• These observations suggest that some prebiotic oligosaccharides may have antiadhesive activity and directly inhibit the adherence of pathogens to the host epithelial cell surface. (unl.edu)
  • Functional deficiency in the protein disulfide isomerase anterior gradient 2 (AGR2) has been linked with CD and leads to epithelial cell ER stress and ileocolitis in mice and humans. (bvsalud.org)
  • Mechanistically, our data reveal that AIEC-induced epithelial cell ER stress triggers CD103+ dendritic cell production of interleukin-23 (IL-23) and that IL-23R is required for ileocolitis in Agr2-/- mice. (bvsalud.org)
  • These live microorganisms have proven health benefits and well-established safety, and have been tested for epithelial cell adhesion and/or resistance to low pH. (naturalmedicineformulas.com)
  • The adhesion to eukaryotic cells is mediated by several proteins, including the Campylobacter adhesion to fibronectin protein (CadF), which binds specifically to fibronectin in the cell membrane. (wikipedia.org)
  • The two strains mediate adhesion by different mechanisms and, when combined, synergically induce the expression of Caco-2 tight junction proteins. (frontiersin.org)
  • For example, sortase-dependent pili from the PRL2010 strain have been shown to bind epithelial Caco-2 cells and the extracellular matrix (ECM) proteins fibronectin and laminin [15], while type IVb tight adherence (Tad) pili have been proven to be essential for UCC2003 colonization of the murine gut [16, 17]. (citiesofdata.org)
  • Probiotics and Antimicrobial Proteins, 15 (2), pp. 387-399. (calbinotox.fr)
  • Most of the identified peptides originated from bacterial cell surface proteins. (calbinotox.fr)
  • In order to explore the underlying mechanisms, we performed tests to assess cell migration and motility, apoptosis, expression of glucose transporter 1 and proapoptotic proteins. (oncotarget.com)
  • Since rate of autophagy in cells was not detected, it is impossible to determine, if there were changes in autophagy that were not reflected as changes in colocalization of these two proteins. (helsinki.fi)
  • To characterize hCMEC/D3 cells for the presence of specific endocytic pathways, proteins involved into each pathway were selected. (helsinki.fi)
  • Upon transfer to PVDF membranes, separated proteins were probed for p-Akt, p-p38, p-JNK, p-ERK1/2 and Grb-2. (morainetownshipdems.org)
  • In type 1 diabetes, the lowered expression of adhesion proteins within the intestinal epithelium favours a greater immune response that may result in destruction of pancreatic β cells by CD8+ T-lymphocytes, and increased expression of interleukin-17, related to autoimmunity. (biomedcentral.com)
  • Open up in another window Open up in another window Body 2 The consequences of IL-1on COX-2 proteins appearance and PGE2 creation in individual T/C28a2 chondrocytes. (californiaehealth.org)
  • After 24?h, incubations were terminated, and PGE2 concentrations in the lifestyle moderate were measured simply by RIA ((a), (c), (e)) and COX-2 proteins was measured simply by American blot ((b), (d), (f)). (g) SP600125 (10? (californiaehealth.org)
  • Campylobacteriosis seems to be dependent on several virulence factors involving adhesion, invasion and bacterial motility adherence. (wikipedia.org)
  • The bacterial samples, regardless of aerobic or anaerobic conditions and treatment methods, showed no changes in their growth behavior. (bvsalud.org)
  • Moreover, growth inhibition experiments demonstrated the ability of the two strains alone and in combination to antagonize diverse Gram-negative and Gram-positive bacterial pathogens during sessile and planktonic growth. (frontiersin.org)
  • Finally, bacterial virulence was unimpaired in epithelial adherence and invasion, and the cysteine substitutions also appeared to increase bacterial resistance to oxidizing and reducing conditions. (biomedcentral.com)
  • MATERIALS AND METHODS Bacterial strains and growth conditions subsp. (citiesofdata.org)
  • Your microbiome consists of over 100 trillion bacterial cells and 33 million genes that live in and on us. (nuvisionhealthcenter.com)
  • This toxin has DNase activity, which causes DNA double-strand breaks during the cell cycle G2 phase, leading eventually to cell apoptosis in HeLa and Caco-2 cells. (wikipedia.org)
  • Purified GOS exhibited the greatest adherence inhibition on both HEp-2 and Caco-2 cells, reducing the adherence of EPEC by 65 and 70%, respectively. (unl.edu)
