• tumor cells
  • A small amount of extramedullary hematopoiesis was observed in the sinusoidal spaces between tumor cells. (e-cmh.org)
  • Tumor cells were diffusely immunoreactive for human melanoma black 45 (HMB45) and Melan A, focally immunoreactive for smooth muscle actin, but not for hepatocyte specific antigen (HSA). (e-cmh.org)
  • Because the expression of classic and nonclassic HLA antigens is crucial for the recognition and elimination of tumor cells by cytotoxic T and/or NK cells, we analyzed the HLA-A, -B, -C, and -G expression in uveal melanoma specimens from 18 patients. (arvojournals.org)
  • Immunotherapy is a promising approach, because it is based on the "natural" way to detect and destroy disseminated tumor cells by the host immune system. (arvojournals.org)
  • A balanced, reciprocal translocation t(1;3)(p36.3;q25) in EHE tumor cells was first described by Mendlick et al in 2001 (PMID 11342784). (wikipedia.org)
  • In order for a LCLC to be subclassified as the rhabdoid phenotype variant, at least 10% of the malignant tumor cells must contain distinctive structures composed of tangled intermediate filaments that displace the cell nucleus outward toward the cell membrane. (wikipedia.org)
  • Expression of immunomarkers in the rhabdoid cells, however, have often been noted to be weaker and more diffuse than those in the more differentiated tumor cells. (wikipedia.org)
  • neoplasms
  • In 1991, Chan and Rosai unified the concept of SETTLE when they described 8 neoplasms situated in the neck and thyroid of children and young adults, previously diagnosed as malignant teratoma of the thyroid, thyroid spindle cell tumor with mucous cysts or thyroid thymoma. (omicsonline.org)
  • Romeo et al have observed chondroblastoma neoplasms to be composed of mesenchymal cells that have completed normal chondrogenesis along with the production of osteoid and collagen I that could be the result of transdifferentiation of chondrocytes towards osteoblasts. (wikipedia.org)
  • phenotype
  • It is well known that sparse and confluent cells present a different functional phenotype. (ahajournals.org)
  • Large cell lung carcinoma with rhabdoid phenotype (LCLC-RP) is a rare histological form of lung cancer, currently classified as a variant of large cell lung carcinoma (LCLC). (wikipedia.org)
  • PEComas
  • Despite much controversy regarding the significance of PECs [ 4 ], including the fact that no normal counterpart of the PEC is known, further descriptions of tumors in multiple anatomic locations composed primarily of these cells has led to them being designated "PEComas" [ 5 ]. (hindawi.com)
  • Neoplasm
  • The results of Romeo and colleagues favor the view of Edel et al of chondroblastoma being cartilaginous in nature but recognize that any definitive determinations regarding the origin of this neoplasm are not possible because of the plasticity of mesenchymal cells when set into different microenvironments and static approaches used in literature. (wikipedia.org)
  • The whorled eosinophilic inclusions in LCLC-RP cells give it a microscopic resemblance to malignant cells found in rhabdomyosarcoma (RMS), a rare neoplasm arising from transformed skeletal muscle. (wikipedia.org)
  • endothelial cells
  • The presence of the Y-chromosome confirmed the fetal origin of these cells and the lacking uptake of fluorescence conjugated low density lipoprotein, specific for endothelial cells, identified polygonally shaped cells as fetal trophoblast cells. (biomedsearch.com)
  • Although in vascular endothelial cells adhesive junctions account for the integrity of the vessel wall, they are not to be considered as static molecular structures that function as intercellular glue. (ahajournals.org)
  • Endothelial cells are maintained in contact to one another by a complex network of transmembrane adhesion proteins anchored to the actin cytoskeleton. (ahajournals.org)
  • In the past years, a large effort was made by several groups to decipher the molecular organization of intercellular junctions in endothelial cells. (ahajournals.org)
  • It is this production of the TAZ-TEAD transcriptome that causes the affected endothelial cells to grow into tumors. (wikipedia.org)
  • predominant
  • Its leukocyte population is distinct, with the presence of large endometrial granular leukocytes being predominant, while polynuclear leukocytes and B cells are scant. (wikipedia.org)
  • granular
