• The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. (nih.gov)
  • Fibroblast Growth Factor 2 Levels in Patients with Major Depressive Disorder: A Meta-analysis. (nih.gov)
  • Several neurotrophic growth factors (including insulin-like growth factor-I and fibroblast growth factor-I) have been identified. (bl.uk)
  • In this series of experiments the ability of insulin-like growth factor-I and fibroblast growth factor-I to facilitate neuromuscular junction regeneration in atrophic muscle was studied. (bl.uk)
  • also known as basic fibroblast growth factor (bFGF). (themmrf.org)
  • The effect of basic fibroblast growth factor on motor neurons in the anterior horn of the injured spinal cord, and on the number of neuromuscular junctions in target organs, remains elusive. (medindia.net)
  • Jianlong Wang and team from Third Xiangya Hospital of Central South University established a rat model of spinal cord injury using a modified Allen's method, which was injected with basic fibroblast growth factor solution via the subarachnoid catheter. (medindia.net)
  • These findings, published in the Neural Regeneration Research (Vol. 8, No. 24, 2013), indicate that basic fibroblast growth factor can protect the endplate through attenuating the decreased expression of calcitonin gene related peptide and acetylcholinesterase in anterior horn motor neurons of the injured spinal cord. (medindia.net)
  • FGF2 , also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene . (wikidoc.org)
  • Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated basic FGF, Heparin-binding growth factor-2, and Endothelial cell growth factor-2. (wikidoc.org)
  • [3] [5] FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules. (wikidoc.org)
  • Like other FGF family members, basic fibroblast growth factor possess broad mitogenic and cell survival activities, and is involved in a variety of biological processes, including embryonic development , cell growth , morphogenesis , tissue repair , tumor growth and invasion. (wikidoc.org)
  • It was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase . (wikidoc.org)
  • Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1 , [13] RPL6 [14] and ribosomal protein S19 . (wikidoc.org)
  • This test measures the amount of IGF-1 (insulin-like growth factor 1) in your blood. (medlineplus.gov)
  • In the study funded by the National Institutes of Health, animals treated with insulin-like growth factor (IGF-II) excelled at remembering to avoid a location where they had previously experienced a mild shock. (nih.gov)
  • Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth factor (IGF)1 and -2 through high-affinity IGFBP/IGF complexes. (rcsb.org)
  • Very preterm infants show low levels of insulin-like growth factor-1 (IGF-1), which is associated with postnatal growth restriction and poor neurologic outcomes. (lu.se)
  • Researchers from the International Agency for Research on Cancer (IARC) and partners have published results showing that insulin-like growth factor-1 (IGF-1) is likely to play a role in the development of breast cancer. (who.int)
  • In one of two complementary studies, IARC scientists analysed data from almost 230 000 women using Mendelian randomization to examine genetic variants known to be associated with circulating concentrations of IGF-1 and insulin-like growth factor-binding protein-3 (IGFBP-3), which may modulate the availability of IGF-1. (who.int)
  • To design a novel, polyvinyl alcohol (PVA)-based polymeric scaffold that permits the controlled release of insulin-like growth factor 1 ( IGF-1 )/ bone morphogenetic protein (BMP)-2 following intervertebral disc administration . (bvsalud.org)
  • 1. In order to assess potential abnormalities in the control of mucosal proliferation, 30 patients with Barrett's oesophagus were studied in order to evaluate the presence and distribution of epidermal growth factor, transforming growth factor-α and epidermal growth factor receptor to determine the Ki-67 labelling index in the affected oesophageal mucosa. (portlandpress.com)
  • 2. The expression of transforming growth factor-α, epidermal growth factor and epidermal growth factor receptor was increased and the Ki-67 labelling index was higher in Barrett's mucosa compared with normal gastric mucosa. (portlandpress.com)
  • The 'intestinal-type' of Barrett's mucosa had the greatest expression of transforming growth factor-α, epidermal growth factor receptor and the highest Ki-67 labelling index compared with the other types of Barrett's metaplasia. (portlandpress.com)
