• Virology
  • He directed the Public Health Research Institute in New York City (1956-1981), and was also the founding editor-in-chief of Virology, the first English-language journal to focus on viruses. (wikipedia.org)
  • Wolfgang Joklik cites the discovery of hemagglutination as one of the "early epoch-making discoveries in virology," stating that it made influenza virus "the first mammalian virus whose replication could be studied biochemically. (wikipedia.org)
  • subtypes
  • In general, these mAbs are induced easily by vaccination, but only infrequently display cross-neutralizing activity against antigenic drift variants or even against HA molecules from viruses of heterologous subtypes. (asmscience.org)
  • mammalian
  • Indeed, it could be said that influenza vies with reovirus and poliovirus for the privilege of becoming the first mammalian virus to be completely characterized chemically and genetically. (springer.com)
  • antibody
  • In these studies, we address the ability of DNA encoding Th1 cytokines to bias the isotype of antibody raised by neonatal or adult immunization with an influenza hemagglutinin expressing DNA (HA-DNA). (umassmed.edu)
  • At low doses of DNA, the plasma membrane form of the influenza virus HA raised higher titers of antibody than the secreted form. (umassmed.edu)
  • A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. (asmscience.org)
  • isolation of influenza virus from nasopharyngeal and or large rise in antibody titer in equine-1 or 2 serum can be used as diagnosis in horses. (wikipedia.org)
  • genes
  • Although there is broad experimental support for the DRiP hypothesis, careful kinetic analysis of the generation of defined peptide class I complexes has been limited to studies of recombinant vaccinia viruses expressing genes derived from other organisms. (jimmunol.org)
  • This was a virus that contained genes from avian, pig and human origin . (pubmedcentralcanada.ca)
  • The structure of the capsid allows the virus to use a small number of viral genes to make a large capsid. (wikipedia.org)
  • Six of the genes are very similar to the H1N2 influenza virus that was found in pigs around 2000. (wikipedia.org)
  • binds
  • Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. (uniprot.org)
  • Haemagglutinin causes red blood cells to clump together and binds the virus to the infected cell. (wikipedia.org)
  • Mice
  • To define the parameters that regulate IgE production in vivo, we generated mice bearing monoclonal populations of B and T lymphocytes specific for influenza virus hemagglutinin (HA) and chicken ovalbumin (OVA), respectively. (nih.gov)
  • molecular biology
  • In the case of influenza, however, this is more than an exercise in molecular biology, for influenza heads the list of pandemic infectious diseases that still pose a major threat to modern man. (springer.com)
  • George Keble Hirst, M.D. (March 2, 1909 - January 22, 1994) was an American virologist and science administrator who was among the first to study the molecular biology and genetics of animal viruses, especially influenza virus. (wikipedia.org)
  • measles virus
  • 17, 855-871 Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion. (wikipedia.org)
  • Oncolytic measles virus in cutaneous T-cell lymphomas mount anti-tumor immune responses in vivo and target interferon resistant tumor cells. (wikipedia.org)
  • antiviral activity
  • Then it was found that the synthetic compound 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en or DANA) which is an analogue of N-acetylneuraminic acid (Neu5Ac), inhibits the release of virus progeny in tissue culture but no antiviral activity in animals was detected. (wikipedia.org)
  • particles
  • Disruption of lipid rafts by cholesterol depletion hinders HIV-1 particle production from virus-producing cells, and cholesterol depletion from virus particles significantly impairs virus infectivity [ 8 ]. (pubmedcentralcanada.ca)
  • In 1941, Hirst discovered that adding influenza virus particles to red blood cells caused them to agglutinate or stick together forming a lattice, a phenomenon called hemagglutination. (wikipedia.org)
  • infectivity
  • Cholesterol depletion impairs virus assembly and infectivity. (pubmedcentralcanada.ca)
  • This study examined the effects of exogenous cholesterol addition (delivered as a complex with methyl beta cyclodextrin) on the production of Molony murine leukemia virus retroviral vector and HIV-1-based lentiviral vector pseudotyped with the vesicular stomatitis virus glycoprotein (VSV-G). Cholesterol supplementation before and during vector production enhanced the infectivity of retroviral and lentiviral vectors up to 4-fold and 6-fold, respectively. (pubmedcentralcanada.ca)