Reference: Inhibition of herpes simplex virus-induced DNA polymerases and cellular DNA polymerase alpha by triphosphates of acyclic guanosine analogs. (neb.com)
The triphosphates of the antiherpes acyclic guanosine analogs (R)- and (S)-enantiomers of 9-(3,4-dihydroxybutyl)guanine [BCVTP and (S)-DHBGTP], 9-(4-hydroxybutyl)guanine (HBGTP), and 9-(2-hydroxyethoxymethyl)guanine (ACVTP) were investigated for their effects on partially purified DNA polymerases of herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) as well as cellular DNA polymerase alpha of calf thymus and Vero cells. (neb.com)
The triphosphates of the four analogs were all competitive inhibitors when dGTP was the variable substrate with both the viral and the cellular DNA polymerases with activated calf thymus DNA or poly(dC)oligo(dG)12-18 as template. (neb.com)
A decrease in the ability of calf thymus DNA to serve as primer template for HSV-2 DNA polymerase was observed after preincubation with the triphosphates of the acyclic guanosine analogs. (neb.com)
3'-Desthiobiotin-GTP or 3'-Biotin GTP are guanosine triphosphate (GTP) analogs which are modified at their 3' position with desthiobiotin or biotin, respectively. (neb.com)
through exchanges of phosphate groups from ATP molecules by the Nucleoside-diphosphate kinase, an enzyme tasked with maintaining an equilibrium between the concentrations of different nucleoside triphosphates. (wikipedia.org)
Ras-GTPases are considered inactive when bound to guanosine diphosphate (GDP) and active when bond to guanosine triphosphate (GTP). (bionity.com)
Nucleotide3
Molybdenum cofactor biosynthesis occurs in four steps: (i) the radical-mediated cyclization of nucleotide, guanosine triphosphate (GTP), to (8S)‑3',8‐cyclo‑7,8‑dihydroguanosine 5'‑triphosphate (3',8‑cH2GTP), (ii) the formation of cyclic pyranopterin monophosphate (cPMP) from the 3',8‑cH2GTP, (iii) the conversion of cPMP into molybdopterin (MPT), (iv) the insertion of molybdate into MPT to form Moco. (wikipedia.org)
Receptor-stimulated guanine-nucleotide-triphosphate binding to guanine-nucleotide-binding regulatory proteins. (eurekamag.com)
The data thus provide evidence for an essential difference between GTP[S] and p[NH]ppG binding to guanine-nucleotide-binding regulatory proteins and suggest that, in addition to the nucleotide-exchange reaction, a (thio)phosphate-group-transfer process via guanine-nucleotide-binding regulatory protein beta subunits is involved in the receptor-stimulated binding of guanine nucleotide triphosphates to guanine-nucleotide-binding regulatory proteins. (eurekamag.com)
GTPases1
Activation of GEFs is required to set off the regulatory signaling of GTPases (GTP stands for guanosine triphosphate). (cincinnatichildrens.org)
Proteins1
A similar inhibition was observed with adenosine 5'-[gamma-thio]triphosphate, probably by its conversion into GTP[S]. These results suggest that the stimulatory actions of guanine nucleotides can be accounted for by the combined activation of PKC and generation of cAMP, resulting from activation of conventional signal-transducing GTP-binding proteins. (ox.ac.uk)
Adenosine1
The Krebs cycle is part of the aerobic degradative process in eukaryotes known as cellular respiration, which is a process that generates adenosine triphosphate (ATP) by oxidizing energy-rich fuel molecules. (encyclopedia.com)
Cyclohydrolase2
For a complete list of articles on Guanosine Triphosphate Cyclohydrolase I Deficiency (GTPCH) please refer to the Online Mendelian Inheritance in Man (OMIM) which is linked below. (pndassoc.org)
Polymorphisms of Nav1.6 sodium channel, Brain-derived Neurotrophic Factor, Catechol-O-methyltransferase and Guanosine Triphosphate Cyclohydrolase 1 genes in trigeminal neuralgia. (cdc.gov)
Membranes2
Antagonist activity of AM211 at the DP2 receptor was confirmed by inhibition of PGD 2 -stimulated guanosine 5′- O -[γ-thio]triphosphate binding to membranes expressing human DP2. (aspetjournals.org)
beta, gamma-imino]triphosphate, p[NH]ppG, and the regulation of binding by the formyl-peptide-receptor agonist, fMet-Leu-Phe, were studied in membranes of differentiated HL-60 cells. (eurekamag.com)
