• benzodiazepine
  • The first such drug, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955, and made available in 1960 by Hoffmann-La Roche, which, since 1963, has also marketed the benzodiazepine diazepam (Valium). (wikipedia.org)
  • However, they are less toxic than their predecessors, the barbiturates, and death rarely results when a benzodiazepine is the only drug taken. (wikipedia.org)
  • seizures
  • WOODCLIFF LAKE, N.J. , Oct. 22, 2012 /PRNewswire/ -- Eisai Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved FYCOMPA (perampanel) as an adjunctive treatment for partial-onset seizures with or without secondarily generalized seizures in patients with epilepsy age 12 and older. (biospace.com)
  • FYCOMPA's approval was primarily based on three Phase III studies (304, 305 and 306), which were multi-center, randomized, double-blind, placebo-controlled, dose-escalation, parallel group studies to evaluate the efficacy and safety of perampanel compared to placebo given as adjunctive therapy in patients age 12 and older with partial-onset seizures. (biospace.com)
  • The most important side effect is an increase in risk for epileptic seizures, which caused the drug to be withdrawn from the market for some time and then caused the recommended dosage to be reduced. (wikipedia.org)
  • Spontaneous reports to the U.S. FDA Adverse Effects Reporting System at the time of the 20 September 2011 U.S. FDA Pediatric Drugs Advisory Committee included musculoskeletal events (39, including 5 cases of tendon rupture) and central nervous system events (19, including 5 cases of seizures) as the most common spontaneous reports between April 2005 and March 2008. (wikipedia.org)
  • Paramethadione (brand name Paradione) is an anticonvulsant in the oxazolidinedione class developed by the Illinois-based pharmaceutical company Abbott Laboratories (known as AbbVie since January 1, 2013 ), and approved by the Food and Drug Administration in 1949 for the treatment of absence seizures, also called partial seizures. (wikipedia.org)
  • Paramethadione (brand name Paradione) was originally approved by the U.S. Food and Drug Administration (FDA) in 1949, as a second-line treatment for petit mal and absence seizures. (wikipedia.org)
  • addiction
  • The vast majority of correctional facilities reject the use of methadone, used for addiction treatment since 1964 and approved by the U.S. Food and Drug Administration for addiction treatment in 1972, as well as a newer anti-addiction drug called buprenorphine, approved in 2002 . (pewtrusts.org)
  • Two-thirds of the nation's 2.3 million inmates are addicted to drugs or alcohol, compared to 9 percent in the general population, according to a study by the National Center on Addiction and Substance Abuse at Columbia University. (pewtrusts.org)
  • Because of opioid drugs' reputation for addiction and fatal overdose, most are controlled substances. (wikipedia.org)
  • dose
  • Part 1 of the study is a dose escalation phase to select the recommended Part 2 dose (RP2D) based on the safety, PK, and PD profiles observed after oral administration of GSK525762. (clinicaltrials.gov)
  • Disease progression may affect dose requirements, which can be addressed by adjusting the programming of the drug pump. (medtronic.com)
  • Safety and effectiveness have not been established for any dose. (blackmountainnaturalfoods.com)
  • Because these two functions frequently overlap, and because drugs in this class generally produce dose-dependent effects (ranging from anxiolysis to loss of consciousness) they are often referred to collectively as sedative-hypnotic drugs. (wikipedia.org)
  • Based on data from the manufacturer, it is expected that 0.6% of the maternal weight-adjusted dose would reach a breastfed infant, though the effects in the infant are unknown. (wikipedia.org)
  • patients
  • Vietnamese guy scammed the UN for a lot of money claiming he discovered a miracle drug for Buy Kratom In Las Vegas painless opiate detox and had some patients die on top of that. (kratomextractworld.com)
  • Patients should call their healthcare provider right away if they have any new or worsening mental problems while taking FYCOMPA. (biospace.com)
  • Patients must not stop FYCOMPA without first talking to their healthcare provider. (biospace.com)
