• bromide
  • While it is rather rare in the Earth's crust, the high solubility of the bromide ion (Br−) has caused its accumulation in the oceans. (wikipedia.org)
  • Although large amounts are toxic and cause bromism, a clear biological role for bromide and hypobromous acid has recently been elucidated, and it now appears that bromine is an essential trace element. (wikipedia.org)
  • As a pharmaceutical, the simple bromide ion (Br−) has inhibitory effects on the central nervous system, and bromide salts were once a major medical sedative, before replacement by shorter-acting drugs. (wikipedia.org)
  • In the early years of the First World War, bromine compounds such as xylyl bromide were used as poison gas. (wikipedia.org)
  • reacts
  • 13. The precursor compound as defined in claim 12 wherein R 11 comprises a chemical group that reacts with a suitable source of a radioisotope suitable for in vivo imaging and is C 1-3 alkylene-LG wherein LG is a leaving group selected from mesylate, tosylate, and triflate. (patentsencyclopedia.com)
  • oxides
  • The present invention includes compounds that are described by general formula (I), its stereoisomers, its radioisotopes, its N-oxides, its polymorphs, its pharmaceutical^ acceptable salts, its pharmaceutical^ acceptable solvates, its useful bio-active metabolites and any suitable combination of the above. (allindianpatents.com)
  • Further the present invention also includes the processes for preparing such compounds of the general formula (I), its stereoisomers, its radioisotopes, its N-oxides, its polymorphs, its pharmaceutical^ acceptable salts, its pharmaceutically acceptable solvates, its useful bio-active metabolites and also includes any suitable combination of the above. (allindianpatents.com)
  • free
  • Elemental bromine is very reactive and thus does not occur free in nature, but in colourless soluble crystalline mineral halide salts, analogous to table salt. (wikipedia.org)
  • claim
  • 2. The in vivo imaging agent as defined in claim 1 wherein said radioisotope suitable for in vivo imaging is selected from 11 C, 18 F and 123 I. (patentsencyclopedia.com)
  • 3. A compound according to claim 1, wherein:A is phenyl;R 1 is selected from C 1 -4alkyl- and C 3 -6cycloalkyl-;R 2 is selected from H, halogen and unsubstituted C 1-6 alkoxy-;R 3 is H or halogen;n and m are both 1;R 5 is H;or a stereoisomer, enantiomer, in vivo-hydrolysable precursor or pharmaceutically-acceptable salt thereof. (patentsencyclopedia.com)
  • 4. A compound according to claim 1, wherein:A is phenyl;R 1 is ethyl or cyclopropyl;R 2 is selected from H, F and --OCH 3 ;R 3 is H or F;n, m and q are each 1;R 5 at each occurrence is independently selected from H, --OH and halogen;or a stereoisomer, enantiomer, in vivo-hydrolysable precursor or pharmaceutically-acceptable salt thereof. (patentsencyclopedia.com)
  • liquid
  • It is the third-lightest halogen, and is a fuming red-brown liquid at room temperature that evaporates readily to form a similarly coloured gas. (wikipedia.org)
  • salt
  • Balard found bromine chemicals in the ash of seaweed from the salt marshes of Montpellier. (wikipedia.org)
  • Bromine was not produced in large quantities until 1858, when the discovery of salt deposits in Stassfurt enabled its production as a by-product of potash. (wikipedia.org)