  • Five cases of 'intestinal-type' Barrett's metaplasia had especially high Ki-67 labelling indices and these patients over-expressed both transforming growth factor-α and epidermal growth factor receptor. (portlandpress.com)
  • The patients with adenocarcinomas in the Barrett's mucosa also over-expressed transforming growth factor-α and epidermal growth factor receptor, but not epidermal growth factor, compared with normal gastric mucosa. (portlandpress.com)
  • 3. In conclusion, both normal gastric mucosa and Barrett's mucosa have potential autocrine growth regulatory mechanisms, but Barrett's mucosa has increased expression of both of the measured ligands and of the epidermal growth factor receptor. (portlandpress.com)
  • The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) is proved to be effective for patients with EGFR sensitive mutations in NSCLC in recent years. (dovepress.com)
  • High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6. (atlasgeneticsoncology.org)
  • Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling. (atlasgeneticsoncology.org)
  • Growth differentiation factor 15 (GDF15) has been associated with food intake and weight regulation in response to metabolic stress. (nature.com)
  • Recently, metabolic research has focused on growth differentiation factor 15 (GDF15), a stress-induced cytokine belonging to the transforming growth factor beta superfamily [ 5 ]. (nature.com)
  • Furthermore, the human T cell hybridoma cell line MP6 that secretes a B cell growth and differentiation factor, recently identified as an isoform of thioredoxin, is also capable of stimulating EBV-infected B cells and lymphoblastoid cell lines. (lu.se)
  • Being only one atom thick and having a unique charge pattern lets these coin-shaped particles grab onto proteins and growth factors that they can then slowly release. (medgadget.com)
  • Human stem cell showing the formation of cartilage related proteins (the portions in red) when treated with growth factor loaded nanoparticles. (medgadget.com)
  • While these disks have not been tried in patients, laboratory experiments have shown that they do trap proteins and growth factors and then release them slowly over a period of about a month. (medgadget.com)
  • Growth factors are naturally occurring, potent proteins that fight against aging and maintain epidermal health," explains Mona Gohara , a board-certified dermatologist based in Connecticut. (whowhatwear.com)
  • Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentation, angiogenesis, wound healing and tumorgenesis. (prospecbio.com)
  • The culture supernatant of animal cells, also known as 'conditioned medium' (CM), contains various factors secreted by the cells themselves, such as growth factors and cytokines. (nature.com)
  • Benzene and its principal metabolites modulate proinflammatory cytokines and growth factors in human epidermal keratinocyte cultures. (cdc.gov)
  • A study was conducted examining the role of proinflammatory cytokines and growth factors in benzene (71432) induced skin carcinogenesis. (cdc.gov)
  • The authors conclude that exposure of human epidermal keratinocytes to relatively low concentrations of benzene or its metabolic products induces selective cytokines and growth factors. (cdc.gov)
  • This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. (nih.gov)
  • The elaboration of interleukin-8 (IL-8) and tumor growth factor alpha (TGFa) by normal human skin keratinocytes in- vitro following exposure to benzene and its metabolic products was assessed. (cdc.gov)
  • International traffic climbed 40.9% versus May 2022 with all markets recording strong growth, led once again by carriers in the Asia-Pacific region. (iata.org)
  • Geneva - The International Air Transport Association (IATA) released May 2023 traffic data showing continued strong growth in air travel demand. (iata.org)
  • According to Grand View Research , "The global curcumin market size was valued at more than $58 million in 2020 and is expected to grow at a compound annual growth rate (CAGR) of 16.1% from 2020 to 2028. (naturalproductsinsider.com)
  • Angiocrine growth factors are molecules found in blood vessels' endothelial cells that can stimulate organ-specific repair activities in damaged or diseased organs. (wikipedia.org)
  • Endothelial cells possess tissue-specific genes that code for unique growth factors, adhesion molecules and factors regulating metabolism. (wikipedia.org)
  • ANN ARBOR, MI - The brains of people with severe depression have lower levels of several related molecules that are key to the development, organization, growth and repair of the brain than the brains of people without the disease, or those with the bipolar form of depression, a new study finds. (biopsychiatry.com)
