Heavy 1981 genes immunoglobulin light chain. Medical search. Frequent questions

Etanercept consists of a fusion protein of the extracellular portion of the p75 TNF-α receptor and the Fc portion of immunoglobulin G (IgG). (medscape.com)
17. Melchers, F., Andersson, J.: Immunoglobulin production in B-lymphocytes: synthesis of the membrane-bound receptor and the secreted serum glycoprotein immunoglobulin M. Biochem. (uni-mainz.de)
19. Melchers, F.: Changes in receptor immunoglobulin turnover during B-lymphocyte differentiation. (uni-mainz.de)
All tachykinins interact with all the three-receptor subtypes with SP preferring NK1, NKA preferring NK2 and NKB (encoded by the TAC3 gene in humans and by the tachykinin 2 (TAC2) gene in rodents) preferring NK3. (niepokorny.org)

Different light chains are responsible for two diseases with diametrically opposite mesangial alterations: Light chain deposition disease which results in the expansion of the mesangium due to accumulation of matrix proteins not present in the normal mesangium and AL (light chain-associated) amyloidosis where the native mesangial matrix is replaced by fibrils (amyloid). (heraldopenaccess.us)
Normal light chains are small molecular weight proteins that are filtered through the peripheral capillary walls and are delivered to the proximal tubules where they are catabolized by endosomal activity in the apical portions of the tubules and their amino acids are then returned to the circulation. (heraldopenaccess.us)
Activated ATF6 mediates transcription of genes encoding ER chaperone proteins also. (cgp60474.com)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
These genes encode precursor proteins, from which the active peptide transmitter Rabbit polyclonal to EGR1 is subsequently cleaved. (niepokorny.org)

The Anti-Kappa F(ab') 2 FITC polyclonal antibody is specific for kappa light chains of human immunoglobulins. (bdbiosciences.com)
A mouse isotyping strip (Serotec, Inc.) indicated that the monoclonal antibody is IgA with kappa light chains. (vin.com)

Mesangial injury represents a crucial event in the pathogenesis of light chain-associated glomerulopathies in patients with plasma cell dyscrasias. (heraldopenaccess.us)
Giannella RA (1981) Pathogenesis of acute bacterial diarrheal disorders. (springer.com)

Standard treatment of L chain-type amyloidosis aims to reduce production of the monoclonal immunoglobulin precursor via chemotherapy or, occasionally, via radiation therapy or surgical resection of a localized amyloidogenic plasmacytoma. (medscape.com)

The 30-kDa membrane-bound c-type cytochrome protein of mitochondria that functions as an electron donor to CYTOCHROME C GROUP in the mitochondrial and bacterial RESPIRATORY CHAIN. (lookformedical.com)

II: the amino acid sequence of the H-chain (mu-type), subgroup H III. (wikipedia.org)
2. Melchers, F.: The N-terminal amino acid sequence in a k-type mouse light chain. (uni-mainz.de)

[ 1 ] Donath-Landsteiner hemolytic anemia is also caused by a cold-reacting immunoglobulin, but most cases are due to polyclonal IgG. (medscape.com)
Comparison of monoclonal and polyclonal antibodies directed against immunoglobulin light and heavy chains in non-Hodgkin's lymphoma. (bdbiosciences.com)

These regulators include canonical genes that control lipid metabolism as well as genes involved in ubiquitination, transcription, and mitochondrial function. (stanford.edu)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Together, this systematic assessment of enhancer-promoter compatibility suggests a multiplicative model tuned by enhancer and promoter class to control gene transcription in the human genome. (nature.com)
These include functions that promote viral gene transcription, inhibition of host mRNA processing, increased degradation of mRNA, and a shutoff of host protein synthesis (29, 52, 58). (moam.info)
They, furthermore, control the expression of cytokines and chemokines as well as transcription factors such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) (Bekhbat et al. (niepokorny.org)

Monomeric IgA is also one of the major immunoglobulin classes present in serum, second only to IgG. (biomedcentral.com)

Fig. 4: Promoter classes correspond to enhancer responsive versus ubiquitously expressed genes. (nature.com)

Kubagawa H, Gathings WE, Levitt D, Kearney JF, Cooper MD. Immunoglobulin isotype expression of normal pre-B cells as determined by immunofluorescence. (bdbiosciences.com)
In contrast, B cells from immunocytomas showed light chain restriction and monoclonal rearrangement for IgH, confirming their neoplastic nature. (bmj.com)
8. Melchers, F.: Biosynthesis, transport and secretion of immunoglobulin in plasma cells. (uni-mainz.de)
11. Melchers, F.: Synthesis, transport and secretion of immunoglobulin in lymphoid cells. (uni-mainz.de)
20. Melchers, F.: Biochemical characterization of immunoglobulin-producing B-lymphocytes at different stages of their differentiation.In: 'Regulation of Growth and Differentiated Function in Eukaryotic Cells,' eds. (uni-mainz.de)
In: 'Regulation of the Immune System: Genes and the Cells in which They Function,' Vol. VI, eds. (uni-mainz.de)
To generate a large number of unselected mutations, we immunized B1-8 H chain transgenic mice with nitrophenyl to stimulate nitrophenyl-specific λ + germinal center B cells and sequenced the unexpressed κ L chains using next-generation methods. (aai.org)
The glomerulopathic light chains interact with mesangial cells where purported receptors regulate the downstream cellular mechanisms that will be activated and result in glomerular alterations. (heraldopenaccess.us)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)

