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  • 2016
  • In August 2016, we issued a Drug Safety Communication warning about the combined use of opioid-containing pain or cough medicines with benzodiazepines or other CNS depressants. (pdr.net)
  • As of 2016, the U.S. FDA recommended that "serious side effects associated with fluoroquinolone antibacterial drugs generally outweigh the benefits for patients with acute sinusitis, acute bronchitis, and uncomplicated urinary tract infections who have other treatment options. (wikipedia.org)
  • Drug Bank- Paramethadione Retrieved November 21, 2016 Von Krosigk, M. (wikipedia.org)
  • reductions
  • When an implanted medical device or drug is withdrawn or recalled, or when negative press reports raise significant concerns about the health risk of that device or drug, multiple impacts, such as market value reductions and reputational declines to a product, brand or manufacturer, may reasonably be expected. (biomedcentral.com)
  • addiction
  • Most rehabs don't offer a science-backed treatment for drug addiction. (businessinsider.com)
  • So this week, the main professional society of addiction scientists launched a pilot program that gives treatment centers a grade based on a set of research-backed criteria designed to ensure patient health and safety. (businessinsider.com)
  • The program is being spearheaded by the American Society of Addiction Medicine, which announced a partnership with nonprofit healthcare accreditation group CARF International. (businessinsider.com)
  • In someone with opioid use disorder, as addiction to painkillers like OxyContin and Vicodin is formally known, using the drugs is not often a pleasurable experience. (businessinsider.com)
  • One of the main misconceptions about medication-assisted treatment is that the medications for drug addiction simply replace the drugs that hooked users - leading to more highs and fueling a pattern of repeated use. (businessinsider.com)
  • Two-thirds of the nation's 2.3 million inmates are addicted to drugs or alcohol, compared to 9 percent in the general population, according to a study by the National Center on Addiction and Substance Abuse at Columbia University. (pewtrusts.org)
  • Anticonvulsant
  • Paramethadione (brand name Paradione) is an anticonvulsant in the oxazolidinedione class developed by the Illinois-based pharmaceutical company Abbott Laboratories (known as AbbVie since January 1, 2013 ), and approved by the Food and Drug Administration in 1949 for the treatment of absence seizures, also called partial seizures. (wikipedia.org)
  • clinical
  • Randomized controlled trials - the gold standard for clinical drug evaluation -can't always predict adverse events in real-world settings. (pubmedcentralcanada.ca)
  • Healthcare payers and providers and pharmaceutical manufacturers, who increasingly rely on the use of evidence-based data to evaluate the effectiveness of innovative therapies relative to current standard-of-care practices, are now looking at additional sources of clinical outcomes data. (pubmedcentralcanada.ca)
  • Abbott Laboratories has agreed to voluntarily withdraw its obesity drug Meridia (sibutramine) from the U.S. market because of clinical trial data indicating an increased risk of heart attack and stroke, the U.S. Food and Drug Administration announced recently. (ohsonline.com)
  • The approval was based on clinical data showing that more people receiving sibutramine lost at least 5 percent of their body weight than people on placebo who relied on diet and exercise alone. (ohsonline.com)
  • Establishing and applying stronger clinical trial methodologies in TCM is imperative for integrating it with modern medicine and achieving the end goal of creating evidence-based options for patient care. (davidsnaturalmarket.com)
  • Our objective was to evaluate the clinical effectiveness of orphan drugs that have been granted marketing licenses in Europe, determine the annual costs of each drug, compare the costs of branded orphan drugs against their generic equivalents, and explore any relationships between orphan drug disease prevalence and annual costs. (bmj.com)
  • The controversy led to several lawsuits and strengthened calls for drug companies to disclose all their clinical research data. (wikipedia.org)
  • Bupropion is one of the most widely prescribed antidepressants, and the available evidence indicates that it is effective in clinical depression - as effective as several other widely prescribed drugs, including fluoxetine (Prozac) and paroxetine (Paxil), although trends favoring the efficacy of escitalopram (Lexapro), sertraline (Zoloft) and venlafaxine (Effexor) over bupropion have been observed. (wikipedia.org)
