• limb
  • The Hand and Orthopedic Upper Extremity Program provides comprehensive care involving occupational and physical therapy, splinting, casting and reconstructive surgeries for infants, children and adolescents with complex congenital, neuromuscular, sports-related oncologic and traumatic upper limb conditions. (childrenshospital.org)
  • Boston Children's Hospital's Orthopedic Center's Hand and Orthopedic Upper Extremity Program is dedicated to the comprehensive care of all upper limb conditions in infants, children and adolescents. (childrenshospital.org)
  • Amniotic band constriction (also known as "amniotic band syndrome", "ADAM complex", "Amniotic band sequence", "Congenital constriction bands" and "Pseudoainhum") is a congenital disorder caused by entrapment of fetal parts (usually a limb or digits) in fibrous amniotic bands while in utero. (wikipedia.org)
  • A number of factors make the identification of the genetic defects underlying human ectrodactyly a complicated process: the limited number of families linked to each split hand/foot malformation (SHFM) locus, the large number of morphogens involved in limb development, the complex interactions between these morphogens, the involvement of modifier genes, and the presumed involvement of multiple gene or long-range regulatory elements in some cases of ectrodactyly. (wikipedia.org)
  • The pathophysiology of cleft hand is thought to be a result of a wedge-shaped defect of the apical ectoderm of the limb bud (AER: apical ectodermal ridge). (wikipedia.org)
  • She was renowned for her innovative techniques for correcting limb deformities. (wikipedia.org)
  • Mice that were lacking both copies of the TWIST gene were spontaneously aborted prior to birth, and had serious deformities including abnormal limb and head defects and failure of the neural tube to properly close. (wikipedia.org)
  • abnormal
  • A contracture is an abnormal pulling forward of the fingers of the hand. (lomalindahealth.org)
  • Typically the result of a failure of the cells to differentiate in utero, contractures are an abnormal pulling forward of the digits of the hand, usually caused by problems with the muscles or skin. (rochesterregional.org)
  • radial
  • The central ray of the hand is affected and usually appears without proximal deficiencies of nerves, vessels, tendons, muscles and bones in contrast to the radial and ulnar deficiencies. (wikipedia.org)
  • disorder
  • It is a rare form of a congenital disorder in which the development of the hand is disturbed. (wikipedia.org)
  • Eventually, this disorder was ruled distinct from a syndrome presented by Prader and Willi (Prader-Willi syndrome) because of its mode of inheritance, gynecomastia, and presence of small hands and feet. (wikipedia.org)
  • involves
  • There is a familial tendency to develop this deformity, which usually involves both hands and affects males more often than females. (rochesterregional.org)
  • Ectrodactyly, split hand, cleft hand, derived from the Greek ektroma (abortion) and daktylos (finger) involves the deficiency or absence of one or more central digits of the hand or foot and is also known as split hand/split foot malformation (SHFM). (wikipedia.org)
  • premature
  • Trigonocephaly (Greek: 'trigonon' = triangle, 'kephale' = head) is a congenital condition of premature fusion of the metopic suture (Greek: 'metopon' = forehead) leading to a triangular shaped forehead. (wikipedia.org)
  • syndrome
  • The identified mutation for SHSF syndrome (split-hand/split-foot syndrome) a duplication on 10q24, and not a mutation of the tp63 gene as in families affected by EEC syndrome (ectrodactyly-ectodermal dysplasia-cleft syndrome). (wikipedia.org)
  • However, the typical hand deformities in patients with Apert Syndrome distinguish it from the other syndromes. (wikipedia.org)
  • Wilson-Turner Syndrome (WTS), also known as Mental Retardation X Linked Syndromic 6 (MRXS6), or Mental Retardation X Linked with Gynecomastia and Obesity is a congenital condition characterized by intellectual disability and associated with childhood-onset obesity. (wikipedia.org)
  • bone
  • This causes either a complete absence of a part of the body, such as the hand, or a missing structure, such as part of the arm bone. (lomalindahealth.org)
  • digits
  • In embryology, the hands and feet have selective cells that die, called selective cell death or apoptosis, causing separation of the digits. (wikipedia.org)