  • Patients should tell their healthcare provider if they have abused prescription medicines, street drugs, or alcohol in the past. (biospace.com)
  • Patients should tell their healthcare provider right away if they become pregnant while taking FYCOMPA. (biospace.com)
  • Patients and their healthcare providers will decide if they should take FYCOMPA while they are pregnant. (biospace.com)
  • Many physicians also receive commissions from prescribing prescription drugs and get "red envelopes" from patients (patients give money or gifts to their wanted physicians for getting treatment) or from sales representatives of drug companies. (wikipedia.org)
  • Hypnotic drugs are regularly prescribed for insomnia and other sleep disorders, with over 95% of insomnia patients being prescribed hypnotics in some countries. (wikipedia.org)
  • Early classes of drugs, such as barbiturates, have fallen out of use in most practices but are still prescribed for some patients. (wikipedia.org)
  • Due to sickle-cell disease patients' being at increased risk for developing osteomyelitis from the Salmonella genus, fluoroquinolones are the "drugs of choice" due to their ability to enter bone tissue without chelating it, as tetracyclines are known to do. (wikipedia.org)
  • insomnia
  • Many hypnotic drugs are habit-forming and, due to a large number of factors known to disturb the human sleep pattern, a physician may instead recommend changes in the environment before and during sleep, better sleep hygiene, the avoidance of caffeine or other stimulating substances, or behavioral interventions such as Cognitive Behavioral Therapy for Insomnia (CBT-I) before prescribing medication for sleep. (wikipedia.org)
  • chronic
  • Some types of chronic pain, including the pain caused by fibromyalgia or migraine, are preferentially treated with drugs other than opioids. (wikipedia.org)
  • occur
  • The patient taking the medication as directed generally does not feel high, and withdrawal does not occur. (pdr.net)
  • The FDA wrote: "An FDA safety review has shown that fluoroquinolones when used systemically (i.e. tablets, capsules, and injectable) are associated with disabling and potentially permanent serious side effects that can occur together. (wikipedia.org)
  • illicit
  • Monitoring for illicit drug use, including urine or blood screening. (pdr.net)
  • As with any controlled substance, corrections officials are wary of methadone and buprenorphine being diverted to other inmates who are not in drug treatment or leaking out of the prison to illicit drug markets. (pewtrusts.org)
  • opioid
  • Opioid drugs include partial agonists, like the anti-diarrhea drug loperamide and antagonists like naloxegol for opioid-induced constipation, which do not cross the blood-brain barrier, but can displace other opioids from binding in those receptors. (wikipedia.org)
  • The weak opioid codeine, in low doses and combined with one or more other drugs, is commonly available without a prescription. (wikipedia.org)
  • Morphine
  • Morphine base has a pK a of 7.9, with an octanol/water partition coefficient of 1.42 at physiologic pH 7.4. (rxlist.com)
  • Vials of DepoDur (morphine sulfate xr liposome injection) should be gently inverted to re-suspend the particles immediately prior to withdrawal from the vial. (rxlist.com)
  • Opioids include opiates, an older term that refers to such drugs derived from opium, including morphine itself. (wikipedia.org)
  • 1994
  • The withdrawal from market of Manoplax due to safety concerns in 1993 caused major pressure from investors, and in 1994, Boots divested its prescription drugs division, which had become no longer viable, to BASF. (wikipedia.org)
  • sedative
  • Where as the term sedative describes drugs that serve to calm or relieve anxiety, the term hypnotic generally describes drugs whose main purpose is to initiate, sustain, or lengthen sleep. (wikipedia.org)
  • 11.7
  • The drug attracted sales of $11.7 billion in the United States alone from 1997 to 2006, including $2.12 billion in 2002, the year before it lost its patent. (wikipedia.org)
  • suicidal
  • Antiepileptic drugs, including FYCOMPA, may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. (biospace.com)