  • Reviews of clinical stimulant research have established the safety and effectiveness of long-term continuous amphetamine use for the treatment of ADHD. (wikipedia.org)
  • Advisory Committee
  • The agency's analysis of SCOUT was the subject of the FDA's Endocrinologic and Metabolic Drugs Advisory Committee meeting on Sept. 15. (ohsonline.com)
  • Spontaneous reports to the U.S. FDA Adverse Effects Reporting System at the time of the 20 September 2011 U.S. FDA Pediatric Drugs Advisory Committee included musculoskeletal events (39, including 5 cases of tendon rupture) and central nervous system events (19, including 5 cases of seizures) as the most common spontaneous reports between April 2005 and March 2008. (wikipedia.org)
  • insomnia
  • Hypnotic drugs are regularly prescribed for insomnia and other sleep disorders, with over 95% of insomnia patients being prescribed hypnotics in some countries. (wikipedia.org)
  • Many hypnotic drugs are habit-forming and, due to a large number of factors known to disturb the human sleep pattern, a physician may instead recommend changes in the environment before and during sleep, better sleep hygiene, the avoidance of caffeine or other stimulating substances, or behavioral interventions such as Cognitive Behavioral Therapy for Insomnia (CBT-I) before prescribing medication for sleep. (wikipedia.org)
  • seizures
  • The most important side effect is an increase in risk for epileptic seizures, which caused the drug to be withdrawn from the market for some time and then caused the recommended dosage to be reduced. (wikipedia.org)
  • Paramethadione (brand name Paradione) was originally approved by the U.S. Food and Drug Administration (FDA) in 1949, as a second-line treatment for petit mal and absence seizures. (wikipedia.org)
  • occur
  • The patient taking the medication as directed generally does not feel high, and withdrawal does not occur. (pdr.net)
  • The FDA wrote: "An FDA safety review has shown that fluoroquinolones when used systemically (i.e. tablets, capsules, and injectable) are associated with disabling and potentially permanent serious side effects that can occur together. (wikipedia.org)
  • approval
  • Such data may come from additional randomized and nonrandomized interventional trials or observational cohort studies (OCSs), any of which may be mandated by the U.S. Food and Drug Administration as a phase 4 post-approval commitment. (pubmedcentralcanada.ca)
  • To represent a broad and diverse patient base and to detect rare adverse events, large community-based, multicenter OCSs are useful in the post-approval setting for new therapeutics. (pubmedcentralcanada.ca)
  • However, the drugs are expensive, and in some instances, the evidence for effectiveness is not convincing at the time of regulatory approval. (bmj.com)
  • Because we could not document the research and development costs associated with the approval of each orphan drug, the influence of this variable on their annual costs could not be ascertained. (bmj.com)
  • For example, at the market level, a broader than expected sell-off of stocks following negative news about a drug or device could be due to the expected loss of revenue, increased manufacturer costs due to litigation or marketing, or an expectation of increased regulation or approval delays. (biomedcentral.com)
  • Abbott Labbortories continued to hold the patent to paramethadione until the approval was withdrawn in 2004 due to the drug no longer being in use. (wikipedia.org)
  • 2004). Withdrawal of Approval of 92 New Drug Applications and 49 Abbreviated New Drug Applications (Report). (wikipedia.org)
  • opioid
  • Opioid drugs include partial agonists, like the anti-diarrhea drug loperamide and antagonists like naloxegol for opioid-induced constipation, which do not cross the blood-brain barrier, but can displace other opioids from binding in those receptors. (wikipedia.org)
  • The weak opioid codeine, in low doses and combined with one or more other drugs, is commonly available without a prescription. (wikipedia.org)
  • Morphine
  • Morphine base has a pK a of 7.9, with an octanol/water partition coefficient of 1.42 at physiologic pH 7.4. (rxlist.com)
  • Vials of DepoDur (morphine sulfate xr liposome injection) should be gently inverted to re-suspend the particles immediately prior to withdrawal from the vial. (rxlist.com)
  • Opioids include opiates, an older term that refers to such drugs derived from opium, including morphine itself. (wikipedia.org)
