• wounds
  • Combing the revolutionary fields of molecular cell biology and materials science, we have designed both a biologically and structurally optimized second generation hydrogel matrix that has the potential to accelerate the healing of both chronic and acute wounds. (nmoe.org)
  • This new strategy for healing wounds is to mimic the properties of normal wound healing and apply it to a chronic wound setting. (nmoe.org)
  • In several case studies, physicians reported a rapid onset of the growth of granulation tissue in a wide array of wounds, including non-healing diabetic foot ulcers (consistent with the results of Cardium's Matrix clinical study), as well as pressure ulcers, venous ulcers and Mohs surgical wounds. (prnewswire.com)
  • From a dermatology perspective, a previously unexplored vertical market, remarkable healing responses have been observed following Mohs surgery for patients diagnosed with squamous and basal cell carcinomas, including deep surgical wounds extending to the periosteum (a membrane that lines the outer surface of bones). (prnewswire.com)
  • Additionally, because of the easy-use and platelet activating capacity, physicians have been employing Excellagen in severe non-healing wounds at near-amputation status, in combination with autologous platelet-rich plasma therapy and collagen sheet products. (prnewswire.com)
  • Taxus Cardium's Excellagen® product, which has been cleared by the FDA for the treatment of chronic non-healing dermal wounds, has previously been shown to be capable of stimulating the rapid regeneration of granulation tissue, and to provide a matrix capable of supporting the viability of cells and other biologics. (corporate-ir.net)
  • In addition to Excellagen's FDA-cleared uses for the treatment of chronic non-healing dermal wounds, its pharmaceutically formulated flowable dermal matrix has been engineered as a platform technology, enabling multiple therapeutic product extensions for tissue regeneration based on stem cells, biologics, peptides and small molecule drugs. (corporate-ir.net)
  • Excellagen® is indicated for the treatment of hard to heal wounds such as diabetic foot ulcers and pressure ulcers as well as other dermal wounds. (corporate-ir.net)
  • Wounds are the result of injuries to the skin that disrupt the other soft tissue. (hindawi.com)
  • Wound healing herbal extracts promote blood clotting, fight infection, and accelerate the healing of wounds. (hindawi.com)
  • 167-58) This invention relates to starch and starch phosphate compositions, to films prepared from such com ositions and to a method of using certain of such films as a dressing for skin wounds which heal primarily by the mechanism of growth of granulation tissue. (google.com)
  • In the pathology and healing of open skin wounds, two general types of Wounds may be differentiated. (google.com)
  • In contrast, there is the second general class of wounds wherein such a large quantity of tissue is removed or lost across the surface of the wound that the raw tissues exposed in the gap of the wound can no longer be juxtaposed nor fused together directly because the degree to which the skin surrounding the wound would have to be stretched is excessive or impossible. (google.com)
  • Heretofore, the most widely used dressing for wounds involving loss of tissue has been dry gauze impregnated with a semi-solid, jelly lubricant such as petrolatum. (google.com)
  • Therefore, the surgical procedure is necessary to be performed to get rid the occupied necrotic tissues of the wounds to provide the space to the regeneration of potential regenerative cells (PRCs) and the exogenous life regenerative nutrients(MEBO Wound Ointment) facilitating the growth of PRCs. (chinaburn.org)
  • Granulation tissue typically grows from the base of a wound and is able to fill wounds of almost any size. (wikipedia.org)
  • Many studies show a prolonged inflammatory phase in diabetic wounds, which causes a delay in the formation of mature granulation tissue and a parallel reduction in wound tensile strength. (wikipedia.org)
  • The wound healing process is not only complex but also fragile, and it is susceptible to interruption or failure leading to the formation of non-healing chronic wounds. (wikipedia.org)
  • Factors that contribute to non-healing chronic wounds are diabetes, venous or arterial disease, infection, and metabolic deficiencies of old age. (wikipedia.org)
  • During early gestation fetal skin wounds have the remarkable ability to heal rapidly and without scar formation. (wikipedia.org)