  • In 2003 Britain's Medicines and Healthcare Products Regulatory Agency (MHRA) analysed study 329 and other GSK studies of paroxetine, concluding that, while there was no evidence of paroxetine's efficacy in children and adolescents, there was "robust evidence" of a causal link between the drug and suicidal behaviour. (wikipedia.org)
  • approval
  • Such data may come from additional randomized and nonrandomized interventional trials or observational cohort studies (OCSs), any of which may be mandated by the U.S. Food and Drug Administration as a phase 4 post-approval commitment. (pubmedcentralcanada.ca)
  • To represent a broad and diverse patient base and to detect rare adverse events, large community-based, multicenter OCSs are useful in the post-approval setting for new therapeutics. (pubmedcentralcanada.ca)
  • When the FDA judges that the unanswered questions are not of sufficient concern to postpone approval to market the drug, they will direct "post-marketing" studies to fill in the blanks. (sciencebasedmedicine.org)
  • Abbott Labbortories continued to hold the patent to paramethadione until the approval was withdrawn in 2004 due to the drug no longer being in use. (wikipedia.org)
  • 2004). Withdrawal of Approval of 92 New Drug Applications and 49 Abbreviated New Drug Applications (Report). (wikipedia.org)
  • clinical
  • Randomized controlled trials - the gold standard for clinical drug evaluation -can't always predict adverse events in real-world settings. (pubmedcentralcanada.ca)
  • Establishing and applying stronger clinical trial methodologies in TCM is imperative for integrating it with modern medicine and achieving the end goal of creating evidence-based options for patient care. (davidsnaturalmarket.com)
  • The controversy led to several lawsuits and strengthened calls for drug companies to disclose all their clinical research data. (wikipedia.org)
  • Bupropion is one of the most widely prescribed antidepressants, and the available evidence indicates that it is effective in clinical depression - as effective as several other widely prescribed drugs, including fluoxetine (Prozac) and paroxetine (Paxil), although trends favoring the efficacy of escitalopram (Lexapro), sertraline (Zoloft) and venlafaxine (Effexor) over bupropion have been observed. (wikipedia.org)
  • Reviews of clinical stimulant research have established the safety and effectiveness of long-term continuous amphetamine use for the treatment of ADHD. (wikipedia.org)
  • Food and Drug Admin
  • The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. (blackmountainnaturalfoods.com)
  • The following month the MHRA and US Food and Drug Administration (FDA) advised doctors not to prescribe paroxetine to the under-18s. (wikipedia.org)
  • Bupropion was approved by the U.S. Food and Drug Administration (FDA), in 2006, for the prevention of seasonal affective disorder (SAD). (wikipedia.org)
  • Ibuprofen
  • Boots diversified into the research and manufacturing of drugs with its development of the Ibuprofen painkiller during the 1960s, invented by John Nicholson and Stewart Adams. (wikipedia.org)
  • The most prominent members of this group of drugs are aspirin, ibuprofen and naproxen, all available over the counter in most countries. (wikipedia.org)
  • evaluate
  • Upon determination of the MTD, twice daily (BID) dosing cohorts may be opened to collect additional safety data and evaluate the preliminary efficacy of GSK525762 administered BID. (clinicaltrials.gov)
  • Abuse
  • however some psychiatrists recommend these drugs, citing research suggesting they are equally potent with less potential for abuse. (wikipedia.org)
  • decrease
  • It, and its competitor, Actos (pioglitazone), are thiazolidinediones (TZD's), a class of drugs that act to decrease insulin resistance. (sciencebasedmedicine.org)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are a drug class that groups together drugs that reduce pain, decrease fever, and, in higher doses, decrease inflammation. (wikipedia.org)
  • indications
  • Only inhalant anthrax and pseudomonal infections in cystic fibrosis infections are licensed indications in the UK due to ongoing safety concerns. (wikipedia.org)
  • study
  • Studies were classified by their level of evidence based on the study design, using published criteria (Agency for Healthcare Research and Quality, 2008). (york.ac.uk)