Guanine2
GTP has the guanine nucleobase attached to the 1' carbon of the ribose and it has the triphosphate moiety attached to ribose's 5' carbon. (wikipedia.org)
The predicted amino acid sequence contains a high concentration of charged amino acids in the carboxy terminal quarter of the molecule, three guanosine 5′-triphosphate (GTP)-binding protein motifs, and a consensus nuclear localization signal. (elsevierpure.com)
Inhibition of luteinizing-hormone exocytosis by guanosine 5'-[gamma-thio]triphosphate reveals involvement of a GTP-binding protein distal to second-messenger generation. (ox.ac.uk)
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. (thermofisher.com)
Derivatives1
The Kds of guanosine triphosphate (GTP), GMP, and cap derivatives interactions with eIF4E were determined. (biosyn.com)
No inhibition was observed with deoxythymidine 5'-triphosphate as substrate and poly(dA)oligo(dT)12-18 as template. (neb.com)
An absence of δ receptors reduced neither the density of VDCCs nor their inhibition by either the GABA B receptor agonist baclofen or intracellular guanosine 5′- O -(3-thio)triphosphate. (aspetjournals.org)
Reactions1
Two enzyme-mediated reactions convert guanosine triphosphate to the cyclic phosphate of pyranopterin. (wikipedia.org)
Activation1
DI-fusion Activation of guanosine 5'-[gamma-(35)S]thio-triphosphate. (ac.be)
The majority of these compounds share a common mechanism of action - they competitively inhibit adenosine triphosphate (ATP) at the catalytic binding site of the targeted protein [ 13 ]. (biomedcentral.com)
The two enzymes differ in their Km values for adenosine triphosphate (ATP):2mM ATP for synthetase I and 0.05 mM ATP for synthetase II. (rhea-db.org)
Cyclic4
Molybdenum cofactor biosynthesis occurs in four steps: (i) the radical-mediated cyclization of nucleotide, guanosine triphosphate (GTP), to (8S)‑3',8‐cyclo‑7,8‑dihydroguanosine 5'‑triphosphate (3',8‑cH2GTP), (ii) the formation of cyclic pyranopterin monophosphate (cPMP) from the 3',8‑cH2GTP, (iii) the conversion of cPMP into molybdopterin (MPT), (iv) the insertion of molybdate into MPT to form Moco. (wikipedia.org)
Two enzyme-mediated reactions convert guanosine triphosphate to the cyclic phosphate of pyranopterin. (wikipedia.org)
A vast number of studies have focused on understanding the nitric oxide (NO) signaling pathway, which culminates with the phosphorylation of the transcription factor cAMP-responsive element-binding protein (CREB) through the increase of the second messenger cyclic guanosine monophosphate (cGMP) and activation of cGMP-dependent protein kinase. (intechopen.com)
Monophosphate1
This enzyme facilitates the conversion of inosine monophosphate to xanthine monophosphate, an intermediate metabolite in the production of guanosine triphosphate. (skintherapyletter.com)
Hydrolysis2
In gluconeogenesis, PEP is formed from the decarboxylation of oxaloacetate and hydrolysis of 1 guanosine triphosphate molecule. (hmdb.ca)
Here, we find that the binding of guanosine triphosphate (GTP) to one subunit inhibits the binding and induces the hydrolysis of GTP by the other. (broadinstitute.org)
Metabolite1
Ribavirin triphosphate is the major intracellular metabolite. (hindawi.com)
Purine2
Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. (wikipedia.org)
PNP is an enzyme in the purine salvage pathway that metabolizes inosine and guanosine to hypoxanthine. (medscape.com)
Triphosphatases1
Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. (embl.de)
Humans1
In contrast to folic acid and riboflavin, however, mammals (including humans) synthesise H4biopterin from guanosine triphosphate (GTP). (i-med.ac.at)
Subunits2
Guanosine 5'-triphosphate (GTP) binding protein alpha subunits (Galpha(i)) are known to participate in the regulation of force in airway smooth muscle. (asahq.org)
They also enhanced binding of guanosine-5'-O-(3-thio)triphosphate and GTP azidoanilide to, and cholera toxin-catalyzed ADP-ribosylation of, Gi protein alpha subunits. (uni-regensburg.de)
These examples are programmatically compiled from various online sources to illustrate current usage of the word 'guanosine triphosphate. (merriam-webster.com)