• Doses
  • A study of hemodynamic function in patients with ejection fractions both above and below 35% showed no clinically significant effects on cardiac output, mean pulmonary arterial pressure, or pulmonary capillary wedge pressure at doses of Corvert up to 0.03 mg/kg. (drugs.com)
  • Larger doses seem to slightly increase blood pressure but not beyond clinical relevance. (wikipedia.org)
  • High blood lactic acid level is a concern if the medication is prescribed inappropriately and in overly large doses. (wikipedia.org)
  • glomerular filt
  • AIMS The primary aim of this study is to assess whether at comparable levels of optimal blood pressure and metabolic control, the ACE inhibitor delapril alone or in combination with the dihydropyridine CCB manidipine slow the rate of glomerular filtration rate (GFR) decline as compared with placebo plus conventional antihypertensive therapy in patients with diabetes mellitus type 2 and hypertension. (clinicaltrials.gov)
  • Pharmacokinetics in women is affected by lower body weight, slower gastrointestinal motility, less intestinal enzymatic activity, and slower glomerular filtration rate. (aafp.org)
  • adverse
  • Similarly, mice overexpressing 11β-HSD1 in the liver develop adverse metabolic features but do not become obese ( 5 ). (diabetesjournals.org)
  • The UK Prospective Diabetes Study, a large clinical trial performed in 1980-90s, provided evidence that metformin reduced the rate of adverse cardiovascular outcomes in overweight patients with type 2 diabetes relative to other antihyperglycemic agents. (wikipedia.org)
  • The Cochrane Collaboration's reviews on the treatment of ADHD in children, adolescents, and adults with pharmaceutical amphetamines stated that while these drugs improve short-term symptoms, they have higher discontinuation rates than non-stimulant medications due to their adverse side effects. (wikipedia.org)
  • CYP2D6
  • Considerable unexplained intersubject variability in the debrisoquine metabolic ratio (urinary debrisoquine/4-hydroxydebrisoquine) exists within individual CYP2D6 genotypes. (aspetjournals.org)
  • Thirteen healthy young volunteers, nine CYP2D6*1 homozygotes [extensive metabolizers (EMs)] and four CYP2D6*4 homozygotes [poor metabolizers (PMs)] took 12.8 mg of debrisoquine hemisulfate by mouth and collected 0- to 8- and 8- to 24-h urines, which were analyzed by gas chromatography-mass spectrometry (GCMS) before and after treatment with β-glucuronidase. (aspetjournals.org)
  • antihypertensive
  • Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. (rxlist.com)
  • renal
  • INTRODUCTION Optimal blood pressure, glycemic and lipid control are of utmost importance to minimize the incidence and the progression of chronic renal and cardiovascular complications in patients with diabetes mellitus type 2. (clinicaltrials.gov)
  • For example, because renal clearance is slower in women, some renally-excreted medications, such as digoxin, may require a dosage adjustment. (aafp.org)
  • intravenous
  • In a study in healthy volunteers, intravenous infusions of Corvert resulted in prolongation of the QT interval that was directly correlated with ibutilide plasma concentration during and after 10-minute and 8-hour infusions. (drugs.com)
  • severe
  • For example, a 2014 review found tentative evidence that people treated with sulfonylureas had a higher risk of severe low blood sugar events (RR 5.64), though their risk of non-fatal cardiovascular events was lower than the risk of those treated with metformin (RR 0.67). (wikipedia.org)
  • Subjects
  • Sato J, Nakata H, Owada E, Kikuta T, Umetsu M, Ito K "Influence of usual intake of dietary caffeine on single-dose kinetics of theophylline in healthy human subjects. (drugs.com)
  • ischemic
  • However, they also found that a subgroup of nonwhite men had elevated rates of death from chronic ischemic heart disease when compared with the overall US population. (epa.gov)
  • higher
  • For example, in a previous study Matanoski and coworkers reported that while mortality of styrene-exposed workers from atherosclerotic heart disease was less than mortality of the overall US population, it was significantly higher among a subgroup of black workers than would be expected based on general population rates. (epa.gov)
  • Treatment
  • For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). (rxlist.com)
