Haemophilia hemophilia a. Medical search. Frequent questions

The medication desmopressin may be used in those with mild haemophilia A. Studies of gene therapy are in early human trials. (wikipedia.org)
People with more severe haemophilia experience more severe and more frequent bleeds, while people with mild haemophilia usually experience more minor symptoms except after surgery or serious trauma. (wikipedia.org)
In cases of moderate haemophilia symptoms are variable which manifest along a spectrum between severe and mild forms. (wikipedia.org)
Children with mild to moderate haemophilia may not have any signs or symptoms at birth, especially if they do not undergo circumcision. (wikipedia.org)
Children with mild haemophilia may not have noticeable symptoms for many years. (wikipedia.org)
Individuals with more severe haemophilia tend to experience more intense and frequent bleeding, whereas those with mild haemophilia typically exhibit milder symptoms unless subjected to surgical procedures or significant trauma. (wikipedia.org)
Those with moderate haemophilia may display variable symptoms, falling within the spectrum between severe and mild forms. (wikipedia.org)
In individuals, especially those with moderate or mild haemophilia, any form of trauma can trigger the first significant bleed. (wikipedia.org)
It was seen that almost 14% of all haemophilia patients and 30% of cases with a mild type of haemophilia have been diagnosed early following an episode of severe oral bleeding, of which the most common sites were the labial frenum and the tongue. (wikipedia.org)
However, mild haemophilia A is known to occur in heterozygous females due to X-inactivation, so it is recommended that levels of factor VIII and IX be measured in all known or potential carriers prior to surgery and in the event of clinically significant bleeding. (wikipedia.org)
Hemophilia A can be mild, moderate, or severe, depending on how little you have of factor VIII. (webmd.com)
The symptoms of hemophilia A depend on whether you have a mild, moderate, or severe case. (webmd.com)
Patients with acquired hemophilia may have no bleeding, mild bleeds, or life-threatening bleeds. (medscape.com)
People with mild hemophilia bleed after surgery, injury, or trauma. (bartleby.com)
A traumatic challenge relatively late in life may have to occur before mild or moderate hemophilia is diagnosed. (medscape.com)

Internal bleeding is common in people with severe haemophilia and some individuals with moderate haemophilia. (wikipedia.org)
Haemophilia substantially elevates the risk of protracted bleeding from ordinary injuries, and in severe cases, bleeding can occur spontaneously without an apparent cause. (wikipedia.org)
In the case of severe haemophilia, patients may complain of multiple oral bleeding episodes throughout their life. (wikipedia.org)
How severe the hemophilia is depends on the amount of factor in the blood. (medlineplus.gov)
In some cases, severe hemophilia may cause bleeding in the brain. (medlineplus.gov)
Severe hemophilia A. In addition to bleeding after an injury, you may have frequent episodes of bleeding, often into the joints and muscles, without being able to figure out a specific cause. (webmd.com)
When you have severe hemophilia A, bleeding can also happen in your brain . (webmd.com)
Severe hemophilia produces spontaneous internal bleeding in joints and muscles. (bartleby.com)
Dedicated physiotherapists (for both adults and children) undertake clinic appointments to regularly assess joint and muscle function for patients with severe haemophilia. (nuh.nhs.uk)
The U.S. Food and Drug Administration on Thursday approved a costly single-dose gene therapy for patients with severe hemophilia A, a life-threatening hereditary bleeding disorder. (medicalxpress.com)
Newborn boys with severe hemophilia may present with prolonged bleeding at circumcision. (medscape.com)
In contrast to persons with severe inherited hemophilia A, in whom joint bleeding is common, patients with acquired hemophilia present with large intramuscular, retroperitoneal, limb, subcutaneous, genitourinary, gastrointestinal, or excessive postoperative or postpartum bleeding. (medscape.com)

People who have a family history of hemophilia are also at higher risk. (medlineplus.gov)
If you have a family history of hemophilia and are pregnant, tests can tell if your baby has the disease. (webmd.com)

There are several different types of hemophilia. (medlineplus.gov)
Different types of hemophilia are classified by different deficient clotting factors in the blood. (bartleby.com)

Who is at risk for hemophilia? (medlineplus.gov)

The Haemophilia Comprehensive Care Centre in Nottingham offers a comprehensive range of clinical and laboratory services for people with haemophilia and other bleeding disorders and their families. (nuh.nhs.uk)
2 Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and NHLS, Johannesburg, South Africa. (nih.gov)

