• may be specific structural abnormalities or general or systemic disorders that affect skeletal growth and development. (msdmanuals.com)
  • chromosomal abnormalities, 7. (who.int)
  • Routine first-trimester combined screening for pre-eclampsia: pregnancy-associated plasma protein-A or placental growth factor? (isuog.org)
  • Since 2008, the Program for Surgical Obstetrics and Placental Abnormalities has offered specialized, compassionate care for women who face a complicated delivery due to a cesarean section identified as being complex, risk for heavy bleeding, or need for an additional surgery or hysterectomy. (brighamandwomens.org)
  • Multiple pregnancies, which are more common as women are using more infertility treatments , increase the risk of premature labor, gestational diabetes, and pregnancy-induced high blood pressure . (webmd.com)
  • Véronique Taché, M.D. , is an assistant professor in the Department of Obstetrics and Gynecology's Division of Maternal Fetal Medicine , where she specializes in caring for women with high-risk pregnancies and collaborates daily with colleagues across multiple disciplines on maternal and fetal health issues. (ucdavis.edu)
  • A diagnostic test to screen for chromosome abnormalities and inherited disorders. (pediatrix.com)
  • Problems at birth (congenital abnormalities) or chromosome problems are often associated with below-normal weight. (adam.com)
  • Skeletal dysplasias, also known as osteochondrodysplasias, are a heterogeneous group of heritable disorders characterized by abnormalities of cartilage and bone growth, resulting in abnormal shape and size of the skeleton and disproportion of the long bones, spine, and head. (medscape.com)
  • Dealing with healthy women whose pregnancy is at markedly increased risk for adverse outcome such as abnormal blood tests, twins or multiple births, recurrent pre-term labor and delivery, premature rupture of membranes, recurrent pregnancy loss and suspected fetal growth restriction. (nebraskamed.com)
  • Newswise - Choosing among cancer treatments increasingly involves determining whether tumor cells harbor specific, mutated "oncogenes" that drive abnormal growth and that may also be especially vulnerable or resistant to particular drugs. (newswise.com)
  • Those who enter the field are taught that oncogenes represent a dominant-acting mutation that is able to help drive abnormal growth within the tumor, and that a normal copy that is not mutated doesn't matter much. (newswise.com)
  • Occasionally, multiple lentigines are associated with rare genetic disorders. (logicalimages.com)
  • Other rare disorders associated with multiple lentigines include generalized lentigines, arterial dissection with lentiginosis, Laugier-Hunziker syndrome , Cantú (hyperkeratosis-hyperpigmentation) syndrome, Cowden disease , centrofacial lentiginosis, and Bannayan-Riley-Ruvalcaba syndrome . (logicalimages.com)
  • Exclu- the outline of the trunk on the screen are helpful, but are subjective and are sion criteria were the presence of any of the ultrasound machine (circular strongly influenced by factors such as fetal congenital abnormalities on ul- or elliptical outline includes the fetal maternal obesity, multiple gestation and trasound, uncertain LMP, ultrasound spine, umbilical vein and stomach). (who.int)
  • Questions on family history are also relevant, as malocclusions, growth and development may be expressions of genetic patterns. (wikipedia.org)
  • The identification of distinctive abnormalities in DNA sequences within the genomes of tumor cells from biopsy specimens is becoming a more common aid to help guide cancer treatment decisions, and the authors of the new study, published in the February 23 edition of Cell , said their discovery of KRAS "imbalances" that emerge over time could be added to a growing list of genetic characteristics that may be clinically valuable. (newswise.com)
  • This is a third blood test, taken around 16 weeks, to check for potential genetic abnormalities. (modernalternativemama.com)
  • This is a genetic test where amniotic fluid is drawn out of the uterus, and fetal cells are checked for any abnormalities. (modernalternativemama.com)
  • In this article, we provide an updated review of the genetic abnormalities and mechanisms that drive carcinogenesis of HCC, and discuss the targeted therapeutics that are being investigated in HCC. (eurekaselect.com)
  • You may be a high-risk pregnancy candidate if you have any pre-existing medical conditions, medical complications that arise during pregnancy, pregnancy complications or premature delivery due to age or past pregnancy issues, as well as abnormalities of the fetus. (nebraskamed.com)