  • Adherence inhibition by GOS was dose dependent, reaching a maximum at 16 mg/ml. (unl.edu)
  • The expression of BfpA, a bundle-forming-pilus protein involved in localized adherence, was not affected by GOS, indicating that adherence inhibition was not due to the absence of this adherence factor. (unl.edu)
  • Based on previous studies, PREP-inhibition seems to increase the amount of Beclin 1 and to affect the phosphorylation of Bcl-2 and Beclin 1, leading to dissociation of the complex. (helsinki.fi)
  • Hypothesis was to see differences in colocalization of Bcl-2 and Beclin 1 in cells treated with different PREP-modifications and for PREP-inhibition to decrease the colocalization. (helsinki.fi)
  • Inhibition of JNK activity by SP600125, p38 activity by SB203580, and Erk1/2 activity by PD98059 led to a decrease in the quantity of PGE2 created. (californiaehealth.org)
  • In vitro characterization revealed that the strains tolerate gastric and bile challenges and display a great adhesion capacity to human intestinal cells. (frontiersin.org)
  • Surface charge and wettability are two prominent physical factors governing cell adhesion and have been extensively studied in the literature. (waset.org)
  • However, a comparison between the two driving forces in terms of their independent and cooperative effects in affecting cell adhesion is rarely explored on a systematic and quantitative level. (waset.org)
  • To study the response of C. albicans adhering to different surfaces on the transcriptional level we have established an in vitro adhesion assay exploiting confluent monolayers of the human colorectal carcinoma cell line Caco-2 or epidermoid vulvo-vaginal A-431 cells. (fraunhofer.de)
  • Obviously, C. albicans is able to respond specifically to very subtle differences in the environment during adhesion to various growth substrates. (fraunhofer.de)
  • All treatments reduced the adhesion ability of the bacteria and it is probably related to the metabolism cell reduction. (preprints.org)
  • Specifically, these oligosaccharides may directly inhibit infections by enteric pathogens due to their ability to act as structural mimics of the pathogen binding sites that coat the surface of gastrointestinal epithelial cells. (unl.edu)
  • Several genes isolated from resistant enterococci ( agg, gelE, ace, cylLLS, esp, cpd, fsrB ) encode virulence factors such as the production of gelatinase and hemolysin, adherence to caco-2 and hep-2 cells, and capacity for biofilm formation. (medscape.com)
  • Title: Different ability of multidrug-resistant and-sensitive counterpart cells to release and capture extracellular vesicles Abstract: Cancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. (up.pt)
  • Forty-seven strains representing 14 different Bacillus species isolated from clinical and food samples were grown in reconstituted infant milk formulae (IMF) and subsequently assessed for adherence to, invasion of, and cytotoxicity toward HEp-2 and Caco-2 cells. (strath.ac.uk)
  • Cell-free supernatant fluids from 38 strains (81%) were shown to be cytotoxic, 43 strains (91%) adhered to the test cell lines, and 23 strains (49%) demonstrated various levels of invasion. (strath.ac.uk)
  • Finally, an exploratory, observational, pilot study involving 36 infants diagnosed with at least one FGID (infant colic and/or functional constipation) showed the probiotic formula was well tolerated and FGID severity was significantly reduced after 14 days of treatment with the 2 strains. (frontiersin.org)
  • The peptide hydrolysates of both strains exhibited anti-inflammatory action through the modulation of pro-inflammatory mediators in LPS-stimulated THP-1 macrophages (COX-2, Pro-IL-1β, IL-1β, and IL-8) and LPS-stimulated HT-29 cells (IL-8). (calbinotox.fr)
  • 0.2% or 0.01% (w/v). As shown in Figure 1B, uvrA mutant cells grown in 0.2% glucose entered stationary phase at a lower optical density (OD600nm≈1.1) in compared to cells of the same strains grown in higher (0.4%) glucose concentration. (faksignaling.com)
  • As shown in Figure 4A, while uvrA cells were unable to grow after a 15 sec exposure to UV light (λ = 254 nm), the wild type and the complemented strains were unaffected by the treatment. (faksignaling.com)
  • Shen, Y.R., Inoue, M. & Ogihara, Y. Effect of Shosaikoto (Kampo medicine) on the adherence of monocytes in hypercholesterolemic rabbit. (kampo.ca)
  • Monocytes were obtained from PBMCs by adherence of the cell mixture to a flat bottom 96 well plate for 1h in a 37C incubator. (morainetownshipdems.org)
