Healthy tissue donors. Medical search. Frequent questions

In 2014, according to the World Marrow Donor Association, stem-cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone-marrow donations, 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). (wikipedia.org)
Organ donation takes healthy organs and tissues from one person for transplantation into another. (medlineplus.gov)
1 After transplantation, donor T cells are activated by antigen-presenting cells. (oncologynurseadvisor.com)
Donate Life America is the 501(c)3 not-for-profit alliance of national organizations and Donate Life State Teams across the United States committed to maximizing the number of organs, eyes and tissue available to save and heal lives through transplantation while developing a culture where donation is embraced as a fundamental human responsibility. (cnet.com)
We analyzed immunoglobulins (Ig) in explanted livers from SAH patients (n=45) undergoing liver transplantation and tissue from corresponding healthy donors (HD, n=10) and found massive deposition of IgG and IgA isotype antibodies associated with complement fragment C3d and C4d staining in ballooned hepatocytes in SAH livers. (elifesciences.org)
CORE works closely with donor families and designated healthcare professionals to coordinate the surgical recovery of organs, tissues and corneas for transplantation. (core.org)
This article´s objective is to reflect about organ donation in living donor transplantation. (bvsalud.org)
Advances in pharmacology and surgery techniques have made possible the transplantation of a range of body parts from a donor body into the living body of a recipient. (bvsalud.org)
Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
More typically, transplantation refers to the transfer of organs (solid organ transplants) or tissues. (msdmanuals.com)
Stem Cell Transplantation Stem cell transplantation is the removal of stem cells (undifferentiated cells) from a healthy person and their injection into someone who has a serious blood disorder. (msdmanuals.com)
Liver Transplantation Liver transplantation is the surgical removal of a healthy liver or sometimes a part of a liver from a living person and then its transfer into a person whose liver no longer functions. (msdmanuals.com)
Heart Transplantation Heart transplantation is the removal of a healthy heart from a recently deceased person and then its transfer into the body of a person who has a severe heart disorder that can no longer be. (msdmanuals.com)
Kidney Transplantation Kidney transplantation is the removal of a healthy kidney from a living or recently deceased person and then its transfer into a person with end-stage kidney failure. (msdmanuals.com)
The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)
Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)

The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood-cell production. (wikipedia.org)

To achieve this, the donor cornea is cut superficially from the endothelial side and the tissue can be separated using specific instruments like Pierse Notched, Acute or Fogla forceps. (bmj.com)
Less often, penetrating keratoplasty is needed, which replaces the full thickness of the cornea with a donor cornea. (guidedogs.org.uk)
EK selectively replaces only the diseased layer of the cornea, leaving healthy areas intact. (cornea.org)
In this procedure the surgeon implants the back 20-30% of the donor cornea into the patient's eye. (cornea.org)
Basically, the endothelium and attached Descemet's membrane has to be peeled off the back of the donor cornea. (cornea.org)
More than 1,085 tissue donors and cornea donors were also honored for enhancing lives through donation. (core.org)
The memorial ceremony held at CORE's Pittsburgh headquarters brought together more than 125 donor families, CORE staff and board members, as well as the extended transplant community to celebrate and remember these special individuals who gave life to others through organ, tissue and cornea donation. (core.org)
Each organ, tissue and cornea donor can save up to eight lives and improve the lives of nearly 75 people. (core.org)

This has been made possible through links with NHS Trusts, the NHS Blood and Transplant Tissue Services, transplant co-ordinators and other collaborators, who understand the importance of human tissue in biomedical research and are committed to supporting the activities of the University's research tissue bank. (sciencedaily.com)
Tissue is then taken from healthy volunteers, from patients donating samples following diagnostic testing and surgery, or from transplant and cadaveric donors. (sciencedaily.com)
Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
It may be performed using cells from the patient's own body (autologous transplant) or cells from a donor (allogeneic transplant). (mayo.edu)
During an ovary transplant, healthy tissue is extracted from the donor ovary. (infertile.com)
This year's speakers included Owen Taylor, an organ recipient, Salma Bashimr, who is awaiting a multi-organ transplant, and Joy Krumenacker, a donor mom. (core.org)
Despite all of these challenges, her family recently discovered another transplant is possible for Salma, but this time, she will need multiple organs to have a chance at a normal, healthy life. (core.org)
Some examples are: "Young at Heart" Seniors Group at Risen Savior Lutheran Church, Healthy Living Class for Older Veterans, Rocky Mountain Liver Transplant Support Group, Beta Sigma Phi Laureate Lambda Sorority in Casper, Longmont Kiwanis Club, Cherry Creek Schools Medical Careers classes. (donoralliance.org)
Is a matched unrelated donor search needed for all allogeneic transplant candidates? (cdc.gov)