  • about two weeks are needed for a cell to migrate from the basal cell layer to the top of the granular cell layer, and an additional two weeks to cross the stratum corneum. (wikipedia.org)
  • granulomas
  • The latter definition would include mere collections of giant cells surrounding inert substances like suture material - the so-called "non-immune granulomas. (wikipedia.org)
  • Granulomas try to wall off these organisms and prevent their further growth and spread. (wikipedia.org)
  • implantation
  • The interaction between mesothelin and MUC16 (also known as CA125) may facilitate the implantation and peritoneal spread of tumors by cell adhesion. (wikipedia.org)
  • In a normal pregnancy, trophoblastic cells aid the implantation of the fertilised egg into the uterine wall. (wikipedia.org)
  • vimentin
  • Epitheloid shaped cells present in both cultures (cotyledon and caruncle) were characterized on a morphological basis as well as by immunofluorescence and Western blot thereby detecting cytokeratin, zonula occludens-1 and vimentin but not alpha-smooth muscle actin and desmin. (biomedsearch.com)
  • inactivation
  • The most common genetic mutation (found in 80-90% of epithelioid sarcomas) is the inactivation of the SMARCB1 gene, or the loss of INI-1 function, which is thought to be a major contributor to disease progression. (wikipedia.org)
  • On a cellular basis, LAM cells carry bi-allelic inactivation of the TSC2 genes, consistent with the "two-hit" tumor suppressor gene model. (wikipedia.org)
  • A variable percentage of cells within the LAM lesion contain mutational inactivation of the Tuberous Sclerosis Complex (TSC1 or TSC2) tumor suppressor genes. (wikipedia.org)
  • prognosis
  • Cell type is the most commonly used predictor of outcome following enucleation, with spindle-A cell melanomas carrying the best prognosis and epithelioid cell melanomas carrying the least favorable prognosis. (uwhealth.org)
  • A patient's prognosis also depends on the nature of his or her mesothelioma diagnosis, including location and cell type, as well as stage classification. (mesothelioma.com)
  • Biphasic cell growth and spread rates are harder to predict, which leads to a highly varied prognosis. (mesothelioma.com)
  • progression
  • In an orthotopic MPM mouse model characterized by our laboratory, MPM cells with MSLN overexpression preferentially localized to the tumor invading edge, colocalized with MMP-9 expression, and promoted decreased survival without an increase in tumor burden progression. (aacrjournals.org)
  • In an orthotopic MPM mouse model characterized by our laboratory, we show that MSLN overexpressing MPM cells preferentially localize to the tumor invading edge and decrease survival without an increase in tumor burden progression. (aacrjournals.org)
  • fetus
  • Prior to seeding the presence of fetal cells in caruncular samples and vice-versa could be demonstrated by the detection of the Y-chromosome via fluorescence in situ hybridization (FISH) provided the fetus was male. (biomedsearch.com)
  • Partial hydatidiform moles have a fetus or fetal cells. (wikipedia.org)
  • peripheral
  • Other histological features of gummas include an intervening zone containing epithelioid cells with indistinct borders and multinucleated giant cells, and a peripheral zone of fibroblasts and capillaries. (wikipedia.org)
  • Several other hormones can contribute to PRL signaling in the breast gland, high levels of insulin caused for example by peripheral insulin resistance (resulting from pregnancy, gestational diabetes or developing diabetes mellitus type 2) will enhance the galactogenic and antiapoptotic effects of PRL and growth hormone by acting synergistically with IGF-1. (wikipedia.org)
  • generally
  • however, due to their low frequency [ 9 - 12 ], which decreases further with aging [ 13 - 15 ], quantities of harvested cells are generally insufficient for direct clinical application. (biomedcentral.com)
  • Small tumors are generally benign, especially when cell division rate is slow, but large tumors disseminate to the liver, omentum and peritoneal cavity. (wikipedia.org)
  • fetal cells
  • In conclusion, the cross-contamination of maternal and fetal cells in manually separated placentomes should be considered in future experiments as it may lead to false positive results dependent on the sensitivity of the method applied. (biomedsearch.com)
  • lung