This latter capacity is abetted by a Gene Synthesis Facility capable of producing multiple kilobases of DNA per week. (utexas.edu)
10. Melchers, F.: Synthesis, transport and secretion of immunoglobulins. (uni-mainz.de)
18. Melchers, F., Lafleur, Anderson, J.: Immunoglobulin M synthesis in resting (Go) and in mitogen-activated B-lymphocytes. (uni-mainz.de)
22. Melchers, F.: Immunoglobulin synthesis and mitogen reactivity: markers for B lymphocyte differentiation. (uni-mainz.de)

The review highlights the discovery of oncogenes and suppressor tumor genes, underlining the crucial role of these achievements in cancer diagnosis and therapies. (jcancer.org)

tally and temporally regulate gene expression (reviewed in references 1, 2, 54, and 68). (moam.info)

Further confirmation that the immunoglobulin was IgA came from molecular weight analysis via SDS-PAGE and positive binding in a Western blot probed with antisera specific for mouse IgA. (vin.com)

Cold agglutinins commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody. (medscape.com)

1975). "[The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal. (wikipedia.org)

Gene regulation in the human genome is controlled by distal enhancers that activate specific nearby promoters 1 . (nature.com)

RNAi is mediated by small (21- to 24-nucleotide [nt]) antisense RNAs that induce gene-specific silencing by virtue of complete or partial complementarity with their respective target mRNAs (2, 13, 72, 73, 75). (moam.info)

12. Melchers, F.: Possible roles of the carbohydrate groups in biological functions of the glycoproteins, immunoglobulin M and G. In: 'Int. Symp. (uni-mainz.de)
The light will cause possible biological stains to change color or fluoresce, assisting in the location process. (ojp.gov)
A gene present on the X and Y sex chromosomes that is used in DNA identification testing to determine the gender of the donor of the DNA in a biological sample. (ojp.gov)

rarely, it may involve monoclonal immunoglobulin G (IgG), immunoglobulin A (IgA), or λ light chain restriction. (medscape.com)

1993). "Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M.". Biochemistry. (wikipedia.org)
High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. (utexas.edu)
Amazingly, the first human cancer gene was cloned only thirty years ago. (jcancer.org)
Without doubt, the first human transforming gene, and more broadly, oncogenes and anti-oncogenes, had been previously theorized by Theodor Boveri. (jcancer.org)
The gene encoding the Ov-phy-1 open reading frame contained 11 introns, similar in structure to the gene encoding human prolyl 4-hydroxylase isoform I. Genomic Southern blot, EST and genomic PCR studies demonstrated that the O. volvulus genome contained between three and eight genes closely related to Ov-phy-1. (embl.de)

A bacterial protein from Pseudomonas, Bordetella, or Alcaligenes which operates as an electron transfer unit associated with the cytochrome chain. (lookformedical.com)

In: 'Biochemistry of Gene Expression in Higher Organisms,' Sydney, eds. (uni-mainz.de)
2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)
Raw and processed data for ExP STARR-seq, motif ExP STARR-seq, HS-STARR-seq and K562 PRO-seq can be found at the NCBI's Gene Expression Omnibus under accession number GSE184426 . (nature.com)
Given that HSV-1 encodes several microRNAs, it is possible that a dynamic equilibrium exists between silencing and silencing suppression that is capable of modulating viral gene expression to promote replication, to evade host defenses, and/or to promote latency. (moam.info)

Improvement can occur in nearly any organ, but improvement in L chain-type amyloidosis neuropathy is rare. (medscape.com)

Monoclonal rearrangements of IgH and TCRγ were studied using seminested polymerase chain reaction (PCR). (bmj.com)
Expressed sequence tag (EST) analysis and developmental polymerase chain reaction (PCR) studies demonstrated that Ov-phy-1 was expressed in L3 and adult parasites. (embl.de)
Producing multiple copies of a chosen DNA region, usually by PCR (Polymerase Chain Reaction). (ojp.gov)