  • 1994
  • The withdrawal from market of Manoplax due to safety concerns in 1993 caused major pressure from investors, and in 1994, Boots divested its prescription drugs division, which had become no longer viable, to BASF. (wikipedia.org)
  • sedative
  • Where as the term sedative describes drugs that serve to calm or relieve anxiety, the term hypnotic generally describes drugs whose main purpose is to initiate, sustain, or lengthen sleep. (wikipedia.org)
  • Because these two functions frequently overlap, and because drugs in this class generally produce dose-dependent effects (ranging from anxiolysis to loss of consciousness) they are often referred to collectively as sedative-hypnotic drugs. (wikipedia.org)
  • pharmaceutical
  • Because low patient volumes make it unfavourable for commercial investment in orphan drug research, drug regulatory authorities have incentives in place to encourage their development and manufacture by pharmaceutical companies. (bmj.com)
  • These efficacy studies also provide the response data that pharmaceutical companies must submit to the Food and Drug Administration (FDA) to obtain indications for developed drugs. (wikibooks.org)
  • Pharmaceutical dextroamphetamine sulfate is available as both a brand name and generic drug in a variety of dosage forms. (wikipedia.org)
  • evaluate
  • Upon determination of the MTD, twice daily (BID) dosing cohorts may be opened to collect additional safety data and evaluate the preliminary efficacy of GSK525762 administered BID. (clinicaltrials.gov)
  • doses
  • The below doses are based on scientific research, publications, traditional use, or expert opinion. (mayoclinic.org)
  • You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy. (mayoclinic.org)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are a drug class that groups together drugs that reduce pain, decrease fever, and, in higher doses, decrease inflammation. (wikipedia.org)
  • dose
  • Part 1 of the study is a dose escalation phase to select the recommended Part 2 dose (RP2D) based on the safety, PK, and PD profiles observed after oral administration of GSK525762. (clinicaltrials.gov)
  • Disease progression may affect dose requirements, which can be addressed by adjusting the programming of the drug pump. (medtronic.com)
  • Based on data from the manufacturer, it is expected that 0.6% of the maternal weight-adjusted dose would reach a breastfed infant, though the effects in the infant are unknown. (wikipedia.org)
  • 11.7
  • The drug attracted sales of $11.7 billion in the United States alone from 1997 to 2006, including $2.12 billion in 2002, the year before it lost its patent. (wikipedia.org)
  • benzodiazepine
  • The first such drug, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955, and made available in 1960 by Hoffmann-La Roche, which, since 1963, has also marketed the benzodiazepine diazepam (Valium). (wikipedia.org)
  • However, they are less toxic than their predecessors, the barbiturates, and death rarely results when a benzodiazepine is the only drug taken. (wikipedia.org)
  • Food and Drug Admin
  • The following month the MHRA and US Food and Drug Administration (FDA) advised doctors not to prescribe paroxetine to the under-18s. (wikipedia.org)
  • Bupropion was approved by the U.S. Food and Drug Administration (FDA), in 2006, for the prevention of seasonal affective disorder (SAD). (wikipedia.org)
  • Ibuprofen
  • Boots diversified into the research and manufacturing of drugs with its development of the Ibuprofen painkiller during the 1960s, invented by John Nicholson and Stewart Adams. (wikipedia.org)
  • The most prominent members of this group of drugs are aspirin, ibuprofen and naproxen, all available over the counter in most countries. (wikipedia.org)
  • data
  • The goal of an OCS is to amass and record key disease- and/or treatment-related data over time for a large heterogeneous patient population treated by a broad base of practitioners ( Lubeck 2007 ). (pubmedcentralcanada.ca)
  • FDA requested the market withdrawal after reviewing data from the Sibutramine Cardiovascular Outcomes Trial (SCOUT). (ohsonline.com)
  • however, these results, combined with other available safety data raised serious questions about Meridia's safety for all patient groups," said Gerald Dal Pan, M.D., M.H.S., director of the Office of Surveillance and Epidemiology in CDER. (ohsonline.com)
  • Electronic searches were also conducted in PubMed, EMBASE and Google Scholar, to assess data on effectiveness, safety and annual costs. (bmj.com)
