AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth CareGeographicals
DigoxinHeart FailureHeartHeart RateCardiac Output, LowHeart Failure, SystolicCardiotonic AgentsHeart Failure, DiastolicStroke VolumeMyocardiumHeart DiseasesVentricular Function, LeftHeart TransplantationCardiomyopathy, DilatedDigitoxinVentricular Dysfunction, LeftHemodynamicsNatriuretic Peptide, BrainChronic DiseaseTreatment FailureAdrenergic beta-AntagonistsCardenolidesTime FactorsTreatment OutcomeMyocardial ContractionVentricular RemodelingDiureticsEchocardiographyCardiac GlycosidesHeart Defects, CongenitalCardiac Pacing, ArtificialFollow-Up StudiesProspective StudiesAngiotensin-Converting Enzyme InhibitorsHeart Function TestsAnti-Arrhythmia AgentsCardiomyopathiesHospitalizationCardiomegalyMyocytes, CardiacMyocardial InfarctionHeart AtriaPrognosisRisk FactorsPropanolaminesDogsExercise TestHeart-Assist DevicesMedigoxinDigitalis GlycosidesSystoleFetal HeartMyocardial IschemiaRetrospective StudiesDisease Models, AnimalSeverity of Illness IndexHeart VentriclesBiological MarkersDouble-Blind MethodHeart ValvesEleutherococcusDiastoleKidney Failure, ChronicAtrial FibrillationHeart BlockSpironolactonePredictive Value of TestsExercise ToleranceArrhythmias, CardiacAtrial Natriuretic FactorSympathetic Nervous SystemVentricular DysfunctionCardiovascular AgentsElectrocardiographyCarbazolesOxygen ConsumptionDrug InteractionsPatient ReadmissionProportional Hazards ModelsEchocardiography, DopplerVentricular PressureRisk AssessmentBlood PressureSurvival AnalysisPulmonary Wedge PressureMineralocorticoid Receptor AntagonistsCohort StudiesSurvival RateNorepinephrineMetoprololCoronary DiseaseCardio-Renal SyndromeFailure to ThrivePacemaker, ArtificialNeriumCardiac Resynchronization TherapyRenal InsufficiencyRadioimmunoassayOuabainVasodilator Agents
Congestive heart fArrhythmiasToxicityDiureticsAmount of digoxinAtrialSerum digoxin concentrationCardiac glycosideAcuteLanoxinImmune fabDigitalisMorbidity and mortaFoxgloveTherapeuticDigitoxinPotassiumMedicationVentricularChronic Heart FMedicationsDiastolic heart failureNauseaClinicalAngiotensinDosesDiagnosisIrregularPatients with heart failureMortality in patientsOverdoseRenal failureDoseRhythmsAllergicVerapamilToxicKidneyIntoxicationMyocardialTabletTreatmentSubstancesEjection fractionInhibitorsSystolic heart failureColchicine
Congestive heart f31
Arrhythmias9
  • This antidote has been shown to be highly effective in treating life-threatening signs of digoxin toxicity such as hyperkalemia, hemodynamic instability, and arrhythmias. (wikipedia.org)
  • Magnesium suppresses digoxin-induced ventricular arrhythmias while phenytoin and lidocaine suppresses digoxin-induced ventricular automaticity and delay afterdepolarizations without depressing AV conduction. (wikipedia.org)
  • Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). (medlineplus.gov)
  • tell your doctor if you have or have ever had thyroid problems, heart arrhythmias, cancer, or kidney disease. (medlineplus.gov)
  • It is used to treat arrhythmias and heart failure. (medicines.org.uk)
  • A test that records the electrical activity of the heart, shows abnormal rhythms (arrhythmias or dysrhythmias), and may detect problems with the heart muscle. (chop.edu)
  • For patient education information, see the Heart Health Center , as well as Atrial Flutter , Arrhythmias (Heart Rhythm Disorders) , Stroke , Supraventricular Tachycardia (SVT, PSVT) , and Palpitations . (medscape.com)
  • Symptomatic arrhythmias may be treated with Digoxin Immune Fab. (tasmanianairrescuetrust.org)
  • Life threatening arrhythmias (ventricular tachycardia, ventricular fibrillation, high degree A-V block, bradyarrhythma, sinus arrest) or hyperkalemia requires administration of Digoxin Immune Fab. (tasmanianairrescuetrust.org)
Toxicity22
  • Digoxin toxicity, also known as digoxin poisoning, is a type of poisoning that occurs in people who take too much of the medication digoxin or eat plants such as foxglove that contain a similar substance. (wikipedia.org)
  • Treatment of severe toxicity is with digoxin-specific antibody fragments. (wikipedia.org)
