• mice
  • We have previously shown that high-dose glucocorticoid treatment reduces neointimal proliferation following arterial injury in mice, but is associated with increased local thrombosis. (bmj.com)
  • The investigators induced heart injury in mice through transverse aortic constriction (TAC). (innovations-report.com)
  • In mice, administration of thymosin β4 has been shown to stimulate formation of new heart muscle cells from otherwise inactive precursor cells present in the outer lining of adult hearts, to induce migration of these cells into heart muscle and recruit new blood vessels within the muscle. (wikipedia.org)
  • Langendorff
  • Rats were used for Langendorff isolated heart perfusion. (bmj.com)
  • Methods Langendorff perfused hearts were perfused with vehicle (normoxic control) or Sunitinib for 120 min and either stained with triphenyl-tetrazolium chloride to assess the level of infarct to risk size (n = 4) or analysed by real time PCR for the expression profile of MKK7 mRNA (n = 6) or analysed by western blot to assess the level of MKK7 activation (n = 4). (bmj.com)
  • arteries
  • There are some problems and issues associated with the use of stem cells to treat heart attacks and blocked arteries in the heart, and with this new method, many of these issues are removed. (medindia.net)
  • However, if it does happen, it is usually related to the use of catheters or other devices that travel through your arteries and heart. (emedtv.com)
  • myocardium
  • Deviant metabolic regulation due to increased flux through aldose reductase in diabetic hearts may influence the ability of the myocardium to withstand ischemia insult. (diabetesjournals.org)
  • It is possible that while the expanding fibroblast population is depositing excess extracellular material, a process that stiffens the heart, it also simultaneously stimulates capillary growth, to deliver more oxygen and nutrients to the expanding myocardium. (innovations-report.com)
  • Researchers
  • The researchers found that those with familial hypercholesterolemia - genetically determined high cholesterol - were more likely to suffer from tendon injury and pain, compared to those who did not. (belmarrahealth.com)
  • tissues
  • After 17 hours, histopathological observations and left ventricular pressure-volume analysis to assess cardiac function with a Millar microtip pressure-volume conductance catheter were performed, and levels of biochemicals of the heart tissues were measured. (ahajournals.org)
  • Regeneration in humans is the regrowth of lost tissues or organs in response to injury. (wikipedia.org)
  • However ongoing research, particularly in the heart and lungs, suggests that there is hope for a variety of tissues and organs to eventually become regeneration-capable. (wikipedia.org)
  • There are some human organs and tissues that regenerate rather than simply scar, as a result of injury. (wikipedia.org)
  • artery
  • When cholesterol is stuck to the artery walls, passing through becomes far more difficult for blood - and the heart has to work harder, too. (belmarrahealth.com)
  • He died by getting horned in the back, breaking several of his ribs which severed an artery that led to his heart. (wikipedia.org)
  • The bull turned and hit him in the back (although he was not gored), breaking several of his ribs which severed an artery that led to his heart. (wikipedia.org)
  • inhibition
  • These results suggest that beneficial inhibition of neointimal proliferation mediated by systemic glucocorticoid administration is negated in part by changes in fibrinolysis leading to large, semi-occlusive thrombi formation at the site of injury. (bmj.com)
  • To determine if aldose reductase inhibition improves tolerance to ischemia, hearts from acute type I diabetic and nondiabetic control rats were isolated and retrograde perfused. (diabetesjournals.org)
  • patients
  • When we profiled the small RNAs circulating in the blood of healthy people versus heart failure patients, we found increases in levels of certain microRNAs expressed by muscle, including three known to originate only in the heart," says Kemal Akat, the first author and a postdoc in the lab. (medicalxpress.com)
  • In patients with ischaemic heart disease, cathepsin-L is elevated in the serum and correlates with disease severity. (bmj.com)
  • Constitutional predisposition to vasovagal syncope: an additional risk factor in patients exposed to electrical injuries? (bmj.com)
  • Patients with a history of vasovagal reactions may be at high risk of developing lethal sinus node or conduction disturbances after electrical injuries. (bmj.com)
  • Patients with inherited high cholesterol have an increased risk of heart-related problems. (belmarrahealth.com)
  • Scientists
  • Scientists at Singapore's Institute of Medical Biology (IMB) and Bioprocessing Technology Institute (BTI) and The Netherlands' University Medical Center Utrecht say that their findings may pave the way for a novel way to improve survival and recovery rate after a heart attack. (medindia.net)
  • Scientists in Thomas Tuschl's Laboratory of RNA Molecular Biology have linked an increase in certain microRNAs circulating in the blood with injury to cardiac muscle . (medicalxpress.com)
  • human heart
  • They have revealed that they chose pigs for the study because it is the closest animal approximation to the human heart in terms of size, structure and function. (medindia.net)
  • Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers. (medicalxpress.com)
  • result
  • Lane Clyde Frost (October 12, 1963 - July 30, 1989) was an American professional bull rider and Professional Rodeo Cowboys Association (PRCA) member, who died in the arena at the 1989 Cheyenne Frontier Days Rodeo as a result of injuries sustained riding the bull Takin' Care of Business. (wikipedia.org)
  • The loan was cut short on 11 February, as a result of Carrick suffering an injury. (wikipedia.org)
  • left
  • On 8 July 2015, Carrick left Hearts to pursue regular first team football, with his contract having been terminated by mutual consent. (wikipedia.org)
  • The injury left him sidelined for the rest of the season and for most of the 2011-12 campaign. (wikipedia.org)
  • Research
  • Writing about their experiments in the journal Stem Cell Research, the team has revealed that heart function among the pigs administered the secretion from the stem cells was also found to improve during the study. (medindia.net)
  • It paves the way for improved recovery after heart attack -- a very practical outcome from stem cell research. (medindia.net)
  • This targeting of research to find ways of combating illness and benefiting people faster is at the heart of what we aim to do at IMB. (medindia.net)
  • American Heart Assoc
  • Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. (heart.org)
  • site
  • Dexamethasone-induced thrombosis at the site of intraluminal wire injury may be attributable to alterations in the endogenous fibrinolytic system rather than changes in platelet activity. (bmj.com)
  • increase
  • Specific over expression of MKK7 in hearts has been shown to increase the sensitivity of cardiomyocytes to external stresses. (bmj.com)
  • found
  • They found three RNAs with potential for use as markers of heart injury. (medicalxpress.com)
  • This opens the possibility of finding many promising biomarkers like those we found from heart muscle , leading to a more universal test then the current monitoring of single proteins. (medicalxpress.com)
  • healthy
  • Signs of trouble: Postdoc Kemal Akat and colleagues used sensitive RNA sequencing techniques to profile the abundance of microRNAs in samples from healthy people and those suffering from heart failure. (medicalxpress.com)
  • However
  • However, when persistent or too intense, ERs will induce and activate ER proapoptosis fators such as CHOP, caspase-12, This study aimed to elucidate Ischaemic postconditioning (IPO) whether attenuates I/R injury by suppressing ER stress-induced apoptosis. (bmj.com)
  • However, advanced stages of remodeling have already begun by day seven following injury. (innovations-report.com)
  • member
  • A member of Hearts Under-20 side, Carrick made his Scottish Premier League debut on 4 August 2012, in a 2-0 win over St Johnstone. (wikipedia.org)
  • vehicle
  • The injury itself is most commonly seen in high-speed vehicle accidents, and the fatality rate is 95% due to the massive loss of blood. (wikipedia.org)
  • skin
  • These multiple properties have provided the impetus for a worldwide series of on-going clinical trials of potential effectiveness of thymosin β4 in promoting repair of wounds in skin, cornea and heart. (wikipedia.org)