• HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. (wikipedia.org)
  • The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
  • The goal of the current study was to assess the association of COVID-19 clinical courses controlled by patients' adaptive immune responses without progression to severe disease with patients' Human Leukocyte Antigen (HLA) genetics, AB0 blood group antigens, and the presence or absence of near-loss-of-function delta 32 deletion mutant of the C-C chemokine receptor type 5 (CCR5). (biomedcentral.com)
  • DQB1*0302 are almost always linked to DR4, DRB1*0401, *0402, and *0404 in caucasians. (wikipedia.org)
  • Another rarer haplotype, DQA1*0401:DQB1*0302 DQA1*0301:DQB1*0302 (DQ8.1) is the most common DQ8 subtype representing over 98% of the DQ8 bearing population. (wikipedia.org)
  • After recalculating the response to CII taking this hyporesponsiveness into account the CII response was higher in RA patients, and was associated with human leucocyte antigen (HLA)-DRB1*0401 and HLA-DQA1*0301-DQB1*0302 (HLA-DQ8). (biomedcentral.com)
  • DQ8 increases the risk for rheumatoid arthritis and is linked to the primary risk locus for RA, HLA-DR4. (wikipedia.org)
  • The first and third DRB1 are most strongly associated with rheumatoid arthritis. (wikipedia.org)
  • We characterized HPV-16 variants by PCR in 107 ICC cases, which were typed for HLA-DQA1 , DRB1 and DQB1 genes and compared to 257 controls. (biomedcentral.com)
  • The HLA-DQA1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
  • Combinations of variations in the HLA-DQA1 gene and other HLA genes affect the risk of type 1 diabetes. (medlineplus.gov)
  • Type 1 diabetes risk is most increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA-DRB1 . (medlineplus.gov)
  • Our results suggest that the association between HLA polymorphism and risk of ICC might be influenced by the distribution of HPV-16 variants. (biomedcentral.com)
  • At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. (medlineplus.gov)
  • One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 bound to the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02 . (medlineplus.gov)
  • The other haplotype, known as DQ8, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 bound to the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 . (medlineplus.gov)
  • Prospective studies in larger patient populations also including novel SARS-CoV-2 variants will be required to assess the impact of HLA genetics on the capacity of mounting protective vaccination responses in the future. (biomedcentral.com)
  • One strong indicator for antigenic involvement in RA is the fact that certain major histocompatibility complex (MHC) class II genotypes [human leucocyte antigen (HLA)-DR4 and HLA-DR1] predispose for the development of the disease [ 1 ]. (biomedcentral.com)
  • To study cellular immune reactivity to CII in patients with RA and in healthy control individuals and to correlate this reactivity to HLA class II genotypes and to the presence of antibodies to CII in serum. (biomedcentral.com)
  • The impact of different HLA genotypes, AB0 blood group antigens, and the CCR5 mutant CD195 were investigated for their role in the clinical course of COVID-19. (biomedcentral.com)
  • People at highest risk of developing type 1 diabetes have one copy of the DR3 haplotype and one copy of the DR4 haplotype in each cell. (medlineplus.gov)
  • Other HLA haplotypes only mildly increase the risk of type 1 diabetes, while some haplotypes seem to protect against developing this condition. (medlineplus.gov)
  • DQ8 is determined by the antibody recognition of β8 and this generally detects the gene product of DQB1*0302. (wikipedia.org)
  • DQB1*0305 gene product reacts slightly more intensely with DQ8 than DQ7 its generally rare in Europe and North America, except in a few indigenous populations. (wikipedia.org)
  • The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
  • The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
  • The protein produced from the HLA-DQA1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQB1 . (medlineplus.gov)