There are many more in need of eye and tissue transplants. (donatelife.gov.au)
Organ donation takes the healthy organs and tissues of someone who has died and transplants them to people waiting for lifesaving organs. (medlineplus.gov)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)

Also, the incidence of patients experiencing rejection is very rare (and graft-versus-host disease impossible) due to the donor and recipient being the same individual. (wikipedia.org)
Leeds and Bradford Hospital Trusts, who currently provide tissue to the bank, work with patients and their families to provide information about the supply of tissue for research purposes and manage the consent procedures which underpin the bank's high ethical standards. (sciencedaily.com)
The multilevel transcriptional data of GSE135055 were generated from the heart tissues of 21 heart failure (HF) patients and 9 healthy donors. (hindawi.com)
These use extremely thin donor tissue (just 5% of corneal thickness) and provide more patients with 20/20 or 20/25 than DSEK. (cornea.org)
Using a solid methodology that includes state-of-the-art microscopy, proteome arrays, and gene ontology assays, it provides strong evidence that liver-derived IgG and IgA with cytotoxic properties and reactivity to both gut-derived E.coli and autoantigens accumulated in hepatocytes of SAH patients but not of healthy controls. (elifesciences.org)
Objectives (1) To compare spontaneous and stimuli-induced adipocytokine secretion by articular adipose tissue (AAT) and synovial membrane (SM) explants obtained from patients with rheumatoid arthritis (RA). (bmj.com)
Methods Tissues were obtained from patients undergoing joint replacement surgery. (bmj.com)
Over the course of a nearly 20-year study published in Mayo Clinic Proceedings , researchers analyzed frozen samples of heart muscle tissue from 106 patients who had surgery for obstructive hypertrophic cardiomyopathy. (mayoclinic.org)
The next step is to look for other elevated ACE2 levels by analyzing available heart tissue from patients who have died from hypertension and other heart diseases. (mayoclinic.org)
Vδ1 T cells infiltrated SSC tissue to a greater extent than normal skin, but SCC patients and healthy subjects had similar amounts circulating. (unipa.it)
However, Vδ2 T cells were present at higher frequencies in circulation than in the tissue of either cancer patients or healthy donors. (unipa.it)
To begin with, a library of saliva and exfoliated cell samples was collected from both healthy donors and patients with mild, moderate and severe dysplasia and cancer from Dublin Dental Hospital. (europa.eu)
The results we obtained have shown how Raman spectroscopy can be used on non-invasive samples, to discriminate between healthy patients and those with oral dysplasia," adds Lyng. (europa.eu)
We used a novel ex vivo model where decellularized lung tissue from IPF patients and healthy donors were repopulated with healthy fibroblasts to monitor locally released mediators. (lu.se)
Results were validated in longitudinally collected serum samples from 38 IPF patients and from 77 healthy. (lu.se)
As many as 17-20% of patients with arthroplasties have complications that result in healing difficulties, ranging from superficial skin loss to more severe areas of skin and subcutaneous tissue necrosis and implant exposure. (medscape.com)
For those patients, if we can engineer and regenerate the parts of the tumor 'eats away', we could preserve healthy lung function. (lu.se)

But some organs and tissues can be donated while the donor is alive. (medlineplus.gov)