  • We also used reliable data to document the prevalence of each orphan disease and identify the annual cost of each orphan drug. (bmj.com)
  • This information reflects FDA's current analysis of data available to FDA concerning this drug. (pdr.net)
  • Tysabri patient data were reported by Elan Corporation or Biogen Idec Inc. Data trends for all products were compared with historical recall or withdrawal events and discussed in the context of public perceptions following such events. (biomedcentral.com)
  • According to Melanie Newman, writing for the BMJ, "[t]he drug only produced a positive result when four new secondary outcome measures, which were introduced following the initial data analysis, were used instead. (wikipedia.org)
  • Further data, from the APPROVe trial, showed a statistically significant relative risk of cardiovascular events of 1.97 versus placebo-which caused a worldwide withdrawal of rofecoxib in October 2004. (wikipedia.org)
  • study
  • Studies were classified by their level of evidence based on the study design, using published criteria (Agency for Healthcare Research and Quality, 2008). (york.ac.uk)
  • The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. (clinicaltrials.gov)
  • Subjects may continue treatment in the study until disease progression, unacceptable toxicity, or withdrawal of consent. (clinicaltrials.gov)
  • They learned a lineage-based medical system from their parents (mostly from their fathers), took imperial exams to enter medical university pre-PRC, or study at TCM universities in modern China. (wikipedia.org)
  • In 2003 Britain's Medicines and Healthcare Products Regulatory Agency (MHRA) analysed study 329 and other GSK studies of paroxetine, concluding that, while there was no evidence of paroxetine's efficacy in children and adolescents, there was "robust evidence" of a causal link between the drug and suicidal behaviour. (wikipedia.org)
  • In a study comparing the safety and efficacy of levofloxacin to that of azithromycin or ceftriaxone in 712 children with community-acquired pneumonia, serious adverse events were experienced by 6% of those treated with levofloxacin and 4% of those treated with comparator antibiotics. (wikipedia.org)
  • Most of these were considered by the treating physician to be unrelated or doubtfully related to the study drug. (wikipedia.org)
  • indications
  • Only inhalant anthrax and pseudomonal infections in cystic fibrosis infections are licensed indications in the UK due to ongoing safety concerns. (wikipedia.org)
  • medical
  • Orphan drugs are therapeutic agents designed for the management of orphan diseases 1 which are defined as medical conditions with a low prevalence. (bmj.com)
  • Medical researchers have repeatedly found that the jail's methadone treatment program has resulted in overall health care cost savings, reduced crime and recidivism, reduced HIV and hepatitis C transmission, and better than average rates of recovery from drug use. (pewtrusts.org)
  • Here in New York, where methadone was first researched at The Rockefeller Institute for Medical Research in the 1960s and methadone clinics are more plentiful than Broadway theaters, use of the drug in the city's jails has never been controversial. (pewtrusts.org)
  • Third, a negative halo effect on an entire category of medical devices can be sustained regardless of the scientific findings pertaining to safety. (biomedcentral.com)
  • In the aftermath of negative press reports on medical device or drug withdrawals, individual consumers are subject to such a "negative halo" effect, by which a drug, device, product or product type is then viewed in a negative light across a variety of contexts, only some of which may have been implicated in the recall or withdrawal. (biomedcentral.com)
  • risk
  • Meridia's continued availability is not justified when you compare the very modest weight loss that people achieve on this drug to their risk of heart attack or stroke," said John Jenkins, M.D., director of the Office of New Drugs in the FDA's Center for Drug Evaluation and Research (CDER). (ohsonline.com)
  • Not only is my patient's sleep and health compromised, but their safety - and the safety of other people, especially those closest to them - is very much at risk. (psychologytoday.com)
  • Due to sickle-cell disease patients' being at increased risk for developing osteomyelitis from the Salmonella genus, fluoroquinolones are the "drugs of choice" due to their ability to enter bone tissue without chelating it, as tetracyclines are known to do. (wikipedia.org)
  • treatment
  • Acceptable comparators (where relevant) were placebo or another drug treatment. (york.ac.uk)