  • Researchers have identified hundreds of different versions (alleles) of the HLA-DQA1 gene, each of which is given a particular number (such as HLA-DQA1*05:01 ). (medlineplus.gov)
  • Hierarchical testing by Cox regression analyses confirmed the significance of the protective effect of the HLA alleles identified (when assessed in composite) in terms of disease duration, whereas AB0 blood group antigen heterozygosity was found to be significantly associated with disease severity (rather than duration) in our cohort. (biomedcentral.com)
  • There is only one common cis-isoform of DQ8 because the linked DQA1*03 alleles(2) occur over the majority of the population, DQ8.1 is the overwhelming majority cis-isoform of DQ8. (wikipedia.org)
  • The DQ2 and DQ8 haplotypes, which may occur separately or together, seem to increase the risk of an inappropriate immune response to the protein gluten, which is found in wheat, rye, and barley. (medlineplus.gov)
  • HLA class II polymorphisms are also associated with genetic susceptibility to ICC. (biomedcentral.com)
  • Univariate HLA analyses identified putatively protective HLA alleles (HLA class II DRB1*01:01 and HLA class I B*35:01, with a trend for DRB1*03:01). (biomedcentral.com)
  • Conversely, analyses also identified HLA alleles (HLA class II DQB1*03:02 und HLA class I B*15:01) not associated with such benefit in the patient cohort of this study. (biomedcentral.com)
  • The current study shows that the presence of HLA class II DRB1*01:01 and HLA class I B*35:01 is of even stronger association with reduced disease duration in mild and moderate COVID-19 than age or any other potential risk factor assessed. (biomedcentral.com)
  • The specificity of T-cells is determined by the T-cell receptor (TCR), a heterodimer of alpha and beta protein chains. (elifesciences.org)
  • DQB1*0302 and is found most often in the haplotype DQA1*0301:DQB1*0302, about 10% of the time it is found in the haplotype DQA1*0302:DQB1*0302. (wikipedia.org)
  • We observed similar proportions of HLA DRB1*1302 carriers in E-P positive cases and controls, but interestingly, this allele was not found in AA cases (p = 0.03, Fisher exact test). (biomedcentral.com)
  • However, the DQ2 and DQ8 haplotypes are also found in 30 percent of the general population, and only 3 percent of individuals with these haplotypes develop celiac disease. (medlineplus.gov)
  • The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
  • For disease diagnosis and confirmation, there is no known association of DQB1*0305 with either coeliac or autoimmune diabetes. (wikipedia.org)
  • The relative increase in CII-reactivity in RA patients as compared with healthy control individuals, and the association of a higher response with RA-associated HLA haplotypes, suggest the existence of a potentially pathogenic cellular reactivity against CII in RA. (biomedcentral.com)
  • DQ8 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. (wikipedia.org)
  • Although false reaction with DQB1*0302 is low, the efficiency of the positive reaction is not good and there is a risk of false detection of DQB1*0305 which could create incompatibility. (wikipedia.org)
  • Infrequently, DQA1*0302:DQB1*0302, but this substitution of the alpha chain, DQA1**0301 versus *0302, is outside the binding cleft and appears not to alter DQ8 function. (wikipedia.org)
  • DQ8.1 also differs from other HLA in population frequencies. (wikipedia.org)
  • The global node for DQ8 is in Central America and northern South America where it reaches the highest frequency for any single DQ serotype, close to 90% phenotype frequency (77% haplotype frequency), and is at relatively high frequency in the indigenous North American population, and the coastal regions of the Gulf of Mexico and up the Mississippi Valley. (wikipedia.org)
  • Levels of DQB1*0305 are probably higher given earlier tests did not discriminate well between different *03. (wikipedia.org)
  • Complete HLA-DQA1, DQB1 genotyping and DRB1*04 subtyping were carried out by polymerase chain reactions with sequence-specific primers. (nih.gov)
  • The effect of the DRB1*04 subtypes was studied in DRB1*04 alleles carried on DQB1*0302-DQA1*03 haplotypes. (nih.gov)