  • The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. (clinicaltrials.gov)
  • Subjects may continue treatment in the study until disease progression, unacceptable toxicity, or withdrawal of consent. (clinicaltrials.gov)
  • They learned a lineage-based medical system from their parents (mostly from their fathers), took imperial exams to enter medical university pre-PRC, or study at TCM universities in modern China. (wikipedia.org)
  • In a study comparing the safety and efficacy of levofloxacin to that of azithromycin or ceftriaxone in 712 children with community-acquired pneumonia, serious adverse events were experienced by 6% of those treated with levofloxacin and 4% of those treated with comparator antibiotics. (wikipedia.org)
  • Most of these were considered by the treating physician to be unrelated or doubtfully related to the study drug. (wikipedia.org)
  • This study, the VIGOR trial, raised the issue of the cardiovascular safety of the coxibs. (wikipedia.org)
  • treatment
  • The goal of an OCS is to amass and record key disease- and/or treatment-related data over time for a large heterogeneous patient population treated by a broad base of practitioners ( Lubeck 2007 ). (pubmedcentralcanada.ca)
  • Medical researchers have repeatedly found that the jail's methadone treatment program has resulted in overall health care cost savings, reduced crime and recidivism, reduced HIV and hepatitis C transmission, and better than average rates of recovery from drug use. (pewtrusts.org)
  • Acceptable comparators (where relevant) were placebo or another drug treatment. (york.ac.uk)
  • The story is a paradigm of how science and public opinion interact to determine the fate of a medical treatment where there is little dissent over effectiveness, but little agreement over safety. (sciencebasedmedicine.org)
  • effects
  • There is no guarantee of strength, purity or safety of products, and effects may vary. (blackmountainnaturalfoods.com)
  • however, it can be effective in alleviating physical withdrawal effects, such as muscle cramps. (wikipedia.org)
  • Barbiturates are drugs that act as central nervous system depressants, and can therefore produce a wide spectrum of effects, from mild sedation to total anesthesia. (wikipedia.org)
  • Opioids are also frequently used non-medically for their euphoric effects or to prevent withdrawal. (wikipedia.org)
  • The term nonsteroidal distinguishes these drugs from steroids, which, among a broad range of other effects, have a similar eicosanoid-depressing, anti-inflammatory action. (wikipedia.org)
  • However, while effective, this drug presented with significant adverse effects, which led to the search for an equally effective analog. (wikipedia.org)
  • assessment
  • Safety and tolerability assessment includes: routine physical examinations, vital sign measurements, echocardiograms, and monitoring of AEs, cardiac safety monitoring consisting of 24 hours of Holter monitoring and triplicate 12-lead ECGs. (clinicaltrials.gov)
  • data
  • This information reflects FDA's current analysis of data available to FDA concerning this drug. (pdr.net)
  • According to Melanie Newman, writing for the BMJ, "[t]he drug only produced a positive result when four new secondary outcome measures, which were introduced following the initial data analysis, were used instead. (wikipedia.org)
  • Further data, from the APPROVe trial, showed a statistically significant relative risk of cardiovascular events of 1.97 versus placebo-which caused a worldwide withdrawal of rofecoxib in October 2004. (wikipedia.org)
  • effective
  • The alcohol based version is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. (wikipedia.org)
  • Pregnancy
  • Zafirlukast is considered to be "pregnancy category B." This is due, in part, to the wide safety margin of zafirlukast in animal studies investigating teratogenicity. (wikipedia.org)
  • emotional
  • The capacity of the Kratom to relaxed the bodily as nicely as the emotional can make the drug a topic sought following by many. (kratomextractworld.com)
  • Such sudden, frequent, extreme, uncontrollable emotional outbursts may lead to social withdrawal and interfere with activities of daily living, social and professional pursuits, and reduce overall healthcare. (wikipedia.org)