DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
MethotrexatePolyglutamic AcidAntirheumatic AgentsFolic Acid AntagonistsTetrahydrofolate DehydrogenaseArthritis, RheumatoidAminopterinAntimetabolites, AntineoplasticLeukemia L1210Reduced Folate Carrier ProteinTrimetrexateFolic AcidDrug Therapy, Combinationgamma-Glutamyl HydrolaseLeucovorinTetrahydrofolatesAbortifacient Agents, NonsteroidalCyclophosphamideDrug ResistanceTreatment OutcomeAntineoplastic Combined Chemotherapy ProtocolsImmunosuppressive AgentsSulfasalazineVincristinePrecursor Cell Lymphoblastic Leukemia-LymphomaDeoxyuridineDrug Administration Schedule6-MercaptopurineDermatologic AgentsPregnancy, EctopicFluorouracilFormyltetrahydrofolatesFolate Receptors, GPI-AnchoredDoxorubicinPhosphoribosylaminoimidazolecarboxamide FormyltransferaseDose-Response Relationship, DrugOsteosarcomaPrednisoneInjections, SpinalCytarabineThymidylate SynthaseLeukemia, LymphoidCentral Nervous System NeoplasmsHydroxychloroquinePregnancy, TubalSarcoma 180Pteroylpolyglutamic AcidsIsoxazolesPsoriasisAsparaginaseRemission InductionGestational Trophoblastic DiseaseBiological TransportHydroxymethyl and Formyl TransferasesProbenecidMucositisTime FactorsAntibodies, MonoclonalDouble-Blind MethodNucleotide DeaminasesCarcinoma, Ehrlich TumorCombined Modality TherapyVinblastineArthritis, JuvenileArthritis, PsoriaticAdministration, OralTrophoblastic NeoplasmsSeverity of Illness IndexLeukemia L5178CisplatinBreast NeoplasmsKineticsHypoxanthinesSurvival Analysis
InjectionFolic acidMonotherapySide effects of methotrexatePatientsRheumatoid arthritis treated with methotrexateDihydrofolate reductaseDose of methotrexateFarmaciaOral methotrexateLiverEctopic pregnancyComprarPharmacieAntimetaboliteMedicationsInhibitorHigh-dose methotrexatePsoriasis or rheumatoid arthritisMedicationReactionsDrug interactionsCombination of methotrexateTreatmentDosesDrugsInjectionsSeverePsoriatic arthritisChemotherapyPlaquenilAntineoplasticTabletPrescriptionIntramuscularPrescriptionsHumiraLymphomaTreat ectopic pregnanciesProgressionTherapyPregnancyDMARDDecreaseMonitor for adverseViagraRisks
Injection19
Folic acid7
Monotherapy7
  • Results of a systematic review exploring the comparative effectiveness of treatments of early rheumatoid arthritis show that treatment efficacy can be improved with combination therapy with anti-TNF or other biologic medications, compared with methotrexate monotherapy. (wikipedia.org)
  • In a group of 107 patients with spondyloarthritis, 25% of those given methotrexate along with adalimumab developed antidrug antibodies by week 26 compared with 47.3% of those who received adalimumab as monotherapy, for a relative risk of 0.53 (95% CI 0.31-0.91), reported Denis Mulleman, MD, PhD, of the University of Tours, and colleagues. (medpagetoday.com)
  • The percentages having inactive disease at that time point were 37% in the methotrexate group and 40% in the adalimumab monotherapy group ( P =0.9). (medpagetoday.com)
  • In the adalimumab monotherapy group, one patient developed psoriasis pustulosa and another had drug-induced liver toxicity associated with prophylaxis for tuberculosis, while in the combination therapy group, one patient developed pneumonia and lower limb ischemia, and another developed nausea, diarrhea, and liver enzyme abnormalities associated with methotrexate and tuberculosis prophylaxis. (medpagetoday.com)
  • These results confirm superiority of pegloticase plus methotrexate co-therapy to pegloticase monotherapy in terms of both treatment efficacy and safety in uncontrolled gout management," investigators concluded. (hcplive.com)
  • The aim of the combination of methotrexate and etanercept in active early rheumatoid arthritis (COMET) trial is to compare remission and radiographic non-progression in patients treated with methotrexate monotherapy or with methotrexate plus etanercept. (nih.gov)
  • 2,3 Approximately 40% of patients respond to methotrexate monotherapy (using the American College of Rheumatology 50 response criterion), 4 with higher response rates possible in combination with other DMARDs, 4 albeit with higher risk of adverse effects. (nps.org.au)
Side effects of methotrexate2
Patients40
  • Methotrexate (MTX) has been associated with reduced risk for cardiovascular disease (CVD) events among patients with rheumatoid arthritis (RA) not exposed to biologic disease-modifying antirheumatic drugs (bDMARDs). (nih.gov)