  • Cell Signaling in Human Monocytes White blood cells collected by apheresis from G-CSF-mobilized normal stem cell donors were obtained from the Stem Cell Assay Laboratory/Hematology Cell Bank of the British Columbia Cancer Agency. (morainetownshipdems.org)
  • Monocytes from these apheresis samples were then isolated using an EasySep kit according to the manufacturers instructions and assessed as >92% CD14+ Rabbit Polyclonal to Glucokinase Regulator by flow cytometry or by adherence. (morainetownshipdems.org)
  • To establish the importance of specific cell signaling pathways to the production of pro-inflammatory cytokines from LPS-stimulated human monocytes, the NF-B inhibitor, Bay11, the p38 inhibitor, SB203580, the PI3K inhibitor, LY294002, and 607737-87-1 supplier the JNK inhibitor, SP 600125, were added to adherent human monocytes cultured in RPMI 1640 made up of 10% AB+ serum in flat bottom 96 well plates. (morainetownshipdems.org)
  • The level of cell polarization in cells grown on transwell permeable supports was characterized at multiple timepoints with four different methods: transepithelial electrical resistance (TEER) measurement, lucifer yellow permeability assay, alkaline phosphatase expression and ZO-1 expression. (helsinki.fi)
  • Nishimura, N., Uemura, T., Iwamoto, K. & Naora, K. Change in tolbutamide permeability in rat jejunum and Caco-2 cells by Sho-saiko-to (Xiao Chai Hu Tang), a Chinese traditional medicine. (kampo.ca)
  • Delayed uptake and non-adherence are associated with doubts about personal need for ART and concerns about taking it [9, 10]. (atm-signaling.com)
  • This finding has raised an intriguing question: Does C. jejuni sense, inject and secrete putative virulence factors into host cells? (assignster.com)
  • These pathotypes employ many virulence factors and effectors subverting the func-tions of host cells to mediate its virulence and pathogenesis. (preprints.org)
  • In present study we characterized human brain endothelial cells, hCMEC/D3, which are widely utilized as BBB in vitro model. (helsinki.fi)
  • Derivatives of 1,3,4-thiadiazole including 2-substituted-thio-1,3,4-thiadiazoles bearing (5-(4-nitrobenzylideneamino) or 5-amino (II, IV, V) and one derivative of 2-substituted-amino-1,3,4-thiadiazole bearing (5- (4-nitrophenyl) (VII) were synthesized and evaluated for their in vitro antileishmanial activity against promastigote and amastigote forms of the Leishmania major . (jrpsjournal.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • However it remains unknown which endocytic pathways are active in brain endothelial cells. (helsinki.fi)
  • As brain endothelial cells are polarized in vivo, the aim of the study was to demonstrate the cell polarization of hCMEC/D3 cells and to study the activity and functionality of different endocytic pathways as a function of cell polarization. (helsinki.fi)
  • Our outcomes claim that activation of Erk1/2, p38, and JNK pathways is one of the signaling cascades that mediate the upregulation of COX-2 appearance and PGE2 creation in individual chondrocytes subjected to proinflammatory cytokine IL-1 .05. (californiaehealth.org)
  • Outcomes IL-1to activate JNK, p38, and Erk1/2 pathways was researched by Traditional western blot evaluation using antibodies aimed against Thr-183/Tyr-185, Thr-180/Tyr-182, and Thr-202/Tyr-204 phosphorylated (ie, turned on) JNK, p38, and Erk1/2, respectively. (californiaehealth.org)
  • DISCUSSION In today's study, Loganic acid we discovered that inhibitors of JNK, p38, and Erk1/2 pathways downregulate IL-1-induced COX-2 appearance and PGE2 creation in individual chondrocytes. (californiaehealth.org)
  • Increased invasion occurred after growth of selected Bacillus species in reconstituted IMF containing glucose. (strath.ac.uk)
  • After personally experiencing muciniphila's innocuity, Cani and his team have started a safety study on 50 human volunteers, confirming the absence of adverse effects, and already showing positive findings: decrease of total cholesterol and decrease of insulin resistance for both live and dead muciniphila , while only the dead cells added a positive effect with significant decrease in liver enzymes and plasma LPS. (probiotical.com)
  • Esophageal cancer cells ESO26 were cultured in the presence and absence of ginger extract at various concentrations for 12, 18, and 24h. (jrpsjournal.com)