  • Many physicians also receive commissions from prescribing prescription drugs and get "red envelopes" from patients (patients give money or gifts to their wanted physicians for getting treatment) or from sales representatives of drug companies. (wikipedia.org)
  • market
  • The drug has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias. (wikipedia.org)
  • reputation
  • Fourth, recovery of a product's safety reputation and prevalent use may take decades in the U.S., even while these products may exhibit widespread use and good safety records in other countries. (biomedcentral.com)
  • conclusions
  • Conclusions The available evidence suggests that there is inconsistency in the quality of evidence of approved orphan drugs, and there is no clear mechanism for determining their prices. (bmj.com)
  • however
  • however, it can be effective in alleviating physical withdrawal effects, such as muscle cramps. (wikipedia.org)
  • however some psychiatrists recommend these drugs, citing research suggesting they are equally potent with less potential for abuse. (wikipedia.org)
  • However, while effective, this drug presented with significant adverse effects, which led to the search for an equally effective analog. (wikipedia.org)
  • people
  • At Rikers, 75 percent of people who enter the jail are addicted to drugs, with 20 percent addicted to heroin or painkillers. (pewtrusts.org)
  • migraine
  • Some types of chronic pain, including the pain caused by fibromyalgia or migraine, are preferentially treated with drugs other than opioids. (wikipedia.org)
  • effective
  • The alcohol based version is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. (wikipedia.org)
  • evidence for effectiveness
  • It's important to note that FDA and the applicant do not agree on whether this drug has met the standard for substantial evidence for effectiveness," Mitchell Mathis, MD , division director of psychiatry products at FDA, said in the opening remarks. (healio.com)
  • Physical
  • In addition to possible physical, social, and psychological harm, use of some drugs may also lead to criminal penalties, although these vary widely depending on the local jurisdiction. (wikipedia.org)
  • however, it can be effective in alleviating physical withdrawal effects, such as muscle cramps. (wikipedia.org)
  • NIDA's viewpoint is supported by the fact that the CSA lists not only physical addictiveness but also "history and current pattern of abuse" and "scope, duration, and significance of abuse" among the factors to be considered in drug scheduling. (wikipedia.org)
  • 2018
  • A longtime supporter of Ohio schools and educators, Bricker once again focused its 2018 donation on education-based initiatives. (bricker.com)
  • During the morning session on March 21, 2018, the Joint Committee will discuss and make recommendations regarding the device reclassification from Class III to Class II of nucleic acid and serology-based point-of-care and laboratory-based in vitro diagnostic devices indicated for use as aids in the diagnosis of human immunodeficiency virus (HIV) infection. (fdalive.com)
  • On March 22, 2018, the Joint Committee will discuss and make recommendations regarding the reclassification from Class III to Class II of nucleic acid and serology-based in vitro diagnostic devices indicated for use as aids in diagnosis of hepatitis C virus (HCV) infection and/or for use as aids in the management of HCV infected patients. (fdalive.com)
  • On Friday, March 23, 2018, the Pediatric Advisory Committee will meet to discuss pediatric-focused safety reviews, as mandated by the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act of 2003. (fdalive.com)
  • reduction
  • The authors noted an apparent superior efficacy of olanzapine to the other drugs in terms of reduction in psychopathology and rate of hospitalizations, but olanzapine was associated with relatively severe metabolic effects such as a major weight gain problem (averaging 9.4 lbs over 18 months) and increases in glucose, cholesterol, and triglycerides. (wikipedia.org)
  • opiates
  • Morphine is physically addictive, and users of heroin and other opiate-derived drugs become physically and psychologically dependent on the high from the opiates, which drives them to seek the drug and perform acts they might not normally engage in (like exchanging drugs for sex acts or sharing needles with another user)[citation needed]. (wikipedia.org)
  • In addition to producing PCP-like mental effects, high doses may cause a false-positive result for PCP and opiates in some drug tests. (wikipedia.org)