  • Digoxin toxicity is often divided into acute or chronic toxicity. (wikipedia.org)
  • In digoxin toxicity, the finding of frequent premature ventricular beats (PVCs) is the most common and the earliest dysrhythmia. (wikipedia.org)
  • In addition, depressed conduction is a predominant feature of digoxin toxicity. (wikipedia.org)
  • Other ECG changes that suggest digoxin toxicity include bigeminal and trigeminal rhythms, ventricular bigeminy, and bidirectional ventricular tachycardia. (wikipedia.org)
  • High amounts of the electrolyte potassium (K+) in the blood (hyperkalemia) is characteristic of digoxin toxicity. (wikipedia.org)
  • Digoxin toxicity increases in individuals who have kidney impairment. (wikipedia.org)
  • The primary treatment of digoxin toxicity is digoxin immune fab, which is an antibody made up of anti-digoxin immunoglobulin fragments. (wikipedia.org)
  • Digoxin toxicity can develop both over prolonged treatment and following an overdose. (anzen.co.in)
  • Digoxin-specific antibody fragments are safe and effective in treating severe toxicity. (anzen.co.in)
  • Owners also need be aware of toxicity signs, as they can be subtle and may look just like a heart failure. (petmd.com)
  • One of the most significant concerns about this condition is toxicity to the heart cells themselves, called myocardial toxicity. (petmd.com)
  • No additional digoxin should be given after you notice symptoms of toxicity in your dog. (petmd.com)
  • Antibody therapy, a medication given to bind with a powerful cardiac stimulant that is in the blood stream, is used in humans with digoxin toxicity and has been used on animals. (petmd.com)
  • Having a digoxin toxicity episode may concern the dog owner into stopping the digoxin treatment, but lower doses can begin again after the blood has dropped below toxic range and the pet has no further signs of toxicity. (petmd.com)
  • If you develop digoxin toxicity, this can lead to various forms of heart rhythm disturbances, some of which resemble the rhythm disturbances for which the product was prescribed. (medicines.org.uk)
  • Introduction - Digoxin is commonly prescribed to elderly patients with heart failure and atrial fibrillation, and macrolide antibiotics markedly increase the risk of digoxin toxicity. (ices.on.ca)
  • Signs and symptoms of digoxin toxicity become more frequent with levels above 2 ng/mL. (tasmanianairrescuetrust.org)
  • Digoxin Immune Fab has been shown to be 80-90% effective in reversing signs and symptoms of digoxin toxicity. (tasmanianairrescuetrust.org)
  • [ 7 ] Spontaneous depolarization of pacemaker or other cells enhanced by digoxin may result in tachyarrhythmias seen in cases of digoxin toxicity. (medscape.com)
  • [ 8 ] Because of its narrow therapeutic index, toxicity may result even with mildly increased digoxin level. (medscape.com)
Diuretics2
Amount of digoxin3
  • First method is based on the amount of digoxin ingested whereas the second method is based on the serum digoxin concentration and the weight of the person. (wikipedia.org)
  • If you are taking this medicine, your doctor may ask you to have regular blood tests to determine the amount of digoxin in the blood. (medicines.org.uk)
  • When a large amount of digoxin has been ingested, especially in patients with impaired renal function, hyperkalemia may be present due to release of potassium from skeletal muscle. (tasmanianairrescuetrust.org)
Atrial6
Serum digoxin concentration1
Cardiac glycoside2
  • Have an irregular heart-beat caused by cardiac glycoside intoxication or conditions such as Wolff-Parkinson-White syndrome. (medicines.org.uk)
  • Digitalis lanata is cultivated for medicine because it makes a cardiac glycoside called digoxin. (futurity.org)
Acute6
  • Transfer patients with severe acute HF to a center with pediatric HF specialists and the expertise and ability to optimize medical therapy, evaluate for heart transplant, and if necessary, provide mechanical support. (medscape.com)
  • The European Society of Cardiology (ESC) has published two new guidelines - ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012, and European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). (bjcardio.co.uk)