Haemophilia is a genetic disorder that is passed through generations on the x chromosomes, that affects the clotting factor in the blood and makes patients more prone to spontaneous and injury-resulted bleeding which is usually internal. (bartleby.com)
Because females have two X chromosomes and haemophilia is rare, the chance of a female having two defective copies of the gene is very remote, so females are almost exclusively asymptomatic carriers of the disorder. (rarediseaseday.org)

Haemophilia A affects about 1 in 5,000-10,000, while haemophilia B affects about 1 in 40,000 males at birth. (wikipedia.org)
Haemophilia A (clotting factor VIII deficiency) is the most common form of the disorder, present in about 1 in 5,000-10,000 male births. (rarediseaseday.org)

Haemophilia A's phenotype has a quite wide range of symptoms encompassing both internal and external bleeding episodes. (wikipedia.org)
The symptoms depend on the severity of haemophilia. (wikipedia.org)
Sometimes they may have some symptoms of hemophilia. (medlineplus.gov)
What are the symptoms of hemophilia? (medlineplus.gov)
[ 1 ] Moreover, the clinical signs and symptoms of acquired hemophilia differ from those of hereditary hemophilia. (medscape.com)
Postpartum acquired hemophilia usually comes to attention 2 to 5 months after delivery, when bleeding symptoms supervene. (medscape.com)

Acquired haemophilia is associated with cancers, autoimmune disorders, and pregnancy. (wikipedia.org)
As haemophilia A and B are both X-linked recessive disorders, females are rarely severely affected. (wikipedia.org)
[ 1 ] Acquired hemophilia can arise in the context of a variety of disorders, including autoimmune diseases and malignancies, or be due to medications, but approximately half of cases are idiopathic. (medscape.com)
What Hemophilia is : a group of hereditary genetic disorders that impair the body's ability to control blood clotting, which is used to stop bleeding when a blood vessel is broken. (rarediseaseday.org)
Like most recessive sex-linked, X chromosome disorders, haemophilia is more likely to occur in males than females. (rarediseaseday.org)
also spelled hemophilia in North America, from the Greek haima αἷμα 'blood' and philia φιλος 'love') is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation, which is used to stop bleeding when a blood vessel is broken. (medicalxpress.com)
The European Haemophilia Consortium (EHC) is a non-profit, non-government organisation that works to improve the quality of life for people with congenital bleeding disorders such as haemophilia, von Willebrand Disease (VWD) and other rare bleeding disorders in Europe. (ehc.eu)
He is now very happy total up the role of the advisor to the newly formed ERIN committee which will use the existing platform to hopefully build an inclusive community for all rare bleeding disorders while continuing the unfinished work for the inhibitor community, especially Haemophilia B inhibitors. (ehc.eu)
For patients in whom hemophilia is suspected, inquire about any history of hemorrhage disproportionate to trauma, spontaneous hemorrhage, bleeding disorders in the family, concomitant illness (especially those associated with acquired hemophilia, such as chronic inflammatory disorders, autoimmune diseases, hematologic malignancies, and allergic drug reactions), and pregnancy. (medscape.com)

A therapeutic challenge in the management of hemophilia A arises from the development of factor VIII inhibitors against factor VIII, often occurring as a consequence of frequent infusions. (wikipedia.org)
Acquired hemophilia is a rare but potentially life-threatening bleeding disorder caused by the development of autoantibodies (inhibitors) directed against plasma coagulation factors, most frequently factor VIII (FVIII). (medscape.com)
[ 1 ] Because inhibitors to FVIII are the most frequently observed in clinical practice, this article focuses on the etiology and management of FVIII autoantibody inhibitors, or acquired hemophilia A. (medscape.com)
The treatment of hemophilia may involve management of hemostasis, management of bleeding episodes, use of factor replacement products and medications, treatment of patients with factor inhibitors, and treatment and rehabilitation of patients with hemophilic synovitis. (medscape.com)
Patients with hemophilia A or B with inhibitors have a lower annualized bleeding rate with concizumab than with no prophylaxis, according to a phase 3 study published online Aug. 31 in the New England Journal of Medicine. (medicalxpress.com)
Persons with haemophilia A (PwHA) with inhibitors to factor VIII often experience decreased health-related outcomes. (nih.gov)