  • The researchers found that levels of molecules called fibroblast growth factors (FGFs), and two of the receptors that bind to them, were significantly lower among people who had been diagnosed with severe clinical depression and had died in a depressed state. (biopsychiatry.com)
  • FGFs are a family of molecules that stimulate cell growth in many areas of the body, and are involved in the growth of multiple tissues and in growth that takes place at various stages of life. (biopsychiatry.com)
  • Some derms question whether topical growth factors can be effective without delivery through micro-needling or laser resurfacing, claiming their molecules are too large to effectively penetrate the top layer of the epidermis. (whowhatwear.com)
  • Growth factors are molecules, enzymes, and are particular pathways that contribute to cell proliferation, or cellular growth and turnover. (whowhatwear.com)
  • The diagnosis of GHD is a multifaceted process requiring comprehensive clinical and auxologic assessment combined with biochemical testing of the GH-insulinlike growth factor (IGF) axis and radiologic evaluation. (medscape.com)
  • Gigantism refers to abnormally high linear growth (see the image below) due to excessive action of insulinlike growth factor I (IGF-I) while the epiphyseal growth plates are open during childhood. (medscape.com)
  • For the diagnostic purpose, biochemical serum markers, ultrasound and Doppler study of uterine and spiral arteries, placental volume and vascularization, first trimester growth pattern are object of assessment today. (nih.gov)
  • Animal cells are generally cultured in basal media supplemented with fetal bovine serum (FBS) which provides the various factors essential for cell growth. (nature.com)
  • Here, we propose a new approach wherein the nutrients in the culture medium are provided by a microalgae extract, and the FBS is replaced by growth factors in the CM. Figure 1 illustrates the preparation process of our serum-free and grain-derived-nutrient-free medium. (nature.com)
  • In my case, I took another risk and added a new product to the mix: an epidermal growth factor serum. (whowhatwear.com)
  • There is also concern that because growth factors are mitogenic, theoretically, they could cause cancer cells to replicate, however, there hasn't been any evidence pointing to topical growth factors doing that. (whowhatwear.com)
  • Another growth factor, called Brain Derived Neurotrophic Factor, has been hypothesized to play a role in the effects of stress on the brain and in the mode of action of antidepressants. (biopsychiatry.com)
  • In research published today (August 20) scientists in Chile and Canada identify the substance in spontaneous ovulators: nerve growth factor beta (NGF-beta)-a neurotrophic protein involved in nerve development, which has the same chemical structure as OIF. (the-scientist.com)
  • Ojeda's own work has identified a role for a different neurotrophic factor in the development and fertilization of oocytes. (the-scientist.com)
  • The study showed that the growth factor works through its own - also little known - IGF-II receptor and depends on activation of an enzyme (GSK3 beta) , and AMPA receptors for the chemical messenger glutamate, both of which are implicated in memory. (nih.gov)
  • They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. (curehunter.com)
  • Risk factors for IUGR are easy to assess but have poor predictive value. (nih.gov)
  • Replacement of GH in adults with GHD markedly reduces central obesity and substantially reduces total cholesterol levels but has produced little change in other risk factors, particularly insulin resistance and dyslipidemia. (medscape.com)
  • WHO's global strategy for the prevention and control of noncommunicable diseases recognizes the vast body of knowledge and experience in this domain.1 One of the main objectives is to reduce the level of exposure to the major risk factors, namely, tobacco use, unhealthy diet and physical inactivity, which should be tackled in an integrated manner. (who.int)
  • Strong evidence shows that unhealthy diet and insufficient physical activity are among the major causal risk factors in coronary heart disease, cerebrovascular strokes, several forms of cancer, type 2 diabetes, hypertension, obesity, osteoporosis, dental caries, and other conditions. (who.int)
  • On the basis of numerous indicators, the charts present the year-over-year growth (%) and impressive healthy compound annual growth rate (CAGR) for the given estimated period. (openpr.com)