  • In contrast with left heart failure (LHF), the course and outcomes of acute or decompensated RHF have been seldom described [ 1 , 2 ]. (ersjournals.com)
  • A large meta-analysis showed no decrease in all-cause mortality, recurrent ischemia, or myocardial infarction, heart failure, and arrhythmia from using routine oxygen therapy in patients with acute myocardial infarction with normal oxygen saturation levels. (the-hospitalist.org)
  • In this study we describe patient characteristics and outcomes of acute heart failure (AHF) in Botswana.Methods: Socio-demographic, clinical and laboratory data were collected from 193 consecutive patients admitted with AHF at Princess Marina Hospital in Gaborone between February 2014 and February 2015. (bvsalud.org)
  • TRUE-AHF: Better to Prevent vs Treat Acute Decompensation Dr Pina interviews Dr Packer about his trial on ularitide infusion in patients with acute decompensated heart failure, which was presented at the American Heart Association meeting. (medscape.com)
Lanoxin4
Immune fab9
  • What Is Digoxin Immune FAB and How Does It Work? (rxlist.com)
  • Digoxin Immune FAB ( Antidote ) is a prescription antidote used for treating digoxin poisoning . (rxlist.com)
  • What Are Dosages of Digoxin Immune FAB? (rxlist.com)
  • What Are Side Effects Associated with Using Digoxin Immune FAB? (rxlist.com)
  • What Other Drugs Interact with Digoxin Immune FAB? (rxlist.com)
  • Digoxin Immune FAB has no noted severe interactions with any other drugs. (rxlist.com)
  • Digoxin Immune FAB has no noted serious interactions with any other drugs. (rxlist.com)
  • Digoxin Immune FAB has no noted moderate interactions with any other drugs. (rxlist.com)
  • What Are Warnings and Precautions for Digoxin Immune FAB? (rxlist.com)
Digitalis5
  • But plants belonging to this genus, Digitalis , also harbor a less visible asset: Chemicals called cardiac glycosides, which have been recorded to treat heart failure since the 1780s, says University at Buffalo biologist Zhen Wang. (buffalo.edu)
  • Scientists say they've found traces of digitalis, or foxglove - a beautiful but potentially heart-stopping plant - in the digestive tract of Cangrande della Scala of Verona. (livescience.com)
  • Known hypersensitivity to digoxin or other forms of digitalis. (tasmanianairrescuetrust.org)
  • Digitalis strengthens the force of contractions of weakened hearts, but it is not a cardiac vitamin that can make a strong heart stronger. (medscape.com)
  • Digoxin and digitoxin are the main digitalis products. (medscape.com)
Morbidity and morta4
  • A retrospective review was conducted to assess the accuracy of diagnosis, the morbidity and mortality of digoxin intoxication, and its incidence in hospitalized patients with heart failure. (nih.gov)
  • While the goal for managing heart disease is to reduce morbidity and mortality, there remain important gaps in our understanding of several critical areas. (vin.com)
  • The overarching goal when managing heart disease is to improve survival by reducing morbidity and mortality. (vin.com)
  • Anaemia and renal dysfunction are associated with an increased morbidity and mortality in heart failure (HF) patients.Objective. (bvsalud.org)
Foxglove6
  • Foxglove plants produce heart medicine. (buffalo.edu)
  • This species of foxglove plant makes digoxin, a chemical that is used sparingly to treat heart failure. (buffalo.edu)
  • How do foxglove plants make heart medicine? (futurity.org)
  • Two studies mark early steps in the quest to understand how foxglove plants make medicinal compounds that treat heart failure. (futurity.org)
  • Current methods for producing digoxin are cumbersome: Because each foxglove plant makes only a little bit of the chemical, farmers must grow the crop in huge quantities, Wang says. (futurity.org)
  • But then, they discovered something more unusual: foxglove pollen in Cangrande's rectum, as well as toxic concentrations of digoxin and digitoxin, two molecules from foxglove plants, in Cangrande's liver and feces samples. (livescience.com)
Therapeutic5