Haemophilia A is inherited as an X-linked recessive trait. (wikipedia.org)
Hemophilia is an X-linked recessive disease in which blood lacks blood-clotting proteins. (bartleby.com)

In both haemophilia A and B, there is spontaneous bleeding but a normal bleeding time, normal prothrombin time, normal thrombin time, but prolonged partial thromboplastin time. (wikipedia.org)
Hemophilia A is an X-linked disorder caused by a deficient or defective clotting factor VIII (FVIII) protein, and characterized by spontaneous or traumatic bleeding into joints and muscles [Ragni]. (bartleby.com)

Haemophilia A (or hemophilia A) is a blood clotting disorder caused by a genetic deficiency in clotting factor VIII, thereby resulting in significant susceptibility to bleeding, both internally and externally. (wikipedia.org)
About 5-10% of people with haemophilia A are affected because they make a dysfunctional version of the factor VIII protein, while the remainder are affected because they produce factor VIII in insufficient amounts (quantitative deficiency). (wikipedia.org)
2] Haemophilia B (factor IX deficiency) occurs in around 1 in about 20,000-34,000 male births. (rarediseaseday.org)
Although it is not impossible for a female to have haemophilia, it is unusual: a female with haemophilia A or B would have to be the daughter of both a male haemophiliac and a female carrier, while the non-sex-linked haemophilia C due to coagulant factor XI deficiency, which can affect either sex, is more common in Jews of Ashkenazi (east European) descent[3] but rare in other population groups. (rarediseaseday.org)

These blood tests would show the type of hemophilia and the severity. (medlineplus.gov)
The severity of acquired hemophilia at clinical presentation can also make its management challenging. (medscape.com)

Most cases occur in elderly persons, but acquired hemophilia is also seen in pregnancy and post partum, and in children. (medscape.com)
Acquired hemophilia due to an autoantibody in previously hemostatically normal individuals tends to affect elderly people who have comorbid conditions, but may also develop post partum. (medscape.com)

It is possible for a new mutation to occur during early development or haemophilia may develop later in life due to antibodies forming against a clotting factor. (wikipedia.org)

Haemophilia patients are considered to be a special group of patients as routinely done procedures may be fatal in them. (wikipedia.org)
Haemophilia patients have lower clotting factor level of blood plasma or impaired activity of the coagulation factors needed for a normal clotting process. (rarediseaseday.org)
Treatment of patients with hemophilia ideally should be provided through a comprehensive hemophilia care center. (medscape.com)
Weight-bearing joints and other joints are principal sites of bleeding in patients with hemophilia. (medscape.com)
Bleeding in the CNS is the leading cause of hemorrhagic death among patients with hemophilia. (medscape.com)

Diagnosis of acquired hemophilia can be difficult, both because the condition is rare and because the patient does not have the usual personal or family history of bleeding episodes, such as is seen in congenital hemophilia. (medscape.com)

Eradication of the inhibitor with immunosuppression should be initiated as soon as the diagnosis of acquired hemophilia is established. (medscape.com)

Haemophilia, or hemophilia (from Ancient Greek αἷμα (haîma) 'blood', and φιλία (philía) 'love of'), is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. (wikipedia.org)
Hemophilia is a genetic disease where there is a defect in the series of protein that forms blood clots. (bartleby.com)
According to the National Hemophilia Foundation (n.d.), von Willebrand disease (VWD) is a genetic disorder caused by missing or defective von Willebrand factor (VWF), a clotting protein. (bartleby.com)
The genetic disorder of Hemophilia is where the clotting factors of the blood are absent or deficient, causing it to be a dangerous disorder to the people who have it. (bartleby.com)
A genetic disorder that affects the blood vessels when injured that results in clotting is Hemophilia. (bartleby.com)
People with one form of the genetic blood disorder hemophilia now have a one-time treatment with a $3.5 million price tag. (medicalxpress.com)