  • For instance, children with a rare genetic condition called congenital growth hormone deficiency will grow at a much slower rate than other children. (medicalnewstoday.com)
  • Patients with growth hormone deficiency (GHD) typically have hyperlipidemia, increased body fat, premature atherosclerotic plaques, delayed bone maturation, and impaired cardiac function. (medscape.com)
  • To our knowledge, this is the first demonstration of potent memory enhancement via a naturally occurring factor that readily passes through the blood-brain barrier - and thus may hold promise for treatment development," explained Cristina Alberini, Ph.D., of Mount Sinai School of Medicine, New York, a grantee of the NIH's National Institute of Mental Health (NIMH). (nih.gov)
  • The main motto of the report is to outline, segment, and project the market concerning global Acne Medicine market dynamics and other factors. (pharmiweb.com)
  • Previous work focused on its ability to stimulate cell growth near its neuron of origin-but NGF in the semen must be acting on distant tissues. (the-scientist.com)
  • Hyposomatotropism is a deficiency in the release of pituitary growth hormone (somatotropin), resulting in short stature. (medscape.com)
  • The diagnosis of growth hormone (GH) deficiency (GHD), or hyposomatotropism, remains controversial. (medscape.com)
  • Lately, attempts at protein and growth factor therapies for cartilage repair have involved delivering large doses to patients, as these substances don't stay around long enough for smaller doses to work. (medgadget.com)
  • Acromegaly is the same disorder of IGF-I excess but occurs after the growth plate cartilage fuses in adulthood. (medscape.com)
  • This duplication was not evident in patients who began abnormal growth at age 9 or 10, but only in those who started to grow excessively before the age of 3. (medscape.com)
  • Protein and calcium are particularly important for bone health and growth. (medicalnewstoday.com)
  • This led Adams and collaborator Marcelo Ratto at Universidad Austral de Chile to hypothesize that OIF was a single protein factor, conserved across species. (the-scientist.com)
  • Compared to grains, microalgae have higher growth capacity and usable protein content in their biomass. (nature.com)
  • binding protein-3 have been the subject of much attention because of their role in juvenile growth and their association with cancers at several sites. (cdc.gov)
  • The body produces hormones that instruct the growth plates to make new bone. (medicalnewstoday.com)
  • This is a rare genetic disorder in which the body is unable to use the growth hormone it produces. (medlineplus.gov)
  • A naturally occurring growth factor significantly boosted retention and prevented forgetting of a fear memory when injected into rats' memory circuitry during time-limited windows when memories become fragile and changeable. (nih.gov)
  • These factors are expected to contribute towards growth of the global functional workwear apparel market significantly during the forecast period. (clickpress.com)
  • Secretion of interleukin-6, tumor necrosis factor alpha, and MCP-1 was not significantly affected by BQ, HQ, or BZT. (cdc.gov)
  • Getting enough sleep may therefore allow optimal growth. (medicalnewstoday.com)
  • Superzyme Biological Growth Factor, 1-0-4 is an OMRI Listed liquid fertilizer that encourages healthy and vigorous roots and optimal plant growth. (arbico-organics.com)
  • 48 hours will generally support visible and extensive mold growth and should be remediated, and excessive exposure to mold-contaminated materials can cause adverse health effects in susceptible persons regardless of the type of mold or the extent of contamination. (cdc.gov)
  • These are made in the pituitary gland and are the most important hormone for growth. (medicalnewstoday.com)
  • Gigantism and acromegaly are most often caused by a tumor in the pituitary gland, a small organ in the base of the brain that controls many functions, including growth. (medlineplus.gov)
  • The commercial introduction of recombinant human growth hormone (rhGH) in 1985 dramatically changed the field of therapy for growth hormone (GH). (medscape.com)
  • Messenger RNA levels are a measure of how active different genes are, and the researchers took care only to study brains that had no complicating factors that would have changed their mRNA levels at death. (biopsychiatry.com)
  • metabolic changes, such as those in steroid hormones and growth factors. (who.int)