  • A twin, triplet or higher-order multiple s pregnancy carries specific risks and complications for both the babies and mother. (brighamandwomens.org)
  • Subjects were excluded if at the time of admission they had intrauterine growth restriction (IUGR), pregnancy-induced hypertension (PIH), multiple pregnancy, abruptio placenta, chromosomal abnormality, or stillbirth. (hindawi.com)
  • Intrauterine growth restriction (IUGR) refers to the poor growth of a baby while in the mother's womb during pregnancy. (adam.com)
  • This will include regular pregnancy ultrasounds to measure the baby's growth, movements, blood flow, and fluid around the baby. (adam.com)
  • It may also be used to confirm a multiple pregnancy. (modernalternativemama.com)
  • The possibility that a mosquito bite during pregnancy could be linked to severe brain abnormalities in newborns alarmed the public and astonished scientists. (who.int)
  • These are to check on baby's growth and development, position, position of the placenta, and a number of other possible abnormalities (for example, if there is a heart defect or the lungs aren't developing properly). (modernalternativemama.com)
  • Moynahan first documented the association of the syndrome with cardiac abnormalities and short stature in 1962. (medscape.com)
  • Of children with RTS, 24-38 percent have cardiac abnormalities, which include atrial and ventricular septal defects, patent ductus arteriosus, coarctation of the aorta, pulmonic stenosis, and bicuspid aortic valve abnormalities [ 5 ]. (cdlib.org)
  • 5. Stevens C, Bhakta M. Cardiac abnormalities in the Rubinstein-Taybi syndrome. (cdlib.org)
  • The most common definition of Intrauterine Growth Restrictio n (IUGR) is a fetal weight that is below the 10th percentile for gestational age as determined through an ultrasound . (americanpregnancy.org)
  • Intrauterine Growth Restriction is also known as Small-for-Gestational-Age (SGA) or fetal growth restriction. (americanpregnancy.org)
  • These charts will help radiologists and clinicians in predicting dates of delivery, assessing fetal growth and identifying intrauterine fetal insufficiency in the Pakistani population. (who.int)
  • Biparietal diameter (BPD), femur assessment of intrauterine growth hospital, Karachi. (who.int)
  • Your risk of gestational diabetes goes up if you are over 25, are pregnant with multiples, are overweight , or have had gestational diabetes or a very large baby in the past, or if someone in your family has diabetes. (webmd.com)
  • ABSTRACT This study aimed to develop growth centiles at different gestational weeks for fetal biparietal diameter, abdominal circumference, femur length and head circumference in a Pakistani cohort. (who.int)
  • During the clinical evaluation, her mother stated that the patient had a syndrome consisting of mental retardation, broad thumbs and great toes, and facial abnormalities. (cdlib.org)
  • In addition, characteristic skeletal findings are broad, short, terminal phalanges of the thumbs and halluces, and postnatal growth retardation with head circumference below the fiftieth percentile. (cdlib.org)
  • A first-trimester ultrasound examination can help diagnose a miscarriage early and the presence of multifetal gestations (multiple fetuses such as twins or triplets). (medicinenet.com)
  • Osteomas have been associated with Gardner syndrome, an autosomal-dominant variant of familial adenomatous polyposis, which consists of multiple cranial osteomas, colonic polyposis, and soft-tissue tumors. (medscape.com)
  • Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms? (ersjournals.com)
  • It is argued here, instead, that abnormalities in multiple pathways involved in wound healing and inflammation lead to the development of idiopathic pulmonary fibrosis, and it is suggested that a new rationale for clinical classification and pathogenesis may be more productive in driving the search for novel therapies in the future. (ersjournals.com)
  • [ 1 ] They are benign growths of dense cortical bone. (medscape.com)
  • More important, the above-referred immune abnormalities do not explain the facial, skeletal, joint, and dental defects in AD HIES. (medscape.com)
  • Taking tolcapone in mid-gestation barely caused embryo lethality, however, the mice developed preeclampsia-like phenotypes, including maternal hypertension, proteinuria and fetal growth restriction. (biorxiv.org)
  • In conclusion, tolcapone causes embryo lethality and growth restriction in early gestation, while in mid-gestation tolcapone causes preeclampsia-like phenotypes in mice with defective trophoblast invasion. (biorxiv.org)