If you die in hospital in a way that donation can be considered, leave it up to your medical team to determine if you are able to become a donor. (donatelife.gov.au)
If you want to be a donor at the end of your life, what's most important is registering and talking to your family about donation so that they know what you want. (donatelife.gov.au)
We want all Australians to talk about organ and tissue donation. (donatelife.gov.au)
The personnel collecting tissue (doctors and nurses authorised to perform the duty) are provided with personal and health-related data of the donor for identification and donation eligibility purposes. (veripalvelu.fi)
After tissue donation, the tissue and the donor's blood samples are coded using batch numbers so that they cannot be connected to an individual person. (veripalvelu.fi)
One donor can save 8 lives, restore sight to 2 people and heal up to 75 more through tissue donation. (cnet.com)
For more information about organ, eye and tissue donation, visit DonateLife.net. (cnet.com)
What is the difference between registering as an organ donor and living donation? (cnet.com)
Living donation decisions are not part of your organ, eye and tissue donation registration. (cnet.com)
Do you know a community group that has questions about organ and tissue donation? (donoralliance.org)
We have trained staff members and volunteers who are available by request to speak to community groups about what organ and tissue donation is and the importance of talking about one's decision with family. (donoralliance.org)
Every year on February 14, National Donor Day raises awareness about the lifesaving benefits of organ, eye, and tissue donation. (medlineplus.gov)
The DRAI project began in early 2006 with the purpose of creating a uniform donor history questionnaire for organ, tissue, and ocular donation organizations and professional associations in the United States. (cdc.gov)
Laboratory testing is one method for detecting infectious disease and understanding expected organ function, however, laboratory tests cannot detect all aspects of infection and donation quality, and gaps that remain can be addressed by collecting accurate information from a proxy (or proxies) providing information on behalf of the deceased donor. (cdc.gov)
Additionally, the goal of creating a single, standardized instrument is to increase the assurance of safe donation by: 1) optimizing identification of suitable donors, 2) minimizing donor loss due to inappropriate exclusion, 3) accurately identifying an organ donor risk designation, and 4) reducing complexity to facilitate comprehension by a bereaved interviewee. (cdc.gov)

Descemet's Membrane Endothelial Keratoplasty (DMEK) is one of the EK procedures in which the diseased Descemet's Membrane and the endothelium are replaced with a healthy donor tissue. (bmj.com)

Thirty-six healthy donors, attending the HSCT center to donate their bone marrow. (karger.com)
Bone marrow-derived stem cells Hematopoietic stem cells Adipogenesis Fibrin gel culture, 3-dimensional cultures Original Paper Cells Tissues Organs 2008;187:186 198 DOI: 10.1159/000111804 Accepted after revision: August 29, 2007. (karger.com)
Regarding the product LY-MSC: Together with announcing their interest in donating tissue, donors of bone marrow tissue provide basic information concerning themselves and give their consent for contacting them in order to manufacture cell therapy products. (veripalvelu.fi)
A medical procedure in which healthy bone marrow stem cells are injected into the body to replace damaged or diseased bone marrow. (mayo.edu)
In total, 1-10% of nucleated cells in adipose tissue are ADSCs, whereas only 0.0001-0.01% of nucleated cells in bone marrow are stem cells ( 5 ). (spandidos-publications.com)
Stem cells (from bone marrow, umbilical cord blood, or blood from a vein) and kidneys are the tissues most often donated by living donors. (msdmanuals.com)
There, she focused on bone tissue engineering - specifically on how to physiological mineral deposition with manufacturing processes outside the body. (lu.se)

ADSCs are abundant and can be easily acquired by liposuction with minimal donor morbidity ( 5 ). (spandidos-publications.com)
Reconstruction must be designed so that the desired functional and aesthetic results can be achieved using the simplest method available and with minimal donor tissue or donor-site morbidity. (medscape.com)

However, persistent inflammation prevents proper tissue regeneration and instead results in fibrosis, the accumulation of connective tissue. (forbes.com)
The organs were created by removing muscle cells from donor organs to leave behind tough hearts of connective tissue. (dailymail.co.uk)
5 , - , 9 This loose connective tissue is composed of extracellular matrix and various types of cells: fat cells-named adipocytes, and the non-fat cells of the stromal vascular fraction that contains preadipocytes, capillary endothelial cells, infiltrating leucocytes and multipotent stem cells. (bmj.com)
Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)

It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). (wikipedia.org)
2 These cells either originate from the patient (autologous) or a donor (allogeneic). (pharmaceuticalcommerce.com)

Lung tissue from COVID-19 victims also could be analyzed to see if ACE2 levels are higher than in normal lung tissue. (mayoclinic.org)
Darcy's lab is focused on engineering lung tissue outside the body for the purpose of regeneration. (lu.se)
Therefore, murine airway CD8 + T cell-responses to aspiration of Aspergillus conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. (cdc.gov)

Q2c What tissue (including post-mortem tissue) does your resource hold? (neurodegenerationresearch.eu)
However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)

