• volatile
  • Charles Walter Suckling, CBE FRS (24 July 1920 - 31 October 2013) was a British chemist who first synthesised halothane, a volatile inhalational anaesthetic in 1951, while working at the Imperial Chemical Industries (ICI) Central Laboratory in Widnes. (wikipedia.org)
  • rats
  • No evidence of an exposure related change in physical appearance or behavior of the rats exposed to N2O and halothane was noted. (cdc.gov)
  • The effect of halothane on mesenteric intralymphatic pressure was examined in 20 rats. (biomedsearch.com)
  • Significant levels of trifluoroacetyl protein antigens were generated when human liver microsomes, and also microsomes from livers of rats pre-treated with isoniazid, phenobarbital or beta-naphtoflavone, were incubated with halothane plus a nicotinamide adenine dinucleotidephosphate (NADPH) generating system. (sigmaaldrich.com)
  • pigs
  • The first gene discovered was named the Halothane gene, Hal, because researchers noticed that pigs with this specific genotype developed PSE meat after being anesthetized with the halothane drug. (wikipedia.org)
  • hydrogen
  • The commercial synthesis of halothane starts from trichloroethylene, which is reacted with hydrogen fluoride in the presence of antimony trichloride at 130 °C to form 2-chloro-1,1,1-trifluoroethane. (wikipedia.org)
  • However, the subtle interplay between these two effects makes prediction of blue-shifting hydrogen bonds difficult as was shown by an surprising observation of a hydrogen bonds red shift of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) upon complex formation with acetone. (wikipedia.org)
  • muscle
  • Storage was at 4 degrees C. For serial testing of halothane during a five month period, halothane 1% or 3% in carbogen was bubbled through a Krebs solution, contained in muscle baths, either using a roller pump (to eliminate vaporizer back pressure) or using carbogen at a line pressure of 4-6 lbs/in2 (27-41 kPa). (biomedsearch.com)
  • When compared to the halothane concentration in gas entering the muscle baths, halothane concentration in Krebs was predictable regardless of method delivery, as long as a gas analyzer indicated the proper concentration. (biomedsearch.com)
  • Study
  • Methods and Results - This study investigated the influence of sex on drug-induced polymorphic ventricular tachycardia (PVT) in Langendorff-perfused male and female mice hearts (n=54) by injecting a bolus of halothane (1.75 mmol/L) in the perfusate while recording ECGs or optical action potentials (APs). (ahajournals.org)
  • male
  • In optically mapped male hearts, halothane reduced APD 75 (17.61±1.6 ms) and then elicited VTs (n=6 of 6), but in female hearts, halothane elicited PVTs (n=1 of 6) or arrested the hearts (n=5 of 6). (ahajournals.org)
  • Heart
  • Halothane sensitises the heart to catecholamines, so it is liable to cause cardiac arrhythmias, occasionally fatal, particularly if hypercapnia has been allowed to develop. (wikipedia.org)