  • Administration of tolcapone in animal gestation has been implicated in fetal growth restriction and malformation, however, the studies are rather limited and the pathogenesis is unknown 10 . (biorxiv.org)
  • The mandible in particular has the most differential typical growth anomalies than any other bone in the human skeleton. (wikipedia.org)
  • Multiple lentigines on the face of a child with LEOPARD syndrome. (medscape.com)
  • LEOPARD syndrome, also known as Noonan syndrome with multiple lentigines, is a rare autosomal dominant disorder most often caused by missense mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase SHP2. (medscape.com)
  • [ 12 ] In one Bosnian family, five patients had the same recurrent mutation Y279C in the PTPN11 gene, but had different phenotypes and a variable expression of multiple lentigines. (medscape.com)
  • [ 12 ] The father had multiple lentigines equally dispersed over his body as depicted below, whereas his son was devoid of lentigines on the left part of the thorax, back, and left arm. (medscape.com)
  • Some women have fetuses with significant abnormalities that can't survive, even with the availability of fetal surgery. (ucdavis.edu)
  • For the fetus, issues include growth abnormalities, particularly when they aren't growing well, or birth defects. (ucdavis.edu)
  • Multiple analyses of HCC have revealed aberrant expression or activity of growth factors and receptors, and the associated signaling pathways. (eurekaselect.com)
  • The medical history includes questions on the general health of the patient, to assess contraindications to treatment of jaw abnormality. (wikipedia.org)
  • An in depth study on growth, bone age, cranial CT scans and plasma somatomedin activity (SM-act) was made of 22 children with Sotos syndrome. (nih.gov)
  • [ 11 ] They revealed that whereas Noonan syndrome is caused by gain-of-function PTPN11 mutations, LEOPARD syndrome mutants are catalytically defective and act as dominant negative mutations that interfere with growth factor/Erk-mitogen-activated protein kinase-mediated signaling. (medscape.com)
  • in 1957 as the broad thumb-hallux syndrome and then was described by Rubinstein and Taybi in 1963 [ 1 ] in children with broad thumbs and toes with facial abnormalities and short stature. (cdlib.org)
  • In addition, he commented, "whether rhGH can be used long-term is unclear, as we know that long-term exposure to high levels of growth hormone in adults may lead to adverse outcomes," such as an increased risk of diabetes, increased bone growth leading to joint abnormalities and increased pressure on nerves, which can result in carpal tunnel syndrome. (medscape.com)
  • In the 1990s, the focus shifted toward elucidating the responsible mutations and characterizing the pathogenetic mechanisms by which the mutations disrupt bone growth. (medscape.com)
  • impaired epiphyseal bone growth, resulting in shortened, malformed bones) sometimes causes the foramen magnum to narrow or fuse with the atlas and thus may compress the spinal cord or brain stem. (msdmanuals.com)
  • In general abnormalities arise within the jaw when there is a disturbance or fault in the fusion of the mandibular processes. (wikipedia.org)
  • LLI may arise during normal growth without apparent reason. (gc.ca)
  • 1. Rubinstein JH, Taybi H. Broad thumbs and toes and facial abnormalities. (cdlib.org)
  • Multiple symmetric lipomatosis represents a group of similar syndromes characterized by the excessive growth of subcutaneous fat, often in the periphery of the body in areas such as the arms, legs, shoulders, and neck (picture the Michelin man). (scienceblogs.com)
  • Ectodermal abnormalities are characterised by loose and dark-coloured skin, and a predisposition to develop multiple papillomata, which when present are highly suggestive of the diagnosis. (atlasgeneticsoncology.org)
  • Therefore, even though zinc seems to have numerous benefits on the development of the weed plant, an excessive amount of zinc has multiple adverse effects on the weed plant. (amsterdammarijuanaseeds.com)
  • During the 1950s and 1970s, many new bone dysplasias were identified based on clinical manifestations, radiographic findings, inheritance patterns, and morphology of the growth plate. (medscape.com)
  • The opposite clinical example of lipodystrophy is multiple symmetric limpomatosis. (scienceblogs.com)
  • Antibody cross-reactivity and similarities in clinical presentation make distinguishing between related flaviviruses difficult, especially in areas where multiple flaviviruses are endemic. (cdc.gov)