A combination of more sensitive third-generation tests (reversed passive hemagglutination and radioimmunoassay (RIA)) for HBsAg screening and exclusive use of non-paid donors reduced the rate of post-transfusion hepatitis B to 0.3%-0.9%/transfusion recipient by the mid-1970s (12,13). (cdc.gov)
Data processing is based on cell therapy products manufacturing and on operating permits granted for tissue collection (national ATMP manufacturing permission, tissue establishment operating permit) as well as on the statutory obligation to retain the personal data of the donor and the recipient of the cell therapy product in order to ensure statutory traceability. (veripalvelu.fi)
Every year during "A Special Place," CORE invites a recipient, a waiting list candidate and a donor family to share their story. (core.org)
Overview of Blood Transfusion A blood transfusion is the transfer of blood or a blood component from one healthy person (a donor) to a sick person (a recipient). (msdmanuals.com)
Probable contamination - The blood culture from the recipient is negative or could not be done, but there is definite bacterial growth in the donor blood product. (medscape.com)

From surgical tissue, fixed tissue to frozen tissue and cerebrospinal fluid (CSF), the brain bank is the number one source to many medical and commercial companies around the world. (kcl.ac.uk)
To unroll the scroll, the surgeon uses small puffs of air and a few surgical tools to ensure the tissue is correctly placed. (cornea.org)
Soft tissue defects of the knee that require reconstructive surgery occur after trauma or following a surgical procedure. (medscape.com)

Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
Recently, adipose tissue has been shown to synthesise and release highly bioactive substances: classical adipokines (eg, leptin, adiponectin) and various proinflammatory factors such as cytokines, chemokines, growth factors and complement components. (bmj.com)
4 5 Adipose tissue is an active endocrine organ, heterogeneous with respect to embryonic origin, body distribution and function. (bmj.com)

In both procedures, damaged tissue is removed and replaced with healthy donor tissue. (guidedogs.org.uk)

Having gained a Human Tissue Authority Licence and ethical approval status, they have now become one of the first University groups in the UK to open as a licensed ethically approved research tissue bank. (sciencedaily.com)

Peripheral blood was obtained from female healthy donors from different ages. (nih.gov)

There are no age limits on who can donate, and even someone with an illness may be able to donate organs or tissue. (medlineplus.gov)

Transplanting tissues or cells from one area of a person's own body to another. (mayo.edu)

Is Australia's drinking culture holding men back from registering to be life-saving organ and tissue donors? (donatelife.gov.au)

These guidelines address the use of tests for the hepatitis B and C viruses to screen donations of blood and plasma collected for transfusion or further manufacture into injectable products, as well as to screen donors of organs, tissues, and semen. (cdc.gov)
Transmission of HBV by transfusion of blood or blood products is rare because of routine screening of blood donors for HBsAg and because of current donor selection and deferral procedures. (cdc.gov)
Screening blood donors for HBsAg began in 1969 and became mandatory in 1972. (cdc.gov)
Retrospective testing of blood donors using first generation tests such as immunodiffusion to detect HBsAg, found that 52%-69% of recipients of HBsAg-positive blood developed hepatitis B (8,9). (cdc.gov)
In addition, recipients of blood from paid donors were at higher risk of developing post-transfusion hepatitis than were recipients of blood from non-paid donors (10,11). (cdc.gov)
The blood and lymphatic vascular systems are essential for the efficient transport of oxygen, nutrients, signaling molecules, and leukocytes to and from peripheral tissues, the removal of waste products, and the preservation of fluid homeostasis. (nature.com)
Donor of tissues for cell therapy product manufacturing: name, personal identity code, address, phone number, e-mail address, sex, laboratory test results (such as virus screening tests), tissue type and blood group. (veripalvelu.fi)
Evaluation of donor eligibility and storing the tissue are not covered by the tissue establishment authorisation granted to the Blood Service. (veripalvelu.fi)
and the parasite can be transmitted through the transfused blood or organs of infected donors. (who.int)
The goal of CIRM Grant ID1-06557 is to generate high quality induced pluripotent stem cells (iPSC) from blood and skin samples from 3000 donors, many of whom suffer from untreatable medical conditions, and place them in a Repository accessible to scientists around the world. (ca.gov)
Donors must regularly undergo ultrasound and blood tests to monitor their developing oocytes. (discovermagazine.com)
Careful donor selection, vigilant screening, lookback programs, inactivation of pathogens, and continuous efforts to develop new techniques for screening and inactivation will be required to make blood products, and thus blood transfusions, continually safe. (medscape.com)
Laboratory at the National Center for Health Statistics (NCHS) in collaboration with the Office of Blood, Organ, and other Tissue Safety, Division of Healthcare Quality Promotion, CDC in collaboration with the American Association of Tissue Banks (AATB). (cdc.gov)