One common early indicator of haemophilia is prolonged bleeding from venepuncture or heelpricks. (wikipedia.org)
While superficial bleeding poses challenges, more critical sites of bleeding include: Joints Muscles Digestive tract Brain A therapeutic challenge in the management of hemophilia A arises from the development by the human body, inhibitor antibodies against factor VIII, often occurring as a consequence of frequent infusions. (wikipedia.org)
Hemophilia is a rare bleeding disorder in which the blood does not clot properly. (medlineplus.gov)
With hemophilia A, your body doesn't have enough of a protein called factor VIII, which it needs to make clots and stop bleeding. (webmd.com)
The National Haemophilia Foundation (2013) website shows that cases of haemophilia go back to the 2n d century, where Jewish boys who have records of uncontrollable bleeding leading to death in their family do not have to undergo circumcision, also cases in 10th century Arabia show deaths of males after uncontrollable bleeding due to trauma. (bartleby.com)
A single gene therapy injection could dramatically reduce the bleeding risk faced by people with hemophilia B, finds a study involving UCL researchers. (medicalxpress.com)
Persons with acquired hemophilia may experience extensive, often life threatening, bleeding before the condition is recognized. (medscape.com)

Jim is aged 66 and has Haemophilia A with a high titer inhibitor which he developed at age 14. (ehc.eu)

In individuals facing this complication, activated factor VII, a precursor to factor VIII in the coagulation cascade, can be administered as a treatment to address hemorrhage in individuals with hemophilia who have developed antibodies against replacement factor VIII. (wikipedia.org)
In these individuals, activated factor VII, a precursor to factor VIII in the coagulation cascade, can be infused as a treatment for haemorrhage in individuals with haemophilia and antibodies against replacement factor VIII. (wikipedia.org)

Missing blood clotting factors are replaced to treat haemophilia. (wikipedia.org)
People with hemophilia have low levels of one of these factors, usually either factor VIII (8) or factor IX (9). (medlineplus.gov)
Haemophilia lowers blood plasma clotting factor levels of the coagulation factors needed for a normal clotting process. (medicalxpress.com)

According to the Haemophilia Foundation Australia (2015), there are over 3,000 cases of haemophilia in Australia, and more than half the cases are in males. (bartleby.com)

There are two main types of haemophilia: haemophilia A, which occurs due to low amounts of clotting factor VIII, and haemophilia B, which occurs due to low levels of clotting factor IX. (wikipedia.org)
The medical management of individuals with hemophilia A frequently entails the administration of factor VIII medication through slow intravenous injection. (wikipedia.org)
Factor VIII is for hemophilia A. Factor IX is for hemophilia B, another type of hemophilia. (webmd.com)

People who are born female who have the gene change on one X chromosome are a "carrier" of hemophilia. (medlineplus.gov)
Hemophilia is much more common in people who were born male since they can get it with a change to the gene on one X chromosome. (medlineplus.gov)
Hemophilia A usually runs in families, but about one-third of people with the disease don't have a family history of it. (webmd.com)

Although it is not impossible for a female to have haemophilia, it is unusual: a female with Haemophilia A or B would have to be the daughter of both a male haemophiliac and a female carrier, while the non-sex-linked Haemophilia C, which can affect either sex, is extremely rare. (medicalxpress.com)

Health-related outcomes assessed at baseline and monthly thereafter: Haemophilia Quality of Life Questionnaire for Adults (Haem-A-QoL), Haemophilia-specific Quality of Life Questionnaire for Children Short Form (Haemo-QoL SF), EuroQol 5-Dimensions 5-Levels (EQ-5D-5L) index utility score (IUS) and visual analogue scale (EQ-VAS) and work/school days. (nih.gov)

In 2016 Jim joined the board of the Irish Haemophilia Society, trying to give something back for all the support they have offered for so many years. (ehc.eu)

A rare type of hemophilia A is acquired hemophilia. (webmd.com)

These signs often prompt blood tests that confirm the presence of haemophilia. (wikipedia.org)
Hemophilia A is a condition that keeps your blood from clotting the way it should. (webmd.com)

Haemophilia C occurs equally in both sexes and is mostly found in Ashkenazi Jews. (wikipedia.org)

Most commonly found in men, Hemophilia can affect women too, though very rarely. (wikipedia.org)

What are the types of hemophilia? (medlineplus.gov)
Most types of hemophilia are inherited. (medlineplus.gov)

In the 1800s haemophilia B was common within the royal families of Europe. (wikipedia.org)

The hemophilia A gene mutation happens on the X chromosome. (webmd.com)
Many fanatics of life science have established that hemophilia is the consequence of a mutation or change in one of the genes. (bartleby.com)

Do a physical exam to look for signs of hemophilia, such as bruising. (medlineplus.gov)

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