  • The DQB1*0302 (odds ratio, OR = 9.0), DQB1*0201 (OR = 3.4) and DQA1*03 (OR = 7.5) alleles were significantly associated with diabetes risk, while the DQB1*0602 (OR = 0.02), DQB1*0301 (OR = 0.08), DQB1*0503 (OR = 0.13), DQB1*0603 (OR = 0.20), DQA1*01 (OR = 0.28) and DQA1*02 (OR = 0.26) alleles were significantly protective. (nih.gov)
  • Of the DQA1-DQB1 genotypes, we point out the extremely high risk of OR = 116 conferred by HLA-DQA1*05-DQB1*0201/DQA1*03-DQB1*0302. (nih.gov)
  • DQB1*0302 and is found most often in the haplotype DQA1*0301:DQB1*0302, about 10% of the time it is found in the haplotype DQA1*0302:DQB1*0302. (wikipedia.org)
  • DQ8 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. (wikipedia.org)
  • There is only one common cis-isoform of DQ8 because the linked DQA1*03 alleles(2) occur over the majority of the population, DQ8.1 is the overwhelming majority cis-isoform of DQ8. (wikipedia.org)
  • A rare haplotype DQA1*0503:DQB1*0302 is detected below 1% of all DQ8 haplotypes in Asia and Mesoamerica. (wikipedia.org)
  • Another rarer haplotype, DQA1*0401:DQB1*0302 DQA1*0301:DQB1*0302 (DQ8.1) is the most common DQ8 subtype representing over 98% of the DQ8 bearing population. (wikipedia.org)
  • Infrequently, DQA1*0302:DQB1*0302, but this substitution of the alpha chain, DQA1**0301 versus *0302, is outside the binding cleft and appears not to alter DQ8 function. (wikipedia.org)
  • Genetic susceptibility to celiac disease is strongly associated with HLA-DQA1*05-DQB1*02 (DQ2) and HLA-DQA1*03-DQB1*0302 (DQ8). (nih.gov)
  • Three of them carried the DQA1*01-DQB*05 haplotype as did 20/61 of those carrying neither DQ2 nor DQ8. (nih.gov)
  • This may implicate a role of the DQA1*01-DQB*05 haplotype. (nih.gov)
  • The disease is strongly and positively associated with both HLA-DRB1*0301-DQA1*0501-DQB1*0201 (DR3-DQ2) and DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8). (medscape.com)
  • [ 106 ] The HLA-DRB1*01-DQA1*01-DQB1*0501 and DRB1*13-DQA1*0103-DQB1*0603 haplotypes are negatively associated with genetic risk for AAD. (medscape.com)
  • Although the association of MICA with AAD appears to be independent from that of HLA class II haplotypes, the strong linkage disequilibrium existing within the DRB1*03-DQA1*0501-DQB1*0201-MICA5.1-HLA-B-extended haplotype has thus far limited the possibility to discriminate the relative contribution of each gene marker, and further studies on large populations are needed to provide an answer to this specific question. (medscape.com)
  • 5. HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China. (nih.gov)
  • 16. DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population. (nih.gov)
  • A Korean study found that the HLA DRB1*0405 allele conferred an increased relative risk of developing VKH compared with the general population, and that the HLA DRB1*0405-DQA1*0302-DQB1*0401 haplotype was associated with poorer visual prognosis [6]. (researchsquare.com)
  • We characterized HPV-16 variants by PCR in 107 ICC cases, which were typed for HLA-DQA1 , DRB1 and DQB1 genes and compared to 257 controls. (biomedcentral.com)
  • The HLA-DQ molecule is composed of 2 chains: DQ alpha (encoded by HLA-DQA1 gene) and DQ beta (encoded by HLA-DQB1 gene). (testcatalog.org)
  • The current molecular method allows typing for both the DQB1 and DQA1 chains. (testcatalog.org)
  • In some cases, the DQ2.2 haplotype may be present with a DQ7.5 haplotype ( DQA1*05:05 with DQB1*03:01 ). (testcatalog.org)
  • In this case, a DQ2.5 molecule can be formed by the combination of DQB1*02:02 from one chromosome and DQA1*05:05 from the other chromosome. (testcatalog.org)
  • 8] This patient had DQA1 0102, 0103 and DQB1 0602, 0601 that were considered as type 1 diabetes-protective HLA alleles. (medscape.com)
  • Human leukocyte antigen (HLA) haplotype DQ2 or DQ8 identified by molecular genetic testing of HLA-DQA1 and HLA-DQB1 . (nih.gov)
  • Celiac disease is a multifactorial disorder resulting from the interaction of HLA-DQA1 and HLA-DQB1 allelic variants known to be associated with celiac disease susceptibility, less well-recognized variants in non-HLA genes, gliadin (a subcomponent of gluten), and other environmental factors. (nih.gov)
