Heavy dyneins. Medical search. Frequent questions

Dynein, axonemal, heavy chain 14 is a protein that in humans is encoded by the DNAH14 gene. (wikipedia.org)

Dynein and kinesin can both be exploited by viruses to mediate the viral replication process. (wikipedia.org)
This is despite the fact that a single dynein motor is able to carry a much smaller load than kinesin. (indiabioscience.org)
The gene Kinesin heavy chain is referred to in FlyBase by the symbol Dmel\Khc (CG7765, FBgn0001308). (yeastrc.org)
Kinesin and dynein superfamily proteins and the mechanism of organelle transport. (embl.de)
Microtubules serve as a rail on which motor proteins, such as kinesin and dynein superfamily proteins, convey their cargoes. (embl.de)
This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins. (embl.de)
Most notably, oMAP4 is required for paraxial microtubule organisation in muscle cells and prevents dynein- and kinesin-driven microtubule-microtubule sliding. (elifesciences.org)
Bovine kinesin is a heterotetramer composed of two heavy (120 kDa) and two light (62 kDa) chains. (bvsalud.org)

This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. (nih.gov)
The inner dynein arm regulates axonemal bending motion in eukaryotes. (rupress.org)

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. (wikipedia.org)
While a postdoctoral student at MIT, Tomomi Kiyomitsu discovered how dynein has a role as a motor protein in aligning the chromosomes in the middle of the cell during the metaphase of mitosis. (wikipedia.org)
The DYNC2H1 gene provides instructions for making a protein that is part of a group (complex) of proteins called dynein-2. (medlineplus.gov)
The dynein-2 complex made with the altered protein cannot function normally, which disrupts IFT from the tip of cilia to the base and causes a buildup of materials at the tip. (medlineplus.gov)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Dynein Heavy Chain Domain Containing Protein 1 (DNHD1) in samples from Tissue homogenates and other biological fluids. (youngresearch.eu)
Description: A sandwich ELISA kit for detection of Dynein Heavy Chain Domain Containing Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (youngresearch.eu)
B) lrd (left-right dynein), the protein (green) mutated by the iv mutation, is also known as DNAH11, DNAHC11, and DLP11. (medscape.com)
When the iv mouse mutation was cloned, it was found to encode a molecular motor protein, an axonemal dynein, and was named lrd , for left-right dynein (human homolog is DNAH11 / DNAHC11 , Dynein heavy chain 11 , axonemal ). (medscape.com)
The LisH motif is likely to possess a conserved protein-binding function and it has been proposed that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly. (embl.de)
This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. (utsouthwestern.edu)
Cytoplasmic dynein is a retrograde motor protein complex that carries cargo such as organelles and growth factors along microtubules from the cell periphery towards the peri-nuclear region. (figshare.com)
Jul 2009;1(1):a000802 and is reprinted with permission of Cold Spring Harbor Press](B) lrd (left-right dynein), the protein (green) mutated by the iv mutation, is also known as DNAH11, DNAHC11, and DLP11. (medscape.com)

All the eight different heavy chains were identified in one 96-nm periodic repeat, as expected from previous biochemical studies. (rupress.org)
Based on mutants, we identified the positions of the AAA rings and the N-terminal tails of all the eight heavy chains. (rupress.org)
Each dyad consists of two heavy chains and has a corresponding radial spoke or a similar feature. (rupress.org)
In each of the six heavy chains (dynein a, b, c, d, e, and g), the N-terminal tail extends from the distal side of the ring. (rupress.org)
In the Chlamydomonas reinhardtii flagellar axoneme, at least 11 dynein heavy chains (three outer arm and eight inner arm) exist, and each could play crucial and distinct roles in proper flagellar functions ( Kagami and Kamiya, 1992 ). (rupress.org)
The heavy chains of the dynein complex are linked to the microtubule by stems that can be seen in this micrograph. (cellimagelibrary.org)
Thin protrusions link the dynein heavy chains to the adjacent doublet. (cellimagelibrary.org)
DYNC1I1 and DYNC1I2 interact with the dynein light chains and the p150 subunit of dynactin at the N terminus and with the heavy chains through WD40 repeats at the intermediate chain C terminus. (embl.de)
In sea urchin flagella two dynein heavy chains α- and β-dynein form a dimeric ODA complex. (researchensemble.com)
In the beta subunit, the beta heavy chain and one or both intermediate chains may contain ATP-binding sites. (umassmed.edu)
The cytoplasmic dynein complex is centred around two homodimerised heavy chains, within which multiple mutations have been identified in human neurological diseases. (figshare.com)
Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (lookformedical.com)