  • Since alginate dressings require moisture to function effectively, they cannot be used for dry wounds and those covered with hard necrotic tissue. (wikipedia.org)
  • It even allows some mammals (like mice) to heal wounds without scars. (wikipedia.org)
  • cellular
  • This linear array forms a flowable, biocompatible and bioactive structural matrix that can promote chemotaxis, cellular adhesion, migration and proliferation to stimulate tissue formation. (prnewswire.com)
  • Wound is defined as disruption of cellular, anatomical, and functional continuity of a living tissue. (hindawi.com)
  • Wound healing is the interaction of a complex cascade of cellular and biochemical actions leading to the restoration of structural and functional integrity with regain of strength of injured tissues. (hindawi.com)
  • It is possible that the main factor has been the damage of the cellular components responsible for the growth of granulation tissue, which determine the production of enzymes according to the necessity. (worldwidescience.org)
  • It is necessary for a network of blood vessels to be established as soon as possible to provide the growing tissue with nutrients, to take away cellular wastes, and transport new leukocytes to the area. (wikipedia.org)
  • Greek: big eaters, from Greek μακρός (makrós) = large, φαγείν (phageín) = to eat) are a type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, cancer cells, and anything else that does not have the types of proteins specific to healthy body cells on its surface in a process called phagocytosis. (wikipedia.org)
  • The cellular phase involves several types of cells working together to mount an inflammatory response, synthesize granulation tissue, and restore the epithelial layer. (wikipedia.org)
  • involves
  • The CE mark process involves interaction between the Company and its notified body, BSI. (biospace.com)
  • Wound care and maintenance involves a number of measures including dressing and administration of painkillers, use of anti-inflammatory agents, topical systemic antimicrobial agents, and healing promoting drugs. (hindawi.com)
  • A healing of a corneal ulcer involves two processes: migration of surrounding epithelial cells followed by mitosis (dividing) of the cells, and introduction of blood vessels from the conjunctiva. (wikipedia.org)
  • The process of scarring is complex, it involves the inflammatory response and remodelling amongst other cell activities. (wikipedia.org)
  • With physical damage or disease suffered by an organism, healing involves the repair of living tissue, organs and the biological system as a whole and resumption of normal functioning. (wikipedia.org)
  • The process of tattooing involves the insertion of pigment into the skin's dermis. (wikipedia.org)
  • Play media Tattooing involves the placement of pigment into the skin's dermis, the layer of dermal tissue underlying the epidermis. (wikipedia.org)
  • The process involves lengthy protocols and prayers and is considered a sacred rite more than an application of artwork. (wikipedia.org)
  • Excellagen
  • The combination of Cyndacel-M™ and Excellagen® improved wound closure and neo-vascularization in a diabetic dermal wound healing model. (corporate-ir.net)
  • The Company has continued to pursue CE mark certification for Excellagen®, responding to all information requested by the Notified Body, and looks forward to completing this process. (corporate-ir.net)
  • The new 510(k) submission further characterizes Excellagen as a dermal wound matrix with structural and functional properties that play essential roles in wound healing. (biospace.com)
  • We believe the research data provided to the FDA in our recent 510(k) submission provide further insight into the significantly accelerated and activated healing response seen with our Excellagen advanced wound care product," stated Christopher J. Reinhard , Chairman and CEO of Cardium. (biospace.com)
  • Advanced forward with applications to support the reimbursement process for Excellagen with the Centers for Medicare & Medicaid Services (CMS) and private insurance providers, and broadened marketing and sales efforts into markets with established CPT ® codes for surgical debridement procedures and in-hospital surgical markets covered under DRG reimbursement systems. (bio-medicine.org)
  • bone
  • Thorough debridement: For the bed sores, especially classified as III and IV degree bedsore, the affected area including dermis, subcutaneous tissue, muscle, tendon and even bone has already been necrotic. (chinaburn.org)