  • Recent studies have shown beyond doubt that the old classification paradigm of "small cell carcinoma vs. non-small cell carcinoma" is now obsolete, and that the correct "subclassification" of lung cancer cases is necessary to assure that patients receive optimum management. (wikipedia.org)
  • Eight major groups of lung carcinomas are recognized in WHO-2004: Squamous cell lung carcinoma Small cell lung carcinoma Adenocarcinoma of the lung Large cell lung carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma Carcinoid tumor Salivary gland-like carcinoma of the lung LCLC-RP are considered variants of large cell carcinoma. (wikipedia.org)
  • While occasional scattered rhabdoid cell formation occurs with considerable frequency in lung carcinomas, this is not considered to be of clinical significance. (wikipedia.org)
  • According to current classification criteria, a tumor can only be diagnosed as LCLC-RP when an undifferentiated large-cell lung carcinoma contains a rhabdoid cell component that makes up at least 10% of the tumor mass. (wikipedia.org)
  • This, together with the fact that recurrent LAM after lung transplantation carries the same TSC2 mutations as the original LAM, has led to the "benign metastasis" hypothesis that LAM cells can migrate or metastasize from one site to another. (wikipedia.org)
  • epithelium
  • This tumor is composed predominantly of spindle and epithelioid cells with glandular or ductular structures lined by a mucinous or respiratory epithelium. (omicsonline.org)
  • This stratified squamous epithelium is maintained by cell division within the stratum basale, in which differentiating cells slowly displace outwards through the stratum spinosum to the stratum corneum, where cells are continually shed from the surface. (wikipedia.org)
  • Clinical
  • In this study, we explored the role of MSLN in tumor invasion and its relationship to MMP-9 secretion using human and murine mesothelioma cells both in vitro and in vivo as well as in clinical specimens from epithelioid MPM patients, known to overexpress MSLN. (aacrjournals.org)
  • pathways
  • This differs from the quick and short-lasting activation induced by growth factors, suggesting that the type of signaling pathways triggered by cell-cell contacts are distinct. (ahajournals.org)
  • Both Indian Hedgehog/Parathyroid Hormone-related Protein (IHh/PtHrP) and fibroblast growth factor (FGF) signaling pathways, important for development of the epiphyseal growth plate, are active in chondroblastoma leading to greater proliferation among the cells in the proliferating/pre-hypertrophic zone (cellular-rich area) versus the hypertrophic/calcifying zone (matrix-rich area). (wikipedia.org)
  • These findings suggest that chondroblastoma is derived from a mesenchymal cell undergoing chondrogenesis via active growth-plate signaling pathways (see Endochondral ossification). (wikipedia.org)
  • site
  • Through this form M. leprae multiplies at the site of entry, usually the skin, invading and colonizing Schwann cells. (wikipedia.org)
  • With cell-mediated immunity impaired, large numbers of M. leprae appear in the macrophages and the infected patients develop papules at the entry site, marked by a folding of the skin. (wikipedia.org)
  • known
  • They have indistinct shape contour, often appear to merge into one another and can form aggregates known as giant cells. (wikipedia.org)
  • Both in vitro and in vivo and in MPM patient samples, we show an association between MSLN overexpression, tumor invasion, and matrix metalloproteinases, a family of enzymes that facilitate tumor cell invasion and known to be upregulated in MPM. (aacrjournals.org)
  • Matrix metalloproteinases (MMP), a family of endopeptidases capable of degrading extracellular matrix, have been shown to be elevated in MPM and are known to increase invasive potential in MPM cells ( 16 ). (aacrjournals.org)
  • Although it has been proposed that mesothelin may be involved in cell adhesion, its biological function is not known. (wikipedia.org)
  • membrane
  • Subsequent cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). (wikipedia.org)
  • mononuclear
  • The average volume of term amniotic fluid collected was approximately 0.4 litres per donor, containing an average of 7 million viable mononuclear cells per litre, and a CFU-F content of 15 per 100,000 MNCs. (biomedcentral.com)
  • Cellular
  • Histologic analysis revealed a highly cellular tumor, which was depicted as a clustering growth pattern that diffusely invaded the spinal cord ( Fig 5 ). (ajnr.org)