  • Since this is a narrow therapeutic index, digoxin overdose can happen. (wikipedia.org)
  • While digoxin is useful at times, the difference between a therapeutic dosage and a toxic dosage can be slight. (petmd.com)
  • Recent reports have indicated using digoxin at levels below therapeutic levels can be beneficial. (petmd.com)
  • Some other drugs with a narrow therapeutic window include warfarin, lithium, digoxin, and phenobarbital. (acsh.org)
  • Specimen must not be drawn within 6 hours of dosing digoxin for therapeutic drug monitoring. (medscape.com)
Digitoxin1
Potassium4
  • Digoxin regulates certain minerals (sodium and potassium) within cardiac cells. (anzen.co.in)
  • Avoid potassium salts in patients with bradycardia or heart block. (tasmanianairrescuetrust.org)
  • Digoxin inhibits sodium-potassium-activated ATPase, thereby decreasing sodium efflux and the trans-membrane potential. (medscape.com)
  • 7. Current prescription for a) potassium chloride, b) digoxin, c) amantadine, or d) levodopa. (who.int)
Medication3
  • If ischemia is detected, medication should be titrated to specific endpoints of heart rate and blood pressure or until the ischemia resolves. (medscape.com)
  • If you are ordered a medication to treat your heart failure, do not stop taking any medication unless your healthcare provider tells you to. (chemocare.com)
  • The FDA has approved digoxin to treat patients with heart failure and arrhythmia, but in the new publication from Trends in Pharmacological Sciences , researchers looked at repurposing the medication for other non-cardiac diseases. (yale.edu)
Ventricular6
  • Atropine may be used if the heart rate is slow while magnesium sulfate may be used in those with premature ventricular contractions. (wikipedia.org)
  • In devices, left ventricular assist devices (LVADs) have been hailed as a step change in the management of heart failure. (bjcardio.co.uk)
  • Ventricular septal defect describes one or more holes in the wall that separates the right and left ventricles of the heart. (wikidoc.org)
  • Ventricular septal defect is one of the most common congenital (present from birth) heart defects. (wikidoc.org)
  • In adults, ventricular septal defects are a rare but serious complication of heart attacks . (wikidoc.org)
  • Hearts from cats with ventricular hypertrophy (HCM), and restrictive cardiomyopathy (RCM) are affected by complex intrinsic and extrinsic factors that affect left ventricular diastolic performance. (vin.com)
Chronic Heart F1
  • Aim To evaluate the incidence of iron deficiency (ID) in men and women with chronic heart failure (CHF) and to compare clinical and functional indexes in patient with and without ID depending on the gender.Material and methods An additional analysis of the study "Prevalence of Iron Deficiency in Patients With Chronic Heart Failure in the Russian Federation (ID-CHF-RF)" was performed. (bvsalud.org)
Medications6
  • Medications like cholestyramine, psyllium, antacids, or aminosalicylic acid should be taken as widely apart as possible from digoxin dosage. (anzen.co.in)
  • You may be able to manage many of these symptoms and ease complications of heart failure with the help of medications, lifestyle adjustments, and, in some cases, medical procedures. (healthline.com)
  • Your doctor may prescribe certain medications to lower your blood pressure and ease the workload of the heart. (healthline.com)
  • Medications or pacemakers are often helpful in treating heart failure initially. (chop.edu)
  • The guidelines stress that when attempting to reduce heart rate, the dose of beta blocker should be maximised before giving additional medications to reduce heart rate. (bjcardio.co.uk)
  • There are many medications available to treat heart failure. (clevelandclinic.org)
Diastolic heart failure7
Nausea2
Clinical4
  • 3) no intoxication--patients whose symptoms or ECG abnormalities were clearly explained by other associated clinical illnesses and persisted after withdrawal of digoxin. (nih.gov)
  • The majority of patients discharged with the diagnosis of digoxin intoxication (133 or 60%) were classified as possibly digoxin intoxicated, and 43 patients (20%) had no clinical evidence to support this diagnosis. (nih.gov)
