SecretorAntigensFUT2GeneHisto-bloodEnzymePhenotypePrecursorGenesSalivaRBCsProtective effectEntericVitroTypeStatusDonorInfectionsArticleCellCellsProductionHisto-blood groupSecretorAntigensImmune systemAntigenMicrobiomeNorovirusSerumExpressionSurveillanceGlycoproteinsReceptorsItemsClinicalResearchDiseaseStudy
Secretor14
- The synthesis of Lewis antigens depends on the interaction of the transferases produced by the Lewis and secretor genes. (keepnotes.com)
- The Lewis and secretor transferases preferentially fucosylate type 1 chains, whereas the H gene (FUT1) preferentially fucosylates type 2 chains. (keepnotes.com)
- o The Lewis fucosyltransferase (FuT 3) is more active than the secretor fucosyltransferase (FuT 2) in newborns, so more type 1 chains are available for conversion to Lea. (keepnotes.com)
- In secretor-fed infants, the relative abundance of the Bifidobacterium longum group was most strongly correlated with high percentages of the order Bifidobacteriale s. (biomedcentral.com)
- Conversely, in non-secretor-fed infants, Bifidobacterium breve was positively correlated with Bifidobacteriale s, while the B. longum group was negatively correlated. (biomedcentral.com)
- Known as the 'secretor' gene because of its role in the expression of ABO blood types in various secreted body fluids (tears, saliva, breast milk, and so on), this gene has well-known mutations that inactivate transferase activity which occur in most populations across the world, including in about 20% of the population of the United States [ 21 ]. (biomedcentral.com)
- The term ABH secretor , as used in blood banking, refers to secretion of ABO blood group antigens in fluids such as saliva, sweat, tears, semen, and serum. (n-equals-one.com)
- In the most rudimentary sense, the secretor gene ( FUT2 at 19q13.3) codes for the activity of the glycosyltransferases needed to assemble aspects of both the ABO and Lewis blood groups. (n-equals-one.com)
- Blood group O non-secretors are the most affected of the non-secretor blood types. (n-equals-one.com)
- Combining both ABH non-secretor phenotype and absence of the Lewis gene, Lewis (a- b-), the relative risk of chronic recurring vulvovaginal candidosis is between 2.41-4.39, depending on the analysis technique and control group. (n-equals-one.com)
- This is especially interesting in light of the fact that many of the fucosyltransferase enzymes convey blood group and/or secretor status. (n-equals-one.com)
- The autosomal dominant ABH secretor gene together with the ABO blood group gene controls the presence and specificity of A, B, and H blood group antigens in human gut mucin glycoproteins. (n-equals-one.com)
- There is evidence that the host's ABO blood group and secretor status affects the specificity of blood group-degrading enzymes produced by his fecal bacteria in vitro. (n-equals-one.com)
- 10) Comparatively small populations of fecal bacteria produce blood group-degrading enzymes but their presence is highly correlated with the ABO /secretor phenotype of the host: Fecal populations of B-degrading bacteria were stable over time, and their population density averaged 50,000-fold greater in blood group B secretors than in other subjects. (n-equals-one.com)
Antigens16
- Immunocytochemical analysis of the 3-D cultures also showed no detectable presence of histo-blood group antigens that participate in NV binding and host tropism. (cdc.gov)
- FUT2 encodes an enzyme that produces histo-blood group antigens (HBGA) on the surface of epithelial cells and in mucosal secretions ( 21 , 22 ). (cdc.gov)
- Development of Lewis antigens o Depending on the genes inherited, Lea and Leb glycoproteins will be present in the saliva of ewborns, but Lewis glycolipids are not detectable in the plasma until about 10 days after birth. (keepnotes.com)
- o Lewis antigens will start to appear shortly after birth, with Lea developing first when the Le gene is present. (keepnotes.com)
- It is based on the premise that individuals have antigens on their red blood cells (RBCs) that correspond to the four main blood groups: A, B, O, and AB. (medscape.com)
- Antibodies (isohemagglutinins) in an individual's plasma are directed against blood group antigens that their own RBCs lack (see Table 1, below). (medscape.com)