  • DW Dodick (Cephalalgia, 2004,24, 298-304) Almotriptan improves response rates when treatment is within 1 hour of migraine onset. (wikipedia.org)
  • Workers
  • This discrepancy is often found in such studies because workers tend to be healthier than the general population (the healthy worker effect). (epa.gov)
  • heart
  • Allopurinol lowers uric acid in the blood and is normally indicated for gout, but studies have showed that it also can reduce the thickness of the left ventricle of the heart in people with heart- and kidney disease. (clinicaltrials.gov)
  • An agent which interferes with the renin (kidney-lung-heart blood pressure control) cycle. (wikipedia.org)
  • levels
  • THC is converted rapidly to 11-hydroxy-THC, which is also pharmacologically active, so the drug effect outlasts measurable THC levels in blood. (wikipedia.org)
  • study
  • In conclusion, this study suggests that the traditional metabolic ratio is not a true measure of the debrisoquine 4-hydroxylation capacity of an individual and thus may, in part, explain the wide intragenotype variation in metabolic ratio. (aspetjournals.org)
  • After 7 days, participants will return to the metabolic unit to repeat the Day 1 and Day 2 study procedures. (clinicaltrials.gov)
  • One week after the second set of study tests, participants will return for a brief physical exam and blood tests. (clinicaltrials.gov)
  • In another study, steady-state concentration and area under the concentration-time curve of theophylline (1200 mg intravenously over 24 hours) increased by 23% and 40%, respectively, in eight healthy volunteers following administration of caffeine (300 mg orally three times a day). (drugs.com)
  • The primary efficacy variable of this study is the rate of GFR decline. (clinicaltrials.gov)
  • Allometry is a well-known study, particularly in statistical shape analysis for its theoretical developments, as well as in biology for practical applications to the differential growth rates of the parts of a living organism's body. (wikipedia.org)
  • type
  • However, limitations of the data make it difficult to assess the roles of factors such as diet, smoking, physical activity, blood pressure or type of job within the industry. (epa.gov)
  • mild
  • Corvert produces mild slowing of the sinus rate and atrioventricular conduction. (drugs.com)
  • phenytoin
  • The pharmacokinetics of fosphenytoin following IV administration of CEREBYX, however, are complex, and when used in an emergency setting (e.g., status epilepticus), differences in rate of availability of phenytoin could be critical. (eci2012.net)
  • Adverse
  • The UK Prospective Diabetes Study, a large clinical trial performed in 1980-90s, provided evidence that metformin reduced the rate of adverse cardiovascular outcomes in overweight patients with type 2 diabetes relative to other antihyperglycemic agents. (wikipedia.org)
  • The Cochrane Collaboration's reviews on the treatment of ADHD in children, adolescents, and adults with pharmaceutical amphetamines stated that while these drugs improve short-term symptoms, they have higher discontinuation rates than non-stimulant medications due to their adverse side effects. (wikipedia.org)
  • onset
  • DW Dodick (Cephalalgia, 2004,24, 298-304) Almotriptan improves response rates when treatment is within 1 hour of migraine onset. (wikipedia.org)
  • cardiac
  • Encouraging reports of the use of near-infrared spectroscopy, a noninvasive method of monitoring cerebral blood oxygenation, during carotid endarterectomy 11 and cardiac surgery 12 must be balanced against the fact that current technology is qualitative rather than quantitative and can only be used to detect trends rather than to provide accurate measurements. (asahq.org)
  • increase
  • Experiments in which mice were treated with CBD followed by THC showed that CBD treatment was associated with a substantial increase in brain concentrations of THC and its major metabolites, most likely because it decreased the rate of clearance of THC from the body. (wikipedia.org)
  • Study
  • Allometry is a well-known study, particularly in statistical shape analysis for its theoretical developments, as well as in biology for practical applications to the differential growth rates of the parts of a living organism's body. (wikipedia.org)