  • Studies and reviews have found that most rheumatoid arthritis patients treated with methotrexate for up to one year had less pain, functioned better, had fewer swollen and tender joints, and had less disease activity overall as reported by themselves and their doctors[citation needed]. (wikipedia.org)
  • Methotrexate (MTX), an inhibitor of purine metabolism, is the first-line therapy for many patients with rheumatoid arthritis (RA) as well as for patients with many other rheumatic diseases. (medscape.com)
  • Methotrexate tablets are contraindicated in patients with a history of severe hypersensitivity reactions to methotrexate, including anaphylaxis ( 4 , 5.2 ). (nih.gov)
  • Monitor patients for infection during and after treatment with methotrexate tablets. (nih.gov)
  • Monitor patients for neurotoxicity and withhold or discontinue methotrexate tablets as appropriate. (nih.gov)
  • Institute appropriate prophylactic measures in patients at risk for tumor lysis syndrome prior to initiation of methotrexate tablets. (nih.gov)
  • Glucarpidase is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall) in patients with kidney disease who are receiving methotrexate to treat certain types of cancer. (nih.gov)
  • in patients whose symptoms were not relieved by methotrexate alone. (nih.gov)
  • Despite the lack of regulatory approval for methotrexate in spondyloarthritis, the drug is often used among patients who have peripheral disease manifestations. (medpagetoday.com)
  • Mulleman's group noted that in retrospective studies, similar reductions in immunogenicity were seen among patients with spondyloarthritis receiving infliximab in combination with methotrexate. (medpagetoday.com)
  • To explore the possibility that co-administration of methotrexate with a TNF inhibitor could lessen the likelihood of development of antidrug antibodies and loss of treatment efficacy, the researchers recruited adult patients with spondyloarthritis in 2013 and 2014 from the network of Western France University Hospitals. (medpagetoday.com)
  • This randomized, open-label study had patients receiving 40 mg subcutaneous injections of adalimumab every other week with or without subcutaneous weekly 10 mg injections of methotrexate. (medpagetoday.com)
  • In this prospective randomized trial, we demonstrate that methotrexate significantly reduced the immunogenicity and ameliorated adalimumab concentration, as a surrogate of drug exposure, in axial spondyloarthritis patients," the investigators wrote. (medpagetoday.com)
  • Minor changes observed are the same as in patients with rheumatoid arthritis not treated with methotrexate. (nih.gov)
  • Ultrasound liver elastography for the detection of liver fibrosis in patients with psoriasis and reactive arthritis on long-term methotrexate therapy: A cross-sectional study. (nih.gov)
  • Methotrexate-associated hepatotoxicity: retrospective analysis of 210 patients with rheumatoid arthritis. (nih.gov)
  • Disentangling Rheumatoid Arthritis patients' implicit and explicit attitudes toward Methotrexate. (nivel.nl)
  • However, even if patients at high risk of poor response of methotrexate were successfully identified, there is currently no clear indication that they will respond better to alternative therapies, such as biological disease-modifying antirheumatic drugs. (ajmc.com)
  • Gehringer C, Martin G, Hyrich K, Verstappen S, Sergeant J. Clinical prediction models for methotrexate treatment outcomes in patients with rheumatoid arthritis: a systematic review and meta-analysis. (ajmc.com)
  • Of the 152 patients included in the trial, 100 received pegloticase plus methotrexate and 52 were placed in the pegloticase plus placebo cohort. (hcplive.com)
  • Based on these findings, this trial strongly supports methotrexate co-administration with pegloticase in uncontrolled gout patients. (hcplive.com)
  • A Randomized Placebo-Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled GOut Receiving Pegloticase (MIRROR RCT): Primary Efficacy and Safety Findings [published online ahead of print, 2022 Sep 13]. (hcplive.com)
  • Both clinical remission and radiographic non-progression are achievable goals in patients with early severe rheumatoid arthritis within 1 year of combined treatment with etanercept plus methotrexate. (nih.gov)
