellent antioxidant results, even far better than vitamin E and vitamin C. Fucoxanthin has a protective effect on human fiber cell damage caused by UV-B. The antioxidant result of fucoxanthin is mostly with managing the task of Na+- K+- ATPase, as well as the task of catalase and glutathione in tissues and molecules brought on by retinol shortage. (zspharmac.com)
In particular I am involved in the design, synthesis and in the preliminary biological evaluation of small molecules and PROTACs against important TFs in acute leukemia. (ugent.be)
Inhibition of HMG-CoA reductase by statin in effect prevents the synthesis of mevalonic acid, a precursor of nonsteroidal isoprenoids, lipid attachment molecules for small G proteins, such as Ras, Rho, and Rac. (cdc.gov)

Impaired neutrophil activity is an important issue in chronic lymphocytic leukemia (CLL), as it contributes to a dysfunctional immune response leading to life-threatening infections in patients. (biomedcentral.com)

The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation. (nature.com)
Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore. (nature.com)
A new study conducted at the University of Kentucky in the United States, and published in the journal Clinical Cancer Research , found that leukemia cancer cells exposed to grapeseed extract (GSE) were rapidly killed through a process of cell suicide known as "apoptosis. (infiniteunknown.net)
In these laboratory studies, an astonishing 76% of leukemia cells committed suicide within 24 hours thanks to the ability of GSE to activate a protein called JNK, which regulates apoptosis. (infiniteunknown.net)

1991). Neoplastic Transformation and the Inverse Dose-rate Effect for Neutrons. (cdc.gov)

1994). Relationship of Leukemia Risk to Radiation Dose Following Cancer of the Uterine Corpus. (cdc.gov)

This single-centre retrospective study included 17 patients affected by IFRS who underwent endoscopic sinus surgery (ESS) at the ENT Department in San Luigi Gonzaga Hospital, Turin, Italy between January 2016 and January 2020. (actaitalica.it)

Microscopic examination of slides with May-Grünwald-Giemsa stained smears of blood and bone marrow, based on the method developed by Arthur von Pappenheim more than 100 years ago, is still the standard and basis of hematological diagnostics, even in the age of immunophenotyping, PCR and Next-Generation Sequencing (NGS). (jenoptik.com)

Refinement of the commonly deleted segment in myeloid leukemias with a del(20q). (atlasgeneticsoncology.org)
Chronic IFRS is an indolent infection with a slow destructive process that most commonly affects the ethmoid and sphenoid sinuses, but may involve any paranasal sinus 6 , 7 . (actaitalica.it)

All of the BTEX chemicals can produce neurological impairment, and exposure to benzene can additionally cause hematological effects including aplastic anemia and acute myelogenous leukemia. (cdc.gov)
The points in the figures showing no-observed-adverse-effect levels (NOAELs) or lowest- observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)
However, on p.276 of IARC Monograph 88 with regard to the ability of formaldehyde to cause leukemia it states: "In summary, there is strong but not sufficient evidence for a causal association between leukemia and occupational exposure to formaldehyde. (who.int)

Besides identifying several novel in-frame fusion genes, we also described two new oncogenic leukemia subtypes. (avhandlingar.se)

MYLOTARG (gemtuzumabozogamicin) together with daunorubicin and cytarabine has been granted a positive opinion for the treatment of patient's age 15 years and above with previously untreated, de novo, CD33-positive acute chronic myelocytic leukemia (AML), except acute promyelocytic leukemia (APL). (medgadget.com)
It affects healthy patients (de novo) as well as patients that already have an underlying hematological disorder, as a side-effect of chemo/radiation therapy. (ugent.be)

In the third study (Article III) we demonstrated the that FLT3N676K promote myeloid expansion of KMT2A-R leukemia in primary human cells. (avhandlingar.se)
Primary hematological resistance occurs rarely, affecting 2-4% of cases, whereas 15-25% of patients may experience primary cytogenetic resistance. (touchoncology.com)

Objective: Analyze the infections that affect the users of a reference center at the moment of diagnosis for HIV infection. (bvsalud.org)

BOSULIF (bosutinib) has been granted a positive opinion for the treatment of adults with newly diagnosed chronic phase Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML). (medgadget.com)

Anatomy25

Organisms22

Diseases60

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes45

Disciplines and Occupations1

Information Science5

Health Care7

Malignancies37

Malignancy9

Cancers9

Lymphoid4

Lymphomas3

Hematopoietic stem2

Myeloid leukemia24

Chronic leukemias2

Prognosis5

Mutations6

Pediatric2

Chemotherapy1

Lymphoma and leukemia1

Heterogeneous2

Tumor3

Multiple myeloma1

Phenotype3

Disorders4

Ophthalmic Manifestations1

Aggressive1

Abstract2

Mutation3

Disease9

Progression3

Clonal1

Epidemiology1

Transplantation2

Manifestations1

Molecules4

Immune1

Apoptosis4

Neoplastic1

19941

Retrospective study1

Microscopic1

Commonly2

Exposure3

Subtypes1

Novo2

Primary2

Diagnosis1

Newly diagnosed1