  • abuse
  • However, the inappropriate use, abuse, and diversion of prescription drugs in America, particularly prescription opioids, has increased dramatically in recent years and has been identified as a national public health epidemic. (netce.com)
  • Substance abuse, also known as drug abuse, is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of substance-related disorder. (wikipedia.org)
  • Widely differing definitions of drug abuse are used in public health, medical and criminal justice contexts. (wikipedia.org)
  • Drug abuse' is no longer a current medical diagnosis in either of the most used diagnostic tools in the world, the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM), and the World Health Organization's International Statistical Classification of Diseases (ICD). (wikipedia.org)
  • Similarly, adopting the view that any (recreational) use of cannabis or substituted amphetamines constitutes drug abuse implies a decision made that the substance is harmful, even in minute quantities. (wikipedia.org)
  • The drugs are classified on their deemed potential for abuse. (wikipedia.org)
  • The Drug Abuse Warning Network (DAWN) and National Household Survey on Drug Abuse (NHSDA) were created in 1972. (wikipedia.org)
  • NIDA is organized into divisions and offices, each of which is involved with programs of drug abuse research. (wikipedia.org)
  • The January 17, 2001 document Basis for the Recommendation for Maintaining Marijuana in Schedule I of the Controlled Substances Act specifically cites SAMHSA's National Household Survey on Drug Abuse, NIDA's Monitoring the Future survey, SAMHSA's Drug Abuse Warning Network, and NIDA's Community Epidemiology Work Group data. (wikipedia.org)
  • reimbursement
  • AHIP was concerned about exposure of its insurance company members to wide claims from policy holders for reimbursement for expensive, investigational drugs obtained through expanded access programs, which might multiply because of the FDA rule liberalization. (blogspot.com)
  • risks
  • Read labels to know the risks certain drugs pose to your liver. (herbalyzer.com)
  • http://www.niko.si/nexium-40-mg-price-south-africa.pdf#relationship nexium tablets pictures The measure, part of a series of proposed SEC changes toreduce risks in the $2.5 trillion money-market industry, wouldlet funds ban withdrawals and charge fees for them in times ofstress like the 2008 credit crisis. (starstx.com)
  • The choice of which antipsychotic to use for a specific patient is based on benefits, risks, and costs. (wikipedia.org)
  • exposure
  • These impurities likely account for its discoloration and fishy (pyrrolidine) or bromine-like odor, which worsens upon exposure to air, moisture, or bases. (wikipedia.org)
  • depression
  • Clinicians assess the sleep hygiene of people who present with insomnia and other conditions, such as depression, and offer recommendations based on the assessment. (wikipedia.org)
  • conditions
  • Worldwide Travel Cover terms and conditions for Personal Healthcare. (docplayer.net)
  • the 2 new allied rules-one on the conditions drug companies must meet to create a program, the other on how they can charge for the drugs-ostensibly give pharma a wider berth. (blogspot.com)
  • also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions. (wikipedia.org)
  • result
  • Victimization can take many forms-from being directly injured in a violent crime, to being robbed, to having your sense of safety violated as result of living in an area where crime exists. (wikipedia.org)
  • treatments
  • It has also supported many treatments such as nicotine patches and gums, and performed research into AIDS and other drug-related diseases. (wikipedia.org)
  • patients
  • It has been argued that a more nuanced view in which the needs of individual patients are matched to the properties of individual drugs is more appropriate. (wikipedia.org)
  • effects
  • Known contraindications include: Hypersensitivities to doxepin, other TCAs, or any of the excipients inside the product used Glaucoma A predisposition to developing urinary retention such as in benign prostatic hyperplasia Use of monoamine oxidase inhibitors in last 14 days Its use in pregnant and lactating women is advised against, although the available preclinical (based on animal studies) evidence suggests it is unlikely to cause any deleterious effects on fetal development. (wikipedia.org)
  • similar
  • Other drugs with a similar chemical structure include α-pyrrolidinopropiophenone (α-PPP), 4'-methyl-α-pyrrolidinopropiophenone (M-α-PPP), 3',4'-methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) and 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (α-PVP). (wikipedia.org)