  • Diagnostic tests after receiving Methotrexate showed tubal patency (open tubes) in 78% of cases and 65% of patients went on to achieve a subsequent pregnancy. (inviafertility.com)
  • 1 Based on efficacy, safety, cost, ability to individualise dose and method of administration, the csDMARD methotrexate is the recommended first-line DMARD for most patients with RA. (nps.org.au)
  • I know that Methotrexate is given to IBD patients along with biologics. (crohnsforum.com)
  • Exacerbation of rheumatoid arthritis in patients treated with methotrexate after administration of folinic acid. (bmj.com)
  • Infection rate and use of antibiotics in patients with rheumatoid arthritis treated with methotrexate. (bmj.com)
  • OBJECTIVE--To investigate prospectively the frequency and type of infections and the use of antibiotics among patients with rheumatoid arthritis (RA) on methotrexate (MTX) and patients with RA without MTX. (bmj.com)
  • These guidelines were developed to address the hesitation clinicians often have when considering off-label methotrexate use in pediatric patients for various inflammatory diseases such as morphea, atopic dermatitis, psoriasis, and alopecia areata. (contemporarypediatrics.com)
  • Most pediatric patients receiving treatment for inflammatory skin disease can safely use methotrexate in conjunction with antibiotics (including TMP/S) and NSAIDs. (contemporarypediatrics.com)
  • Patients given methotrexate can receive live virus vaccine boosters (e.g. (contemporarypediatrics.com)
  • The investigators added that generally, methotrexate offers accessibility, reliability, and the ability to be started or stopped by clinicians and patients as needed without compromising effectiveness during re-exposure. (contemporarypediatrics.com)
  • Determine the safety and efficacy of sirolimus when administered with tacrolimus and methotrexate for the prevention of acute graft-versus-host disease (GVHD) in patients with hematological malignancies undergoing hematopoietic stem cell transplantation from unrelated donors. (knowcancer.com)
  • To see if methotrexate could prevent fibrosis in these patients, Franklin and Lauren Gibson, MD, compared the records of 86 patients they had treated with methotrexate to 163 they had not. (medscape.com)
  • The success of methotrexate in patients with a high incidence of diabetes is encouraging, said Tomasz Stryjewski, MD, a retina specialist at Tallman Eye Associates in Lawrence, Massachusetts. (medscape.com)
  • Stryjewski, who developed ADX-2191 with Dean Eliott, MD, a professor of ophthalmology at Harvard Medical School in Boston, Massachusetts, said the study provided a better understanding of which retinal reattachment patients are good candidates for methotrexate. (medscape.com)
  • Cytotec is used for reducing the risk of stomach ulcers in certain patients who take nonsteroidal methotrexate package insert tablet . (oberperflhof.com)
  • Scholars@Duke publication: Ambulatory high-dose methotrexate administration among pediatric osteosarcoma patients in an urban, underserved setting is feasible, safe, and cost-effective. (duke.edu)
Rheumatoid arthritis treated with methotrexate2
  • Those individuals with rheumatoid arthritis treated with methotrexate have been found to have a lower risk of cardiovascular events such as myocardial infarctions and strokes. (wikipedia.org)
  • Severe, disseminated, life threatening herpes zoster infection in a patient with rheumatoid arthritis treated with methotrexate. (bmj.com)
Dihydrofolate reductase3
  • Methotrexate is an antimetabolite chemotherapeutic agent that binds to the enzyme dihydrofolate reductase, which is involved in the synthesis of purine nucleotides. (medscape.com)
  • Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. (sigmaaldrich.com)
  • Background: Methotrexate (MTX) is an inhibitor of dihydrofolate reductase (DHFR), an enzyme involved in nucleotide synthesis, and is widely used in therapy, but its effi cacy is often compromised by the development of resistance in cancer cells. (medscimonit.com)
Dose of methotrexate4
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Oral methotrexate5
Liver7
  • Methotrexate may cause liver damage, especially when it is taken for a long period of time. (nih.gov)
