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  • tissue
  • To understand and recognize the basic biological processes of growth, differentiation, maintenance and adaptation of human body tissues at the molecular, cellular and tissue level. (tue.nl)
  • The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells. (wikipedia.org)
  • Effects mediated by the AT2 receptor are suggested to include inhibition of cell growth, fetal tissue development, modulation of extracellular matrix, neuronal regeneration, apoptosis, cellular differentiation, and maybe vasodilation and left ventricular hypertrophy. (wikipedia.org)
  • Birth Weight
  • Diagnosis is suggested in children with the following: low birth weight, severe growth retardation, typical facial features, and characteristic radiological findings. (wikipedia.org)
  • regulation
  • It was harder to get food in the hot savannas and as mammalian brains are prone to overheating - 5 or 6 °C rise in temperature can lead to heatstroke - so there was a need for the development of better heat regulation. (wikipedia.org)
  • hormone
  • The major role of IGF-2 is as a growth promoting hormone during gestation. (wikipedia.org)
  • Growth hormone 2 (GH2), also known more commonly as placental growth hormone (PGH) or as growth hormone variant (GH-V), is a protein that in humans is encoded by the GH2 gene. (wikipedia.org)
  • Its cogener is growth hormone 1 (GH1), or pituitary growth hormone. (wikipedia.org)
  • As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. (wikipedia.org)
  • Mutations in this gene lead to placental growth hormone/lactogen deficiency. (wikipedia.org)
  • Dwarfism may also be caused by malnutrition or other hormonal deficiencies, such as insufficient growth hormone secretion, hypopituitarism, decreased secretion of growth hormone-releasing hormone, deficient growth hormone receptor activity and downstream causes, such as insulin-like growth factor 1 (IGF-1) deficiency. (wikipedia.org)
  • pregnant
  • Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children. (wikipedia.org)
  • Effects
  • Some of these effects include delayed mental development, Pervasive developmental disorder (PDD), morphological abnormalities in the cerebral surface. (wikipedia.org)
  • research
  • The study focuses on five primary areas of research: Growth and physical development Behavioral and cognitive development Asthma and atopy Diseases in childhood Health and healthcare The children form a prenatally recruited birth cohort that will be followed until young adulthood. (wikipedia.org)
  • cell
  • Subsequently, western blot analyses evidenced significantly increased mammalian target of rapamycin (mTOR) activity, a major regulator of translation and cell growth, in Hccs+/- hearts compared to controls. (ahajournals.org)
  • From a functional standpoint, PAX3c, PAX3d, and PAX3h stimulate activities such as cell growth whereas PAX3e and PAX3g inhibit these activities, and PAX3a and PAX3b show no activity or inhibit these endpoints. (wikipedia.org)
  • body
  • It is also good for healthy body growth, fetal development and vision. (hubpages.com)
  • In the heat of the savannas, better cooling mechanisms were required, which were achieved through the loss of body hair and development of more efficient perspiration. (wikipedia.org)
  • The loss of body hair led to the development of dark skin, which acted as a mechanism of natural selection against folate depletion, and to a lesser extent, DNA damage. (wikipedia.org)
  • neural
  • Pax-7 plays a role in neural crest development and gastrulation, and it is an important factor in the expression of neural crest markers such as Slug, Sox9, Sox10 and HNK-1. (wikipedia.org)
  • life
  • Poor length growth is apparent as early as the first year of life. (wikipedia.org)
  • Generation R is a prospective, population based cohort study from fetal life until young adulthood in a multi-ethnic urban population in Rotterdam, the Netherlands. (wikipedia.org)
  • early
  • Genetic evidence also supports this notion, demonstrating that around 1.2 million years ago there was a strong evolutionary pressure which acted on the development of dark skin in early members of the genus Homo. (wikipedia.org)