  • The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
  • The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
  • The HLA-DQA1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
  • The protein produced from the HLA-DQA1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQB1 . (medlineplus.gov)
  • Researchers have identified hundreds of different versions (alleles) of the HLA-DQA1 gene, each of which is given a particular number (such as HLA-DQA1*05:01 ). (medlineplus.gov)
  • One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 bound to the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02 . (medlineplus.gov)
  • The other haplotype, known as DQ8, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 bound to the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 . (medlineplus.gov)
  • Combinations of variations in the HLA-DQA1 gene and other HLA genes affect the risk of type 1 diabetes. (medlineplus.gov)
  • Type 1 diabetes risk is most increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA-DRB1 . (medlineplus.gov)
  • One haplotype, written as DRB1*03:01-DQA1*05:01-DQB1*02 , is called DR3. (medlineplus.gov)
  • The other haplotype, written as DRB1*04:01/02/04/05/08-DQA1*03:01-DQB1*02 , is called DR4. (medlineplus.gov)
  • 9. Human leukocyte antigen-DRB1*1501 and DQB1*0602 alleles are cervical cancer protective factors among Uighur and Han people in Xinjiang, China. (nih.gov)
  • Other HLA and non-HLA genes contribute to the risk for AAD. (medscape.com)
  • The human leukocyte antigen (HLA) system is the locus of genes that encode for major histocompatibility complex (MHC), representing a set of cell surface molecules mediating the interaction of leukocytes [4]. (researchsquare.com)
  • For predicting prognosis and refractoriness to treatment, the focus in recent years has transitioned from the identification of HLA genes associated with increased risk of VKH to the identification of alternate genes [9,10]. (researchsquare.com)
  • This genetic association is with certain HLA genes in the class II region (DQ alpha 1, DQ beta 1). (testcatalog.org)
  • A single haplotype (heterozygote) of DQ2.5 is permissive for presence of celiac genes. (testcatalog.org)
  • However, only a double haplotype (homozygous) of DQ2.2 is permissive for presence of celiac genes. (testcatalog.org)
  • These results underline the primary importance of HLA-DQ alleles in susceptibility to celiac disease, and the extreme rarity of celiac patients carrying neither the DQ2 or DQ8 heterodimers nor one half of the DQ2 heterodimer alone. (nih.gov)
  • 14. HLA-DRB1 and MHC class 1 chain-related A haplotypes in Basque families with celiac disease. (nih.gov)
  • Most (90%-95%) patients with celiac disease have 1 or 2 copies of HLA-DQ2 haplotype (see below), while the remainder have HLA-DQ8 haplotype. (testcatalog.org)
  • In one study of celiac disease, only 0.7% of patients with celiac disease lacked the HLA alleles mentioned above. (testcatalog.org)
  • Typing of these haplotypes is important in celiac disease as they carry different risk association. (testcatalog.org)
  • Molecular genetic testing of first-degree relatives of a proband (including young children) to monitor those with known celiac disease-susceptibility alleles for early evidence of celiac disease in order to institute gluten-free diet early in the disease course. (nih.gov)
  • At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. (medlineplus.gov)
  • However, the DQ2 and DQ8 haplotypes are also found in 30 percent of the general population, and only 3 percent of individuals with these haplotypes develop celiac disease. (medlineplus.gov)
  • It was observed that DRB1-*0404 was more frequent among DRB1*04-positive AAD patients from the USA [ 107 ] and Norway [ 108 ] compared with both DRB1*04-positive healthy control subjects and DRB1*04-positive T1DM patients. (medscape.com)
  • These split antigens are the allele products of the DQB1*0302 and DQB1*0305, respectively. (wikipedia.org)