- These are the different transferases necessary to produce the various ABO antigens (mainly glycolipoproteins) on blood components. (medscape.com)
- this gene encodes for the transferases necessary to produce ABO antigens (mainly glycoproteins) that are affiliated with bodily fluids other than blood (eg, saliva). (medscape.com)
- The frequency of ABO blood group antigens varies in different populations. (medscape.com)
- Typical isoantigens are the BLOOD GROUP ANTIGENS. (lookformedical.com)
- Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)
- If people are ABH secretors, they will secrete antigens according to their blood groups. (n-equals-one.com)
- For example, group O people will secrete H antigen, group A people will secrete A and H antigens, etc. (n-equals-one.com)
- One of the innate defenses against superficial infections by Candida species appears to be the ability of an individual to secrete the water-soluble form of his ABO blood group antigens into body fluids. (n-equals-one.com)
- 5) The inability to secrete blood group antigens in saliva also appears to be a risk factor in the development or persistence of chronic hyperplastic candidosis. (n-equals-one.com)
- 9) Human feces contain enzymes produced by enteric bacteria that degrade the A, B, and H blood group antigens of gut mucin glycoproteins. (n-equals-one.com)
FUT25
- The mutations of fucosyltransferase genes α(1,2)-fucosyltransferase (FUT2 or Se) and α(1,3/1,4)- fucosyltransferase (FUT3 or Le), are responsible for the polymorphism of Lewis blood group phenotypes. (tmu.edu.tw)
- The methods used in this study are clinically applicable in population studies of the FUT2 gene polymorphism to explore relationships among different ethnic groups and correlations between phenotype and genotype. (tmu.edu.tw)
- A major finding from human NV volunteer studies is that persons with strains containing 2 mutated alleles of the α(1,2) fucosyltransferase ( FUT2 ) gene were resistant to NV infection ( 16 - 20 ). (cdc.gov)
- The Lewis gene (FUT3) is linked to Se (FUT2) and H (FUT1), all located on chromosome 19. (keepnotes.com)
- Among the genes that build HMGs in the mammary gland is the fucosyltransferase 2 (FUT2) gene, which catalyzes the transfer of fucose residues by an α1,2-linkage to glycans found in human milk. (biomedcentral.com)
Gene1
- This it does in concert with the gene for group O, or H ( FUT1 ). (n-equals-one.com)
Histo-blood1
- BACKGROUND: The human Lewis histo-blood group system belongs to a family of structurally related oligosaccharides. (tmu.edu.tw)
Enzyme1
- Alpha-2-L-fucosyltransferase is the enzyme responsible for adding fructose to the primary galactose of the oligosaccharide chain. (medscape.com)
Phenotype1
- o As a result, cord blood and RBCs from newborn infants phenotype as Le(a -b-). o Some can be shown to be weakly Le(a+) when tested with a potent anti-Lea or with methods more sensitive than direct agglutination. (keepnotes.com)
Precursor1
- HBGA are complex carbohydrates distinguished by different monosaccharides added to a precursor oligosaccharide by fucosyltransferase enzymes ( 2 3, 24 ). (cdc.gov)
Genes1
- Genome-wide comparison between healthy nonsmokers (n = 60) grouped as "high MUC5AC expressors" vs "low MUC5AC expressors" identified 528 genes significantly up-regulated and 15 genes significantly down-regulated in the high vs low expressors. (biomedcentral.com)
Saliva2
- It was known early in the century that ABO blood group substances occur in human tissues and secretions in two forms, water-soluble and alcohol-soluble, and that persons with these substances in saliva (secretors) have more water-soluble substances in their tissues than those lacking the substance in their saliva (non-secretors). (n-equals-one.com)
- One of the primary differences in physiology between secretors and non-secretors has to do with qualitative and quantitative differences in blood type antigen components of their saliva, mucus, and other body secretions. (n-equals-one.com)
RBCs2
- RBCs = red blood cells. (medscape.com)
- These individuals are known as Bombay and are able to receive only Bombay type blood, because they make antibodies to not only type A, B, or AB donor RBCs but also to type O donor red cells (anti-H), causing hemolysis of the transfused donor RBCs. (medscape.com)