The biopsy tissue is then sent to a lab, where the cartilage cells are manipulated to start growing. (healthline.com)
Cells Tissues Organs (2021) 209 (4-6): 209-214. (karger.com)
Cells Tissues Organs (2019) 207 (1): 15-20. (karger.com)
Cells Tissues Organs (2008) 188 (1-2): 139-149. (karger.com)
The easy accessibility of hematopoietic cells, which are not tightly embedded in tissue, has supported. (karger.com)
Cells Tissues Organs (2008) 187 (3): 186-198. (karger.com)
Cells Tissues Organs (2005) 180 (4): 195-203. (karger.com)
For the most part, these mutations don't have any effect on healthy cells, and those cells continue chugging along, unfazed. (livescience.com)
But sometimes mutations can be detrimental - the new set of instructions can, for example, tell a healthy cell to divide and multiply rapidly and prevent other cells from stopping this uncontrolled cell growth. (livescience.com)
Healthy cells can thus turn cancerous. (livescience.com)
We have found that genetic mutations associated with cancer are widespread in normal tissues, revealing how our own cells mutate, compete and evolve to colonize our tissues as we age," co-author Iñigo Martincorena, a group leader at the Wellcome Sanger Institute in the United Kingdom, said in the statement. (livescience.com)
Researchers then injected stem cells which multiplied and grew around the structure, eventually turning into healthy heart cells. (dailymail.co.uk)
The lab-grown organs have been created using these types of cells - the body's immature 'master cells' which have the ability to turn into different types of tissue. (dailymail.co.uk)
The bank will operate under the name 'Ethical Tissue' on a not-for-profit basis and will provide access to a wide range of human tissue and tissue products such as viable cells, cell fractions and arrays. (sciencedaily.com)
Donor T-cells proliferate and inflammatory mediators are recruited. (oncologynurseadvisor.com)
Treatment focuses on blocking the expansion of donor T cells, as GVHD develops from the expansion of these cells. (oncologynurseadvisor.com)
Extracorporeal photopheresis inactivates antigen-presenting cells and T cells, whereas TNF antagonists decrease cellular activation and local tissue damage. (oncologynurseadvisor.com)
Cell therapy products are medicines with live cells, and they are always manufactured from a biological tissue. (veripalvelu.fi)
Transplanting organs, tissues or cells from one person to another. (mayo.edu)
Using specific types of stem cells to repair damaged tissues and treat disease. (mayo.edu)
The process of removing all the cells from a donor organ, such as a heart or lung, leaving behind just a tissue scaffold. (mayo.edu)
This happens when DNA "processing errors," coupled with damage from external carcinogens and other factors, cause mutations that allow cells to go into reproductive overdrive, growing out of control and eventually overtaking healthy cells, bypassing the body's ability to police and repair errors and eventually crowding out the body's healthy tissue. (protomag.com)
The study would benefit from a broader analysis of gut microbiota proteome and further characterization of B cells infiltrating the liver tissue including their numbers/field and their origin (infiltrating versus resident cells). (elifesciences.org)
1 By contrast, cellular therapy uses healthy transplanted human cells to grow, replace, or repair damaged tissue that causes disease. (pharmaceuticalcommerce.com)
The good news is that optical spectroscopic techniques have shown promise in characterising tissues, cells and biofluids. (europa.eu)
Using exfoliated cells or saliva to screen and monitor for oral lesions also means that the need for invasive tissue biopsies could be greatly reduced. (europa.eu)
A healthy individual has around one million dopamine cells in the brain. (lu.se)
The cells come from aborted foetuses, if the women allow the tissue to be used by the researchers. (lu.se)
It is not possible to use cells from adult donors. (lu.se)
In the United States, being paid to donate an organ is illegal, but reimbursement for cells and tissues is allowed. (msdmanuals.com)
These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)