  • However, in deciding whether a patient's symptoms are due to digoxin, the clinical state together with serum electrolyte levels and thyroid function are important factors. (tasmanianairrescuetrust.org)
  • Understanding CV Hemodynamics Key in Heart Failure Dr Piña interviews Dr Burkhoff, a physician and biomechanical engineer who developed a software application of cardiovascular physiology and hemodynamics for use in teaching and clinical practice. (medscape.com)
Angiotensin1
Doses3
  • Older adults should usually receive low doses of digoxin because higher doses may cause serious side effects. (medlineplus.gov)
  • This compound is toxic in large quantities, but it's prescribed sparingly, in small doses, to treat heart failure and certain heart rhythm abnormalities. (futurity.org)
  • Patients who have intentionally or accidently ingested massive doses of digoxin should receive activated charcoal orally or by nasogastric tube regardless of the time since ingestion since digoxin recirculates to the intestine by enterohepatic circulation. (tasmanianairrescuetrust.org)
Diagnosis6
  • Read on to learn more about the prevention, diagnosis, and treatment of systolic heart failure. (medicalnewstoday.com)
  • This allows the measurement of various pressures inside the heart to aid in the diagnosis of heart failure. (chop.edu)
  • We reviewed the medical records of 219 patients discharged with the diagnosis of digoxin intoxication between 1980 and 1988. (nih.gov)
  • Of these, 563 were receiving digoxin and in 27 the diagnosis of digoxin intoxication was made by their clinicians. (nih.gov)
  • The recommendations on devices, drugs and diagnosis in heart failure were developed by the ESC in collaboration with a heart failure association of the ESC. (bjcardio.co.uk)
  • I have met patients who were first diagnosed as having a respiratory issue," says heart failure specialist Miriam Jacob, MD . "Over time, when their symptoms didn't improve with appropriate treatment, heart failure was entertained as a diagnosis. (clevelandclinic.org)
Irregular6
  • This medicine works by correcting irregular heartbeats to a normal rhythm and strengthens the force of the heart-beat, which is why it is useful in heart failure. (medicines.org.uk)
  • If you have abnormal heart rhythm (heart block) and you are taking this medicine, contact your doctor immediately if you feel one or more of the following symptoms: fainting, short-lasting loss of consciousness, dizziness or light-headedness, fatigue (tiredness), shortness of breath, chest pain, irregular heart-beat or confusion. (medicines.org.uk)
  • If you have a sinoatrial disorder (a disorder in the conduction of electrical impulses in the heart such as Sick Sinus Syndrome), in some patients with a sinoatrial disorder this medicine can cause a slow and/or irregular heart-beat. (medicines.org.uk)
  • medicines used to control irregular heart rhythms and extra heart beats. (heartfailurematters.org)
  • an irregular heart rhythm. (heartfailurematters.org)
  • a class of medicines used to treat high blood pressure, angina and some irregular heart rhythms. (heartfailurematters.org)
Patients with heart failure3
Mortality in patients1
  • Digoxin: Clues to a Threshold for This Last-Resort Drug Dr De Ferrari provides details on a substudy of the ARISTOTLE trial that examined digoxin blood levels and mortality in patients with and without heart failure. (medscape.com)
Overdose1
Renal failure1
  • Blood pressure assessment is particularly relevant in face of diseases known to raise blood pressure or effect heart structures such as chronic renal failure and hyperthyroidism. (vin.com)
Dose5
  • Different brands of digoxin have different amounts of active drug and your dose would need to be changed. (medlineplus.gov)
  • The effect of felodipine on blood pressure is principally a consequence of a dose related decrease of peripheral vascular resistance in man, with a modest reflex increase in heart rate (see Cardiovascular Effects ). (nih.gov)