  • Although AAD, T1DM and thyroid diseases share similar HLA predisposition, it has been shown in several studies that the association of HLA class II haplotypes is still highly significant in patients with isolated AAD and does not depend on the coexistence of other autoimmune disorders in the same patient. (medscape.com)
  • There was thus pronounced age heterogeneity in DRB1 and DQB1 predisposition to Type II diabetes. (ox.ac.uk)
  • DQ8 increases the risk for rheumatoid arthritis and is linked to the primary risk locus for RA, HLA-DR4. (wikipedia.org)
  • Among DRB1*04 subtypes, DRB1*0403 was significantly protective (OR = 0.05, CI 95% 0.01-0.45). (nih.gov)
  • On the other hand, it was observed that the DRB1*0403 subtype, which was already known to confer strong protection for T1DM, was absent among 56 DRB1*04-positive AAD patients, but present in 27% DRB1*04-positive healthy control subjects, thus also conferring protection for the development of AAD. (medscape.com)
  • The mechanisms by which DRB1*0403 modulates disease susceptibility are still unclear. (medscape.com)
  • 2. A variant upstream of HLA-DRB1 and multiple variants in MICA influence susceptibility to cervical cancer in a Swedish population. (nih.gov)
  • Inside the pocket: Critical elements of HLA-mediated susceptibility to cervical precancerous lesions. (cdc.gov)
  • In summary, the clinical outcome of patients with advanced MDS might be influenced by HLA allelic loss, wich allows subclonal expansions to evade cytotoxic-T and NK cell attack. (oncotarget.com)
  • HLA class II polymorphisms are also associated with genetic susceptibility to ICC. (biomedcentral.com)
  • Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients. (cdc.gov)
  • HLA-DRB1 Polymorphisms and Rheumatologic Manifestations in Chronic Hepatitis C. (cdc.gov)
  • The first and third DRB1 are most strongly associated with rheumatoid arthritis. (wikipedia.org)
  • 17. Class II allele and haplotype frequencies in Mexican systemic lupus erythematosus patients: the relevance of considering homologous chromosomes in determining susceptibility. (nih.gov)
  • 04 alleles during systemic corticosteroid therapy in patients with VKH disease. (researchsquare.com)
  • HLA, and HLA-DRB1*04 in particular, therefore plays a key role in immune systemic function, as well as in the pathogenesis of autoimmune diseases, including VKH [5]. (researchsquare.com)
  • Our results suggest that the association between HLA polymorphism and risk of ICC might be influenced by the distribution of HPV-16 variants. (biomedcentral.com)
  • Anti-staphylococcal responses and their relationship with HLA-DR-DQ polymorphism in granulomatosis with polyangiitis: a preliminary evidence of association with disease outcome. (cdc.gov)
  • Some studies have focused attention on the frequency of HLA-DRB1*04 subtypes in different populations of AAD and T1DM patients, and healthy control subjects. (medscape.com)
  • A protective subtype may induce a deletion of autoreactive T cells more efficiently than a susceptible one or, alternatively, some DRB1*04 subtypes may present autoantigenic peptides more efficiently than others. (medscape.com)
  • DQ8.1 also differs from other HLA in population frequencies. (wikipedia.org)
  • There are 3 places where haplotype frequency is elevated, Central and South America, NE Pacific Rim, and Northern Europe. (wikipedia.org)
  • The global node for DQ8 is in Central America and northern South America where it reaches the highest frequency for any single DQ serotype, close to 90% phenotype frequency (77% haplotype frequency), and is at relatively high frequency in the indigenous North American population, and the coastal regions of the Gulf of Mexico and up the Mississippi Valley. (wikipedia.org)
  • Since AAD and T1DM share the same HLA haplotypes, the frequency of the 'high-risk' HLA markers is approximately threefold higher in Scandinavia than in Mediterranean countries, but the prevalence rate of AAD is only slightly higher in Norway [ 2 ] than in Italy, [ 1 ] and the relative contribution of genetic factors and environmental agents for the development of clinical AAD remains to be elucidated. (medscape.com)