  • Generally bone fracture treatment consists of a doctor reducing (pushing) displaced bones back into place via relocation with or without anaesthetic, stabilizing their position to aid union, and then waiting for the bone's natural healing process to occur. (wikipedia.org)
  • Age, Bone type, drug therapy and pre existing bone pathology are factors which affect healing. (wikipedia.org)
  • The healing process is mainly determined by the periosteum (the connective tissue membrane covering the bone). (wikipedia.org)
  • The periosteum is one source of precursor cells which develop into chondroblasts and osteoblasts that are essential to the healing of bone. (wikipedia.org)
  • Remodeling phase v. Remodeling to original bone contour After fracture, the first change seen by light and electron microscopy is the presence of blood cells within the tissues adjacent to the injury site. (wikipedia.org)
  • The remodeling process substitutes the trabecular bone with compact bone. (wikipedia.org)
  • This process can be enhanced by certain synthetic injectable biomaterials, such as cerament, which are osteoconductive and actively promote bone healing. (wikipedia.org)
  • Bone tissue is exposed to the oral environment, and a localized inflammatory reaction takes place in the adjacent marrow spaces. (wikipedia.org)
  • infection
  • In order to create an effective wound healing treatment, it should be one that is able to regenerate lost skin and protect a patient from infection and disease. (nmoe.org)
  • The definition of diabetic foot by World Health Organization is that lower extremities infection, ulceration and deep tissue damage on DM patients are caused by the neuropathies and various extents of distal vascular disorders. (chinaburn.org)
  • These work to phagocytize old or damaged tissue, and protect the healing tissue from pathogenic infection. (wikipedia.org)
  • Wound care encourages and speeds wound healing via cleaning and protection from reinjury or infection. (wikipedia.org)
  • Since alveolar osteitis is not primarily an infection, there is not usually any pyrexia (fever) and cervical lymphadenitis (swollen glands in the neck), and only minimal edema (swelling) and erythema (redness) is present in the soft tissues surrounding the socket. (wikipedia.org)
  • phases
  • Multiple factors, such as infections, stress, diabetes, smoking and obesity, can lead to impaired wound healing by interfering with one or more of these phases [ 2 ]. (intechopen.com)
  • In this article, wound healing is depicted in a discrete timeline of physical attributes (phases) constituting the post-trauma repairing process. (wikipedia.org)
  • There are three major phases of fracture healing, two of which can be further sub-divided to make a total of five phases:[citation needed] 1. (wikipedia.org)
  • open wound
  • When examined 48 hours after infliction, the tissue surfaces of a clean, open wound of this type seem to be covered with tiny red granules, with an appearance similar to a pile of rough velvet. (google.com)
  • pathogens
  • This is necessary both to aid the healing process and to protect against invading pathogens, as the wound often does not have an effective skin barrier to act as a first line of defense. (wikipedia.org)
  • These large phagocytes are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. (wikipedia.org)
  • pathology
  • Healing and Repair Chapter 9 from an "Introduction to Pathology" on a Tuskegee University website Reference list is found on image main page. (wikipedia.org)
  • blood
  • Not all authorities include blood or lymph as connective tissue because they lack the fiber component. (wikipedia.org)
  • When a monocyte enters damaged tissue through the endothelium of a blood vessel, a process known as the leukocyte extravasation, it undergoes a series of changes to become a macrophage. (wikipedia.org)
  • This happens through the process of phagocytosis, where white blood cells "eat" debris by engulfing it. (wikipedia.org)
  • dressings
  • In wound healing, in particular, the increasing healthcare costs and the antibiotic resistance demonstrated by several microorganisms have encouraged researchers and companies in the development of innovative wound dressings with antibacterial properties and capability to promote and enhance the healing process. (intechopen.com)
  • dense
  • A particular type of fibroblasts, embedded in dense fascial tissues, has been proposed as being cells specialized for the biosynthesis of the hyaluronan-rich matrix. (wikipedia.org)
  • Dense irregular connective tissue provides strength in multiple directions by its dense bundles of fibers arranged in all directions. (wikipedia.org)