  • funds
  • Yet the aid group Partners in Health (PIH) is doing just that, using funds that come not from the government or the United Nations but from donations collected by the Boston-based group, which has worked for 23 years to boost the capacity of Haiti's public health sector. (blogspot.com)
  • known
  • While it's simple to use, our formula is a complex blend of plant-based ingredients known to provide excellent liver support, and our homeopathic experts go to great lengths to assure purity and quality. (herbalyzer.com)
  • It is widely known for the production of drugs such as MS Contin, Oxycontin, and Ryzolt. (wikipedia.org)
  • center
  • The IOCs were subordinate to the National Air Defense Operations Center (ADOC), based in Baghdad, that controlled air defense nationally. (wikipedia.org)
  • aids
  • NIDA has also conducted research into diseases associated with drug use, such as AIDS and Hepatitis. (wikipedia.org)
  • products
  • The market economy was based on extracting and processing natural resource and agricultural products for local consumption, such as mining, gristmills and sawmills, and the export of agricultural products. (wikipedia.org)
  • continuing education
  • This activity was planned by and for the healthcare team, and learners will receive 3 Interprofessional Continuing Education (IPCE) credit(s) for learning and change. (netce.com)
  • order
  • citation needed] Of US federal inmates in 2010, about half (51%) were serving time for drug offenses and many others likely committed crimes under the influence of one or more drugs, over drug-related disputes (turf battles, etc.), or in order to obtain money to buy drugs-factors which were not necessarily cited in their charges. (wikipedia.org)
  • In the UK, following the ACMD's report on substituted cathinone derivatives, MDPV is a Class B drug under The Misuse of Drugs Act 1971 (Amendment) Order 2010, making it illegal to sell, buy, or possess without a license. (wikipedia.org)
  • group
  • Work is well under way on the 320-bed facility being constructed by Partners in Health, a Boston-based nonprofit group. (blogspot.com)
  • This act of violence can be argued to be a kind of hate crime since the crime committed is primarily based upon the victim's membership in a certain demographic group. (wikipedia.org)
  • company
  • Pfizer Inc. (which may be referred to as Pfizer, the Company, we , us or our ) is a research-based, global pharmaceutical company. (sec.gov)
  • Under a marketing strategy that Arthur Sackler had pioneered decades earlier, the company aggressively pressed doctors to prescribe the drug, wooing them with free trips to pain-management seminars and paid speaking engagements. (wikipedia.org)
  • long term
  • In some cases criminal or anti-social behavior occurs when the person is under the influence of a drug, and long term personality changes in individuals may occur as well. (wikipedia.org)
  • appropriate
  • Drug-seeking tactics that addicts undergo to obtain the medication include "doctor shopping", which is visiting a number of different physicians to obtain additional prescriptions and refusal to follow up with appropriate examinations. (wikipedia.org)
  • However
  • Comparison of the cited figures, however, can provide the prescriber with some basis for estimating the relative contributions of drug and nondrug factors to the untoward event incidence rate in the population studied. (rxlist.com)
  • sold
  • Founding Shawmut Design and Construction, based in Boston, in 1982, Ansara sold the business to its employees in 2006. (blogspot.com)
  • MDPV remained an obscure stimulant until around 2004 when it was reportedly sold as a designer drug. (wikipedia.org)
  • second
  • As experience with these agents has grown, several studies have questioned the utility of broadly characterizing antipsychotic drugs as "atypical/second generation" as opposed to "first generation," noting that each agent has its own efficacy and side-effect profile. (wikipedia.org)
  • help
  • For centuries, homeopathic practitioners have relied on natural, plant-based ingredients to help detoxify the body and promote healthy body functions. (herbalyzer.com)
  • Society
  • He started as editor-in-chief, the official journal of the Society of Pharmacovigilance, India (SoPI) in 2003 - "Journal of Pharmacovigilance & Drug Safety (ISSN 0972-8899)" Rahman is a founder Trustee member of Ibn Sina Academy of Medieval Medicine and Sciences. (wikipedia.org)