Protective effect1
- To explore the role of α 1,3-fucosyltransferase in the mediation of rheumatoid arthritic inflammation, the protective effect of Sparstolonin B on rheumatoid arthritis (RA), and the mechanisms that regulate the NLRP3 inflammasome. (hindawi.com)
Enteric1
- BACKGROUND: Diabetes can lead to extensive damage to the enteric nervous system (ENS), causing gastrointestinal motility disorders. (bvsalud.org)
Vitro2
- From these critical studies, putative NV receptors were identified, and thus it was hypothesized that a successful in vitro cell culture system would most likely possess these receptors to support NV replication. (cdc.gov)
- We also performed in vitro experiments with Sparstolonin B and detected changes in 1,3-fucosyltransferase activity by ELISA. (hindawi.com)
Type4
- In the human gastroduodenal junction where NV has been shown to bind HBGA type 1 (Lewis b [Le b ]), is found exclusively on epithelial surfaces, whereas HBGA type 2 is primarily found at the glandular level ( 19 , 24 - 26 ). (cdc.gov)
- ABO grouping is a test performed to determine an individual's blood type. (medscape.com)
- Type O blood is the most frequent, and type B and AB are the least frequent (see Table 2, below). (medscape.com)
- A type and cross needs to be completed before blood is issued to prevent ABO incompatibility. (medscape.com)
Status1
- We found that VE was similar by age group, presence of underlying health conditions, and pregnancy status on the test date, as well as among immunocompromised participants. (cdc.gov)
Donor1
- ABO testing is performed to prevent an adverse transfusion reaction that could be caused by ABO incompatibility between the blood of a patient (recipient) and that of a donor. (medscape.com)
Infections1
- The lack of an efficient cell culture system in which to study NoV infections has hindered development of antiviral drugs to control or limit NoV outbreaks ( 5 ). (cdc.gov)
Article1
- Is the Subject Area "Blood groups" applicable to this article? (plos.org)
Cell1
- Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
Cells1
- Although lectins were already known because of their ability to agglutinate red blood cells, 3 the involvement of lectins and glycans in PCD had not been elucidated. (nature.com)
Production1
- These two groups are both involved in the production of short-chain fatty acids and lactate, which alter the pH of the environment, modulate the microbiota, and have other systemic properties [ 19 ]. (biomedcentral.com)
Histo-blood group4
- Immunocytochemical analysis of the 3-D cultures also showed no detectable presence of histo-blood group antigens that participate in NV binding and host tropism. (cdc.gov)
- FUT2 encodes an enzyme that produces histo-blood group antigens (HBGA) on the surface of epithelial cells and in mucosal secretions ( 21 , 22 ). (cdc.gov)
- The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and c. (nih.gov)
- 9. ABO histo-blood group might modulate predisposition to Crohn's disease and affect disease behavior. (nih.gov)
Secretor4
- Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype. (nih.gov)
- The activity of FUT2 and FUT3 is influenced by a woman's Secretor (Se) and Lewis (Le) blood group status. (dsm.com)
- It is well-established that approximately 80% of the global population carries the secretor gene - this group is called "secretors" - while approximately 20% do not and are referred to as "non-secretors. (dsm.com)
- A well-known case of individual variability is exemplified by the degree of OS fucosylation in human milk, which depends on the secretor/non-secretor and Lewis blood group statuses of different women [ 1 ]. (biomedcentral.com)
Antigens5
- It is based on the premise that individuals have antigens on their red blood cells (RBCs) that correspond to the four main blood groups: A, B, O, and AB. (medscape.com)
- Antibodies (isohemagglutinins) in an individual's plasma are directed against blood group antigens that their own RBCs lack (see Table 1, below). (medscape.com)
- These are the different transferases necessary to produce the various ABO antigens (mainly glycolipoproteins) on blood components. (medscape.com)
- The frequency of ABO blood group antigens varies in different populations. (medscape.com)