Electron microscopic examination of cilia showed absence of the outer dynein arms. (nih.gov)
Dynein transports various cellular cargos , provides forces and displacements important in mitosis , and drives the beat of eukaryotic cilia and flagella . (wikipedia.org)
Axonemal dynein causes sliding of microtubules in the axonemes of cilia and flagella and is found only in cells that have those structures. (wikipedia.org)
Coordinated beating and bend propagation of cilia and flagella are generated by active sliding of peripheral doublet microtubules driven by ensembles of various types of dyneins. (rupress.org)
The dynein-2 complex is found in cell structures known as cilia. (medlineplus.gov)
Dynein-2 is involved in a process called intraflagellar transport (IFT), by which materials are carried within cilia. (medlineplus.gov)
Specifically, dynein-2 is a motor that uses energy from the molecule ATP to power the transport of materials from the tip of cilia to the base. (medlineplus.gov)
Like the mutations that cause asphyxiating thoracic dystrophy, these genetic changes impair the function of the dynein-2 complex and disrupt IFT within cilia. (medlineplus.gov)
The absence of outer dynein arms in the spermatozoa and airway cilia of humans with the Kartagener triad (ie, situs inversus totalis , sinusitis, and bronchiectasis) was also noted by Björn Afzelius (see the image below). (medscape.com)
The absence of outer dynein arms in the spermatozoa and airway cilia of humans with the Kartagener triad (i.e., situs inversus totalis , sinusitis, and bronchiectasis) was also noted by Bj ö rn Afzelius (see the image below). (medscape.com)

cytoplasmic dyneins and axonemal dyneins , which are also called ciliary or flagellar dyneins. (wikipedia.org)
of native dyneins in three conformational says were also analysed to compare the post-powerstroke axonemal dyneins and conservation of structural features among evolutionarily distant species (Supplementary Fig. 2). (researchensemble.com)
Physique 2 structures of sea urchin axonemal dyneins in the post-powerstroke state as revealed by cryo-ET. (researchensemble.com)

Orthologous to human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1). (zfin.org)
1} Homozygosity or compound heterozygosity for missense or nonsense mutations in the cytoplasmic dynein 2 heavy chain 1 gene {DYNC2H1} are reported in SRPS3. (pediatriconcall.com)

Here we showthat Lis1 is enriched in neurons relative to levels in other cell types,and that Lis1 interacts with the microtubule motor cytoplasmic dynein.Production of more Lis1 in non-neuronal cells increases retrogrademovement of cytoplasmic dynein and leads to peripheral accumulation ofmicrotubules. (embl.de)
Dyneins are large microtubule motor proteins required for mitosis intracellular transport and ciliary and flagellar motility1 2 They generate force through a powerstroke mechanism which is an ATP-consuming cycle of pre- and post-powerstroke conformational changes that cause relative motion between different dynein domains3-5. (researchensemble.com)

that is, one or the other of its stalks is always attached to the microtubule so that the dynein can "walk" a considerable distance along a microtubule without detaching. (wikipedia.org)

The 'Legs at odd angles' (Loa) mouse has a missense 'T' to 'A' point mutation in the cytoplasmic dynein heavy chain gene (Dync1h1), resulting in a phenylalanine to tyrosine substitution at position 580. (figshare.com)

[2] [3] Dynein carries organelles, vesicles and possibly microtubule fragments along the axons of neurons toward the cell body in a process called retrograde axonal transport . (wikipedia.org)
Importins associated with dynein are an important component of retrograde injury signalling complexes and enable transport of direct importin cargoes, such as transcription factors, as well as secondary cargoes that bind scaffolding molecules associated with importins. (nature.com)

Applying a polymerase chain reaction-based approach, we identified a 1.5-kb partial complementary DNA of DNAH5 encoding a Chlamydomonas-related axonemal heavy dynein chain within the critical disease interval of this new PCD locus. (nih.gov)

Unveiling the metal mutation nexus: Exploring the genomic impacts of heavy metal exposure in lung adenocarcinoma and colorectal cancer. (cdc.gov)

Mammalian cytoplasmic dynein-1 complexes contain two copies of the same intermediate chain (typically DYNC1I2 in most cells, DYNC1I1 in neurons) and same light intermediate chain. (embl.de)

The nudF gene of the filamentous fungus Aspergillus nidulans acts in the cytoplasmic dynein /dynactin pathway and is required for distribution of nuclei. (xenbase.org)

We used cryo-electron tomography to reconstruct the three-dimensional structure of inner dynein arms from Chlamydomonas reinhardtii . (rupress.org)