  • Taken together these results indicate that M. smegmatis growth rate is limited by the amount of carbon available and also that absence of UvrA does not affect M. smegmatis growth under nutrient-limited conditions. (faksignaling.com)
  • Huang, Y., Marumo, K. & Murai, M. Antitumor effects and pharmacological interaction of xiao-chai-hu-tang (sho-saiko-to) and interleukin 2 in murine renal cell carcinoma. (kampo.ca)
  • MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. (up.pt)
  • Most of them generally follow the same pathway to make immune-activated cytotoxic T lymphocytes (CTLs) abundantly infiltrate into tumor tissues and destroy tumor cells [ 6 ]. (thno.org)
  • The adherence of EPEC strain E2348/69 on HEp-2 and Caco-2 cells, in the presence of fructooligosaccharides, inulin, galactooligosaccharides (GOS), lactulose, and raffinose was determined by cultural enumeration and microscopy. (unl.edu)
  • Researchers have identified strain HN019 as having excellent probiotic potential based upon its ability to survive the transit through the human gastrointestinal tract, adhere to epithelial cells, and proliferate. (naturalmedicineformulas.com)
  • In this context C. albicans is able to adhere to a plethora of different cell types providing different microenvironments for colonization. (fraunhofer.de)
  • Unintentional non-adherence is linked to limitations in capacity or resources that reduce the ability to adhere to the treatment as intended. (atm-signaling.com)
  • With previously results using major articular chondrocytes [17 Regularly, 18], our outcomes present that IL-1 em /em causes an instant activation of JNK, p38, and Erk1/2 MAP kinases in immortalized Loganic acid individual T/C28a2 chondrocytes. (californiaehealth.org)
  • Our aim is to clarify the currently described effects of probiotics in the prevention and management of type 1 (T1D) and type 2 (T2D) diabetes mellitus. (biomedcentral.com)
  • While PCR primer studies revealed that many different Bacillus species contained DNA sequences encoding the hemolysin BL (HBL) enterotoxin complex and B. cereus enterotoxin T, not all of these isolates expressed these diarrheagenic genes after growth in reconstituted IMF. (strath.ac.uk)
  • The Field Guide, which is publicly available online, outlines 4 assessment phases: 1) convene team members and determine assessment activities, 2) design and administer the readiness assessment, 3) evaluate assessment data, and 4) develop an implementation plan. (cdc.gov)
  • 1) adherence, (2) number needed to harm and (3) assessment of temporal relationship Savolitinib between bisphosphonate treatment and fracture type 8. (faksignaling.com)
  • It is essential for cell homeostasis and survival and has been related to various diseases and pathophysiology. (helsinki.fi)
  • SP600125 (a lately created JNK inhibitor) however, not its harmful control substance N1-methyl-1,9-pyrazolanthrone downregulated COX-2 PGE2 and expression formation within a dose-dependent manner. (californiaehealth.org)
  • Whole cell lysates were prepared for Western blotting by washing cells once with cold PBS followed by the addition of SDS sample buffer (1x) to the cell pellets. (morainetownshipdems.org)
  • Whole cell lysates in SDS sample buffer were loaded onto 10% polyacrylamide gels. (morainetownshipdems.org)
  • Two parallel immunoblots had been operate from same cell lysates using antibodies against the Thr-183/Tyr-185, Thr-180/Tyr-182, and Thr-202/Tyr-204 phosphorylated (ie, turned on) JNK (p-JNK), p38 (p-p38), and Erk1/2 (p-Erk1/2) and against total JNK, p38, and Erk1/2. (californiaehealth.org)
  • Of note, the TME is rich in immunosuppressive cells (e.g., tumor-associated macrophages (TAMs), regulatory T cells (Tregs), immature dendritic cells (iDCs) and myeloid-derived suppressor cells (MDSCs)), that can suppress antitumor immunity as a result of secretion of various cytokines and chemokines, which enables tumor escape from immune surveillance [ 8 ]. (thno.org)
  • Here, we show that ileal expression of AGR2 correlates with mucosal Enterobactericeae abundance in human inflammatory bowel disease (IBD) and that Agr2 deletion leads to ER-stress-dependent expansion of mucosal-associated adherent-invasive Escherichia coli (AIEC), which drives Th17 cell ileocolitis in mice. (bvsalud.org)
  • Peptide hydrolysate significantly decreased secretion of pro-inflammatory cytokine IL-8 in lipopolysaccharide (LPS)-stimulated human colon epithelial HT-29 cells. (calbinotox.fr)