Our extensive range of highly-preserved tissue samples provide invaluable insights for our scientists working to improve the diagnosis and treatment of the most severe diseases and disorders affecting the brain. (kcl.ac.uk)
The bank collects tissues and fluid from the entire brain and spinal cord, a sample of postmortem CSF, a small sample of muscle from the back, and a limited number of muscle, pituitary and pineal glands, and gut samples. (alzforum.org)
The types of research projects using samples or data sourced from Ethical Tissue involve many areas of biomedical science. (sciencedaily.com)
An exception to identification codes and batch labels of samples and products: with cell therapy products manufactured from the patient's own tissue and with relative donations, we have a statutory obligation to label the products also with the personal identification codes of the patient and the donor. (veripalvelu.fi)
Alongside the physical samples, the DBCBB also features a large database containing demographic, clinical and developmental histories from the donors. (mcgill.ca)
Procedures for the shipping, infectious disease testing, and processing of donor samples were successfully implemented with the seven Tissue Collectors. (ca.gov)
To date, over 700 samples have been received from these Tissue Collectors and derivation of the first 50 patient-derived iPSC lines has been completed on schedule. (ca.gov)
Cellular Dynamics International (CDI) has continued to generate passage 5 iPSC lines from donor samples submitted to us by Tissue Collectors throughout the state of California. (ca.gov)
By the end of year three, we have generated iPSC clones from 1737 donor samples (out of 2670 received). (ca.gov)
Because of delays in receiving donor samples from our Tissue Collectors we have requested and received a one-year No Cost Extension to complete the activities associated with the grant by 30 November 2017. (ca.gov)
The team was able to develop a comprehensive Raman spectral database of healthy donor and mild, moderate and severe dysplasia samples. (europa.eu)

The ultra-thin DMEK grafts are so fragile that sometimes the precious donor tissue tears while separating the layers and it cannot be salvaged. (cornea.org)

Donors must have longitudinal and/or clinical/medical records. (alzforum.org)

The Kidney Precision Medicine Project (KPMP) plans to construct a spatially specified tissue atlas of the human kidney at a cellular resolution with near comprehensive molecular details. (biorxiv.org)
The atlas will have maps of healthy, acute kidney injury and chronic kidney disease tissues. (biorxiv.org)

King's Brain Bank is also part of the Brains for Dementia Research initiative, in which brain tissue from regularly assessed individuals provides the best resource for scientists working to understand dementia. (kcl.ac.uk)
To their surprise, the brains of the healthy donors who had the polymorphism displayed biomarkers that are known to play a role in neurodegenerative brain disease. (eurekalert.org)

The contact details of the donor are disclosed from the stem cell register with the donor's consent. (veripalvelu.fi)
Center for Regenerative Biotherapeutics protocols have been developed to generate adult stem cell-derived bonelike, nerve-like and heart-like tissues. (mayo.edu)
First year progress on grant ID1-06557, " Generation and Characterization of High-Quality, Footprint-Free Human Induced Pluripotent Stem Cell (iPSC) Lines From 3000 Donors to Investigate Multigenic Disease" has met all agreed-upon milestones. (ca.gov)

Afterward they transplanted the thawed strips into mice that, thanks to genetic engineering, lacked an immune system and so couldn't reject the foreign tissue. (discovermagazine.com)
The second hurdle is that the immune system can reject donor material. (lu.se)

We may soon be able to grow unlimited numbers of perfectly healthy, fertilizable human eggs in the laboratory. (discovermagazine.com)

This failed tissue regeneration is key to osteoarthritis. (forbes.com)

We used the CliniMACS Plus system located in our Cell and Tissue. (karger.com)

The Brain Bank was established in 1989 with the aim of providing high quality, clinically and neuropathologically well-characterised human brain and spinal cord tissue to the neuroscience community. (kcl.ac.uk)
The University of Bradford has unveiled a new facility to provide UK biomedical researchers access to a wide range of human tissue and tissue products. (sciencedaily.com)
In 2007 the group running the bank decided to expand their activities in response to the ever-increasing demands for access to a wider range of human tissue for use in biomedical research. (sciencedaily.com)
Mrs Sandie Martin, Head of Ethical Tissue, said: "This new and improved facility makes us a leader amongst current sources for processing and supply of human tissue to all types of biomedical research groups. (sciencedaily.com)
Our ability to provide researchers directly with ethical approval will ensure a very efficient process that enables them to receive human tissue in a significantly reduced time frame. (sciencedaily.com)
We've put together a sound business plan, developed an excellent network of tissue suppliers and we've satisfied all the regulatory and ethical regulations associated with the sourcing, storage and distribution of human tissues. (sciencedaily.com)
As the DBCBB contains tissue from psychiatrically healthy individuals and from those affected with psychiatric and neurological disorders, it allows for unique discoveries on the human brain and human illnesses, but also for research conducted in animals to be translated to humans. (mcgill.ca)
In human oocytes, the level of mitochondria carried over from the donor egg was about 4% of that from the standard protocol, with no evidence of damaged chromosomes, and high rates of normal early embryonic development. (eurekalert.org)
No one knew whether human ovarian tissue could survive the process--after all, that kind of deep freeze normally kills mature eggs. (discovermagazine.com)
Creating artificial human lung scaffolds from computer models (left), to 3D bioprinting (center), Darcy's team created tubes and branches out of decellularized tissue. (lu.se)