These results suggest that the alpha heavy chain contains the site of ATP binding and hydrolysis in the alpha subunit. (umassmed.edu)

Familia de adenosina-trifosfatasas mecánicas asociadas a los microtúbulos, que emplean la energía de la hidrólisis del ATP para mover orgánulos a lo largo de los microtúbulos en procesos como la mitosis, la meiosis y el transporte axónico. (bvsalud.org)

The differences observed in the post-powerstroke conformations of different dynein isoforms may be due to spatial constraints between the complexes in the axoneme or to intrinsically different functions of the dyneins. (researchensemble.com)

Putative dynein heavy chain [Ensembl]. (ntu.edu.sg)

Cytoplasmic dynein positions the spindle at the site of cytokinesis by anchoring to the cell cortex and pulling on astral microtubules emanating from centrosome . (wikipedia.org)

The dynein f dimer is located close to the surface of the A-microtubule, whereas the other six heavy chain rings are roughly colinear at a larger distance to form three dyads. (rupress.org)

DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al. (wikipedia.org)

Rai et al describe how as a team, dyneins are able to carry a much higher load than a team of kinesins. (indiabioscience.org)
Kinesins and dyneins are motor proteins present in cells, and facilitate the transport of viruses and organelles such as mitochondria throughout the cytoplasm via microtubules. (indiabioscience.org)
Roop Mallik's team found that dyneins have the ability to change step size depending upon the load being carried, as opposed to which kinesins take fixed steps. (indiabioscience.org)

Dyneins are a family of cytoskeletal motor proteins that move along microtubules in cells . (wikipedia.org)
[1] Additionally, dynein motor is also responsible for the transport of degradative endosomes retrogradely in the dendrites. (wikipedia.org)
Shown is the order of regions of interest for human cytoplasmic dynein 2 motor domains as they occur from the linker to C-terminal. (wikipedia.org)
By varying the size of their steps, dynein motor proteins work effectively as teams to carry heavy loads around the cell. (the-scientist.com)
Dynein heavy chain, hydrolytic ATP-binding dynein motor. (ntu.edu.sg)

Dynein is involved in the movement of chromosomes and positioning the mitotic spindles for cell division. (wikipedia.org)
Dynein pulls the microtubules and chromosomes to one end of the cell. (wikipedia.org)

To interact with the B-microtubule through stalks, the inner-arm dyneins must have either different handedness or, more probably, the opposite orientation of the AAA rings compared with the outer-arm dyneins. (rupress.org)

Our classification of dyneins from active flagella revealed that this α-ODA was in the pre-I and the β-ODA in the pre-II state in more than 90% of the classified ODA dimers. (researchensemble.com)

Cytoplasmic dynein helps to position the Golgi complex and other organelles in the cell. (wikipedia.org)
In addition, associations of KLC with the dynein complex is altered in Loa. (figshare.com)

i.e. the pre-I dyneins were held in place (instead of diffusing in space) by their tails anchoring to the cargo-microtubule and other domains contacting neighbouring axonemal structures. (researchensemble.com)

A high resolution image of portion of an isolated cilium exposing two rows of outer dynein arms arising from subfiber A of each doublet. (cellimagelibrary.org)

Human cytoplasmic dynein 2 domains. (wikipedia.org)

Outer dynein arms (green) and inner dynein arms (blue) are shown. (medscape.com)

Cytoplasmic dynein, found in all animal cells and possibly plant cells as well, performs functions necessary for cell survival such as organelle transport and centrosome assembly. (wikipedia.org)

Dynein, axonemal heavy chain 10 opposite strand (DNA100S) evolved from ancestrally noncoding DNA, which has been verified by the presence of disabling sequences in chimp, gorilla, gibbon, macaque, and mouse. (anthropogeny.org)
Lis1 deficiency produces the opposite phenotype.Our results indicate that abundance of Lis1 in neurons may stimulatespecific dynein functions that function in neuronal migration and axongrowth. (embl.de)

Anatomy6

Organisms4

Chemicals and Drugs9

Phenomena and Processes3

Information Science2

Chain 141

Kinesin8

Inner dynein arm2

Protein12

Chains12

Cilia10

Axonemal dyneins3

DYNC2H12

Microtubule motor2

Attached to the microtubule1

DYNC1H11

Retrograde2

DNAH51

Mutation1

DYNC1I11

Dynactin1

Chlamydomonas1

Subunit1

Mitosis1

Isoforms1

Ensembl1

Cytokinesis1

Dimer1

DNAH141

Kinesins3

Motor5

Chromosomes2

Outer arm1

Classification1

Complex2

Structures1

Doublet1

Human1

Arms1

Organelle transport1

Opposite2