  • Lactobacillus rhamnosus is an anaerobic facultative heterofermentative rod-shaped bacterium that can live in different parts of the human body, including the gastrointestinal tract (GIT) 2 . (nature.com)
  • Human embryonic kidney cells 293 (HEK-293) and hPREP knockout cell line created from them by using CRISPR/Cas9-silencing were used in the experiments. (helsinki.fi)
  • 5 million human infections each year 2 with a staggering economic burden of between $1. (assignster.com)
  • Shosaikoto increases calprotectin expression in human oral epithelial cells. (kampo.ca)
  • Cell Viability Assays In parallel studies, whole human blood samples (70 L/well) were collected at the end of the 7 h incubation period to determine the effect of DMSO, DMSO2 and DMS on cell viability using propidium iodide staining. (morainetownshipdems.org)
  • After 15 min of incubation on ice, cells were pelleted by centrifugation at 335 x for 5 min, followed by a wash step with cold PBS made up of 2% FBS and 0.05% sodium azide (HFN). (morainetownshipdems.org)
  • Two experiments were performed on regular HEK-cells: inhibitor experiment with KYP-2047 (1 or 10 µM) and overexpression experiment (transfection with either active or inactive hPREP plasmid). (helsinki.fi)
  • SP600125, SB203580, and PD98059 suppressed IL-1(100?pg/mL) and increasing concentrations of (a), (b) SP600125 (JNK inhibitor), (c), (d) SB203580 (p38 inhibitor), and (e), (f) PD98059 (Erk1/2 inhibitor). (californiaehealth.org)
  • In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1, reducing insulin sensitivity. (biomedcentral.com)
  • Title: Metabolic dysfunction biomarkers as predictors of early diabetes Abstract: During the pathophysiological course of type 2 diabetes (T2D), several metabolic imbalances occur. (up.pt)
  • It has many medical beneficial properties such as anti-proliferation and antiapoptotic effects on cancerous esophageal cells. (jrpsjournal.com)
  • Results showed that the process of cell proliferation has been stopped. (jrpsjournal.com)
  • Specifically, following the 7 h incubation assay, red blood cells were lysed by the addition of 2.5 mL of ammonium chloride solution (StemCell Technologies) in polystyrene flow tubes. (morainetownshipdems.org)
  • Then, the viability was determined by 3-(4,5-dimethylthiazol)-2,5-diphenyl tetrazolium bromide (MTT) assay. (jrpsjournal.com)
  • Using whole-genome DNA microarrays comprising probes for almost 7000 predicted ORFs we found that transcriptional profiles of C. albicans adhering to Caco-2 or to A-431 cells, although very similar, still significantly differ from those of Candida cells adhering to plastic surfaces. (fraunhofer.de)
  • In the laboratory, enterococci are distinguished by their morphologic appearance on Gram stain and culture (gram-positive cocci that grow in chains) and their ability to (1) hydrolyze esculin in the presence of bile, (2) their growth in 6.5% sodium chloride, (3) their hydrolysis of pyrrolidonyl arylamidase and leucine aminopeptidase, and (4) their reaction with group D antiserum. (medscape.com)
  • Autophagy is a pathway for cells to degrade intracellular components that are no longer needed or are detrimental for the cells. (helsinki.fi)
  • Even after arriving at their sites of action, prior to the release of their cargo and clearance, NPs must effectively penetrate through the cell membrane and navigate intracellular compartment networks to get to their subcellular mark. (biomedcentral.com)
  • The researcher designed a targeted GOS using LPLDL enzymes to enhance the growth, and the effect of the combination was prebiotic on Bifidobacteria , and removed more cholesterol than the bacteria alone and other combinations. (probiotical.com)
  • Cheng, P.W., Ng, L.T. & Lin, C.C. Xiao chai hu tang inhibits CVB1 virus infection of CCFS-1 cells through the induction of Type I interferon expression. (kampo.ca)
  • p21 , Bax , and Bcl-2 gene expression was measured using quantitative polymerase chain reaction (PCR). (jrpsjournal.com)
  • These results claim that SB203580 and SP600125 didn't inhibit COX-2 activity, but decreased the expression of COX-2 rather. (californiaehealth.org)
  • We assessed their cytotoxic effect after sensitizing cancer cells with insulin. (oncotarget.com)
  • Scientific evidence suggests increased inflammatory stress is related to molecular mechanisms leading to insulin resistance, and the intestinal microbiota interacts with environmental factors and susceptible genetic factors, contributing to the development of diabetes [ 2 ]. (biomedcentral.com)
