• These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell. (lookformedical.com)
  • We are studying the mechanism of viral membrane fusion and its inhibition by drugs and antibodies. (stanford.edu)
  • It contains many strains as well as antigenic subtypes of the integral membrane proteins hemagglutinin ( VIRAL HEMAGGLUTININS ) and NEURAMINIDASE . (nih.gov)
  • In mink infected with chicken/49 no signs of disease were observed, while the mink infected with mink/84 showed severe signs of respiratory disease, with inflammatory lesions spreading throughout the lung and viral antigen present in substantial numbers of cells in the lung, nasal mucosa, and trachea. (biomedcentral.com)
  • We describe the first report of RNA sequencing of 5' capped (Pol II) RNAs isolated from acutely hepatitis C virus (HCV) infected Huh 7.5 cells that provides a general approach to identifying differentially expressed annotated and unannotated genes that participate in viral-host interactions. (mdpi.com)
  • Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. (lookformedical.com)
  • In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. (lookformedical.com)
  • Here we demonstrated that MDV vaccination induced interferon (IFN)-γ+CD8α+ γδ T cells and transforming growth factor (TGF)-ß+ γδ T cells in lungs. (bvsalud.org)
  • His work covers various topics, including B cell responses to viral infection and vaccination, human primary immunodeficiency, and biology of lymphocyte development and function and to elucidate etiology of immunological disorders. (stanford.edu)
  • The first published study to assert that untreated lymphoid cells were able to confer a natural immunity to tumors was performed by Dr. Henry Smith at the University of Leeds School of Medicine in 1966, leading to the conclusion that the "phenomenon appear[ed] to be an expression of defense mechanisms to tumor growth present in normal mice. (wikipedia.org)
  • The variola and vaccinia viruses can be differentiated by their growth characteristics and host range. (microbiologynote.com)
  • Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. (nature.com)
  • All 4 sub- most rapidly evolving gene product (3) and plays a major stitutions are located within or adjacent to known role in viral attachment and evasion from the adaptive antibody-binding sites. (cdc.gov)
  • In this regard, gamma delta (γδ) T cells may play a significant role in prevention of viral spread and tumor surveillance. (bvsalud.org)
  • Despite this novel strategy for generating the 'backbone' of live-attenuated viruses, both seasonal and pandemic vaccines would still require incorporation of viral antigens (usually hemagglutinin and NA) specific to the circulating virus. (medscape.com)
  • It contains many strains as well as antigenic subtypes of the integral membrane proteins hemagglutinin ( VIRAL HEMAGGLUTININS ) and NEURAMINIDASE . (nih.gov)
  • Most RIDTs detected viral antigens in samples with the highest influenza virus concentrations, but detection varied by virus type and subtype at lower concentrations. (cdc.gov)
  • Increased viral polymerase activity mediates adaptation of AIVs to a mammalian host 26 . (nature.com)
  • We describe interactions between the S protein and cellular receptors, co-receptors, and antagonists, as well as a hypothetical mechanism of the homotrimeric spike structure destabilization that triggers the fusion of the viral envelope with the cell membrane at physiological pH and mediates the viral nucleocapsid entry into the cytoplasm. (bvsalud.org)
  • Epidemiological studies in humans and experimental studies in animal have shown that viral infections can induce or protect from autoimmunopathologies depending on several factors including genetic background, host-elicited immune responses, type of virus strain, viral load, and the onset time of infection. (mdpi.com)
  • Hence, gene reassortment of influenza A wild type (wt) viruses is performed with a highly egg adapted donor virus, A/Puerto Rico/8/1934 (PR8), to provide the high yield reassortant (HYR) viral 'seeds' for vaccine production. (nih.gov)
  • The main objective of this study is the identification of the molecular signature in all eight gene segments of influenza A HYR candidate vaccine seeds associated with high growth in ovo. (nih.gov)
  • Tumorigenesis is initiated when cells are freed from growth restraints, later promotion results when the immune system is evaded favoring further mutations and increased loss of cell control. (biomedcentral.com)
  • Adamantanes (amantadine and rimantadine) act by blocking activity of the viral M2 proton channel, thus preventing virus uncoating and inhibiting release of the viral genome into host cells. (medscape.com)
  • This approach has now been successfully applied to peptide hormones, small bio‐active peptides, interferon, viral hemagglutinins, and a number of small neurotransmitter ligands. (philpapers.org)
  • The first published study to assert that untreated lymphoid cells were able to confer a natural immunity to tumors was performed by Dr. Henry Smith at the University of Leeds School of Medicine in 1966, leading to the conclusion that the "phenomenon appear[ed] to be an expression of defense mechanisms to tumor growth present in normal mice. (wikipedia.org)
  • In mink infected with chicken/49 no signs of disease were observed, while the mink infected with mink/84 showed severe signs of respiratory disease, with inflammatory lesions spreading throughout the lung and viral antigen present in substantial numbers of cells in the lung, nasal mucosa, and trachea. (biomedcentral.com)
  • Deletion of the viral thymidine kinase in a meq-deleted recombinant Marek's disease virus reduces lymphoid atrophy but is less protective. (usda.gov)