1 In RA, numerous cytokines play a fundamental role in inflammation and joint destruction and are thought to originate primarily from synoviocytes and leucocytes that massively infiltrate synovial tissue. (bmj.com)
In this two-part explorative proteomic study, we demonstrate how proteins associated with tissue remodeling, inflammation and chemotaxis such as MMP7, CXCL13 and CCL19 are released in response to aberrant extracellular matrix (ECM) in IPF lung. (lu.se)

Living donors can also donate only a part of the liver or a lung or a pancreas. (msdmanuals.com)

You can donate a portion of your liver (the liver regenerates and grows back) or one of your kidneys (you have two & can live a healthy life with just one). (cnet.com)

In the new study, the researchers wanted to understand what mutations are present in healthy people. (livescience.com)

They used gene sequencing - a method that reveals the genetic makeup of a tissue - to see how many known cancer-associated mutations each donor carried. (livescience.com)
The esophagus is not the only body in the tissue that carries such mutations. (livescience.com)
The study may improve the odds of having a healthy baby for women who carry mutations in their mitochondrial DNA. (eurekalert.org)
In a mother carrying such mutations, one technique that is used to reduce the chances of disease transmission is spindle-chromosomal complex transfer (SCCT), in which the nuclear chromosomes are removed from an unfertilized egg while they are arranged along a structure called the spindle complex, and transferred to a donor egg cell that has healthy mitochondria. (eurekalert.org)

During DMEK, the patient's existing endothelium is removed and replaced with this specially prepared donor tissue. (cornea.org)

To decrease the potential for disease transmission, donors are screened for risk factors by medical history and for evidence of infection by specific testing. (cdc.gov)
If the tissue donor is diagnosed with some disease to be reported under the Communicable Diseases Act, data will be disclosed to the National Infectious Diseases Register as required by the above-mentioned act. (veripalvelu.fi)
A disease that causes tissues or organs to deteriorate in structure or function over time. (mayo.edu)
Comparison of these "patient-derived" iPSC lines with those from healthy donors can help to illuminate the underlying cause of disease and also to serve as a system for discovering drugs to treat the disease in question. (ca.gov)
After egg fertilization, during embryo formation, some of them may multiply to form a significant fraction of the mitochondria in some tissues, and so cause disease. (eurekalert.org)

Roger Gosden is the most outspoken champion of transplanting ovarian tissue and has provided much of the experimental support for it. (discovermagazine.com)

In the United States those voluntary donors receive several thousand dollars for each harvest of eggs, and it is hard-earned pay. (discovermagazine.com)

In April 2004, Dr. Silber, along with David Levine, MD, an obstetrician on staff at St. Luke's who is board certified in both Gynecology and Urogynecology, and Jorge Pineda, MD, board certified in Obstetrics and Gynecology and Reproductive Endocrinology, transplanted an ovary from a healthy, fertile 24 year-old female into her infertile identical twin sister [see video] . (infertile.com)

This new model of punch will help to identify the peripheral edge of the DMEK lenticule which in turn helps to excise the tissue exclusively, further reducing the donor tissue wastage, as seen with the current tissue preparation methods. (bmj.com)
The biggest hurdle with DMEK is the preparation of the donor tissue. (cornea.org)

Ross Procedure - "Borrowing" your healthy valve and moving it into the position of the damaged valve aortic valve and replacing the "borrowed" valve with a new valve. (goredforwomen.org)
As the donor selection procedure progresses, the donor will provide further information on his/her health condition. (veripalvelu.fi)
After the patient is prepped for the procedure and their diseased tissue is removed, the surgeon places the prepared donor tissue in a solution which changes it to a tinted blue color temporarily so the surgeon can better see it. (cornea.org)
In mice, the procedure resulted in normal development of embryos and healthy offspring, with no evidence of expansion of donor-egg mitochondrial population in offspring tissues. (eurekalert.org)
A common procedure that may require reconstructive surgery to achieve adequate soft tissue coverage of the knee is total knee arthroplasty (TKA). (medscape.com)