- We have previously shown that varicella-zoster virus (VZV) and cytomegalovirus (CMV) infection of diploid human fibroblasts (HEL) results in neo-expression of Lewis antigens sialyl Lewis x (sLe(x)) and Lewis y (Le(y)), respectively, after transcriptional activation of different combinations of dormant human fucosyltra. (shengsci.com)
Immune system4
- With clinical evidence for the ability of HMOs to support a balanced microbiome and the immune system, 6,7 these oligosaccharides have recently been added to infant formulas, offering some of the benefits of human milk to formula-fed infants. (dsm.com)
- Human OS can also improve the development of the newborn naive immune system [ 6 ] and brain [ 4 ]. (biomedcentral.com)
- Goblet cells dispersed among the intestinal epithelial cells are chiefly responsible for the synthesis and secretion of mucins within the gut and are heavily influenced by interactions with the immune system. (frontiersin.org)
- As the bridge between the internal and external environments, it is no surprise then that roughly 70% of the immune system resides within the GI tract ( 1 ). (frontiersin.org)
Antigen1
- Lewis antigen is regarded as a specific binding receptor for norovirus, and Lewis-like antigen is also present in oysters as a vehicle for norovirus transmission, but the pathway for synthesis of this carbohydrate in oysters has not been elucidated. (schinafish.cn)
Microbiome1
- 1. Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome. (nih.gov)
Norovirus1
- Specific recommendations include standardized collection of clinical specimens during norovirus outbreaks, use of two recently launched surveillance systems for reporting of norovirus outbreaks, and use of appropriate control measures focusing on hand hygiene, environmental disinfection, and exclusion of ill persons (Box). (cdc.gov)
Serum1
- Its larger kit size is ideal for high-throughput automated workflows used for the analysis of biological samples such as blood serum or plasma (see our workflow below). (ludger.com)
Expression2
- To investigate the impact of ST6GAL1 expression in experimental systems, we analyzed the transcriptome and the phenotype of the CRC cell lines SW948 and SW48 after retroviral transduction with ST6GAL1 cDNA. (shengsci.com)
- Induction of sialyl-Lex expression by herpes simplex virus type 1 is dependent on viral immediate early RNA-activated transcription of host fucosyltransferase genes. (shengsci.com)
Surveillance1
- CONCLUSION: We suggest to apply the same review standards of new drug development process to herbal preparations and incorporate them into the adverse drug reaction or poison surveillance system. (bvsalud.org)
Glycoproteins1
- Ludger V-Tag system is designed for the analysis of glycopeptides generated from the digestion of therapeutic glycoproteins such as monoclonal antibodies (mAb) . (ludger.com)
Receptors1
- From these critical studies, putative NV receptors were identified, and thus it was hypothesized that a successful in vitro cell culture system would most likely possess these receptors to support NV replication. (cdc.gov)
Items1
- Based on the food items listed in the 'Blood-Type' diets, subjects received one positive point for consuming one serving of each recommended food item and one negative point for consuming one serving of an item on the list of foods to avoid. (n-equals-one.com)
Clinical1
- The ABO test may be part of a group of tests performed in various clinical settings. (medscape.com)
Research2
- To this end, a group of DSM scientists recently completed research to assess and rank HMO concentration from healthy mothers throughout lactation at a global level. (dsm.com)
- Kidney and Blood Pressure Research 48 (1), pp. 424-435. (uni-regensburg.de)
Disease1
- The ABO system is regarded as the most important blood-group system in transfusion medicine because of severe hemolytic transfusion reactions and, to a lesser degree, hemolytic disease of the newborn . (medscape.com)
Study2
- The lack of an efficient cell culture system in which to study NoV infections has hindered development of antiviral drugs to control or limit NoV outbreaks ( 5 ). (cdc.gov)
- The study misclassifies numerous foods or lumps them into impossible-to-categorize groups. (n-equals-one.com)