  • Craniocervical junction abnormalities are congenital or acquired abnormalities of the occipital bone, foramen magnum, or first two cervical vertebrae that decrease the space for the lower brain stem and cervical cord. (msdmanuals.com)
  • Individuals with jaw abnormalities have both functional and aesthetic impairment. (wikipedia.org)
  • For a given BMI, multiple symmetric lipomatosis patients are reported to carry 50% more fat tissue than healthy individuals. (scienceblogs.com)
  • 12] Studies in toll-like receptor (TLR)-mediated signaling in patients with HIES did not reveal anty abnormalities either. (medscape.com)
  • Laboratory work-up, and chest and abdominal imaging did not reveal any abnormalities. (ispub.com)
  • Growth abnormalities: whereas new-born are often macrosomic and macrocephalic they exhibit severe feeding difficulties and failure to thrive during the first months of life, up to two years of age. (atlasgeneticsoncology.org)
  • Multiple sources of exposure were included in the butterfly study. (eurekalert.org)
  • We believe Woodside is a stand-out, long term growth opportunity for investors seeking oil and gas exposure. (thebull.com.au)
  • A first-trimester ultrasound also helps to evaluate the mother's reproductive system to detect anatomical abnormalities and pathologies. (medicinenet.com)
  • Radiographs show short, thick, ribbonlike long bones with multiple fractures and callus formation at all sites (ribs, long bones). (medscape.com)
  • FIO manifests clinically with generalized bone pain and multiple fractures of both the axial and appendicular skeletons. (medscape.com)
  • Patient 1 was a 48-year-old Indian man who presented with a 10-year history of generalized bone pain, multiple fractures, and muscle weakness and was bed-bound at the time of presentation. (medscape.com)
  • He was found to have an elevated serum alkaline phosphatase, a pseudo-fracture of the right scapula, multiple rib fractures, bilateral coxa vara, and femoral neck fractures. (medscape.com)
  • 4) Multiple fractures. (who.int)
  • Multiple births means you are carrying more than one baby (twins, triplets, quadruplets, etc. (webmd.com)
  • A jaw abnormality is a disorder in the formation, shape and/or size of the jaw. (wikipedia.org)
  • [ 2 ] Disseminated disease is known as multiple myeloma and carries a much less favorable prognosis than solitary plasmacytoma. (medscape.com)
  • meningioma, and multiple myeloma. (cdc.gov)
  • The histomorphology analysis of placentas from tolcapone treated mice exhibited abnormalities in trophoblast layer and the hampered trophoblast invasion in decidua. (biorxiv.org)
  • Special emphasis is placed on diseases and medication which cause altered metabolism, that may affect growth and tissue reactions. (wikipedia.org)
  • The weed plant needs various nutrients for steady growth and development. (amsterdammarijuanaseeds.com)
  • The cannabis growing mediums that you see on the market have a high value of micronutrients that plays a significant role in the growth and development of the plant. (amsterdammarijuanaseeds.com)
  • Generally, zinc contributes highly in facilitating physiological processes for the plants' growth and development. (amsterdammarijuanaseeds.com)
  • Lack of this nutrient causes multiple abnormalities in the growth and development of your cannabis plant. (amsterdammarijuanaseeds.com)
  • Genes are pieces of DNA (molecules that carry instructions for development, functioning, growth and reproduction) inside each cell that tell the cell what to do and when to grow and divide. (vicc.org)
  • After delivery, the newborn's growth and development depends on the severity and cause of IUGR. (adam.com)
  • Many patients have multiple abnormalities. (msdmanuals.com)
  • Some acute myeloid leukemia patients have an abnormality in the structure of a gene called FLT3. (vicc.org)
  • In AD HIES and sporadic cases, HIES manifests as a disease that affects multiple organ systems, including the skeleton, connective tissue, and dentition. (medscape.com)
  • Larger regions of connective tissue in developing skull where multiple sutures meet are called Fontanelles. (amrita.edu)
  • As growth and ossification progress, the connective tissue of the fontanelle is invaded and replaced by bone. (amrita.edu)
  • Epidermal growth factor receptor (EGFR) abnormalities relevant to tumor progression. (bvsalud.org)
  • Furthermore, in the mouse models, GMI was discovered to suppress tumor growth. (bvsalud.org)
  • Our study indicates that GMI is an EGFR degrader for inhibiting EGFR-expressing tumor growth. (bvsalud.org)
  • After the age of 2 years, delta SDS/year remained very stable (-0.1-0.2), concurring with growth velocities in the upper normal range. (nih.gov)