  • If you drink or have ever drunk large amounts of alcohol or if you have or have ever had liver disease, your doctor may tell you not to take methotrexate unless you have a life-threatening form of cancer because there is a higher risk that you will develop liver damage. (nih.gov)
  • Your doctor may order liver biopsies (removal of a small piece of liver tissue to be examined in a laboratory) before and during your treatment with methotrexate. (nih.gov)
  • Methotrexate may cause liver problems, and using it with other medications that can also affect the. (drugs.com)
  • Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have low blood cell counts, a weak immune system, alcoholism or chronic liver disease, or if you are pregnant or breastfeeding. (cigna.com)
  • When given in high intravenous doses, methotrexate can cause acute elevations in serum enzymes, and long term methotrexate therapy has been associated with frequent but mild elevations in serum liver enzymes and, more importantly, with development of chronic liver injury, progressive fibrosis, cirrhosis and portal hypertension. (nih.gov)
  • Methotrexate, liver and rheumatoid arthritis in tropical areas]. (nih.gov)
Ectopic pregnancy7
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Antimetabolite1
  • Methotrexate is an antimetabolite used in the treatment of neoplastic diseases, severe psoriasis, and rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis. (blogspot.com)
Medications6
  • You should only take methotrexate to treat cancer or certain other conditions that are very severe and that cannot be treated with other medications. (nih.gov)
  • It is also important to know that methotrexate interacts with some common medications. (medicalnewstoday.com)
  • Methotrexate is in a class of medications called antimetabolites. (nih.gov)
  • Potential causes include concomitant viral infection, recent methotrexate dosing prior to blood collection, administration of other medications, and recent alcohol consumption. (contemporarypediatrics.com)
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Inhibitor1
  • However, in rheumatoid arthritis, using methotrexate in combination with a TNF inhibitor has been shown to lessen the immunogenicity that can develop with the use of biologics. (medpagetoday.com)
High-dose methotrexate1
  • BACKGROUND: We describe the safety, feasibility, and provide a cost-estimate of outpatient high-dose methotrexate administration (HDMTX) among an urban, underserved population. (duke.edu)
Psoriasis or rheumatoid arthritis1
  • Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. (drugs.com)
Medication5
  • Methotrexate is available as a generic medication. (wikipedia.org)
  • Methotrexate may also be used for purposes not listed in this medication guide. (cigna.com)
  • Your doctor will evaluate if it is safe to give you Methotrexate before ordering the medication. (inviafertility.com)
  • Methotrexate is the 'gold-standard' in treating rheumatoid arthritis, however, the medication is much maligned with respect to potential toxicity. (nps.org.au)
  • Levitra is a prescription medication for the treatment of erectile dysfunction (ED) plaquenil or methotrexate . (onlinehome.us)
Reactions3
  • Methotrexate may cause serious or life-threatening skin reactions. (nih.gov)
  • Serious adverse reactions, including death, have been reported with methotrexate. (nih.gov)
  • Methotrexate as a corticosteroid-sparing agent in leprosy reactions: A French multicenter retrospective study. (bvsalud.org)
Drug interactions1
Combination of methotrexate1
Treatment22
  • If you do develop lymphoma, it might go away without treatment when you stop taking methotrexate, or it might need to be treated with chemotherapy. (nih.gov)
  • Your doctor will order certain lab tests before, during, and after your treatment to check your body's response to methotrexate and to treat side effects before they become severe. (nih.gov)
  • Although originally designed as a chemotherapy drug, in lower doses methotrexate is a generally safe and well-tolerated drug in the treatment of certain autoimmune diseases. (wikipedia.org)
  • Methotrexate is one of the first-line therapies for the treatment of rheumatoid arthritis. (wikipedia.org)