In this surgery, the sterile twin received ovarian cortical tissue from her sister by means of a minilaparotomy. (infertile.com)
One version of the approach he envisions involves giving a woman back some of her ovarian tissue if she has been somehow sterilized. (discovermagazine.com)
In one set of experiments, begun in 1994, he removed ovaries from ewes, froze strips of the ovarian tissue, then later reimplanted the tissue in the same animals. (discovermagazine.com)
Gosden and his colleagues explored this idea by freezing strips of ovarian tissue donated by women undergoing medical treatments. (discovermagazine.com)

Learn how to join the Missouri organ and tissue donor registry. (mo.gov)
As two leading organizations addressing the issue of a shortage of viable organs, it was only natural for us to partner to offer a donor registration opportunity in this living will registry app. (cnet.com)
Your donor registration will be in the National Donate Life Registry, RegisterMe.org. (cnet.com)

These results provide further evidence of induction of immune responses to fungi based on their ability to invade host tissue. (cdc.gov)

OPOs), eye banks, and tissue banks is to address the lack of standardization among these organizations, which affects quality program review processes. (cdc.gov)

Surprisingly, they found that one of the mutated genes, NOTCH1, was more common in healthy tissues than in cancerous ones. (livescience.com)

The control group used heart tissue from 39 healthy donor hearts. (mayoclinic.org)
Removing these medications in a patient whose heart has elevated protein levels of ACE2 could cause even more tissue damage. (mayoclinic.org)

Different degrees of precancer can be defined as mild, moderate and severe dysplasia , depending on the degree of cellular and tissue change. (europa.eu)

Also called a mosaicplasty, this surgery uses healthy cartilage from elsewhere in the knee to replace cartilage that has significantly worn away. (healthline.com)

Accepts donations from U.K. residents with MS or other conditions, and healthy volunteers who register with the bank. (alzforum.org)

Wondering what was behind those reports, McAninch and colleagues at Rush previously obtained and analyzed brain tissue from the University of Miami Brain Bank from deceased Caucasian male organ donors who at their time of death were young and healthy, without known thyroid problems, to see if they could find any clues. (eurekalert.org)

Most organ and tissue donations occur after the donor has died. (medlineplus.gov)

Release of the contracture leaves large skin defects and exposes bow-stringed hamstring tendons and major vessels and nerves in the popliteal fossa, requiring soft tissue coverage. (medscape.com)

Brain and spinal cord tissue is one of the most important resources for neuroscience research. (kcl.ac.uk)
London Neurodegenerative Diseases Brain Bank provides a variety of tissue to further research projects among the neuroscience community worldwide. (kcl.ac.uk)
Highly trusted by the research community and beyond, the brain bank assures quality standards of tissue provision. (kcl.ac.uk)
Affiliated with the Montreal Neurological Institute (The Neuro) at McGill University, the McConnell Brain Imaging Centre (BIC) is a one-of-a-kind, multidisciplinary neuroimaging centre recognized internationally for its advances in the acquisition and analysis of multimodal imaging data, as well as for its groundbreaking discoveries related to structural, functional and molecular mechanisms of the healthy and diseased brain. (mcgill.ca)
Again, McAninch and colleagues also continued to collaborate with the University of Miami Brain Bank to obtain and study brain tissue from young, healthy African American brain donors. (eurekalert.org)

Anatomy2

Organisms1

Diseases4

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes10

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Named Groups3

Health Care4

Transplantation16

Destroyed tissue an1

Cornea8

Transplant9

Transplants3

Patients17

Organs and tissues1

Donation15

Endothelial Keratoplasty1

Bone7

Minimal donor2

Connective tissue4

Autologous2

Lung tissue3

Post-mortem2

Recipient5

Surgical3

Adipose tissue3

Damaged tissue is removed1

Ethically-approved1

Peripheral blood1

Donate organs1

Person's1

Life-savin1

Blood13

Cells31

Samples11

Grafts1

Clinical1

Kidney2

Brains2

Stem-cell3

Reject2

Laboratory1

Regeneration1

Cell and Tissue1

Human10

Inflammation2

Pancreas1

Liver1

Researchers1

Mutations4

Endothelium1

Disease5

Experimental1

Voluntary1

Identical1

DMEK2

Procedure5

Ovarian4

Registry3

Evidence1

OPOs1

Genes1

Heart2

Cellular1

Cartilage1

Volunteers1

Time1

Occur1

Nerves1

Brain5