  • A new therapeutic approach to diabetes that combines insulin and an inhibitor of the epidermal growth factor (EGF) betacellulin could limit the progression of diabetic macular edema (DME), Cleveland Clinic researcher Bela Anand-Apte, MD, PhD, said at the American Society for Cell Biology Annual Meeting, on Dec. 17 in San Francisco. (biospace.com)
  • Achievement of final adult height consistent with a child's genetic potential remains the primary therapeutic endpoint for recombinanat human growth hormone (rhGH) therapy in the pediatric population. (medscape.com)
  • Here, we developed a novel medium containing nutrients extracted from microalga and cell-secreted growth factors. (nature.com)
  • The supernatant, containing the RL34 cell-secreted growth factors, was used as the conditioned medium (CM). This CM, with CVE added as a nutrient source, was applied to primary bovine myoblast cultures. (nature.com)
  • Review of these articles revealed that growth factors and low-power laser used locally can reduce the severity of radiation-induced oral mucositis, stimulating cell proliferation and consequently, promote healing. (bvsalud.org)
  • Our results show that the murine thymoma cell line EL-4 is superior to peripheral blood mononuclear cells in both cellular outgrowth and cloning experiments, whereas monocyte-derived factors and monocyte cell lines were less capable than peripheral blood mononuclear cells in enhancing cellular outgrowth and cloning. (lu.se)
  • Delivering Growth Factors through a Polymeric Scaffold to Cell Cultures Containing both Nucleus Pulposus and Annulus Fibrosus. (bvsalud.org)
  • struggled with business growth in his rural community at the beginning of his entrepreneurial journey and reached out to SCORE for assistance. (score.org)
  • Farming is a business and SCORE has been very helpful with everything from accounting, marketing, business growth and employee management issues," he explains. (score.org)
  • Global Acne Medicine Market Business Growth, Development. (pharmiweb.com)
  • the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. (wikidoc.org)
  • But with many governments planning major infrastructure projects as well as the increased investment in the green energy transition and manufacturing construction, there are significant trends emerging that should drive growth in the future. (deloitte.com)
  • Other factors such as classification, business atmosphere, size, effectual trends within business area unit, and SWOT analysis have been included during this analysis study. (pharmiweb.com)
  • Capacity factor and useful life also factor into the calculation. (powermag.com)
  • This report studies the top producers and consumers who focus on product capacity, production, value, consumption, market share, and growth opportunity in the following key regions. (ipsnews.net)
  • Capacity increased 23.2%, and the load factor rose 5.1 percentage points to 85.1%, highest among the regions. (iata.org)
  • GH supplementation is an injected medicine that contains manufactured human growth hormone. (medlineplus.gov)
  • Researchers identify a nerve growth factor in semen that stimulates ovulation in certain mammals, and which could shed light on human infertility. (the-scientist.com)
  • ab134002 is for simultaneous detection of 41 Human Growth Factors. (abcam.com)
  • Recognizing the importance of environmental factors as determinants of human health, African ministers of health and environment adopted the Libreville Declaration on Health and Environment in Africa3 in 2008. (who.int)
  • While epidermal growth factors, aka EGF, may not have the buzzy recognition that other skincare ingredients like retinol does, they have been studied extensively, especially in regard to their potential reparative and wound healing benefits. (whowhatwear.com)
  • But journal growth can have a negative effect on citation performance measures, especially on the Journal Impact Factor (JIF). (sspnet.org)
  • Some aspects of population growth, trade, and factor mobility / André Sapir. (who.int)
  • Population growth and aging were identified as major contributing factors. (medscape.com)
  • Reduced fetal growth is seen in about 10% of the pregnancies but only a minority has a pathological background and is known as intrauterine growth restriction or fetal growth restriction (IUGR / FGR). (nih.gov)
  • Whereas for temperature and pollution, the growth response is less coherent among trees, and fades within 2 years, the insect outbreaks synchronize growth among all downy birches. (springer.com)
  • Swelling, pH , and temperature tests and analysis of the controlled release of growth factors (GFs) from this system were performed. (bvsalud.org)
  • Together, IGF-1 and GH promote normal growth of bones and tissues. (medlineplus.gov)