  • Patients without information on CD4 cell counts were significantly less often heterosexual (P = 0.007) and more often had an unknown transmission risk (P (atm-signaling.com)
  • Of the 47 Bacillus isolates examined, 3 isolates of B. cereus and 1 isolate of B. subtilis produced the HBL enterotoxin after 18 h of growth in brain heart infusion broth. (strath.ac.uk)
  • However, eight isolates belonging to the species B. cereus, B. licheniformis, B. circulans, and B. megaterium were found to produce this enterotoxin after growth in reconstituted IMF when assessed with the B. cereus enterotoxin (diarrheal type) reversed passive latex agglutination (RPLA) kit. (strath.ac.uk)
  • [ 2 ] According to National Nosocomial Infections Surveillance (NNIS) data from January 2003 through December 2003, more than 28% of enterococcal isolates in ICUs of the more than 300 participating hospitals were vancomycin-resistant. (medscape.com)
  • Thioglycosides have received considerable attention because they are widely employed as biological inhibitors [ 2 - 6 ], inducers [ 7 - 9 ]. (oncotarget.com)
  • Prebiotic oligosaccharides are thought to provide beneficial effects in the gastrointestinal tract of humans and animals by stimulating growth of selected members of the intestinal microflora. (unl.edu)
  • Primary antibodies were used at 1/1000 dilution, and Grb-2 was used as a loading control. (morainetownshipdems.org)
  • IL-2 and IFN-γ), immune checkpoint blockade (ICB) therapy (e.g., anti-PD-1/PD-L1 antibodies), and adoptive T-cell transfer (e.g., chimeric antigen receptor (CAR) T-cell therapy) [ 3 - 5 ]. (thno.org)
  • However, there were no significant differences in colocalization of Beclin 1 and Bcl-2 in any of the experiments but it was nearly 100 percent in all treatments. (helsinki.fi)
  • Conjugation of glucose with metabolic agents to selectively target cancer cells was inspired by the widespread use of radiolabeled glucose analog to visualize tumors and their metastases. (oncotarget.com)
  • key recommendations for adherence support are shown in Box 1 [8]. (atm-signaling.com)
  • Efforts have been made to increase drug carrier targeting efficiency by attaching cell receptor-targeted ligands to the particle surface [ 7 ]. (biomedcentral.com)
  • can be diagnosed by isolation of the organism from faeces and identification by growth-dependent tests, immunological assays, or genomic analyses. (wikipedia.org)
  • Induction of autophagy in the latter pathway is dependent on the interaction of Bcl-2 and Beclin 1. (helsinki.fi)
  • IL-1improved COX-2 appearance within a concentration-dependent way, getting detectable at 10?pg/mL and increasing to 1000 up?pg/lmL (Body 2a). (californiaehealth.org)
  • Immunotherapy is currently considered as a promising next-generation therapeutic strategy for various cancers thanks to its ability to modulate cell-specific immune responses toward tumors [ 1 ], which has gradually remodeled the landscape of clinical anticancer modality [ 2 ]. (thno.org)
  • The emergence of multifunctional nanomaterials can expectedly endow these therapeutic cargoes with high solubility, favorable pharmacokinetic distribution, cell-specific delivery, and controlled release. (thno.org)
  • Sho-saiko-to (Xiao-Chai-Hu-Tang) and crude saikosaponins inhibit hepatitis B virus in a stable HBV-producing cell line. (kampo.ca)
  • Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. (oncotarget.com)
  • In addition, with regard to potential adjuvant activity, all crosslinked flagella filaments were able to induce wild-type levels of epithelial NF-κB in a cell reporter system. (biomedcentral.com)
  • The anti-inflammatory activity of peptide hydrolysate was investigated under inflammatory conditions in two cell models. (calbinotox.fr)
  • The intensity of Beclin 1 in the nuclei was stronger than in other parts of the cell in all samples, which could indicate a stronger activity of its nuclear tasks compared to autophagy. (helsinki.fi)
  • Combining a cell wall-active agent such as ampicillin or vancomycin with an aminoglycoside may result in synergistic bactericidal activity against enterococci. (medscape.com)
  • Considering the reported antileishmanial effects of thiadiazole derivatives and the importance of this disease, some of the thiadiazole derivatives with modifications at sulfur atom or amine group attached to the 2-position were synthesized and evaluated for antileishmanial activity. (jrpsjournal.com)