  • Likewise, a 2016 study found the use of methotrexate, in combination with anti-TNF agents, has been shown to be effective for the treatment of ulcerative colitis. (wikipedia.org)
  • Since the 1940s , doctors have used methotrexate as a treatment for cancer . (medicalnewstoday.com)
  • Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. (drugs.com)
  • With evolving experience with methotrexate, the treatment of selected ectopic pregnancies has been revolutionized. (medscape.com)
  • Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis. (sigmaaldrich.com)
  • Viagra is indicated for the treatment of erectile dysfunction in men methotrexate dosage psoriatic arthritis . (terminally-incoherent.com)
  • There is a need for clinical prediction models (CPMs) that can successfully guide providers in using methotrexate for the treatment of rheumatoid arthritis , found a systemic review and meta-analysis. (ajmc.com)
  • Therefore, once the methodological limitations outlined above are addressed, there is scope to develop an accurate CPM of methotrexate outcomes to guide treatment decisions in rheumatoid arthritis (upon undertaking appropriate impact assessment studies). (ajmc.com)
  • In July 2022, the US Food and Drug Administration (FDA) expanded labeling of pegloticase co-administered with methotrexate based on results of the phase 4, multicenter, randomized, double-blind, placebo-controlled, parallel-group MIRROR trial, which analyzed differences in treatment response for concomitant therapy compared with placebo in adults with uncontrolled gout. (hcplive.com)
  • 274 participants were randomly assigned to receive combined treatment and 268 methotrexate alone. (nih.gov)
  • Methotrexate is the preferred medical treatment for ectopic pregnancies and has been used for more than 25 years. (inviafertility.com)
  • Rheumatoid arthritis treatment has been revolutionised by the use of DMARDs like methotrexate. (nps.org.au)
  • Methotrexate is the gold standard for rheumatoid arthritis (RA) treatment. (nps.org.au)
  • Several consensus-based guidelines for the use of methotrexate (MTX) in pediatric inflammatory skin diseases have been developed, according to new findings, filling an unmet need by providing evidence-based recommendations for effective treatment options. (contemporarypediatrics.com)
  • Test doses were shown to be unnecessary for initiating low-dose (≤1 mg/kg) methotrexate treatment in pediatric individuals affected by inflammatory skin diseases. (contemporarypediatrics.com)
  • Cialis is indicated for the treatment of erectile dysfunction plaquenil or methotrexate . (onlinehome.us)
  • I am very nervous about going on methotrexate as it does opposite to my treatment for melanoma. (melanoma.org)
  • I have tried to reach out for anyone on treatment or stopped and on methotrexate but not much response. (melanoma.org)
Doses3
  • Use of low doses of methotrexate together with NSAIDs such as aspirin or analgesics such as paracetamol is relatively safe in people being treated for rheumatoid arthritis, with appropriate monitoring. (wikipedia.org)
  • It is important to note that taking methotrexate by mouth involves taking weekly - not daily - doses. (medicalnewstoday.com)
  • Initial protocols for medical therapy required long-term hospitalization and multiple doses of methotrexate and were associated with significant side effects. (medscape.com)
Drugs3
  • According to the Arthritis Foundation , medical professionals regard methotrexate as one of the safest arthritis drugs. (medicalnewstoday.com)
  • Methotrexate has an average rating of 6.6 out of 10 from a total of 328 ratings on Drugs.com. (drugs.com)
  • In contrast to other cytotoxic drugs, no carcinogenesis has been demonstrated with methotrexate. (nih.gov)
Injections2
  • If your doctor recommends the injectable form of methotrexate, the appropriate dose is usually injected one or more times weekly, either in cycles (i.e., some weeks no injections are given) or on a regular basis, depending on the type of cancer being treated. (pharmasave.com)
  • NEW YORK - Intravitreal methotrexate injections can reduce the need for reoperation after surgery for retinal detachment, even in eyes with complex pathology, researchers say. (medscape.com)
Severe2
  • Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis in adults, and to treat active polyarticular-course juvenile rheumatoid arthritis in children. (cigna.com)
