• synthetic
  • Schally, Block and the Athens scientists showed that a synthetic agonist of GHRH , JI-38, stimulated the growth and migration of fibroblasts in mouse models, which are necessary for wound healing and skin repair. (healthcanal.com)
  • tumor
  • 0.05-0.001) inhibited tumor growth as demonstrated by a 58% decrease in final tumor volume, 54% reduction in tumor weight, and the extension of tumor-doubling time from 8.5 ± 1.38 to 12 ± 1.07 days as compared with controls. (aacrjournals.org)
  • The growth of tumor cells in vitro was stimulated by IGF-I and inhibited by GH-RH antagonist JV-1-38 and a GH-RH antiserum. (aacrjournals.org)
  • glucose
  • Administration of human growth hormone has been shown to reduce visceral adipose tissue (fat deep within the abdomen), but it can lead to side effects including elevated blood glucose, swelling, bone pain, and carpal tunnel syndrome. (hivandhepatitis.com)
  • A recent study in normal mice showed significant differences in body composition, muscle growth, glucose metabolism, memory and cardiac function in the mice being administered the GHRP-6 (2). (wikipedia.org)
  • Examorelin does not affect plasma levels of glucose, luteinizing hormone (LH), follicle-stimulating hormone (FSH), or thyroid-stimulating hormone (TSH) in humans. (wikipedia.org)
  • agonist
  • In addition to sparking fibroblast growth for wound healing, this particular JI-38 agonist also activated other genes and the expression of smooth muscle actin-alpha, yet another sign of the activity of fibroblasts. (healthcanal.com)
  • The present data show that the natural beta-agonist epinephrine (EPI) stimulates GH release through an additional alpha-adrenergic mechanism. (kuleuven.be)
  • amino acid
  • Amino acid supplements, including L-ornithine, are frequently marketed to bodybuilders and weightlifters with claims for increasing levels of human growth hormone (HGH), muscle mass and strength. (wikipedia.org)
  • Doping
  • Presented by Dr. Kageyama on June 15, 2011, during the Developments and Challenges in the Detection of Doping with Peptide Hormones Symposium in Rome. (wada-ama.org)
  • cardiovascular risk
  • The investigators will study their body composition, cardiovascular risk measures, insulin sensitivity, and growth hormone dynamics, with the hypothesis that abdominal fat, independent of general obesity, will be strongly associated with arterial wall thickening and atherosclerotic inflammation. (clinicaltrials.gov)
  • Humans
  • Examorelin substantially and dose-dependently increases plasma levels of growth hormone (GH) in animals and humans. (wikipedia.org)
  • In addition, similarly to pralmorelin (GHRP-2) and GHRP-6, it slightly and dose-dependently stimulates the release of prolactin, adrenocorticotropic hormone (ACTH), and cortisol in humans. (wikipedia.org)
  • Examorelin releases more GH than does growth hormone-releasing hormone (GHRH) in humans, and produces synergistic effects on GH release in combination with GHRH, resulting in "massive" increases in plasma GH levels even with only low doses of examorelin. (wikipedia.org)
  • Testosterone, testosterone enanthate, and ethinylestradiol, though not oxandrolone, have been found to significantly potentiate the GH-releasing effects of examorelin in humans. (wikipedia.org)
  • A partial and reversible tolerance to the GH-releasing effects of examorelin occurs in humans with long-term administration (50-75% decrease in efficacy over the course of weeks to months). (wikipedia.org)
  • increases
  • Pretreatment with the 5-hydroxytryptamine3 (5-HT3) receptor antagonist, MDL-72222, the 5-HT1A/5-HT2 antagonist, spiperone, and the mixed beta adrenergic/5-HT1B antagonists, l-propranolol and CGP361A, did not attenuate clonidine-induced increases in growth hormone levels. (aspetjournals.org)
  • In contrast, pretreatment with the non-selective 5-HT1/2 antagonist, metergoline, and the 5-HT1C/5-HT2-selective antagonist, mesulergine, reduced clonidine-induced increases in growth hormone levels 81 to 87% without affecting clonidine-induced decreases in locomotor activity. (aspetjournals.org)
  • Two other 5-HT1C/5-HT2 antagonists, ritanserin and mianserin, also attenuated (47%) clonidine-induced increases in growth hormone levels. (aspetjournals.org)