• vaccine
  • Therefore, we focused our efforts on developing a broadly protective influenza vaccine based on the Informational Spectrum Method (ISM). (pubmedcentralcanada.ca)
  • Using a novel manufacturing platform based on transient expression of influenza surface glycoproteins in Nicotiana benthamiana, we have recently demonstrated that a candidate Virus-Like Particle (VLP) vaccine can be generated within 3 weeks of release of sequence information. (nih.gov)
  • Increasing the immunogenicity of the RBD of other HA subtypes may be a step toward a universal influenza vaccine. (asmscience.org)
  • The quadrivalent influenza vaccine licensed by the CDC is currently designed to protect against both co-circulating lineages and has been shown to have greater effectiveness in prevention of influenza caused by influenza B virus than the previous trivalent vaccine. (wikipedia.org)
  • Full-scale production of a vaccine that could prevent any illness at all from the strain would require at least three months after the virus's emergence to begin, but it is hoped that vaccine production could increase until one billion doses were produced by one year after the initial identification of the virus. (wikipedia.org)
  • This hemagglutination inhibition assay (HIA) can be applied to many other viruses carrying a hemagglutinin molecule, including rubella, measles, mumps, parainfluenza, adenoviruses, polyomaviruses and arboviruses, and is still widely used in influenza surveillance and vaccine testing. (wikipedia.org)
  • Virology
  • He directed the Public Health Research Institute in New York City (1956-1981), and was also the founding editor-in-chief of Virology, the first English-language journal to focus on viruses. (wikipedia.org)
  • Wolfgang Joklik cites the discovery of hemagglutination as one of the "early epoch-making discoveries in virology," stating that it made influenza virus "the first mammalian virus whose replication could be studied biochemically. (wikipedia.org)
  • Hussein Naim is a Lebanese-Swiss biochemist and molecular virologist, known for his research in cell biology (membrane protein sorting and internalization) and virology (measles, SARS, HIV and Influenza). (wikipedia.org)
  • genes
  • Although there is broad experimental support for the DRiP hypothesis, careful kinetic analysis of the generation of defined peptide class I complexes has been limited to studies of recombinant vaccinia viruses expressing genes derived from other organisms. (jimmunol.org)
  • This was a virus that contained genes from avian, pig and human origin . (pubmedcentralcanada.ca)
  • The structure of the capsid allows the virus to use a small number of viral genes to make a large capsid. (wikipedia.org)
  • Six of the genes are very similar to the H1N2 influenza virus that was found in pigs around 2000. (wikipedia.org)
  • genome
  • Transcription of the influenza ribonucleic acid genome by a virion polymerase. (springer.com)
  • Once this has happened, the contents of the virus, including its RNA genome, are free to pour out into the cell's cytoplasm. (wikipedia.org)
  • The Influenza B virus genome is 14548 nucleotides long and consists of eight segments of linear negative-sense, single-stranded RNA. (wikipedia.org)
  • particles
  • Disruption of lipid rafts by cholesterol depletion hinders HIV-1 particle production from virus-producing cells, and cholesterol depletion from virus particles significantly impairs virus infectivity [ 8 ]. (pubmedcentralcanada.ca)
  • In 1941, Hirst discovered that adding influenza virus particles to red blood cells caused them to agglutinate or stick together forming a lattice, a phenomenon called hemagglutination. (wikipedia.org)
  • Virol
  • 67, 4831-4841 Measles Viruses with Altered Envelope Protein Cytoplasmic Tails Gain Cell Fusion Competence.J. Virol. (wikipedia.org)
  • binds
  • Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. (uniprot.org)
  • Haemagglutinin causes red blood cells to clump together and binds the virus to the infected cell. (wikipedia.org)
  • Mice
  • To define the parameters that regulate IgE production in vivo, we generated mice bearing monoclonal populations of B and T lymphocytes specific for influenza virus hemagglutinin (HA) and chicken ovalbumin (OVA), respectively. (nih.gov)
  • genetic
  • A precise understanding of the evolution of novel variants of influenza virus, by antigenic drift or genetic reassortment, is crucial to the development of satisfactory combative measures, whether based on immunization, chemoprophylaxis, chemotherapy, or even ecological control. (springer.com)
  • Such interactions allow the virus membrane to fuse with the membrane of the host cell so that viral genetic material can be transferred to the cell. (rxpgnews.com)
  • Essentially, virosomes represent reconstituted empty influenza virus envelopes, devoid of the nucleocapsid including the genetic material of the source virus. (wikipedia.org)
  • The genetic material of a virus is stored within a viral protein structure called the capsid. (wikipedia.org)
  • measles virus
  • 17, 855-871 Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion. (wikipedia.org)
  • Oncolytic measles virus in cutaneous T-cell lymphomas mount anti-tumor immune responses in vivo and target interferon resistant tumor cells. (wikipedia.org)
  • antiviral
  • Then it was found that the synthetic compound 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en or DANA) which is an analogue of N-acetylneuraminic acid (Neu5Ac), inhibits the release of virus progeny in tissue culture but no antiviral activity in animals was detected. (wikipedia.org)