Chemotherapy is based on the principle that, as in myeloma, proliferation of a plasma cell clone causes L chain-type amyloidosis. (medscape.com)
Many more studies have been published on the treatment of myeloma than of L chain-type amyloidosis, because myeloma is more common and the response to therapy can be more easily monitored. (medscape.com)
In L chain-type amyloidosis, determining the response to therapy is difficult and requires indirect measurements of end-organ damage, serial biopsies, or serial P component scans when available. (medscape.com)
After melphalan and prednisone were demonstrated to be useful for myeloma, the regimen was tried for L chain-type amyloidosis. (medscape.com)
[ 13 , 14 ] Taken together, these studies demonstrated a survival benefit of melphalan and prednisone compared with placebo in L chain-type amyloidosis. (medscape.com)
Many experts consider melphalan plus prednisone to be standard therapy for L chain-type amyloidosis for patients not enrolled in a clinical trial, and it is the only regimen that has been shown to prolong survival compared with no chemotherapy. (medscape.com)
[ 15 ] Nevertheless, other chemotherapeutic regimens used for multiple myeloma are also expected to benefit patients with L chain-type amyloidosis and are reasonable therapeutic options for this disease. (medscape.com)
In two studies of patients with L chain-type amyloidosis treated with melphalan-containing regimens, 5% of patients developed myelodysplasia within 3 years of treatment. (medscape.com)
The glomerulopathies associated with monoclonal light chains are Light Chain Deposition Disease (LCDD) and AL (light chainrelated) amyloidosis, each creating completely different alterations in the mesangium. (heraldopenaccess.us)

gene products that are expressed throughout the nervous and immune systems. (niepokorny.org)

Disease caused by gene mutation (colour blindness) and chromosomal mutation (Down Syndrome). (physicscatalyst.com)

Nothing in biology is understandable except in the light of genetics. (deltastate.edu)

Store vials at 2°C to 8°C. Conjugated forms should not be frozen and should be protected from exposure to light. (bdbiosciences.com)
Store undiluted at 4°C and protected from prolonged exposure to light. (bdbiosciences.com)

Immunoglobulin A (IgA) molecules are important components of mucosal fluids. (biomedcentral.com)
Equipment used to produce visible and invisible light at various wavelengths to enhance or visualize items of evidence (fluids, fingerprints, clothing fibers, etc. (ojp.gov)

Flow cytometry was performed on a BD FACSCalibur™ instrument and the histograms were derived from the gated events based on light scattering characteristics of viable splenocytes. (bdbiosciences.com)
The physicochemical and conformational characteristics of the abnormal light chains are primarily responsible for the downstream events affecting the mesangial milieu. (heraldopenaccess.us)
The characteristics of a single copy of a specific gene, or of a single copy of a specific location on a chromosome. (ojp.gov)

In humans, the production of IgA per day is greater than that of the other classes of immunoglobulins combined [ 1 ]. (biomedcentral.com)
Wells yielding absorbance (405 nm) readings above 0.2 were considered positive for production of immunoglobulin. (vin.com)

Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. (academicinfluence.com)

Ig mu chain C region is a protein that in humans is encoded by the IGHM gene. (wikipedia.org)

The structure of IgA is similar to that of other immunoglobulins. (biomedcentral.com)

However, we observed species- and chain-specific targeting patterns, demonstrating the need for multiple SHM targeting models. (aai.org)

The document must be interpreted in light of specific information regarding the patient and in conjunction with other sources of authority. (cdc.gov)
The results indicated the antibody produced by the hybridoma was specific for dolphin IgG heavy chain. (vin.com)

This chemokine is encoded by multiple genes. (lookformedical.com)

Normal and tubulopathic light chains do not interact with the mesangium thus mesangial homeostasis is maintained intact. (heraldopenaccess.us)

Each heavy chain is composed of four subdomains: the variable region of the heavy chain (VH), and the constant regions α1 (Cα1), Cα2 and Cα3, whereas the light chains have two subdomains, the variable region of the light chain (VL) and the constant region (CL) (Figure 1 ). (biomedcentral.com)

Promoters of variably expressed genes lack these motifs and show stronger responsiveness to enhancers. (nature.com)

Anatomy6

Organisms4

Diseases13

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes26

Disciplines and Occupations1

Information Science3

Receptor4

Proteins5

Kappa light chains2

Pathogenesis2

Precursor1

Membrane1

Amino acid seq2

Polyclonal2

Transcription5

Serum1

Enhancer1

Cells9

Synthesis4

Tumor1

Regulate1

Molecular1

Monoclonal antibody1

19751

Regulation1

Partial1

Biological3

Restriction1

Human5

Bacterial1

Expression4

Occur1

Polymerase3

Amyloidosis9

Immune1

Disease1

Biology1

Exposure to light2

Fluids2

Characteristics3

Production2

Cell1

Humans1

Structure1

Species1

Specific2

Multiple1

Normal1

Region1

Lack1