  • To treat high blood pressure or after a heart attack, the usual starting dose of perindopril is 4 mg taken once daily. (medbroadcast.com)
  • [ 2 ] General adult dose of digoxin is 0.75-1.5 mg for digitalization and 0.125-0.5 mg daily for maintenance. (medscape.com)
  • Using propensity score-matched controls, post hoc subgroup analysis of the ARISTOTLE trial showed an independent dose-dependent association between serum digoxin levels and mortality in those receiving digoxin, with a 19% higher adjusted hazard of death for each increase of 0.5 ng/mL (P = .001). (the-hospitalist.org)
Rhythms1
Allergic1
Verapamil4
Toxic2
  • The fluid and electrolyte balance also needs to be corrected, as abnormalities are a significant contributor to the toxic effects to the heart. (petmd.com)
  • The toxic range for digoxin is greater than 2.5 ng/mL. (medscape.com)
Kidney4
Intoxication1
Myocardial1
  • This unloading of the heart reduces myocardial energy consumption and oxygen requirements, and probably accounts for the effectiveness of nifedipine in chronic stable angina. (nih.gov)
Tablet2
  • Digoxin comes as a tablet, capsule, or pediatric elixir (liquid) to take by mouth. (medlineplus.gov)
  • Digoxin is available in tablet and solution (for intravenous use) dosage forms. (anzen.co.in)
Treatment13
  • The level of digoxin for treatment is typically 0.5-2 ng/mL. (wikipedia.org)
  • Though treatment for systolic heart failure is available, there is no cure. (medicalnewstoday.com)
  • The American Heart Association describes the stages of heart failure: A, B, C, and D. These stages help the doctor guide the management and treatment of CHF. (healthline.com)
  • For that reason, the veterinarian will need to monitor the digoxin blood levels throughout treatment. (petmd.com)
  • Therefore, the veterinarian will take a blood sample to determine the serum digoxin level throughout the treatment, but additional blood analyses for electrolytes, organ function and cell counts are also important. (petmd.com)
  • Careful management and frequent follow-up exams are critical, especially if digoxin is part of another treatment plan. (petmd.com)
  • At times, treatment of the underlying disorder (eg, thyroid disease, valvular heart disease) is necessary to effect conversion to sinus rhythm. (medscape.com)
  • Treatment of mild to moderate heart failure in adults. (tasmanianairrescuetrust.org)
  • That's why if you've been diagnosed with asthma or bronchitis , and your cough doesn't improve with treatment, you should be evaluated for heart failure . (clevelandclinic.org)
  • Once heart failure has been diagnosed and appropriate treatment started, the cough should improve or go away," assures Dr. Jacob. (clevelandclinic.org)
  • But if you're experiencing heart cough symptoms or have been diagnosed with asthma or bronchitis and your cough doesn't improve with treatment, you should talk to your doctor about heart failure. (clevelandclinic.org)
  • ACE inhibitors thus help limit fluid retention and are one of the mainstays of systolic heart failure treatment. (msdmanuals.com)
  • This novel trial uses mobile apps to reward or punish heart failure patients for good or poor adherence to treatment regimens. (medscape.com)
Substances1
Ejection fraction6
Inhibitors4
  • Uptake of [ 3 H]digoxin in SCHH was not inhibited by a variety of substrates or inhibitors for OATP1B1, OATP1B3, OATP2B1, organic anion transporter 2, organic cation transporter 1, and monocarboxylate transporter 8. (aspetjournals.org)
  • By doing so, ACE inhibitors cause arteries and veins to widen (dilate) and help the kidneys excrete excess water, thus decreasing the amount of work the heart has to do. (msdmanuals.com)
  • The drugs prolong life better than ACE inhibitors or ARBs alone in people with systolic heart failure. (msdmanuals.com)
  • Halting HF in Patients With Diabetes: Insights From EMPA-REG A substudy of EMPA-REG finds that SGLT2 inhibitors may slow the onset of heart failure. (medscape.com)
Systolic heart failure6
Colchicine1
  • You should also read Chuck Dinerstein's recent article about how colchicine may be useful in treating heart disease. (acsh.org)