  • 542 outpatients who were methotrexate-naive and had had early moderate-to-severe rheumatoid arthritis for 3-24 months were randomly assigned to receive either methotrexate alone titrated up from 7.5 mg a week to a maximum of 20 mg a week by week 8 or methotrexate (same titration) plus etanercept 50 mg a week. (nih.gov)
Psoriatic arthritis7
Chemotherapy2
  • Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. (wikipedia.org)
  • Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents. (wikipedia.org)
Plaquenil7
Antineoplastic1
  • Methotrexate is an antineoplastic and immunosuppressive agent widely used in the therapy of leukemia, lymphoma, solid tumors, psoriasis and rheumatoid arthritis. (nih.gov)
Tablet6
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Intramuscular2
  • Up to 15 mg of methotrexate was given weekly by the intramuscular route. (nih.gov)
  • It appears that methotrexate is approximately as effective as intramuscular gold and D-penicillamine but that it has a quicker onset of response and less serious toxicity. (nih.gov)
Prescriptions1
  • As we begin another new year, many rheumatology practices will again receive prior authorization requests from Medicare Part D for all methotrexate prescriptions. (the-rheumatologist.org)
Humira1
  • Adding methotrexate to adalimumab (Humira) in axial spondyloarthritis was associated with reduced immunogenicity, as shown by a lower rate of developing antidrug antibodies, French researchers reported. (medpagetoday.com)
Lymphoma2
  • Taking methotrexate may increase the risk that you will develop lymphoma (cancer that begins in the cells of the immune system). (nih.gov)
  • Methotrexate is used to treat certain types of cancer such as leukemia, non-Hodgkin's lymphoma, breast cancer, head and neck cancer, stomach cancer, bladder cancer, bone cancer, and choriocarcinoma (a type of uterine cancer). (pharmasave.com)
Treat ectopic pregnancies1
  • Methotrexate is an abortifacient and is used to treat ectopic pregnancies, provided the fallopian tube has not ruptured. (wikipedia.org)
Progression2
  • X-rays also showed that the progress of the disease slowed or stopped in many people receiving methotrexate, with the progression being completely halted in about 30% of those receiving the drug. (wikipedia.org)
  • A 2017 review notes that methotrexate alone can significantly reduce the progression of RA at dosages of 7.5-25 mg per week . (medicalnewstoday.com)
Therapy4
  • If you take methotrexate while you are being treated with radiation therapy for cancer, methotrexate may increase the risk that the radiation therapy will cause damage to your skin, bones, or other parts of your body. (nih.gov)
  • Optimizing Methotrexate Therapy - Medscape - Dec 14, 2010. (medscape.com)
  • They noted that the relatively low 10 mg/week dosage of methotrexate may have contributed to the finding that 25% of the combination therapy group did develop immunogenicity, and that higher or weight-based dosing could have minimized this. (medpagetoday.com)
  • An increasing amount of clinical data indicates that low-dose methotrexate therapy for rheumatoid arthritis is both effective and free of serious side effects. (nih.gov)
Pregnancy7
  • Methotrexate with dilation and curettage is used to treat molar pregnancy. (wikipedia.org)
  • For non-neoplastic diseases, methotrexate tablets are contraindicated in pregnancy. (nih.gov)
  • Verify pregnancy status in females of reproductive potential before starting methotrexate tablets ( 4 , 5.1 ). (nih.gov)
  • Methotrexate should not be used during pregnancy to treat arthritis or psoriasis. (cigna.com)
  • Methotrexate is sometimes used to treat cancer during pregnancy. (cigna.com)
  • Use effective birth control to prevent pregnancy while you are using methotrexate and for at least 6 months after your last dose. (cigna.com)
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using methotrexate. (cigna.com)
DMARD2
Decrease2
  • Methotrexate may cause a decrease in the number of blood cells made by your bone marrow. (nih.gov)
  • Methotrexate may decrease the activity of your immune system, and you may develop serious infections. (nih.gov)
Monitor for adverse1
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Risks1