  • Frequency of HLA alleles among COVID-19 infected patients: Preliminary data from Saudi Arabia. (cdc.gov)
  • To assess over-representation of high-risk alleles for Type I (insulin-dependent) diabetes mellitus, the prevalence of high-risk alleles in diabetic patients was expressed relative to the prevalence of low-risk alleles, non-DR3/non-DR4, that provided a reference denominator in both the diabetic patients and in 200 non-diabetic control subjects. (ox.ac.uk)
  • CONCLUSION/HYPOTHESIS: The age of presentation of Type I diabetes in adulthood was in part dependent on the DRB1/DQB1 genotype. (ox.ac.uk)
  • The influence of HLA genotype on the severity of COVID-19 infection. (cdc.gov)
  • 1. A cis-eQTL of HLA-DRB1 and a frameshift mutation of MICA contribute to the pattern of association of HLA alleles with cervical cancer. (nih.gov)
  • Study of the HLA associations in patients not carrying these heterodimers has been limited by the rarity of such patients. (nih.gov)
  • 12. Susceptible and Protective Associations of HLA Alleles and Haplotypes with Cervical Cancer in South India. (nih.gov)
  • As is the case for many other autoimmune diseases, the major genetic markers associated with AAD are located in the HLA region on chromosome 6. (medscape.com)
  • We performed a SNP array on chromosome 6 in CD34 + purified blasts from 19 patients diagnosed with advanced MDS and 8 patients with other myeloid malignancies to evaluate the presence of loss of heterozygosity (LOH) in HLA and its impact on disease progression. (oncotarget.com)
  • 4. Protective association of HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population. (nih.gov)
  • Can presence of HLA type I and II alleles be associated with clinical spectrum of CHIKV infection? (cdc.gov)
  • HLA-DQ typing can be performed by serological or molecular methods. (testcatalog.org)
  • HLA-DQ2 and DQ8, as typed by serology, are usually based on the molecular typing of the DQB1 chain only. (testcatalog.org)
  • For disease diagnosis and confirmation, there is no known association of DQB1*0305 with either coeliac or autoimmune diabetes. (wikipedia.org)
  • 6. The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos. (nih.gov)
  • METHODS: The antibodies to islet cells and those to glutamic acid decarboxylase were measured in 1712 white Caucasian diabetic subjects at diagnosis of diabetes and they were genotyped for HLA DRB1*03 and DRB1*04 and the high-risk DRB1*04-DQB1* 0302 haplotype. (ox.ac.uk)
  • People at highest risk of developing type 1 diabetes have one copy of the DR3 haplotype and one copy of the DR4 haplotype in each cell. (medlineplus.gov)
  • Other HLA haplotypes only mildly increase the risk of type 1 diabetes, while some haplotypes seem to protect against developing this condition. (medlineplus.gov)
  • Conclusion: Alleles of HLA-DRB1*04 might affect visual prognosis and be related to early response after initiation of treatment in VKH disease. (researchsquare.com)
  • A role of genetic factors such as HLA alleles in the development of VKH was first considered in 1976, and was supported by the simultaneous development of VKH in monozygotic twins [3]. (researchsquare.com)
  • For that reason, we report an investigation of correlations between HLA04 allele type and visual outcomes before and after steroid treatment in the real world. (researchsquare.com)
  • None of these four patients carried the DQB1*06 allele that has previously been reported in this sub-group of patients. (nih.gov)
  • In the group aged 25-34 years, 32 % of patients with ICA or GADA or both had DRB1*03/DRB1*04-DQB1*0302 compared with 10% in those aged 55-65 years and expected 3% prevalence. (ox.ac.uk)
  • HLA-DRB1*04 may predict the severity of disease in a group of Iranian COVID-19 patients. (cdc.gov)
  • LOH HLA was not detected in the remaining 24 patients, who all had adverse risk factors. (oncotarget.com)
  • 11. Study of HLA class II loci reveals DQB1*03:03:02 as a risk factor for asthma in a Pakistani population. (nih.gov)
  • EBV protection- and susceptibility-related HLA alleles and EBV status in the Chinese population: A single-center study. (cdc.gov)