• accelerate
  • The results presented today suggest that this leads to improved perfusion, or delivery of blood, to biological tissue," said miRagen President and CEO William S. Marshall, Ph.D. "We believe this preclinical activity observed with MRG-110 demonstrates its potential to accelerate wound healing in healthy skin and in pathological conditions, providing support for its evaluation in future human clinical trials. (pharmiweb.com)
  • Excellagen® can activate platelets, triggering release of essential growth factors and is believed to function as an acellular biological modulator to activate the wound healing process and significantly accelerate the growth of granulation tissue. (corporate-ir.net)
  • endothelial cells
  • Receptor activation gives rise to a signal transduction cascade that leads to gene activation and diverse biological responses, including cell differentiation, proliferation, and matrix dissolution, thus initiating a process of mitogenic activity critical for the growth of endothelial cells, fibroblasts, and smooth muscle cells. (wikipedia.org)
  • cellular
  • Wound is defined as disruption of cellular, anatomical, and functional continuity of a living tissue. (hindawi.com)
  • Wound healing is the interaction of a complex cascade of cellular and biochemical actions leading to the restoration of structural and functional integrity with regain of strength of injured tissues. (hindawi.com)
  • Greek: big eaters, from Greek μακρός (makrós) = large, φαγείν (phageín) = to eat) are a type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, cancer cells, and anything else that does not have the types of proteins specific to healthy body cells on its surface in a process called phagocytosis. (wikipedia.org)
  • bone
  • Thorough debridement: For the bed sores, especially classified as III and IV degree bedsore, the affected area including dermis, subcutaneous tissue, muscle, tendon and even bone has already been necrotic. (chinaburn.org)
  • Generally bone fracture treatment consists of a doctor reducing (pushing) displaced bones back into place via relocation with or without anaesthetic, stabilizing their position to aid union, and then waiting for the bone's natural healing process to occur. (wikipedia.org)
  • Age, Bone type, drug therapy and pre existing bone pathology are factors which affect healing. (wikipedia.org)
  • The role of bone healing is to produce new bone without a scar as seen in other tissues which would be a structural weakness or deformity. (wikipedia.org)
  • The healing process is mainly determined by the periosteum (the connective tissue membrane covering the bone). (wikipedia.org)
  • The periosteum is one source of precursor cells which develop into chondroblasts and osteoblasts that are essential to the healing of bone. (wikipedia.org)
  • Remodeling phase v. Remodeling to original bone contour After fracture, the first change seen by light and electron microscopy is the presence of blood cells within the tissues adjacent to the injury site. (wikipedia.org)
  • The remodeling process substitutes the trabecular bone with compact bone. (wikipedia.org)
  • This process can be enhanced by certain synthetic injectable biomaterials, such as cerament, which are osteoconductive and actively promote bone healing. (wikipedia.org)
  • Bone tissue is exposed to the oral environment, and a localized inflammatory reaction takes place in the adjacent marrow spaces. (wikipedia.org)
  • regenerate
  • In order to create an effective wound healing treatment, it should be one that is able to regenerate lost skin and protect a patient from infection and disease. (nmoe.org)
  • It is the process by which the cells in the body regenerate and repair to reduce the size of a damaged or necrotic area and replace it with new living tissue. (wikipedia.org)
  • Healing must happen by repair in the case of injury to cells that are unable to regenerate (e.g. neurons). (wikipedia.org)
  • After the limb or tail has been autotomized, cells move into action and the tissues will regenerate. (wikipedia.org)
  • open wound
  • When examined 48 hours after infliction, the tissue surfaces of a clean, open wound of this type seem to be covered with tiny red granules, with an appearance similar to a pile of rough velvet. (google.com)
  • diabetic
  • The combination of Cyndacel-M™ and Excellagen® improved wound closure and neo-vascularization in a diabetic dermal wound healing model. (corporate-ir.net)
  • The definition of diabetic foot by World Health Organization is that lower extremities infection, ulceration and deep tissue damage on DM patients are caused by the neuropathies and various extents of distal vascular disorders. (chinaburn.org)
  • Wound Healing Society
  • The data will be presented today, April 27, at the 2018 Wound Healing Society (WHS) Annual Meeting in Charlotte, North Carolina, by Rusty Montgomery, Ph.D., Director of Research, miRagen Therapeutics. (pharmiweb.com)
  • somatic
  • Reddy MV, Randerath K. 32P-analysis of DNA adducts in somatic and reproductive tissues of rats treated with the anticancer antibiotic, mitomycin C. Mutat Res. (springer.com)
  • Strategies include the rearrangement of pre-existing tissue, the use of adult somatic stem cells and the dedifferentiation and/or transdifferentiation of cells, and more than one mode can operate in different tissues of the same animal. (wikipedia.org)
  • infection
  • These work to phagocytize old or damaged tissue, and protect the healing tissue from pathogenic infection. (wikipedia.org)
  • Since alveolar osteitis is not primarily an infection, there is not usually any pyrexia (fever) and cervical lymphadenitis (swollen glands in the neck), and only minimal edema (swelling) and erythema (redness) is present in the soft tissues surrounding the socket. (wikipedia.org)
  • phases
  • Multiple factors, such as infections, stress, diabetes, smoking and obesity, can lead to impaired wound healing by interfering with one or more of these phases [ 2 ]. (intechopen.com)
  • The phases of wound healing normally progress in a predictable, timely manner, and if they do not, healing may progress inappropriately to either a chronic wound such as a venous ulcer or pathological scarring such as a keloid scar [ 3 ]. (hindawi.com)
  • There are three major phases of fracture healing, two of which can be further sub-divided to make a total of five phases:[citation needed] 1. (wikipedia.org)
  • pathology
  • Healing and Repair Chapter 9 from an "Introduction to Pathology" on a Tuskegee University website Reference list is found on image main page. (wikipedia.org)
  • blood
  • Not all authorities include blood or lymph as connective tissue because they lack the fiber component. (wikipedia.org)
  • When a monocyte enters damaged tissue through the endothelium of a blood vessel, a process known as the leukocyte extravasation, it undergoes a series of changes to become a macrophage. (wikipedia.org)
  • pathogens
  • This is necessary both to aid the healing process and to protect against invading pathogens, as the wound often does not have an effective skin barrier to act as a first line of defense. (wikipedia.org)
  • These large phagocytes are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. (wikipedia.org)
  • dressings
  • In wound healing, in particular, the increasing healthcare costs and the antibiotic resistance demonstrated by several microorganisms have encouraged researchers and companies in the development of innovative wound dressings with antibacterial properties and capability to promote and enhance the healing process. (intechopen.com)
  • dense
  • A particular type of fibroblasts, embedded in dense fascial tissues, has been proposed as being cells specialized for the biosynthesis of the hyaluronan-rich matrix. (wikipedia.org)
  • Dense irregular connective tissue provides strength in multiple directions by its dense bundles of fibers arranged in all directions. (wikipedia.org)